Month: November 2022

Liu, Yong-Liang; Wang, Xiao-Ping; Li, Ya published an article in 2022. The article was titled 《Lewis Base-catalyzed β-Addition of (Arylsulfonyl) fluoromethane Derivatives to Allenoates》, and you may find the article in ChemistrySelect.Quality Control of Benzyl 2-bromoacetate The information in the text is summarized as follows:

A highly selective TMG-catalyzed β-addition of (arylsulfonyl)fluoromethane derivatives to allenoates has been developed. Cyano, nitro, and ester-functionalized (arylsulfonyl)fluoromethanes were all suitable substrates, giving a series of structurally diverse β-addition products bearing a stereogenic fluorinated carbon center. A possible reaction pathway was also presented. After reading the article, we found that the author used Benzyl 2-bromoacetate(cas: 5437-45-6Quality Control of Benzyl 2-bromoacetate)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is a synthetic chemical produced for industry from benzyl alcohol and acetic acid, but is also naturally present in the essential oils of many plants, including jasmine and ylang ylang.Quality Control of Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kvasovs, Nikita; Gevorgyan, Vladimir published an article in 2022. The article was titled 《Accessing Illusive E Isomers of α-Ester Hydrazones via Visible-Light-Induced Pd-Catalyzed Heck-Type Alkylation》, and you may find the article in Organic Letters.Category: bromides-buliding-blocks The information in the text is summarized as follows:

A visible-light-induced Pd-catalyzed stereoselective synthesis of alkylated ester hydrazones has been developed. This method operates via generation of a nucleophilic carbon-centered radical from alkyl bromide, iodide, or redox-active ester, followed by its addition to hydrazones, and a subsequent desaturation by palladium. The majority of products have E configuration, which are inaccessible by conventional condensation methods. In addition, a sequential C,N-alkylation protocol has been developed: a reaction between 1,3-dihalides and glyoxylate-derived hydrazone, delivering tetrahydropyridazines, e.g., I. In the experimental materials used by the author, we found (Bromomethyl)cyclopropane(cas: 7051-34-5Category: bromides-buliding-blocks)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Uji, Hirotaka; Watabe, Naoki; Komi, Tatsuya; Sakaguchi, Tomoki; Akamatsu, Ryo; Mihara, Kenta; Kimura, Shunsaku published an article in 2022. The article was titled 《Downsizing to 25-nm Reverse Polymeric Micelle Composed of AB3-type Polydepsipeptide with Comprising siRNA》, and you may find the article in Chemistry Letters.Application of 5437-45-6 The information in the text is summarized as follows:

Amphiphilic block polydepsipeptides of AB-type and AB3-type (hydrophilic A block: poly(sarcosine), hydrophobic B block: poly(l-lactic acid)) were prepared, and the N-terminals were arranged by guanidium or guanidino-peptide nucleic acid for loading siRNA in a reverse polymeric micelle. The amphiphilic polymers were successfully dispersed and assembled into reverse micelles in triglyceride or diisopropyl adipate. With loading siRNA into the core of the polymeric micelles, the micelle size was reduced down to a diameter of 25 nm in the case of the guanidino-peptide nucleic acid used as the capturing site. This small-size reverse micelle may be available for a transdermal drug delivery system (DDS) for siRNA. In the experiment, the researchers used many compounds, for example, Benzyl 2-bromoacetate(cas: 5437-45-6Application of 5437-45-6)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is a synthetic chemical produced for industry from benzyl alcohol and acetic acid, but is also naturally present in the essential oils of many plants, including jasmine and ylang ylang.Application of 5437-45-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Huai-Wei; Wu, Jia-Xue; Huang, Xian-Qiang; Li, Da-Cheng; Wang, Su-Na; Lu, Yi; Dou, Jian-Min published an article in 2022. The article was titled 《RhIII-Catalyzed C-H N-Heteroarylation and Esterification Cascade of Carboxylic Acid with Organoboron Reagents and 1,2-Dichloroethane in One-Pot Synthesis》, and you may find the article in Organic Letters.HPLC of Formula: 76006-33-2 The information in the text is summarized as follows:

A RhIII-catalyzed C(sp2)-H N-heteroarylation and esterification cascade of aryl carboxylic acids with N-heteroaromatic boronates and 1,2-dichloroethane in a one-pot synthesis has been disclosed. The strong coordinating ability of ortho- and meta-substituted pyridine boronates and pyrazoles as well as unsubstituted pyrimidine allows them to serve as the coupling partners. This protocol allows late-stage modification of the key precursor of roflumilast and compounds of pharmaceutical interest, which highlights the potential application of this synthetic method. The experimental part of the paper was very detailed, including the reaction process of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2HPLC of Formula: 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. The most pervasive is the naturally produced bromomethane.HPLC of Formula: 76006-33-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhang, Jian-Xin; Shu, Wei published an article in Organic Letters. The title of the article was 《Ni-Catalyzed Reductive 1,2-Cross-Dialkylation of Unactivated Alkenes with Two Alkyl Bromides》.Category: bromides-buliding-blocks The author mentioned the following in the article:

Herein, a Ni-catalyzed reductive 1,2-dialkylation of unactivated aliphatic alkenes had been developed using two different alkyl bromides to gave (cyanoethyl)-alkyl-aryl-propanamides R1CH2CHR2CH2C(O)NHAr [R1 = cyanomethyl, H2CCO2Et, (2-oxotetrahydrofuran-3-yl); R2 = Et, n-Pr, 3-phenylpropyl, etc.; Ar = Ph, 4-MeC6H4, 3-MeOC6H4, etc.]. The reaction proceeded smoothly under mild conditions to install two Csp3-Csp3 bonds onto directed aliphatic alkenes, demonstrating excellent chemo- and regioselectivity with good functional group tolerance. In the experimental materials used by the author, we found (Bromomethyl)cyclopropane(cas: 7051-34-5Category: bromides-buliding-blocks)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Belitz, Florian; Seitz, Ann-Katrin; Goebel, Jonas F.; Hu, Zhiyong; Goossen, Lukas J. published an article in Organic Letters. The title of the article was 《Ru-Catalyzed C-H Arylation of Acrylic Acids with Aryl Bromides》.Formula: C7H5BrO2 The author mentioned the following in the article:

In the presence of a [Ru(p-cymene)Cl2]2/triethylphosphine/lithium carbonate catalyst system, aryl bromides underwent (Z)-selective couplings with unprotected 2-arylacrylic acids to form (Z)-1,2-diarylacrylic acids. This vinylic C-H functionalization proceeds in high yields of up to 94% and (Z/E)-ratios of up to 99:1, tolerating a wide range of functional groups. Mechanistic studies indicate that the vinylic C-H activation proceeds via base-assisted cyclometalation rather than via a Heck-type mechanism, which explains its orthogonal stereoselectivity.5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Formula: C7H5BrO2) was used in this study.

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Formula: C7H5BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Tavella, Christian; Luciano, Giorgio; Lova, Paola; Patrini, Maddalena; D’Arrigo, Cristina; Comoretto, Davide; Stagnaro, Paola published an article in RSC Advances. The title of the article was 《2,5-Diisopropenylthiophene by Suzuki-Miyaura cross-coupling reaction and its exploitation in inverse vulcanization: a case study》.Application of 3141-27-3 The author mentioned the following in the article:

A novel thiophene derivative, namely 2,5-diisopropenylthiophene (DIT) was synthesized by Suzuki-Miyaura cross-coupling reaction (SMCCR). The influence of reaction parameters, such as temperature, solvent, stoichiometry of reagents, role of the base and reaction medium were thoroughly discussed in view of yield optimization and environmental impact minimization. Basic design of experiment (DoE) and multiple linear regression (MLR) modeling methods were used to interpret the obtained results. DIT was employed as a comonomer in the copolymerization with waste elemental sulfur through a green process, inverse vulcanization (IV), to obtain sulfur-rich polymers named inverse vulcanized polymers (IVPs) possessing high refractive index (n 1̃.8). The DIT comonomer was purposely designed to (i) favor the IV process owing to the high reactivity of the isopropenyl functionalities and (ii) enhance the refractive index of the ensuing IVPs owing to the presence of the sulfur atom itself and to the high electronic polarizability of the π-conjugated thiophene ring. A series of random sulfur-r-diisopropenylthiophene (S-r-DIT) copolymers with sulfur content from 50-90 weight% were synthesized by varying the S/DIT feed ratio. Spectroscopic, thermal and optical characterizations of the new IVPs were carried out to assess their main chem.-phys. features. In addition to this study using 2,5-Dibromothiophene, there are many other studies that have used 2,5-Dibromothiophene(cas: 3141-27-3Application of 3141-27-3) was used in this study.

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used in the preparation of soluble α,ω-diformyl-a-oligothiophenes.Application of 3141-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Pieters, Priscilla F.; Laine, Antoine; Li, He; Lu, Yi-Hsien; Singh, Yashpal; Wang, Lin-Wang; Liu, Yi; Xu, Ting; Alivisatos, A. Paul; Salmeron, Miquel published an article in ACS Nano. The title of the article was 《Multiscale Characterization of the Influence of the Organic-Inorganic Interface on the Dielectric Breakdown of Nanocomposites》.SDS of cas: 17696-11-6 The author mentioned the following in the article:

Nanoscale engineered materials such as nanocomposites can display or be designed to enhance their material properties through control of the internal interfaces. Here, we unveil the nanoscale origin and important characteristics of the enhanced dielec. breakdown capabilities of gold nanoparticle/polymer nanocomposites. Our multiscale approach spans from the study of a single chem. designed organic/inorganic interface to micrometer-thick films. At the nanoscale, we relate the improved breakdown strength to the interfacial charge retention capability by combining scanning probe measurements and d. functional theory calculations At the meso- and macroscales, our findings highlight the relevance of the nanoparticle concentration and distribution in determining and enhancing the dielec. properties, as well as identifying this as a crucial limiting factor for the achievable sample size. In the experiment, the researchers used 8-Bromooctanoic acid(cas: 17696-11-6SDS of cas: 17696-11-6)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid.SDS of cas: 17696-11-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhu, Peiyu; Zhang, Jian; Yang, Yifei; Wang, Lixun; Zhou, Jinpei; Zhang, Huibin published an article in Molecular Diversity. The title of the article was 《Design, synthesis and biological evaluation of isoxazole-containing biphenyl derivatives as small-molecule inhibitors targeting the programmed cell death-1/ programmed cell death-ligand 1 immune checkpoint》.HPLC of Formula: 76006-33-2 The author mentioned the following in the article:

Monoclonal antibodies targeting the programmed cell death-1/ programmed cell death-ligand 1 (PD-1/PD-L1) immune checkpoint have achieved enormous success in cancer immunotherapy. But the antibody-based immunotherapies carry a number of unavoidable deficiencies such as poor pharmacokinetic properties and immunogenicity. Small-mol. PD-1/PD-L1 inhibitors offer the superiority of complementarity with monoclonal antibodies and represent an appealing alternative. A novel series of isoxazole-containing biphenyl compounds were designed, synthesized and evaluated as PD-1/PD-L1 inhibitors in this paper. The structure-activity relationship of the novel synthesized compounds indicated that the ring-closure strategy of introducing isoxazole could be employed and the 3-cyanobenzyl group was significant for the inhibitory activity against the PD-1/PD-L1 protein-protein interactions. Mol. docking studies were performed to help understand the binding mode of the small-mol. inhibitor with the PD-L1 dimer. In particular, compound II-12 was a promising anti-PD-1/PD-L1 inhibitor with the IC50 value of 23.0 nM, providing valuable information for future drug development. In the experimental materials used by the author, we found 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2HPLC of Formula: 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products. HPLC of Formula: 76006-33-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Feng, Rui; Wang, Mian; Qian, Jingqi; He, Qingqing; Zhang, Man; Zhang, Jiaqi; Zhao, Hongwei; Wang, Baomin published an article in Microchemical Journal. The title of the article was 《Monoclonal antibody-based enzyme-linked immunosorbent assay and lateral flow immunoassay for the rapid screening of paraquat in adulterated herbicides》.Formula: C6H11BrO2 The author mentioned the following in the article:

The use of the herbicide paraquat has been banned in many countries due to its high toxicity. However, there is an issue that illegal addition of paraquat in herbicide products. Therefore, a rapid, sensitive, and portable method will be useful to detect paraquat in adulterated herbicides for regulation purpose. In the present study, an indirect competition ELISA (icELISA) was developed with a new paraquat-specific monoclonal antibody (mAb) for paraquat detection. The icELISA results showed a 50% inhibitory concentration (IC50) of 7.63 ng/mL with a working range (IC20-IC80) of 1.68-33.1 ng/mL. In addition, a lateral flow immunoassay (LFIA) with a cut-off value of 20.0 ng/mL was also developed. The LFIA showed no detection of the herbicides diquat, glyphosate and glufosinate up to 50μg/mL. Nine herbicide samples were collected across Hainan province, China and analyzed by the LFIA dipsticks. One out of the nine samples was tested pos., which was confirmed with icELISA and HPLC. The accuracy of the LFIA was further verified through onsite tests in different places in China. Forty-seven com. herbicide products were tested via the LFIA dipsticks, of which 9 samples were pos. and confirmed with HPLC anal. The paraquat LFIA exhibited the most promising potential as the point of care (POC) device for the rapid screening of paraquat in adulterated herbicide products. The experimental part of the paper was very detailed, including the reaction process of Ethyl 4-bromobutyrate(cas: 2969-81-5Formula: C6H11BrO2)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Formula: C6H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary