Month: November 2022

In 2017,Yamada, Takeshi; Miki, Shouta; Ul’Husna, Anisa; Michikawa, Akiko; Nakatani, Kazuhiko published 《Synthesis of Naphthyridine Carbamate Dimer (NCD) Derivatives Modified with Alkanethiol and Binding Properties of G-G Mismatch DNA》.Organic Letters published the findings.Product Details of 3395-91-3 The information in the text is summarized as follows:

Bis(naphthyridinecarbamates) of (mercaptoalkyl)dipropanolamines were prepared as thiol-containing DNA-binding compounds selective for G-G mismatches; in the presence of the G-G mismatch, the compounds undergo dimerization to form DNA complexes of the corresponding disulfides. The disulfide dimers of the naphthyridinecarbamates of (mercaptoalkyl)dipropanolamines produced 1:1 complexes with the dsDNA 5′-TCAACGGTTGA-3′:3′-AGTTGGCAACT-5′ with improved thermal stability and with higher pos. cooperativities than the corresponding thiols. The dimerization of bis(naphthyridinecarbamate) of a (mercaptoalkyl)dipropanolamine was selectively accelerated in the presence of CGG repeat DNA but not on CAG repeat DNA. In the experiment, the researchers used Methyl 3-bromopropanoate(cas: 3395-91-3Product Details of 3395-91-3)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Product Details of 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2018,Hu, Xiao-Qiang; Hu, Zhiyong; Zhang, Guodong; Sivendran, Nardana; Goossen, Lukas J. published 《Catalytic C-N and C-H Bond Activation: ortho-Allylation of Benzoic Acids with Allyl Amines》.Organic Letters published the findings.Recommanded Product: 76006-33-2 The information in the text is summarized as follows:

A facile insertion of ruthenium into aromatic C-H and allylic C-N bonds are the key steps in a [Ru(p-cymene)Cl2]2-catalyzed ortho-C-H allylation of benzoic acids. This protocol allows drawing on the large pool of allylic amines for state-of-the-art ortho-functionalizations of arenes I (R = 2-Et, 2-F, 3-Me, etc.), turning neutral amines into leaving groups. Concise syntheses of biol. active compounds provide further evidence of the synthetic potential of this methodol. In the experimental materials used by the author, we found 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Recommanded Product: 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Recommanded Product: 76006-33-2Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2018,Novikova, Daria S.; Grigoreva, Tatyana A.; Zolotarev, Andrey A.; Garabadzhiu, Alexander V.; Tribulovich, Vyacheslav G. published 《Advanced palladium free approach to the synthesis of substituted alkene oxindoles via aluminum-promoted Knoevenagel reaction》.RSC Advances published the findings.Recommanded Product: Methyl 3-(bromomethyl)benzoate The information in the text is summarized as follows:

A synthetic route for the synthesis of (E)-3-((3-((4-Chlorophenyl)(phenyl)methylene)-2-oxoindolin-1-yl)methyl)benzoic acid (I), as well as for the design of focused libraries of direct AMP-activated protein kinase (AMPK) activators was developed based on a convergent strategy. The proposed scheme corresponded to the current trends in C-H bond functionalization. The use of aluminum isopropoxide as catalyst for synthesis of substituted indolinones II [R1 = H, 4-Cl, 4-OMe, etc.; R2 = H, Me, Ph, etc.; stereo = E, Z] via Knoevenagel condensation of oxindole with benzophenones was a noticeable point of this work.Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Recommanded Product: Methyl 3-(bromomethyl)benzoate) was used in this study.

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Recommanded Product: Methyl 3-(bromomethyl)benzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2018,Nishimoto, Yoshihiro; Yi, Junyi; Takata, Tatsuaki; Baba, Akio; Yasuda, Makoto published 《Regio- and stereoselective allylindation of alkynes using InBr3 and allylic silanes: synthesis, characterization, and application of 1,4-dienylindiums toward skipped dienes》.Molecules published the findings.Electric Literature of Br3In The information in the text is summarized as follows:

Regioselective anti-allylindation of alkynes was achieved using InBr3 and allylic silanes. Various types of alkynes and allylic silanes were applicable to the present allylindation. This sequential process used the generated 1,4-dienylindiums to establish novel synthetic methods for skipped dienes. The 1,4-dienylindiums were characterized by spectral anal. and treated with I2 to stereoselectively give 1-iodo-1,4-dienes. The Pd-catalyzed cross coupling of 1,4-dienylindium with iodobenzene successfully proceeded in a one-pot manner to afford the corresponding 1-aryl-1,4-diene. In the experiment, the researchers used Indium(III) bromide(cas: 13465-09-3Electric Literature of Br3In)

Indium(III) bromide(cas: 13465-09-3) is used in organic synthesis as a water tolerant Lewis acid. It efficiently catalyzes the three-component coupling of β-keto esters, aldehydes and urea (or thiourea) to afford the corresponding dihydropyrimidinones.Electric Literature of Br3In

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,ChemPhysChem included an article by Urner, Leonhard H.; Schade, Boris; Schulze, Maiko; Folmert, Kristin; Haag, Rainer; Pagel, Kevin. Electric Literature of C4H7BrO2. The article was titled 《Switchable Solubility of Azobenzene-Based Bolaamphiphiles》. The information in the text is summarized as follows:

The ability to design amphiphiles with predictable solubility properties is of everlasting interest in supramol. chem. Relevant structural parameters include the hydrophobic-hydrophilic balance and structural flexibility. In this work, we investigate the water solubility of azobenzene-based triglycerol bolaamphiphiles (TGBAs). In particular, we analyzed the structural effects of backbone hydrophobicity, flexibility, and cis/trans isomerization on the water solubility of a subset of five TGBAs. This leads to the first example of a non-ionic bolaamphiphile whose water solubility can be changed by irradiation with light. The underlying kinetics were monitored using liquid chromatog. and a closer anal. of the underlying aggregation processes provides a mechanistic understanding of the light-driven dissolution process. We anticipate that the results obtained will help to engineer bolaamphiphiles with predictable solution properties in the future. In addition to this study using 4-Bromobutanoic acid, there are many other studies that have used 4-Bromobutanoic acid(cas: 2623-87-2Electric Literature of C4H7BrO2) was used in this study.

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Electric Literature of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Dyes and Pigments included an article by Ma, Xiao-Qiang; Wang, Yun; Wei, Tai-Bao; Qi, Li-Hua; Jiang, Xiao-Mei; Ding, Jin-Dong; Zhu, Wen-Bo; Yao, Hong; Zhang, You-Ming; Lin, Qi. Computed Properties of C6H12Br2. The article was titled 《A novel AIE chemosensor based on quinoline functionalized Pillar[5]arene for highly selective and sensitive sequential detection of toxic Hg2+ and CN-》. The information in the text is summarized as follows:

Aggregation-induced emission (AIE) is widely used for fluorescence on-off-on detection ions and mol. Herein, the authors report a novel AIE chemosensor through self-assembly of quinoline functionalized pillar[5]arene (SPQ5). The SPQ5 can bind with Hg2+ tightly through coordinating reaction. By introducing Hg2+ into AIE-based chemosensor, metal-coordinated chemosensor (SPQ5-Hg2+) was obtained, the SPQ5-Hg2+ could high selectively and sensitively detection of CN- by competitive coordinating interactions. The LODs of SPQ5 for Hg2+ and CN- are 2.53 × 10-8 M and 7.71 × 10-8 M, resp. Hg2+ test kit was prepared by loading the SPQ5 chemosensor on a silica gel plate, which could more convenient and efficiency detection Hg2+ and CN-. The chemosensor SPQ5 could instant sense the Hg2+ and CN- by the changing of fluorescence color and fluorescence intensity. Notably, the fluorescence intensity changes of SPQ5 upon the addition of Hg2+ and CN- were used as an IMP logic gate at the mol. level, using Hg2+ and CN- as chem. inputs and the fluorescence intensity signal as the output. However, the test kit by loading SPQ5 on a silica gel plate was prepared for convenient detection of Hg2+. This study provides a practical application for the sensing of toxic ions in aqueous solution by the construction of supramol. system. In the part of experimental materials, we found many familiar compounds, such as 1,6-Dibromohexane(cas: 629-03-8Computed Properties of C6H12Br2)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.Computed Properties of C6H12Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Organic Letters included an article by Tian, Ming-Qing; Wang, Cong; Hu, Xu-Hong; Loh, Teck-Peng. Synthetic Route of C4H7Br. The article was titled 《Divergent C-H Oxidative Radical Functionalization of Olefins to Install Tertiary Alkyl Motifs Enabled by Copper Catalysis》. The information in the text is summarized as follows:

An efficient tertiary alkylation reaction of olefins with 1,3-dicarbonyl compounds was developed by virtue of copper catalyst without the use of expensive ligands or additives. In contrast to alkyl Heck-type reaction, alkyl halide is not required. Notably, by varying the nitrogen and air atm., the reaction selectively produces alkylation and alkylation-oxygenation products, resp. Initial investigations revealed that an α-carbonyl alkyl radical species might be involved in the process. In addition to this study using (Bromomethyl)cyclopropane, there are many other studies that have used (Bromomethyl)cyclopropane(cas: 7051-34-5Synthetic Route of C4H7Br) was used in this study.

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Synthetic Route of C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Electrochimica Acta included an article by Wu, Hong Yue; Yang, Qian; Gao, Xue Lang; Zhu, Zhao Yu; Sun, Qi Hui; Zhang, Qiu Gen; Zhu, Ai Mei; Liu, Qing Lin. Quality Control of 1,6-Dibromohexane. The article was titled 《Novel crosslinked aliphatic anion exchange membranes with pendant pentafluorophenyl groups》. The information in the text is summarized as follows:

To enhance the performance of anion exchange membranes (AEMs) by constructing effective ion channels, the authors synthesized novel aliphatic polymers with pentafluorophenyl pendent groups via superacid catalyzed polyhydroxyalkylation and quaternization by grafting multi-cation crosslinker through the Menshutkin reaction. The procedure adopted in this study for preparing the AEMs circumvented the use of precious metal catalysts and made it easy to control the reaction conditions. Compared with the traditional aliphatic AEMs, the AEMs prepared by the new strategy exhibited well-developed microphase-separated structures by increasing the hydrophilic/hydrophobic difference between the polymer backbones and the side chains. Also, the multi-cation crosslinker not only provides ion exchange groups but also constrains the swelling of the AEMs. As the authors expected, the well-defined ion channels were validated by TEM and small angle x-ray scattering (SAXS). The CPFBP-TQA-100 membrane shows a highest ion conductivity of 76.85 mS cm-1 and a swelling ratio of only 24.8% at 80°. A maximum power d. of 116.7 mW cm-2 is achieved by a single cell using the CPFBP-TQA-100 membrane at a c.d. of 300 mA cm-2 at 80°. Besides, all the AEMs display excellent thermal stability and reasonable alk. stability. The results came from multiple reactions, including the reaction of 1,6-Dibromohexane(cas: 629-03-8Quality Control of 1,6-Dibromohexane)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.Quality Control of 1,6-Dibromohexane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Visible-light-mediated Minisci C-H alkylation of heteroarenes with unactivated alkyl halides using O2 as an oxidant》 were Dong, Jianyang; Lyu, Xueli; Wang, Zhen; Wang, Xiaochen; Song, Hongjian; Liu, Yuxiu; Wang, Qingmin. And the article was published in Chemical Science in 2019. Category: bromides-buliding-blocks The author mentioned the following in the article:

A protocol for direct visible-light-mediated Minisci C-H alkylation of heteroarenes, e.g., lepidine with unactivated alkyl halides RX (R = Pr, benzyl, 2-phenoxyethyl, adamantan-1-yl, etc.; X = Br, I) using mol. oxygen as an oxidant at room temp was reported. This mild protocol is compatible with a wide array of sensitive functional groups and has a broad substrate scope. Notably, functionalization of heterocyclic compounds e.g., I with unactivated alkyl halides proceeds smoothly under the standard conditions. The robustness of this protocol is further demonstrated by the late-stage functionalization of complex nitrogen-containing natural products and drugs e.g., II. In the experiment, the researchers used (Bromomethyl)cyclopropane(cas: 7051-34-5Category: bromides-buliding-blocks)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Catalyst-free ambient temperature synthesis of isoquinoline-fused benzimidazoles from 2-alkynylbenzaldehydes via alkyne hydroamination》 were Mishra, Manisha; Twardy, Dylan; Ellstrom, Clifford; Wheeler, Kraig A.; Dembinski, Roman; Torok, Bela. And the article was published in Green Chemistry in 2019. Electric Literature of C7H5BrO The author mentioned the following in the article:

An efficient environmentally benign route for the synthesis of benzimidazo[2,1-a]isoquinoline has been developed by reacting 2-ethynylbenzaldehyde and related substituted alkynylbenzaldehydes with variously substituted ortho-phenylenediamines and aliphatic amines in ethanol. This method provides a convenient, room temperature, atom-economical, and catalyst-free access to diversely substituted isoquinoline fused benzimidazoles. Regioselectivity of the reaction, as referred to o-phenylenediamines, was confirmed by X-ray crystallog. The reaction was found to occur in three major steps (imine formations, cyclization, and aromatization) and a mechanism has been proposed. In addition to this study using o-Bromobenzaldehyde, there are many other studies that have used o-Bromobenzaldehyde(cas: 6630-33-7Electric Literature of C7H5BrO) was used in this study.

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Electric Literature of C7H5BrOSynthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary