Month: November 2022

Noureldin, Nada A.; Richards, Jennifer; Kothayer, Hend; Baraka, Mohammed M.; Eladl, Sobhy M.; Wootton, Mandy; Simons, Claire published their research in BMC Chemistry in 2021. The article was titled 《Design, computational studies, synthesis and in vitro antimicrobial evaluation of benzimidazole based thio-oxadiazole and thio-thiadiazole analogues》.HPLC of Formula: 3395-91-3 The article contains the following contents:

Two series of benzimidazole based thio-oxadiazole and thio-thiadiazole analogs were designed and synthesized as novel antimicrobial drugs through inhibition of phenylalanyl-tRNA synthetase (PheRS), which is a promising antimicrobial target. Compounds were designed to mimic the structural features of phenylalanyl adenylate (Phe-AMP) the PheRS natural substrate. A 3D conformational alignment for the designed compounds and the PheRS natural substrate revealed a high level of conformational similarity, and a mol. docking study indicated the ability of the designed compounds to occupy both Phe-AMP binding pockets. A mol. dynamics (MD) simulation comparative study was performed to understand the binding interactions with PheRS from different bacterial microorganisms. The synthetic pathway of the designed compounds proceeded in five steps starting from benzimidazole. The fourteen synthesized compounds 5a-d, 6a-c, 8a-d and 9a-c were purified, fully characterised and obtained in high yield. In vitro antimicrobial evaluation against five bacterial strains showed a moderate activity of compound 8b with MIC value of 32 μg/mL against S. aureus, while all the synthesized compounds showed weak activity against both E. faecalis and P. aeruginosa (MIC 128 μg/mL). Compound 8b provides a lead compound for further structural development to obtain high affinity PheRS inhibitors. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-bromopropanoate(cas: 3395-91-3HPLC of Formula: 3395-91-3)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.HPLC of Formula: 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chen, Da; Hao, Shiqiang; Fan, Liubing; Guo, Yangwu; Yao, Jiyong; Wolverton, Christopher; Kanatzidis, Mercouri G.; Zhao, Jing; Liu, Quanlin published their research in Chemistry of Materials in 2021. The article was titled 《Broad Photoluminescence and Second-Harmonic Generation in the Noncentrosymmetric Organic-Inorganic Hybrid Halide (C6H5(CH2)4NH3)4MX7·H2O (M = Bi, In, X = Br or I)》.SDS of cas: 13465-09-3 The article contains the following contents:

Recent discoveries in organic-inorganic metal halides reveal superior semiconducting and polarization properties. Herein, we report three organic-inorganic metal halides, (PBA)4BiBr7·H2O, (PBA)4BiI7·H2O, and (PBA)4InBr7·H2O [(PBA)+ = C6H5(CH2)4NH3+], with band gaps of ~3.52, ~2.29, and ~4.05 eV, resp. They possess zero-dimensional structures containing the inorganic octahedra [MX6]3- (M = Bi, In, X = Br, I) and unbound X- ions and crystallize in the C2 space group. (PBA)4BiI7·H2O shows a second-harmonic-generation (SHG) response in the IR region, approx. 1.3 times that of AgGaS2; (PBA)4BiBr7·H2O and (PBA)4InBr7·H2O show SHG responses in the UV region, approx. 0.4 and 0.6 times that of KH2PO4, resp. The large SHG responses are attributed to the synergistic contribution of the octahedral distortion of [MX6]3- (M = Bi, In, X = Br, I) and the ordered arrangement of the benzene ring-containing organic cation PBA+. Upon UV and visible-light excitations at room temperature, (PBA)4BiBr7·H2O, (PBA)4BiI7·H2O, and (PBA)4InBr7·H2O exhibit broad red-light luminescence with large Stokes shifts of 290, 237, and 360 nm, resp., due to self-trapped exciton emission. All of these properties demonstrate that this series of metal halides are potential multifunctional optoelectronic materials. The experimental part of the paper was very detailed, including the reaction process of Indium(III) bromide(cas: 13465-09-3SDS of cas: 13465-09-3)

Indium(III) bromide(cas: 13465-09-3) is used in organic synthesis as a water tolerant Lewis acid. It efficiently catalyzes the three-component coupling of β-keto esters, aldehydes and urea (or thiourea) to afford the corresponding dihydropyrimidinones.SDS of cas: 13465-09-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bisenieks, Egils; Vigante, Brigita; Petrovska, Ramona; Turovska, Baiba; Muhamadejev, Ruslan; Soloduns, Vitalijs; Velena, Astrida; Pajuste, Karlis; Saso, Luciano; Klovins, Janis; Duburs, Gunars; Mandrika, Ilona published an article in 2021. The article was titled 《The Specificity and Broad Multitarget Properties of Ligands for the Free Fatty Acid Receptors FFA3/GPR41 and FFA2/GPR43 and the Related Hydroxycarboxylic Acid Receptor HCA2/GPR109A》, and you may find the article in Pharmaceuticals.Related Products of 5437-45-6 The information in the text is summarized as follows:

The paradigm of ligand-receptor interactions postulated as “”one compound-one target”” has been evolving; a multi-target, pleiotropic approach is now considered to be realistic. Novel series of 1,4,5,6,7,8-hexahydro-5-oxoquinolines, pyranopyrimidines and S-alkyl derivatives of pyranopyrimidines have been synthesized in order to characterize their pleiotropic, multitarget activity on the FFA3/GPR41, FFA2/GPR43, and HCA2/GPR109A receptors. Hexahydroquinoline derivatives have been known to exhibit characteristic activity as FFA3/GPR41 ligands, but during this study we observed their impact on FFA2/GPR43 and HCA2/GPR109A receptors as well as their electron-donating activity. Oxopyranopyrimidine and thioxopyranopyrimidine type compounds have been studied as ligands of the HCA2/GPR109A receptor; nevertheless, they exhibited equal or higher activity towards FFA3/GPR41 and FFA2/GPR43 receptors. S-Alkyl derivatives of pyranopyrimidines that have not yet been studied as ligands of GPCRs were more active towards HCA2/GPR109A and FFA3/GPR41 receptors than towards FFA2/GPR43. Representative compounds from each synthesized series were able to decrease the lipopolysaccharide-induced gene expression and secretion of proinflammatory cytokines (IL-6, TNF-α) and of a chemokine (MCP-1) in THP-1 macrophages, resembling the effect of HCA2/GPR109A ligand niacin and the endogenous ligand propionate. This study revealed groups of compounds possessing multitarget activity towards several receptors. The obtained data could be useful for further development of multitarget ligands. The experimental part of the paper was very detailed, including the reaction process of Benzyl 2-bromoacetate(cas: 5437-45-6Related Products of 5437-45-6)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is an aromatic chemical, usually appearing as a clear liquid with a moderate sweet-jasmine fragrance. This compound appears as a component of some of our fragrance blends.Related Products of 5437-45-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ghosh, Subhendu; Khandelia, Tamanna; Patel, Bhisma K. published an article in 2021. The article was titled 《Solvent-Switched Manganese(I)-Catalyzed Regiodivergent Distal vs Proximal C-H Alkylation of Imidazopyridine with Maleimide》, and you may find the article in Organic Letters.Reference of Bromopentacarbonylmanganese(I) The information in the text is summarized as follows:

A sustainable Mn(I)-catalyzed exclusive solvent-dependent functionalization of imidazopyridine with maleimide via an electrophilic metalation at the distal (in 2,2,2-trifluoroethanol (TFE)) and chelation assisted at the proximal (in THF (THF)) was developed. The strategy was successfully applied to the drug Zolimidine and a broad range of substrates, thereby reflecting the method’s versatility. The experimental process involved the reaction of Bromopentacarbonylmanganese(I)(cas: 14516-54-2Reference of Bromopentacarbonylmanganese(I))

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Reference of Bromopentacarbonylmanganese(I)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kaithal, Akash; Hoelscher, Markus; Leitner, Walter published an article in 2021. The article was titled 《Carbon monoxide and hydrogen (syngas) as a C1-building block for selective catalytic methylation》, and you may find the article in Chemical Science.Category: bromides-buliding-blocks The information in the text is summarized as follows:

A catalytic reaction using syngas (CO/H2) as feedstock for the selective β-methylation of alcs. was developed whereby carbon monoxide acts as a C1 source and hydrogen gas as a reducing agent. The overall transformation occurs through an intricate network of metal-catalyzed and base-mediated reactions. The mol. complex [Mn(CO)2Br[HN(C2H4PiPr2)2]] 1 comprising earth-abundant manganese acts as the metal component in the catalytic system enabling the generation of formaldehyde from syngas in a synthetically useful reaction. This new syngas conversion opens pathways to install Me branches at sp3 carbon centers utilizing renewable feedstocks and energy for the sy nthesis of biol. active compounds, fine chems., and advanced biofuels.Bromopentacarbonylmanganese(I)(cas: 14516-54-2Category: bromides-buliding-blocks) was used in this study.

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hu, Xuefu; Wang, Zhiye; Su, Yuming; Chen, Peican; Jiang, Yibin; Zhang, Cankun; Wang, Cheng published an article in 2021. The article was titled 《Metal-Organic Layers with an Enhanced Two-Photon Absorption Cross-Section and Up-Converted Emission》, and you may find the article in Chemistry of Materials.Application of 4316-58-9 The information in the text is summarized as follows:

Two-photon absorption (TPA) of many chromophores can be enhanced by building them into the structure of metal-organic frameworks (MOFs). However, light scattering of MOFs defocuses the light beam and thus decreases the nonlinear optical effects like TPA. Nanoscale two-dimensional (2D) metal-organic layers (MOLs) are 2D analogs of MOFs with low light scattering. In this work, we obtained a MOL containing tri(4-carboxylic-biphenyl)-4′-amine (H3TCBPA) that exhibited a TPA cross-section of 13 000 ± 2000 GM, which is ~7 times that of the H3TCBPA ligand in homogeneous solution (1850 ± 200 GM). The MOL also gave bright up-converted fluorescence thanks to efficient TPA and a high fluorescence quantum yield. The theor. calculation showed that a large dipole moment of the excited state due to electron redistribution between the ligands and the metal-connecting nodes in the MOL is the reason for the TPA enhancement. This work illustrates MOLs as 2D materials with enhanced TPA for generating bright upconverted fluorescence. The experimental process involved the reaction of Tris(4-bromophenyl)amine(cas: 4316-58-9Application of 4316-58-9)

In other references, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Application of 4316-58-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Zhifang; Li, Zuojie; Du, Tao; Chen, Yan; Wang, Qingpeng; Li, Guoshuai; Liu, Min; Zhang, Ning; Li, Dacheng; Han, Jun published an article in 2021. The article was titled 《Design, synthesis and biological evaluation of dihydro-2-quinolone platinum(IV) hybrids as antitumor agents displaying mitochondria injury and DNA damage mechanism》, and you may find the article in Dalton Transactions.Related Products of 3395-91-3 The information in the text is summarized as follows:

The design of novel platinum(IV) complexes with mitochondria injury competence, besides the DNA damage mechanism, is a promising way to develop new platinum drugs. Herein, dihydro-2-quinolone (DHQLO) as a mitocan was incorporated into the platinum(IV) system for the first time to prepare a new series of DHQLO platinum(IV) compounds Complex 1b could effectively inhibit the proliferation of tumor cells in vitro and in vivo. It accumulated at higher levels in both whole cells and DNA, and easily underwent intercellular reduction to release platinum(II) and DHQLO moieties. The released platinum(II) complex caused serious DNA damage by covalent conjunction with the DNA duplex, and remarkably increased the expression of the γ-H2AX protein. Moreover, 1b also caused serious mitochondria injury to induce mitochondrial membrane depolarization and increase ROS generation. Such actions upon DNA and mitochondria activate the p53 apoptotic pathway synergetically in tumor cells by upregulating the protein p53 and apoptotic proteins caspase9 and caspase3, which efficiently promoted the apoptotic death of tumor cells. Compound 1b with such synergic mechanism exhibited great potential in reversing cisplatin resistance and improving antitumor efficacies. After reading the article, we found that the author used Methyl 3-bromopropanoate(cas: 3395-91-3Related Products of 3395-91-3)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Related Products of 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Guo, Sheng-Qiang; Yang, Hui-Qing; Jiang, Yu-Zhen; Wang, Ai-Lian; Xu, Guo-Qiang; Luo, Yong-Chun; Chen, Zhao-Xu; Zheng, Haixue; Xu, Peng-Fei published an article in 2022. The article was titled 《Organophotoredox catalytic four-component radical-polar crossover cascade reactions for the stereoselective synthesis of β-amido sulfones》, and you may find the article in Green Chemistry.Electric Literature of C20H20BrP The information in the text is summarized as follows:

Herein, a green and reliable strategy for the diastereoselective synthesis of β-amido sulfones R1S(O)2CH(R2)CH(Ar)NHC(O)R3 (R1 = Me, 4-methylphenyl, naphth-2-yl, etc.; R2 = H, Me, Et, Pr, isopropyl; Ar = Ph, 3,4-dichlorophenyl, naphth-2-yl, etc.; R3 = Me, cyclopopyl, Ph, etc.) and I through organophotoredox catalytic four-component radical-polar crossover cascade reactions was reported. This transformation features excellent atom-, step-, and redox economy and diastereoselectivity. Moreover, DFT calculation studies were performed to provide some insights into the origin of diastereoselectivity. In addition to this study using Ethyltriphenylphosphonium bromide, there are many other studies that have used Ethyltriphenylphosphonium bromide(cas: 1530-32-1Electric Literature of C20H20BrP) was used in this study.

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. It is also used as catalysts in the synthesis of certain organic compounds and as a pharmaceutical intermediate.Electric Literature of C20H20BrP

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Noten, Efrey A.; McAtee, Rory C.; Stephenson, Corey R. J. published an article in Chemical Science. The title of the article was 《Catalytic intramolecular aminoarylation of unactivated alkenes with aryl sulfonamides》.Recommanded Product: 1530-32-1 The author mentioned the following in the article:

In this work, an intramol. alkene aminoarylation cascade that exploits the electrophilicity of a nitrogen-centered radical to form a C-N bond, then repurposes the nitrogen atom’s sulfonyl activating group as a traceless linker to form a subsequent C-C bond was disclosed. This photoredox catalysis protocol enabled the preparation of densely substituted arylethylamines I [R1 = H, Me; R2 = H, Me, i-Pr, BrCH2CH2, Ph; R1R2 = H2COCH2, (CH2C)3, (CH2C)5; R3= 2-pyridyl, 2,6-di-FC6H3, 2,4,6-tri-ClC6H2, etc.] from com. abundant aryl sulfonamides and unactivated alkenes under mild conditions. Reaction optimization, scope, mechanism, and synthetic applications were discussed. In the experiment, the researchers used many compounds, for example, Ethyltriphenylphosphonium bromide(cas: 1530-32-1Recommanded Product: 1530-32-1)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. It is also used as catalysts in the synthesis of certain organic compounds and as a pharmaceutical intermediate.Recommanded Product: 1530-32-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Suzuki, Itaru; Takenaka, Yuya; Morishita, Yoshitaka; Shibata, Ikuya published an article in Chemistry Letters. The title of the article was 《One-step Preparation of N-Unprotected Aziridines from 2H-Azirines by Addition of Ketene Silyl Acetals Catalyzed by Lewis Acids》.Safety of Indium(III) bromide The author mentioned the following in the article:

The nucleophilic addition of ketene silyl acetals 2 into 2H-azirines 1 proceeded in the presence of Lewis acids such as InX3 or Sc(OTf)3 to give N-unprotected aziridines 3. The mild Lewis acidity of the catalyst is important for the achievement of this coupling. The generated aziridine 3 could then be transformed into either oxazolines or γ-amino carbonyls. In addition to this study using Indium(III) bromide, there are many other studies that have used Indium(III) bromide(cas: 13465-09-3Safety of Indium(III) bromide) was used in this study.

Indium(III) bromide(cas: 13465-09-3) is used as a catalyst to produce dithioacetals when unactivated alkynes react with thiols and fields such as optics and microelectronics that utilize semiconductor technology have wide uses for indium in high-performing solar cells.Safety of Indium(III) bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary