Month: November 2022

The author of 《Chemoselective formal β-functionalization of substituted aliphatic amides enabled by a facile stereoselective oxidation event》 were Bauer, Adriano; Maulide, Nuno. And the article was published in Chemical Science in 2019. Category: bromides-buliding-blocks The author mentioned the following in the article:

A facile and stereoselective dehydrogenation event enabling the functionalization of aliphatic amides, e.g., 1-(indolin-1-yl)-2-methylpropan-1-one at different positions in a one-pot fashion has been described. Derivatives of relevant pharmaceuticals were formally functionalized in the β-position in late-stage manner. A single-step synthesis of incrustoporine from a simple precursor further showcases the potential utility of this approach. The experimental part of the paper was very detailed, including the reaction process of Ethyl 5-bromovalerate(cas: 14660-52-7Category: bromides-buliding-blocks)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Gemini surfactant as multifunctional corrosion and biocorrosion inhibitors for mild steel》 were Pakiet, Marta; Kowalczyk, Iwona; Leiva Garcia, Rafael; Moorcroft, Robert; Nichol, Tim; Smith, Thomas; Akid, Robert; Brycki, Bogumil. And the article was published in Bioelectrochemistry in 2019. Category: bromides-buliding-blocks The author mentioned the following in the article:

Biocorrosion is an important type of corrosion which leads to economic losses across oil and gas industries, due to increased monitoring, maintenance, and a reduction in platform availability. Ideally, a chem. compound engineered to mitigate against biocorrosion would possess both antimicrobial properties, as well as efficient corrosion inhibition. Gemini surfactants have shown efficacy in both of these properties, however there still remains a lack of electrochem. information regarding biocorrosion inhibition. The inhibition of corrosion and biocorrosion, by cationic gemini surfactants, of carbon steel was investigated. The results showed that the inhibition efficiency of the gemini surfactants was high (consistently >95%), even at low concentrations Gemini surfactants also showed strong antimicrobial activity, with a min. inhibitory concentration (0.018 mM). Corrosion inhibition was investigated by electrochem. impedance spectroscopy (EIS) and linear polarisation resistance (LPR), with biocorrosion experiments carried out in an anaerobic environment. Surface morphol. was analyzed using SEM (SEM). In the part of experimental materials, we found many familiar compounds, such as 1,6-Dibromohexane(cas: 629-03-8Category: bromides-buliding-blocks)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Synthesis of a C1-C12 Fragment of Gulmirecin B》 were Rengarasu, Rathikrishnan; Maier, Martin E.. And the article was published in Synlett in 2019. Application of 1530-32-1 The author mentioned the following in the article:

The synthesis of a C1-C14 fragment I of the macrolide antibiotic gulmirecin B through formation of the C7-C8 bond by addition of a vinyllithium intermediate to a C1-C7 aldehyde was investigated. This crucial coupling was successful with a vinyllithium reagent corresponding to a C8-C12 fragment. The C8-C12 vinyl bromide II was prepared from L-malic acid. The C1-C7 aldehyde III building block was synthesized from hex-5-enoic acid by using an Evans alkylation, a cross-metathesis, and an asym. dihydroxylation as key steps. In the experimental materials used by the author, we found Ethyltriphenylphosphonium bromide(cas: 1530-32-1Application of 1530-32-1)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.Application of 1530-32-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Magnetic Lignosulfonate-Supported Pd Complex: Renewable Resource-Derived Catalyst for Aqueous Suzuki-Miyaura Reaction》 were Nasrollahzadeh, Mahmoud; Issaabadi, Zahra; Varma, Rajender S.. And the article was published in ACS Omega in 2019. Electric Literature of C7H5BrO2 The author mentioned the following in the article:

A novel strategy is described to prepare magnetic Pd nanocatalyst by conjugating lignin with Fe3O4 nanoparticles via activation of calcium lignosulfonate, followed by combination with Fe3O4 nanoparticles. Tethering 5-amino-1H-tetrazole to calcium lignosulfonate-magnetite hybrid through 3-chloropropyl triethoxysilane enabled coordination of Pd salt with Fe3O4-lignosulfonate@5-amino-1H-tetrazole. The underlying changes of the lignosulfonate are identified, and the structural morphol. of attained Fe3O4-lignosulfonate@5-amino-1H-tetrazole-Pd(II) (FLA-Pd) is characterized by Fourier transform IR, thermogravimetry DTA, energy-dispersive spectrometry, field-emission SEM, transmission electron microscopy, and vibrating sample magnetometer (VSM). The synthesized FLA-Pd displayed high activity for phosphine-free C(sp2)-C(sp2) coupling in water, and the catalyst could be reused for seven successive cycles.4-Bromobenzoic acid(cas: 586-76-5Electric Literature of C7H5BrO2) was used in this study.

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Electric Literature of C7H5BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Decorated Peptide Nanofibers with Cu Nanoparticles: An Efficient Catalyst for the Multicomponent Synthesis of Chromeno[2,3-d]pyrimidin-8-amines, Quinazolines and 2H-Indazoles》 were Taherinia, Zahra; Ghorbani-Choghamarani, Arash; Hajjami, Maryam. And the article was published in ChemistrySelect in 2019. Safety of o-Bromobenzaldehyde The author mentioned the following in the article:

An efficient, simple and green protocol was developed for the synthesis of 7,10-diaryl-7H-benzo[7,8]chromeno[2,3-d]pyrimidin-8-amines I (R1 = Ph, 2-ClC6H4, 4-HOC6H4, etc.), 2-R2-substituted indazoles (R2 = Ph, 4-MeC6H4, 2,4-Cl2C6H3, etc.) and 2-R3-substituted quinazolines (R3 = Ph, 4-MeOC6H4) in the presence of peptide nanofibers decorated with Cu nanoparticles. Peptide nanofiber was synthesized by self-assembly technique. The effect of succinic anhydride was evaluated in two conditions: (i) without adding succinic anhydride at pH 4, (ii) by adding succinic anhydride at pH 5. Synthesized peptide nanofiber was characterized by 1H, 13C, DEPT NMR spectroscopies (Distortionless enhancement by polarization transfer), CHNSO, SEM, fluorescence spectroscopy, UV/Vis, FTIR and transmission electron microscopy (TEM). The experimental process involved the reaction of o-Bromobenzaldehyde(cas: 6630-33-7Safety of o-Bromobenzaldehyde)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Safety of o-BromobenzaldehydeIt is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Design and synthesis of parthenolide-SAHA hybrids for intervention of drug-resistant acute myeloid leukemia》 were Ge, Weizhi; Liu, Zhongquan; Sun, Yu; Wang, Tianpeng; Guo, Hongyu; Chen, Xinyi; Li, Shengzu; Wang, Mengmeng; Chen, Yue; Ding, Yahui; Zhang, Quan. And the article was published in Bioorganic Chemistry in 2019. Product Details of 17696-11-6 The author mentioned the following in the article:

A series of parthenolide-SAHA hybrids were synthesized and evaluated for their anti-AML activities against HL-60 and HL-60/ADR cell lines. The most active compound 26 exhibited high activity against HL-60/ADR cell line with IC50 value of 0.15 μM, which demonstrated 16.8-fold improvement compared to that of the parent compound PTL (IC50 = 2.52 μM). Moreover, it was six times more potent than the reference drug SAHA (IC50 = 0.90 μM) and fifty-one times more potent than ADR (IC50 = 7.72 μM). The preliminary mol. mechanism of 26 indicated that compound 26 could significantly induce apoptosis of HL-60/ADR cells. The effect of compound 26 was mainly through mitochondria pathway. Further investigation revealed that the protein level of HDAC1 and HDAC6 were reduced after the treatment of compound 26 with a dose-dependent manner. Compound 26 could significantly decrease ABCC1 expression, which increased the accumulation of intracellular drug for overcoming the drug resistance. On the base of these results, compound 26 might be considered as a promising candidate for further evaluation as a potential anti-AML drug. In the experiment, the researchers used 8-Bromooctanoic acid(cas: 17696-11-6Product Details of 17696-11-6)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Product Details of 17696-11-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Repositioning Salirasib as a new antimalarial agent》 were Porta, Exequiel O. J.; Bofill Verdaguer, Ignasi; Perez, Consuelo; Banchio, Claudia; Ferreira de Azevedo, Mauro; Katzin, Alejandro M.; Labadie, Guillermo R.. And the article was published in MedChemComm in 2019. Related Products of 539-74-2 The author mentioned the following in the article:

Malaria is a serious tropical disease that kills thousands of people every year, mainly in Africa, due to Plasmodium falciparum infections. Salirasib is a promising cancer drug candidate that interferes with the post-translational modification of Ras. This S-farnesyl thiosalicylate inhibits isoprenylcysteine carboxyl methyltransferase (ICMT), a validated target for cancer drug development. There is a high homol. between the human and the parasite enzyme isoforms, in addition to being a druggable target. Looking to repurpose its structure as an antimalarial drug, a collection of S-substituted derivatives of thiosalicylic acid were prepared by introducing 1,2,3-triazole as a diversity entry point or by direct alkylation of the thiol. We further investigated the in vitro toxicity of FTS analogs to Plasmodium falciparum in the asexual stages and in Vero cells. An antiplasmodial activity assay was performed using a simple, high-sensitivity methodol. based on nanoluciferase (NLuc)-transfected P. falciparum parasites. The results showed that some of the analogs were active at low micromolar concentration, including Salirasib. The most potent member of the series has S-farnesyl and the 1,2,3-triazole moiety substituted with phytyl. However, the compound substituted with methyl-naphthyl shows promising physicochem. and activity values. The low cytotoxicity in eukaryotic cells of the most active analogs provided good therapeutic indexes, being starting-point candidates for future antimalarial drug development. In the experimental materials used by the author, we found Ethyl 3-bromopropanoate(cas: 539-74-2Related Products of 539-74-2)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Related Products of 539-74-2 Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Carbamate as an accelerating group in intermolecular Pauson-Khand reaction》 was published in Tetrahedron Letters in 2020. These research results belong to Asano, Shota; Itto-Nakama, Kaori; Arimoto, Hirokazu. Category: bromides-buliding-blocks The article mentions the following:

The Pauson-Khand reaction (PKR) is a powerful means for the construction of cyclopentenones. However, its applications are limited to the intramol. version of this reaction because poor yield and regioselectivity are often the major problems in intermol. PKR. Herein, it was shown that a carbamate moiety in alkene substrate accelerates this intermol. PKR. The reaction of N-4-dimethylaminophenyl O-allyl carbamate with alkyne-cobalt complex gave cyclopentenones in high yields (up to 90%) and regioselectivity (>9:1). The results came from multiple reactions, including the reaction of 4-Bromobutanoic acid(cas: 2623-87-2Category: bromides-buliding-blocks)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Direct C(sp2)-H alkylation of unactivated arenes enabled by photoinduced Pd catalysis》 was published in Nature Communications in 2020. These research results belong to Kim, Daeun; Lee, Geun Seok; Kim, Dongwook; Hong, Soon Hyeok. Quality Control of (Bromomethyl)cyclopropane The article mentions the following:

Here, the catalytic C(sp2)-H alkylation reactions of unactivated arenes with alkyl bromides via visible-light induced Pd catalysis was reported. The reaction proceeded smoothly under mild conditions without any skeletal rearrangement of the alkyl groups. The direct syntheses of structurally diverse linear and branched alkylarenes, including the late-stage phenylation of biol. active mols. and an orthogonal one-pot sequential Pd-catalyzed C-C bond-forming reaction, were achieved with exclusive chemoselectivity and exceptional functional group tolerance. Comprehensive mechanistic investigations through a combination of exptl. and computational methods revealed a distinguishable Pd(0)/Pd(I) redox catalytic cycle and the origin of the counter-intuitive reactivity differences among alkyl halides. In addition to this study using (Bromomethyl)cyclopropane, there are many other studies that have used (Bromomethyl)cyclopropane(cas: 7051-34-5Quality Control of (Bromomethyl)cyclopropane) was used in this study.

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Quality Control of (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《A Ru(II)-Mn(I) Supramolecular Photocatalyst for CO2 Reduction》 was published in Organometallics in 2020. These research results belong to Fabry, David C.; Koizumi, Hiroki; Ghosh, Debashis; Yamazaki, Yasuomi; Takeda, Hiroyuki; Tamaki, Yusuke; Ishitani, Osamu. Computed Properties of C5BrMnO5 The article mentions the following:

Supramol. photocatalysts for CO2 reduction, constituted of redox photosensitizer, catalyst, and bridging ligand, play crucial roles in constructing hybrid systems with solid materials and photoelectrochem. cells for artificial photosynthesis. The authors report the 1st supramol. photocatalysts with a Mn(I) catalyst [MnBr(CO)3(BL)] and photosensitizer unit(s) [Ru(dmb)2(BL)]2+ (dmb = 4,4′-dimethyl-2,2′-bipyridine, BL = bridging ligand). A 1:1 ratio between the redox photosensitizer and catalyst units showed higher activity for HCOOH formation in comparison to the corresponding mixed system of mononuclear complexes. The experimental part of the paper was very detailed, including the reaction process of Bromopentacarbonylmanganese(I)(cas: 14516-54-2Computed Properties of C5BrMnO5)

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Computed Properties of C5BrMnO5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary