Month: November 2022

《Synthesis of conjugated polymers via cyclopentannulation reaction: Promising materials for iodine adsorption》 was published in Polymer Chemistry in 2020. These research results belong to Baig, Noorullah; Shetty, Suchetha; Al-Mousawi, Saleh; Alameddine, Bassam. Application of 523-27-3 The article mentions the following:

A new class of conjugated polymers is prepared by means of a versatile palladium-catalyzed cyclopentannulation reaction using a series of specially designed diethynyl aryl synthons with the com. available 9,10-dibromoanthracene DBA monomer. The target polymers, CPP1-3, display high solubility and excellent chem. stability, which allow their structural and photophys. characterization by various instrumental anal. techniques such as gel permeation chromatog. (GPC), and 1H- and 13C-NMR, Fourier transform IR, UV-vis absorption, and emission spectroscopy. GPC chromatograms of CPP1-3 display a high relative weight-average (Mw) mol. weight in the range of 15.8 to 34.3 kDa with a polydispersity index (D = Mw/Mn) of ~2.5. Investigation of the iodine adsorption properties of CPP1-3 reveals their high uptake, namely ~200 wt% for CPP2, whose sorption property was sustained even after its reuse several times.9,10-Dibromoanthracene(cas: 523-27-3Application of 523-27-3) was used in this study.

9,10-Dibromoanthracene(cas: 523-27-3) can be sublimated and oxidized to generate anthraquinone. Soluble in hot benzene and hot toluene, slightly soluble in alcohol, ether and cold benzene, insoluble in water.Application of 523-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Manganese Diphosphine and Phosphinoamine Complexes Are Effective Catalysts for the Production of Biofuel Alcohols via the Guerbet Reaction》 was published in Organometallics in 2020. These research results belong to King, Ashley M.; Sparkes, Hazel A.; Wingad, Richard L.; Wass, Duncan F.. SDS of cas: 14516-54-2 The article mentions the following:

We report a variety of manganese-based catalysts containing both chelating diphosphine (bis(diphenylphosphino)methane (dppm: 1, 2, and 7) or 1,2-bis(diphenylphosphino)ethane (dppe: 3)), and mixed-donor phosphinoamine (2-(diphenylphosphino)ethylamine (dppea: 4-6)) ligands for the upgrading of ethanol and methanol to the advanced biofuel isobutanol. These catalysts show moderate selectivity up to 74% along with turnover numbers greater than 100 over 90 h, with catalyst 2 supported by dppm demonstrating superior performance. The pos. effect of substituting the ligand backbone was also displayed with a catalyst supported by C-phenyl-substituted dppm (8) having markedly improved performance compared to the parent dppm catalysts. Catalysts supported by the phosphinoamine ligand dppea are also active for the upgrading of ethanol to n-butanol. These results show that so-called PNP-pincer ligands are not a prerequisite for the use of manganese catalysts in Guerbet chem. and that simple chelates can be used effectively. In addition to this study using Bromopentacarbonylmanganese(I), there are many other studies that have used Bromopentacarbonylmanganese(I)(cas: 14516-54-2SDS of cas: 14516-54-2) was used in this study.

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.SDS of cas: 14516-54-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《N -Methylated 1,8-Diaminonaphthalenes as Bifunctional Nucleophiles in Reactions with α,ω-Dihalogenoalkanes: A Facile Route to Heterocyclic and Double Proton Sponges》 was published in Synthesis in 2020. These research results belong to Kolupaeva, Ekaterina V.; Ozeryanskii, Valery A.; Pozharskii, Alexander F.. SDS of cas: 623-24-5 The article mentions the following:

The reaction of 1-dimethylamino-8-(methylamino)naphthalene with 1,3-dibromopropane chemoselectively leaded to the product of N, N’-heterocyclization, while in the case of 1,4-dibromobutane and 1,2-bis(bromomethyl)benzene the process resulted in heterocyclization onto the same nitrogen atom with the formation of previously unknown 1-dimethylamino-8-pyrrolidino- and 1-dimethylamino-8-isoindolino-naphthalenes. The same reactions conducted without adding any auxiliary base leaded to the formation of N, N’-linked double proton sponges as a new type of polynitrogen organic receptor. Proceeding as a sequence of quaternization-demethylation-cyclization steps, this heterocyclization process was used to construct six-membered rings (piperidino, morpholino), albeit in lower yields. The ability of 1,2-dibromoethane to brominate N-alkylated 1,8-diaminonaphthalenes was described. It is shown for the first time that a com. available 1,8-bis(dimethylamino)naphthalene (DMAN) can be used as a starting material in a heterocyclization reaction, which via a one-pot approach and in a short time can be converted into 1,5-dimethylnaphtho[1,8- bc]-1,5-diazacyclooctane or 1-dimethylamino-8-(pyrrolidin-1-yl)naphthalene. In the experiment, the researchers used many compounds, for example, 1,4-Bis(bromomethyl)benzene(cas: 623-24-5SDS of cas: 623-24-5)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Organobromine compounds are produced naturally by marine creatures (sponges, corals, sea slugs, tunicates, sea fans) and seaweed, plants, fungi, lichen, algae, bacteria, microbes, and some mammals. SDS of cas: 623-24-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Copper and L-(-)-quebrachitol catalyzed hydroxylation and amination of aryl halides under air》 was written by Liang, Xinjie; Li, Hui; Du, Fangyu; Zhang, Yongsheng; Dong, Jinhua; Bao, Xuefei; Wu, Ying; Chen, Guoliang. Formula: C7H5BrO2 And the article was included in Tetrahedron Letters in 2020. The article conveys some information:

L-(-)-Quebrachitol, a natural product obtained from waste water of the rubber industry, was utilized as an efficient ligand for the copper-catalyzed hydroxylation and amination of aryl halides to selectively give phenols and aryl amines in water or 95% ethanol. In addition, the hydroxylation of 2-chloro-4-hydroxybenzoic acid was validated on a 100-g scale under air. In the experimental materials used by the author, we found 4-Bromobenzoic acid(cas: 586-76-5Formula: C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Formula: C7H5BrO2 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Development of a practical non-noble metal catalyst for hydrogenation of N-heteroarenes》 was written by Papa, Veronica; Cao, Yixuan; Spannenberg, Anke; Junge, Kathrin; Beller, Matthias. Category: bromides-buliding-blocks And the article was included in Nature Catalysis in 2020. The article conveys some information:

The chemoselective reduction of quinolines and related N-heterocycles by mol. hydrogen, using a simple Mn(I) complex [Mn(CO)5Br] was reported. Under very mild reaction conditions this catalytic system was able to reduce a wide range of quinolines, affording high yields of the corresponding tetrahydroquinolines, a scaffold present in many bioactive compounds, including marketed pharmaceuticals. Mechanistic studies revealed the formation of the active catalyst and also show the important role of a concomitantly formed Mn(II) species and HBr for the hydrogenation of the heterocyclic substrates. The results came from multiple reactions, including the reaction of Bromopentacarbonylmanganese(I)(cas: 14516-54-2Category: bromides-buliding-blocks)

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Antiviral efficacy against influenza virus and pharmacokinetic analysis of a novel MEK-inhibitor, ATR-002, in cell culture and in the mouse model》 was written by Laure, Martin; Hamza, Hazem; Koch-Heier, Julia; Quernheim, Martin; Mueller, Christin; Schreiber, Andre; Mueller, Gerhard; Pleschka, Stephan; Ludwig, Stephan; Planz, Oliver. Formula: C4H7Br And the article was included in Antiviral Research in 2020. The article conveys some information:

Antiviral therapies against influenza are required, especially for high-risk patients, severe influenza and in case of highly pathogenic influenza virus (IV) strains. This may be overcome by targeting host cell factors that are required for IV propagation. IV induces a variety of host cell signaling cascades, such as the Raf/MEK/ERK kinase pathway. MEK-inhibitors block the activation of the pathway on the bottleneck of the signaling cascade leading to impaired virus propagation. In the present study, we aimed to compare the antiviral potency and bioavailability of the MEK-inhibitor CI-1040 vs. its major active metabolite ATR-002, in vitro as well as in the mouse model. In cell culture assays, an approx. 10-fold higher concentration of ATR-002 is required to generate the same antiviral activity as for CI-1040. Interestingly, we observed that considerably lower concentrations of ATR-002 were required to achieve a reduction of the viral load in vivo. Pharmacokinetic studies with ATR-002 and CI-1040 in mice have found the Cmax and AUC to be far higher for ATR-002 than for CI-1040. Our results thereby demonstrate the in vivo superiority of the active metabolite ATR-002 over CI-1040 as an antiviral agent despite its weaker cell membrane permeability. Therefore, ATR-002 is an attractive candidate for development as an efficient antiviral agent, especially given the fact that a treatment based on cellular pathway inhibition would be far less likely to lead to viral drug resistance. The experimental part of the paper was very detailed, including the reaction process of (Bromomethyl)cyclopropane(cas: 7051-34-5Formula: C4H7Br)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Formula: C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Introduction of heterocyclic ring to phenanthroimidazole moiety for efficient blue emitting ionic small molecule LECs》 was written by John, Jino C.; Shanmugasundaram, Kanagaraj; Puthanveedu, Archana; Rao, C. V. S. Brahmmananda; Gopakumar, Gopinadhanpillai; Choe, Youngson. Computed Properties of C6H12Br2 And the article was included in Organic Electronics in 2020. The article conveys some information:

Two novel phenanthroimidazole based luminogens were designed and synthesized through simple synthetic procedures. Two different hetero atoms containing (S, O) rings were introduced into the phenanthroimidazole moiety to obtain the efficient blue emitting luminogens. The optical, thermal, electronic, electrochem. and electroluminescence properties of both the derivatives have been thoroughly characterized. Both the synthesized compounds showed good thermal stability which is necessary for the LEC fabricating material. The photoluminescence quantum yields are good for both the compounds The theor. calculations done for electronic structure predictions are in good agreement with the exptl. studies done by cyclic voltammetry. Moreover, the LEC devices fabricated show strong blue emission in 459 and 461 nm for devices 1 and 2 resp. The CIE graph show good intensity for the devices 1 and 2 at (0.18,0.22) and (0.19,0.19) resp. These CIE coordinates fall in the strong and intense blue emission region. Comparing the brightness, the compound 2 shows better brightness of 1289 than that of compound 1 of 1177 cd m-2. The c.d. is also higher for the compound 2 which shows 342, when the compound 1 shows a c.d. of 166 mA cm-2. Both the compounds show very good external quantum efficiency too. In addition to this study using 1,6-Dibromohexane, there are many other studies that have used 1,6-Dibromohexane(cas: 629-03-8Computed Properties of C6H12Br2) was used in this study.

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.Computed Properties of C6H12Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hermann, Theresa; Hochegger, Patrick; Dolensky, Johanna; Seebacher, Werner; Saf, Robert; Kaiser, Marcel; Maeser, Pascal; Weis, Robert published their research in Pharmaceuticals in 2021. The article was titled 《New acyl derivatives of 3-aminofurazanes and their antiplasmodial activities》.Computed Properties of C9H9BrO2 The article contains the following contents:

An N-acylated furazan-3-amine of a Medicines for Malaria Venture (MMV) project has shown activity against different strains of Plasmodium falciparum. Seventeen new derivatives were prepared and tested in vitro for their activities against blood stages of two strains of Plasmodium falciparum. Several structure-activity relationships were revealed. The activity strongly depended on the nature of the acyl moiety. Only benzamides showed promising activity. The substitution pattern of their Ph ring affected the activity and the cytotoxicity of compounds In addition, physicochem. parameters were calculated (log P, log D, ligand efficiency) or determined exptl. (permeability) via a PAMPA. The N-(4-(3,4-diethoxyphenyl)-1,2,5-oxadiazol-3-yl)-3-(trifluoromethyl)benzamide possessed good physicochem. properties and showed high antiplasmodial activity against a chloroquine-sensitive strain (IC50(NF54) = 0.019 μM) and even higher antiplasmodial activity against a multiresistant strain (IC50(K1) = 0.007 μM). Compared to the MMV compound, the permeability and the activity against the multiresistant strain were improved. The results came from multiple reactions, including the reaction of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Computed Properties of C9H9BrO2)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Computed Properties of C9H9BrO2 The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Jian; Mu, Keman; Yang, Peng; Feng, Xinqian; Zhang, Di; Fan, Xiangyu; Wang, Qiantao; Mao, Shengjun published their research in Bioorganic Chemistry in 2021. The article was titled 《Synthesis, antiepileptic effects, and structure-activity relationships of α-asarone derivatives: In vitro and in vivo neuroprotective effect of selected derivatives》.SDS of cas: 1530-32-1 The article contains the following contents:

In the present study, we compared the antiepileptic effects of α-asarone derivatives to explore their structure-activity relationships using the PTZ-induced seizure model. Our research revealed that electron-donating methoxy groups in the 3,4,5-position on Ph ring increased antiepileptic potency but the placement of other groups at different positions decreased activity. Besides, in allyl moiety, the optimal activity was reached with either an allyl or a 1-butenyl group in conjugation with the benzene ring. The compounds 5 (I) and 19 (II) exerted better neuroprotective effects against epilepsy in vitro (cell) and in vivo (mouse) models. This study provides valuable data for further exploration and application of these compounds as potential anti-seizure medicines. In addition to this study using Ethyltriphenylphosphonium bromide, there are many other studies that have used Ethyltriphenylphosphonium bromide(cas: 1530-32-1SDS of cas: 1530-32-1) was used in this study.

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. It is also used as catalysts in the synthesis of certain organic compounds and as a pharmaceutical intermediate.SDS of cas: 1530-32-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Huang, Hong-Gui; Li, Weishuang; Zhong, Dayou; Wang, Hu-Chong; Zhao, Jing; Liu, Wen-Bo published their research in Chemical Science in 2021. The article was titled 《Trifluoromethanesulfonyl azide as a bifunctional reagent for metal-free azidotrifluoromethylation of unactivated alkenes》.Computed Properties of C4H7BrO2 The article contains the following contents:

A simple and metal-free method that rapidly provides these building blocks, e.g., I from abundant alkenes RR1C=CR2R3 (R = 3-[(pyridin-3-yl)carbonyloxy]propyl, C8H17, CH2C6H5, etc.; R1 = H, Me, n-Pr; R2 = R3 = H, Me) and trifluoromethanesulfonyl azide (N3SO2CF3). This unprecedented two-component reaction employs readily available N3SO2CF3 as a bifunctional reagent to concurrently incorporate both CF3 and N3 groups, which avoids the use of their expensive and low atom economic precursors. A wide range of functional groups, including bio-relevant heterocycles and amino acids, was tolerated. Application of this method was further demonstrated by scale-up synthesis (5 mmol), product derivatization to CF3-containing medicinal chem. motifs, as well as late-stage modification of natural products, e.g., 5-(2,2,2-trifluoroethyl)pyrrolidin-2-one and drug derivatives In addition to this study using 4-Bromobutanoic acid, there are many other studies that have used 4-Bromobutanoic acid(cas: 2623-87-2Computed Properties of C4H7BrO2) was used in this study.

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Computed Properties of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary