Month: November 2022

Yuan, Yuehua; Zhou, Wenfa; Tian, Maozhong; Song, Jiangtao; Bai, Yunfeng; Feng, Feng; Song, Yinglin published an article in 2021. The article was titled 《Synthesis, characterization and third-order nonlinear optical behaviour of three novel ethyne-linked donor/acceptor chromophores》, and you may find the article in Dyes and Pigments.Name: 2,5-Dibromothiophene The information in the text is summarized as follows:

Three novel ethyne-linked donor/acceptor chromophores, BAB, BAS and SAS were synthesized. The results of BAB in femtosecond and nanosecond Z-scan at 532 nm reveal that the transition from saturable absorption (SA) to reverse saturable absorption (RSA), while that of BAS and SAS display RSA. The femtosecond Z-scan results for all compounds at 600 nm-800 nm indicate the obvious RSA, which can be mainly attributed to the two-photon absorption (TPA). The TA results demonstrate that all compounds display strong excited-state absorption and long lifetime, and the evolution of TA spectra for these compounds reveals the relaxation process from the local excited-state (LE) to charge transfer state (CTS). With different conjugation extent and intramol. charge transfer (ICT), the nonlinear response and excited-state dynamics of these chromophores could be dramatically modulated. The threshold of BAS/DCM solution excited at 532 nm with nanosecond pulse was 0.631 J/cm2. These compounds may be the potential candidates for future application in optical limiting. In the experiment, the researchers used 2,5-Dibromothiophene(cas: 3141-27-3Name: 2,5-Dibromothiophene)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used as starting reagent for the synthesis of α,α′-didecylquater-, -quinque- and -sexi-thiophenes.Name: 2,5-Dibromothiophene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pantelic, Nebojsa D.; Bozic, Bojan; Zmejkovski, Bojana B.; Banjac, Nebojsa R.; Dojcinovic, Biljana; Wessjohann, Ludger A.; Kaluderovic, Goran N. published an article in 2021. The article was titled 《In vitro evaluation of antiproliferative properties of novel organotin(IV) carboxylate compounds with propanoic acid derivatives on a panel of human cancer cell lines》, and you may find the article in Molecules.Name: Methyl 3-bromopropanoate The information in the text is summarized as follows:

The synthesis of novel triphenyltin(IV) compounds, Ph3SnLn (n = 1-3), with oxaprozin (3-(4,5-diphenyloxazol-2-yl)propanoic acid), HL1, and the new propanoic acid derivatives 3-(4,5-bis(4-methoxylphenyl)oxazol-2-yl)propanoic acid, HL2, and 3-(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)propanoic acid, HL3, has been performed. The ligands represent com. drugs or their derivatives and the tin complexes have been characterized by standard anal. methods. The in vitro antiproliferative activity of both ligands and organotin(IV) compounds has been evaluated on the following tumor cell lines: human prostate cancer (PC-3), human colorectal adenocarcinoma (HT-29), breast cancer (MCF-7), and hepatocellular cancer (HepG2), as well as on normal mouse embryonic fibroblast cells (NIH3T3) with the aid of MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-12 diphenyltetrazolium bromide) and CV (crystal violet) assays. Contrary to the inactive ligand precursors, all organotin(IV) carboxylates showed very good activity with IC50 values ranging from 0.100 to 0.758 μM. According to the CV assay (IC50 = 0.218 ± 0.025 μM), complex Ph3SnL1 demonstrated the highest cytotoxicity against the caspase 3 deficient MCF-7 cell line. Inductively coupled plasma mass spectrometry (ICP-MS) anal. indicated a two-fold lower concentration of tin in MCF-7 cells in comparison to platinum. To investigate the mechanism of action of the compound Ph3SnL1 on MCF-7 cells, morphol., autophagy and cell cycle anal., as well as the activation of caspase and ROS/RNS and NO production, has been performed. Results suggest that Ph3SnL1 induces caspase-independent apoptosis in MCF-7 cells.Methyl 3-bromopropanoate(cas: 3395-91-3Name: Methyl 3-bromopropanoate) was used in this study.

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Name: Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yang, Yu-Zhong; Li, Yang; Lv, Gui-Fen; He, De-Liang; Li, Jin-Heng published an article in 2022. The article was titled 《Nickel-Catalyzed C-S Reductive Cross-Coupling of Alkyl Halides with Arylthiosilanes toward Alkyl Aryl Thioethers》, and you may find the article in Organic Letters.Reference of (Bromomethyl)cyclopropane The information in the text is summarized as follows:

A nickel-catalyzed C-S reductive cross-coupling of alkyl halides with arylthiosilanes for producing alkyl aryl thioethers is developed. This reaction is initiated by umpolung transformations of arylthiosilanes followed by C-S reductive cross-coupling with alkyl halides to manage an electrophilic alkyl group onto the electrophilic sulfur atom and then construct a C(sp3)-S bond, and features exquisite chemoselectivity, excellent tolerance of diverse functional groups, and wide applications for late-stage modification of biol. relevant mols. The experimental process involved the reaction of (Bromomethyl)cyclopropane(cas: 7051-34-5Reference of (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Reference of (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kachkovskyi, Georgii; Cieslak, Marcin; Graczyk, Piotr; Zawadzki, Przemyslaw; Kalinowska-Tluscik, Justyna; Werlos, Mateusz published an article in 2022. The article was titled 《Photocatalytic Approach to α,α-Difluoroalkyl Alcohols》, and you may find the article in Synthesis.Quality Control of 4-Bromobutanoic acid The information in the text is summarized as follows:

A convenient approach to previously poorly accessible α,α-difluoroalkyl alcs. R1R2OHCCF2R3 [R1 = Ph, 3-MeC6H4, 4-MeOC6H4, etc.; R2 = H, Me; R3 = i-Pr, t-Bu, cyclohexyl, etc.] by visible light-mediated photocatalysis was developed. Broad scope of the transformation together with exptl. simplicity and scalability using flow techniques opened good prospects for further studies of properties (including biol.) of these novel products. The results came from multiple reactions, including the reaction of 4-Bromobutanoic acid(cas: 2623-87-2Quality Control of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Quality Control of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Biesen, Lukas; Krenzer, Julius; Nirmalananthan-Budau, Nithiya; Resch-Genger, Ute; Mueller, Thomas J. J. published an article in Chemical Science. The title of the article was 《Asymmetrically bridged aroyl-S,N-ketene acetal-based multichromophores with aggregation-induced tunable emission》.Safety of Tris(4-bromophenyl)amine The author mentioned the following in the article:

Asym. bridged aroyl-S,N-ketene acetals and aroyl-S,N-ketene acetal multichromophores can be readily synthesized in consecutive three-, four-, or five-component syntheses in good to excellent yields by several successive Suzuki-couplings of aroyl-S,N-ketene acetals and bis(boronic)acid esters. Different aroyl-S,N-ketene acetals as well as linker mols. yield a library of 23 multichromophores with substitution and linker pattern-tunable emission properties. This allows control of different communication pathways between the chromophores and of aggregation-induced emission (AIE) and energy transfer (ET) properties, providing elaborate aggregation-based fluorescence switches. In the experiment, the researchers used many compounds, for example, Tris(4-bromophenyl)amine(cas: 4316-58-9Safety of Tris(4-bromophenyl)amine)

In other references, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Safety of Tris(4-bromophenyl)amine

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Jung, Garyn L.; McDaniel, Katherine L.; LoPachin, Richard M.; Geohagen, Brian C.; Smith, Alicia; Huffstickler, Mitchell; Herr, David W. published an article in NeuroToxicology. The title of the article was 《In vivo neurophysiological assessment of in silico predictions of neurotoxicity: Citronellal, 3,4-dichloro-1-butene, and benzyl bromoacetate》.Application In Synthesis of Benzyl 2-bromoacetate The author mentioned the following in the article:

Neurotoxicants may be widespread in the environment and can produce serious health impacts in the human population. Screening programs that use in vitro methods have generated data for thousands of chems. However, these methods often do not evaluate repeated or prolonged exposures, which are required for many neurotoxic outcomes. Addnl., the data produced by such screening methods may not include mechanisms which play critical biol. roles necessary for in vivo neurotoxicity. The Hard and Soft Acids and Bases (HSAB) in silico model focuses on chem. structure and electrophilic properties which are important to the formation of protein adducts. A group of structurally diverse chems. have been evaluated with an in silico screening approach incorporating HSAB parameters. However, the predictions from the expanded chem. space have not been evaluated using in vivo methods. Three chems. predicted to be cumulative toxicants were selected for in vivo neurotoxicol. testing. Adult male Long-Evans rats were treated orally with citronellal (CIT), 3,4-dichloro-1-butene (DCB), or benzyl bromoacetate (BBA) for 8 wk. Behavioral observations were recorded weekly to assess motor function. Peripheral neurophysiol. measurements were derived from nerve excitability (NE) tests which involved compound muscle action potentials (CMAPs) in the tail and foot, and mixed nerve action potentials (MNAPs) in the tail. Compound nerve action potentials (CNAPs) and nerve conduction velocity (NCV) in the tail were also quantified. Peripheral inputs into the central nervous system were examined using somatosensory evoked potentials recorded from the cortex (SEPCTX) and cerebellum (SEPCEREB). CIT or BBA did not result in significant alterations to peripheral nerve or somatosensory function. DCB reduced grip-strength and altered peripheral nerve function. The MNAPs required less current to reach 50% amplitude and had a lower calculated rheobase, suggesting increased excitability. Increased CNAP amplitudes and greater NCV were also observed Novel changes were found in the SEPCTX with an abnormal peak forming in the early portion of the waveforms of treated rats, and decreased latencies and increased amplitudes were observed in SEPCEREB recordings. These data contribute to testing an expanded chem. space from an in silico HSAB model for predicting cumulative neurotoxicity and may assist with prioritizing chems. to protect human health. In the experiment, the researchers used Benzyl 2-bromoacetate(cas: 5437-45-6Application In Synthesis of Benzyl 2-bromoacetate)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is an aromatic chemical, usually appearing as a clear liquid with a moderate sweet-jasmine fragrance. This compound appears as a component of some of our fragrance blends.Application In Synthesis of Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Li, Cheng-Kun; Tao, Ze-Kun; Shoberu, Adedamola; Zhang, Wei; Zou, Jian-Ping published an article in Organic Letters. The title of the article was 《Copper-Catalyzed Cross-Coupling of Alkyl and Phosphorus Radicals for C(sp3)-P Bond Formation》.Recommanded Product: 8-Bromooctanoic acid The author mentioned the following in the article:

A Cu(I)-catalyzed cross-coupling of alkyl- and P-centered radicals for C(sp3)-P bond formation is introduced. Diacyl peroxides, generated in situ from aliphatic acids and H2O2, serve as a source for alkyl radicals and also an initiator for the generation of P radicals from H-P(O) compounds In the experiment, the researchers used 8-Bromooctanoic acid(cas: 17696-11-6Recommanded Product: 8-Bromooctanoic acid)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid.Recommanded Product: 8-Bromooctanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Lo, Chang-Lun; Akula, Pavan Sudheer; Hong, Bor-Cherng; Lee, Gene-Hsiang; Chien, Su-Ying published an article in Organic Letters. The title of the article was 《Total Synthesis of Ulodione A via a Double-Alkylation and DABCO Promoted Ring-Expansion Rearrangement Sequence》.COA of Formula: C7H13BrO2 The author mentioned the following in the article:

First total synthesis of ulodione A has been achieved via the key-step reactions of DIPEA-promoted dialkylation of 1,3-cyclopentadione with a bromonitroolefin and DABCO promoted/catalytic semipinacol-like ring-expansion rearrangement, with regioselective transformation of the nitrocyclohexane intermediates to their cyclopentenone counterparts via a sequence of reactions in a one-pot operation. Structures of six products were unequivocally established by X-ray crystallog. The results came from multiple reactions, including the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7COA of Formula: C7H13BrO2)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.COA of Formula: C7H13BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Inomata, Tomohiko; Matsunaga, Ayaka; Jin, Guangzhu; Kitagawa, Takuma; Muramatsu, Mizuho; Ozawa, Tomohiro; Masuda, Hideki published an article in RSC Advances. The title of the article was 《Improvements in photoelectric performance of dye-sensitised solar cells using ionic liquid-modified TiO2 electrodes》.Reference of 4-Bromobutanoic acid The author mentioned the following in the article:

One of the major problems in dye-sensitized solar cells (DSSCs) is the aggregation of dyes on TiO2 electrodes, which leads to undesirable electron transfer. Various anti-aggregation agents, such as deoxycholic acid, have been proposed and applied to prevent dye aggregation on the electrodes. In this study, we designed and synthesized a phosphonium-type ionic liquid that can be modified on the TiO2 electrode surface and used as a new anti-aggregation agent. Although the modification of the ionic liquid onto the electrode reduced the amount of dye adsorbed on the electrode, it showed a significant anti-aggregation effect, thereby improving the photovoltaic performance of DSSCs with N3 and J13 dyes. This finding suggests that ionic liquids are effective as anti-aggregation agents for DSSCs. The experimental part of the paper was very detailed, including the reaction process of 4-Bromobutanoic acid(cas: 2623-87-2Reference of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Reference of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Duan, Shengzu; Zi, Yujin; Wang, Lingling; Cong, Jielun; Chen, Wen; Li, Minyan; Zhang, Hongbin; Yang, Xiaodong; Walsh, Patrick J. published an article in Chemical Science. The title of the article was 《α-Branched amines through radical coupling with 2-azaallyl anions, redox active esters and alkenes》.Related Products of 1530-32-1 The author mentioned the following in the article:

Herein, a unique cascade reaction that enables the preparation of α-branched amines I (R = Me, Ad, oxan-4-ylmethyl, etc.; R1 = H, Me, Ph; R2 = Ph; R1R2 = -(CH2)2CH(Ph)(CH2)2-; R3 = H, Me; R4 = Ph, 4-chlorophenyl, furan-3-yl, etc.) and 3-methyl-1,2,2-triphenylpentan-1-amine bearing aryl or alkyl groups at the β- or γ-positions is reported. The cascade is initiated by reduction of redox active esters II to alkyl radicals. The resulting alkyl radicals are trapped by styrene derivatives, R1C(R2)=CHR3 leading to benzylic radicals. The persistent 2-azaallyl radicals and benzylic radicals are proposed to undergo a radical-radical coupling leading to functionalized amine products I and 3-methyl-1,2,2-triphenylpentan-1-amine. Evidence is provided that the role of the nickel catalyst is to promote formation of the alkyl radical from the redox active ester and not promote the C-C bond formation. The synthetic method introduced herein tolerates a variety of imines III and redox active esters II, allowing for efficient construction of amine building blocks. The experimental part of the paper was very detailed, including the reaction process of Ethyltriphenylphosphonium bromide(cas: 1530-32-1Related Products of 1530-32-1)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.Related Products of 1530-32-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary