Month: November 2022

《Ferrocene functionalized upconversion nanoparticle nanosystem with efficient near-infrared-light-promoted fenton-like reaction for tumor growth suppression》 was written by Zhou, Jimin; Zhu, Xiangfeng; Cheng, Qianya; Wang, Yuxuan; Wang, Ruiqi; Cheng, Xingwen; Xu, Jiajia; Liu, Kuntang; Li, Lin; Li, Xueming; He, Mingfang; Wang, Jian; Xu, Heng; Jing, Su; Huang, Ling. Synthetic Route of C4H7BrO2 And the article was included in Inorganic Chemistry in 2020. The article conveys some information:

By taking advantage of the efficient Forster resonance energy transfer (FRET) between near-IR (NIR)-responsive lanthanide-doped upconversion nanoparticles (UCNPs) and Fenton reagent ferrocenyl compounds (Fc), a series of Fc-UCNPs was designed by functionalizing NaYF4:Yb,Tm nanoparticles with Fc1-Fc5via surface-coordination chem. Fc-UCNP-Lipo nanosystems were then constructed by encapsulating Fc-UCNP inside liposomes for efficient delivery. Fc-UCNP can effectively release ·OH via a NIR-promoted Fenton-like reaction. In vitro and in vivo studies of Fc1-UCNP-Lipo confirmed the preferential accumulation in a tumor site followed by an enhanced uptake of cancer cells. After cellular internalization, the released Fc1-UCNP can effectively promote ·OH generation for tumor growth suppression. Such a Fc1-UCNP-Lipo nanosystem exhibits advantages such as easy fabrication, low drug dosage, and no ferrous ion release. By integrating the advantages of NIR-responsive lanthanide-doped UCNPs, a ferrocenyl compound Fc that catalyzes intracellular H2O2 for ·OH generation in tumor sites, as well as good delivery capability of liposomes, Fc-UCNP-Lipo nanosystem was constructed to realize significant tumor growth suppression via a NIR-promoted Fenton-like reaction. A good overlap of absorption spectra of Fc and emission spectra of UCNP is essential for efficient FRET. This nanosystem exhibits merits of low dosage and sustained and on-demand cancer therapy. In the part of experimental materials, we found many familiar compounds, such as 4-Bromobutanoic acid(cas: 2623-87-2Synthetic Route of C4H7BrO2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Synthetic Route of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Highly Active Manganese-Based CO2 Reduction Catalysts with Bulky NHC Ligands: A Mechanistic Study》 was written by Yang, Yong; Zhang, Zhenyu; Chang, Xiaoyong; Zhang, Ya-Qiong; Liao, Rong-Zhen; Duan, Lele. Safety of Bromopentacarbonylmanganese(I) And the article was included in Inorganic Chemistry in 2020. The article conveys some information:

Because of the strong σ-donor and weak π-acceptor of the N-heterocyclic carbene (NHC), Mn-NHC complexes are active for the reduction of CO2 to CO with high activity. However, some NHC-based Mn complexes showed low catalytic activity and required very neg. potentials. The authors report herein that complex fac-[MnI(bis-MesNHC)(CO)3Br] [1; bis-MesNHC = 3,3-bis(2,4,6-trimethylphenyl)-(1,1′-diimidazolin-2,2′-diylidene)methane] could catalyze the electrochem. reduction of CO2 to CO with high activity (TOFmax = 3180 ± 6 s-1) at a less neg. potential. Due to the introduction of the bulky Mes groups, a 1-electron-reduced intermediate {[Mn0(bis-MesNHC)(CO)3]0 (2•)} was isolated as a packed dimer and crystallog. characterized. Stopped-flow FTIR spectroscopy was used to prove the direct reaction between doubly reduced intermediate fac-[Mn(bis-MesNHC)(CO)3]- and CO2; the tetracarbonyl Mn complex [Mn+(bis-MesNHC)(CO)4]+ ([2-CO]+) was captured, and its further reduction proposed as the rate-limiting step. The Mes groups on the NHC ligand improve the catalytic performance of 1 with respect to electrochem. reduction of CO2 to CO. The rate-limiting step probably is the reduction of the tetracarbonyl Mn+ species. In the experimental materials used by the author, we found Bromopentacarbonylmanganese(I)(cas: 14516-54-2Safety of Bromopentacarbonylmanganese(I))

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Safety of Bromopentacarbonylmanganese(I)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《A Mechanistic and Cautionary Case Study on the Use of Alternating Potential in Electrochemical Reactions》 was written by Wills, Alfie G.; Poole, Darren L.; Alder, Catherine M.; Reid, Marc. Application of 4316-58-9 And the article was included in ChemElectroChem in 2020. The article conveys some information:

A mechanistic study on use of alternating potential (i. e. electrode polarity switching) in synthetic organic electrochem. method development using the IKA ElectraSyn 2.0 is described. Unexpected product selectivity challenges revealed that alternating potential facilitated direct, rather than mediated, electrochem. benzylic C-H oxidation of toluene derivatives While constant potential irresp. of the direction of electrode polarity was expected, our in-depth anal. revealed changes in the magnitude of applied potential with periodic switching of electrode polarity. These findings highlight an equipment engineering concern that is likely to influence and inform optimization strategies for a wide range of synthetic organic electrochem. methods under development. The results came from multiple reactions, including the reaction of Tris(4-bromophenyl)amine(cas: 4316-58-9Application of 4316-58-9)

In other references, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Application of 4316-58-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Molecularly engineered hole-transport material for low-cost perovskite solar cells》 was written by Pashaei, Babak; Bellani, Sebastiano; Shahroosvand, Hashem; Bonaccorso, Francesco. Product Details of 4316-58-9 And the article was included in Chemical Science in 2020. The article conveys some information:

Triphenylamine-N-phenyl-4-(phenyldiazenyl)aniline (TPA-AZO) is synthesized via a facile CuI-catalyzed reaction and used as a hole transport material (HTM) in perovskite solar cells (PSCs), as an alternative to the expensive spiro-type mol. materials, including com. 2,2′,7,7′-tetrakis[N,N-di(4-methoxyphenyl)amino]-9,9′-spirobifluorene (spiro-OMeTAD). Exptl. and computational investigations reveal that the HOMO (HOMO) level of TPA-AZO is deeper than that of spiro-OMeTAD, and optimally matches with the conduction band of the perovskite light absorber. The use of TPA-AZO as a HTM results in PSC prototypes with a power conversion efficiency (PCE) approaching that of the spiro-OMeTAD-based reference device (17.86% vs. 19.07%). Moreover, the use of inexpensive starting reagents for the synthesis of TPA-AZO makes the latter a new affordable HTM for PSCs. In particular, the cost of 1 g of TPA-AZO ($22.76) is significantly lower compared to that of spiro-OMeTAD ($170-475). Overall, TPA-AZO-based HTMs are promising candidates for the implementation of viable PSCs in large-scale production In the experiment, the researchers used Tris(4-bromophenyl)amine(cas: 4316-58-9Product Details of 4316-58-9)

In general, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Product Details of 4316-58-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Masked phenolic-selenium conjugates: potent and selective antiproliferative agents overcoming P-gp resistance》 was written by Begines, Paloma; Sevilla-Horrillo, Lucia; Puerta, Adrian; Puckett, Rebecca; Bayort, Samuel; Lagunes, Irene; Maya, Ines; Padron, Jose M.; Lopez, Oscar; Fernandez-Bolanos, Jose G.. Reference of 4-Bromobutanoic acid And the article was included in Pharmaceuticals in 2020. The article conveys some information:

Cancer accounts for one of the most complex diseases nowadays due to its multifactorial nature. Despite the vast number of cytotoxic agents developed so far, good therapeutic approaches are not always reached. In recent years, multitarget drugs are gaining great attention against multifactorial diseases in contraposition to polypharmacy. Herein we have accomplished the conjugation of phenolic derivatives with an ample number of organochalcogen motifs with the aim of developing novel antiproliferative agents. Their antioxidant, and antiproliferative properties (against six tumor and one non-tumor cell lines) were analyzed. Moreover, in order to predict P-gp-mediated chemoresistance, the P-glycoprotein assay was also conducted in order to determine whether compounds prepared herein could behave as substrates of that glycoprotein. Selenium derivatives were found to be significantly stronger antiproliferative agents than their sulfur isosters. Moreover, the length and the nature of the tether, together with the nature of the organoselenium scaffold were also found to be crucial features in the observed bioactivities. The lead compound, bearing a methylenedioxyphenyl moiety, and a diselenide functionality, showed a good activity (GI50 = 0.88-2.0μM) and selectivity towards tumor cell lines (selectivity index: 14-32); moreover, compounds considered herein were not substrates for the P-gp efflux pump, thus avoiding the development of chemoresistance coming from such mechanism, commonly found for widely-used chemotherapeutic agents. The results came from multiple reactions, including the reaction of 4-Bromobutanoic acid(cas: 2623-87-2Reference of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Reference of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Monsigny, Louis; Cejas Sanchez, Joel; Piatkowski, Jakub; Kajetanowicz, Anna; Grela, Karol published their research in Organometallics in 2021. The article was titled 《Synthesis and Catalytic Properties of a Very Latent Selenium-Chelated Ruthenium Benzylidene Olefin Metathesis Catalyst》.Safety of Ethyltriphenylphosphonium bromide The article contains the following contents:

Herein, authors describe a study of the synthesis, characterization, and catalytic properties of a cis-dichlorido seleno-chelated Hoveyda-Grubbs type complex (Ru8). Such a complex has been obtained through a straightforward and high-yielding synthetic protocol in three steps from the com. available 2-bromobenzaldehyde in good overall yield (54%). The catalytic profile, especially the latency of this complex, has been probed through selected olefin metathesis reactions such as ring-closing metathesis (RCM), self-cross-metathesis (self-CM) and ring-opening metathesis polymerization (ROMP). In addition to its high latency, the selenium Hoveyda-type complex Ru8 exhibits a switchable behavior upon thermal activation. Of interest, while the corresponding sulfur-chelated Hoveyda type catalyst is reported to be only activated by heat, the selenium analog was active upon both heat and light irradiation The results came from multiple reactions, including the reaction of Ethyltriphenylphosphonium bromide(cas: 1530-32-1Safety of Ethyltriphenylphosphonium bromide)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. It is also used as catalysts in the synthesis of certain organic compounds and as a pharmaceutical intermediate.Safety of Ethyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Klingstedt, Therese; Shirani, Hamid; Ghetti, Bernardino; Vidal, Ruben; R. Nilsson, K. Peter published their research in ChemBioChem in 2021. The article was titled 《Thiophene-Based Optical Ligands That Selectively Detect Aβ Pathology in Alzheimer′s Disease》.Synthetic Route of C4H2Br2S The article contains the following contents:

In several neurodegenerative diseases, the presence of aggregates of specific proteins in the brain is a significant pathol. hallmark; thus, developing ligands able to bind to the aggregated proteins is essential for any effort related to imaging and therapeutics. Here we report the synthesis of thiophene-based ligands containing nitrogen heterocycles. The ligands selectively recognized amyloid-β (Aβ) aggregates in brain tissue from individuals diagnosed neuropathol. as having Alzheimer′s disease (AD). The selectivity for Aβ was dependent on the position of nitrogen in the heterocyclic compounds, and the ability to bind Aβ was shown to be reduced when introducing anionic substituents on the thiophene backbone. Our findings provide the structural and functional basis for the development of ligands that can differentiate between aggregated proteinaceous species comprised of distinct proteins. These ligands might also be powerful tools for studying the pathogenesis of Aβ aggregation and for designing mols. for imaging of Aβ pathol. In the experimental materials used by the author, we found 2,5-Dibromothiophene(cas: 3141-27-3Synthetic Route of C4H2Br2S)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used in the preparation of soluble α,ω-diformyl-a-oligothiophenes.Synthetic Route of C4H2Br2S

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Yahuan; Wang, Zheng; Zhao, Ziwei; Gao, Pengxiang; Ma, Ning; Liu, Qingbin published their research in Molecular Catalysis in 2021. The article was titled 《Efficient base-free hydrodehalogenation of organic halides catalyzed by a well-defined diphosphine-ruthenium(II) complex》.Related Products of 2635-13-4 The article contains the following contents:

A base-free, robust catalytic system based on the diphosphine-ruthenium(II) complex cation has been developed for the hydrodehalogenation of a wide range of aryl- and alkyl-chlorides/bromides (27 examples) with mol. hydrogen. Notably, the reaction proceeds at 120°C with low catalyst loading (0.1 mol%) and exhibits a good tolerance toward functional groups, such as amido, carboxyl, sulfonyl, methoxyl, ester groups. Moreover, a mechanism for the diphosphine-ruthenium(II) complex cation catalyzed dehalogenation process has been proposed. This hydrodehalogenation methodol. shows a potential application for the organic transformation and degradation of organic halides.5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Related Products of 2635-13-4) was used in this study.

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Related Products of 2635-13-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Kai; Deng, Zi-Hao; Xie, Si-Jun; Zhai, Dan-Dan; Fang, Hua-Yi; Shi, Zhang-Jie published their research in Nature Communications in 2021. The article was titled 《Synthesis of arylamines and N-heterocycles by direct catalytic nitrogenation using N2》.HPLC of Formula: 7073-94-1 The article contains the following contents:

Herein, an example of direct catalytic nitrogenation was reported to afford valuable diarylamines, triarylamines, and N-heterocycles from easily available organohalides using dinitrogen (N2) as the nitrogen source in a one-pot/two-step protocol. In this protocol, lithium nitride, generated in situ with the use of lithium as a reductant, was confirmed as a key intermediate. Structurally diversified polyanilines were also generated in one pot, showing great potential for materials chem. This chem. provided an alternative pathway for catalytic nitrogenation to synthesize highly valuable N-containing chems. from dinitrogen. With this method, 15N atoms were easily incorporated into organic mols. In the experimental materials used by the author, we found 1-Bromo-2-isopropylbenzene(cas: 7073-94-1HPLC of Formula: 7073-94-1)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. HPLC of Formula: 7073-94-1 Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Xin; Liu, Jun; Chen, Jinyao; Zhang, Ming; Tian, Chuan; Peng, Xiaoping; Li, Gang; Chang, Wenqiang; Lou, Hongxiang published their research in Bioorganic Chemistry in 2021. The article was titled 《Azole-triphenylphosphonium conjugates combat antifungal resistance and alleviate the development of drug-resistance》.HPLC of Formula: 17696-11-6 The article contains the following contents:

Azole antifungals are commonly used to treat fungal infections but have resulted in the occurrence of drug resistance. Therefore, developing azole derivatives (AZDs) that can both combat established drug-resistant fungal strains and evade drug resistance is of great importance. In this study, we synthesized a series of AZDs with a fluconazole (FLC) skeleton conjugated with a mitochondria-targeting triphenylphosphonium cation (TPP+). These AZDs displayed potent activity against both azole-sensitive and azole-resistant Candida strains without eliciting obvious resistance. Moreover, two representative AZDs, I and II, exerted synergistic antifungal activity with Hsp90 inhibitors against C. albicans strains resistant to the combination treatment of FLC and Hsp90 inhibitors. AZD 25, which had minimal cytotoxicity, was effective in preventing C. albicans biofilm formation. Mechanistic investigation revealed that AZD II inhibited the biosynthesis of the fungal membrane component ergosterol and interfered with mitochondrial function. Our findings provide an alternative approach to address fungal resistance problems. The experimental part of the paper was very detailed, including the reaction process of 8-Bromooctanoic acid(cas: 17696-11-6HPLC of Formula: 17696-11-6)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid.HPLC of Formula: 17696-11-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary