Month: November 2022

In 2022,Mohamed, Mohamed Gamal; Mansoure, Tharwat Hassan; Samy, Maha Mohamed; Takashi, Yasuno; Mohammed, Ahmed A. K.; Ahamad, Tansir; Alshehri, Saad M.; Kim, Jeonghun; Matsagar, Babasaheb M.; Wu, Kevin C.-W.; Kuo, Shiao-Wei published an article in Molecules. The title of the article was 《Ultrastable Conjugated Microporous Polymers Containing Benzobisthiadiazole and Pyrene Building Blocks for Energy Storage Applications》.Application of 4316-58-9 The author mentioned the following in the article:

In recent years, conjugated microporous polymers (CMPs) have become important precursors for environmental and energy applications, compared with inorganic electrode materials, due to their ease of preparation, facile charge storage process, π-conjugated structures, relatively high thermal and chem. stability, abundance in nature, and high surface areas. Therefore, in this study, we designed and prepared new benzobisthiadiazole (BBT)-linked CMPs (BBT-CMPs) using a simple Sonogashira couplings reaction by reaction of 4,8-dibromobenzo(1,2-c;4,5-c′)bis(1,2,5)thiadiazole (BBT-Br2) with ethynyl derivatives of triphenylamine (TPA-T), pyrene (Py-T), and tetraphenylethene (TPE-T), resp., to afford TPA-BBT-CMP, Py-BBT-CMP, and TPE-BBT-CMP. The chem. structure and properties of BBT-CMPs such as surface areas, pore size, surface morphologies, and thermal stability using different measurements were discussed in detail. Among the studied BBT-CMPs, we revealed that TPE-BBT-CMP displayed high degradation temperature, up to 340 °C, with high char yield and regular, aggregated sphere based on thermogravimetric anal. (TGA) and SEM (SEM), resp. Furthermore, the Py-BBT-CMP as organic electrode showed an outstanding specific capacitance of 228 F g-1 and superior capacitance stability of 93.2% (over 2000 cycles). Based on theor. results, an important role of BBT-CMPs, due to their electronic structure, was revealed to be enhancing the charge storage. Furthermore, all three CMP polymers featured a high conjugation system, leading to improved electron conduction and small bandgaps. In the experiment, the researchers used Tris(4-bromophenyl)amine(cas: 4316-58-9Application of 4316-58-9)

In other references, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Application of 4316-58-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Hu, Ming-Hao; Lin, Jia-Hong; Huang, Qiong published an article in Bioorganic Chemistry. The title of the article was 《Discovery of a fluorescent, long chain-bridged bispurine that selectively targets the c-MYC G-quadruplex》.SDS of cas: 629-03-8 The author mentioned the following in the article:

G-quadruplexes (G4s) are special nucleic acid structures which are involved in the regulation of some key biol. events like transcription and translation, which are now treated as promising therapeutic targets for cancers. Stabilizing the promoter G4 by small-mol. ligands can suppress the c-MYC oncogene transcription, thus inhibiting cancer cell proliferation. So far, targeting the very structure, a number of ligands have been reported. However, most of them showed unsatisfactory specificity to the c-MYC G4 over other G4s, resulting in uncertain side effects. In this contribution, we discovered a new class of bispurines bridged with flexible hydrocarbon chains, which presented somewhat selectivity to the c-MYC G4 possibly by adaptive binding, which then showed clear inhibition on the c-MYC expression rather than other G4-driven oncogenes. Moreover, these novel mols. had the potential to fluorescently label G4s. We believed that this study may shed light on the discovery of new functional small mols. targeting a specific G4 structure.1,6-Dibromohexane(cas: 629-03-8SDS of cas: 629-03-8) was used in this study.

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.SDS of cas: 629-03-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Fan, Chaochao; Wang, Yue; Zhao, Jie; Zhao, Yanxia; Yang, Dong; Li, Boyang; Yu, Le; Yang, Xiao-Juan; Wu, Biao published an article in Inorganic Chemistry. The title of the article was 《Reversible [4 + 2] Photooxygenation in Anion-Coordination-Driven-Assembled A2L2-Type Complexes》.Category: bromides-buliding-blocks The author mentioned the following in the article:

Two bis-bis(urea) ligands (L1 and L2) incorporating the photoactive 9,10-diphenylanthracene fragment were designed for the construction of anion-coordination-driven assemblies and subsequent oxygenation of anthracene moieties for singlet oxygen storage. The corresponding A2L2-type sulfate complexes [TEA]4[(SO4)2(L1)2] (1) and [TEA]4[(SO4)2(L2)2] (2), where TEA = tetraethylammonium, were achieved by coordinating the ligands L1 or L2 with sulfate anions. Both 1 and 2 were able to undergo [4 + 2] photooxygenation to form endoperoxide photoproducts and , which can be partially converted back to the original anthracene compounds after heating. The structures of 1-EPO and 2-EPO were unambiguously confirmed by x-ray crystallog., NMR and UV-vis spectroscopy, and high-resolution electrospray ionization mass spectrometry. The results came from multiple reactions, including the reaction of 9,10-Dibromoanthracene(cas: 523-27-3Category: bromides-buliding-blocks)

9,10-Dibromoanthracene(cas: 523-27-3) is synthesized by the bromination of anthracene. The bromination reaction is carried out at room temperature using carbon tetrachloride as a solvent. Using 80-85% anthracene as raw material, adding bromine to react for half an hour, the yield is 83-88%.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Li, Xing-Ren; Hu, Kun; Yan, Bing-Chao; Li, Xiao-Nian; Sun, Han-Dong; Liu, Yang; Puno, Pema-Tenzin published an article in Bioorganic Chemistry. The title of the article was 《Scopariusicides D-M, ent-clerodane-based isomeric meroditerpenoids with a cyclobutane-fused γ/δ-lactone core from Isodon scoparius》.Formula: C7H5BrO2 The author mentioned the following in the article:

Scopariusicides D-M (1-10), ten new ent-clerodane-based meroditerpenoids with a cyclobutane-fused γ/δ-lactone core, were isolated from Isodon scoparius. Their structures were determined by comprehensive anal. of spectroscopic data, single-crystal X-ray diffraction, chem. transformation, and TDDFT ECD calculation A plausible biosynthetic pathway of 1-10 was proposed in which the asym. cyclobutane ring was formed via a crossed “”head-to-tail”” intermol. [2 + 2] cycloaddition in anti/syn facial approaches between an ent-clerodane lactone and a cis-4-hydroxycinnamic acid. Bioactivity evaluation manifested that 5 exhibited significant neuroprotective effect against corticosterone-induced injury in PC12 cells, while 6 and 7 exhibited moderate immunosuppressive activity against human T cell proliferation stimulated by anti-CD3/anti-CD28 mAb. The experimental process involved the reaction of 4-Bromobenzoic acid(cas: 586-76-5Formula: C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Formula: C7H5BrO2 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Ou, E.; Xu, Chao; Jia, Qi; Xu, Xiaojia; Chen, Zhenyu; Liu, Jiansong; Zhang, Hanyuan; Xu, Geng; Zhao, Yu published an article in Chemistry & Biodiversity. The title of the article was 《Synthesis and in Vivo Evaluation of Triphenylphosphonium Conjugated Trimetazidine with Enhanced Cardioprotection and Ability to Restore Mitochondrial Function》.Formula: C8H15BrO2 The author mentioned the following in the article:

Trimetazidine exhibits great therapeutic potential in cardiovascular diseases and mitochondria-mediated cardioprotection by trimetazidine has been widely reported. In this study, to enhance its cardioprotection, the triphenylphosphonium-based modification of trimetazidine was conducted to deliver it specifically to mitochondria. Fifteen triphenylphosphonium (TPP) conjugated trimetazidine analogs were designed and synthesized. Their protective effects were evaluated in vivo using a tert-Bu hydroperoxide (t-BHP) induced zebrafish injury model. Structure-activity relationship correlations revealed the best way to couple the TPP moiety to trimetazidine, and led to a new conjugate (18a) with enhanced therapeutic properties. Compared to trimetazidine, 18a effectively protects against heart injury in the zebrafish model at a much lower concentration Further study in t-BHP treated zebrafish and H9c2 cells demonstrated that 18a protects against cardiomyocyte death and damage by inhibiting excessive production of ROS, maintaining mitochondrial morphol., and preventing mitochondrial dysfunction. Consequently, 18a can be regarded as a potential therapeutic agent for cardioprotection. The results came from multiple reactions, including the reaction of 8-Bromooctanoic acid(cas: 17696-11-6Formula: C8H15BrO2)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid.Formula: C8H15BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Yano, Masafumi; Inada, Yoshinori; Hayashi, Yuki; Nakai, Misaki; Mitsudo, Koichi; Kashiwagi, Yukiyasu published an article in Dyes and Pigments. The title of the article was 《Near-infrared absorption of a benzothiophene-appended triphenylamine radical cation: A novel molecular design of NIR-II dye》.Safety of Tris(4-bromophenyl)amine The author mentioned the following in the article:

A triphenylamine with 3 benzothiophene rings was designed and synthesized in 87% yield. The compound showed absorption at 386 nm and blue emission at ∼442 nm, with a fluorescence quantum yield of 0.57. The compound showed high thermostability. The radical cation obtained by 1-electron oxidation was stable in solution and showed a significant absorption in the NIR-II region (λmax = 1213 nm). DFT calculations confirmed the exptl. data. The experimental part of the paper was very detailed, including the reaction process of Tris(4-bromophenyl)amine(cas: 4316-58-9Safety of Tris(4-bromophenyl)amine)

In other references, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Safety of Tris(4-bromophenyl)amine

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Walker, Rebecca; Pociecha, Damian; Faidutti, Camilla; Perkovic, Eva; Storey, John M. D.; Gorecka, Ewa; Imrie, Corrie T. published an article in Liquid Crystals. The title of the article was 《Remarkable stabilisation of the intercalated smectic phases of nonsymmetric dimers by tert-butyl groups》.SDS of cas: 17696-11-6 The author mentioned the following in the article:

The synthesis and characterization of two groups of nonsym. dimers, the 1-(4-cyanobiphenyl-4′-yloxy)-ω-(4-alkylbenzylidene-4′-oxy)alkanes and the 1-(4-cyanobiphenyl-4′-yl)-ω-(4-alkylbenzylidene-4′-oxy)alkanes, are reported. The length and parity of the flexible spacer are varied. The tert-Bu homologues show higher m.ps. than the corresponding sec-Bu or Bu substituted dimers and suggesting that chain branching improves packing efficiency within the crystalline structure. The branched chain homologues have a stronger tendency to exhibit smectic phases than the n-butyl-substituted dimers and are exclusively smectic for longer spacers. A comparison of the nematic-isotropic transition temperatures (TNI) for the dimers and containing the different terminal chains is possible for one set of materials, and reveals a large reduction in TNI on passing from the Bu to sec-butyl-substituted, but a much smaller decrease on changing sec-Bu for tert-Bu. A different trend is observed for the smectic A-isotropic transition temperatures for which the tert-Bu substituted dimers and show a higher value than the corresponding sec-Bu homolog, and only marginally lower than that of the n-butyl-substituted dimers. This surprising behavior is interpreted in terms of the ability of the tert-Bu group to pack more efficiently into the intercalated smectic A phase as the spacer length increases. In the experiment, the researchers used 8-Bromooctanoic acid(cas: 17696-11-6SDS of cas: 17696-11-6)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid.SDS of cas: 17696-11-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zheng, Chenggong; Yan, Fangpei; Liu, Yaomei; Chen, Rui; Zheng, Kaiting; Xiao, Hua; Li, Xiao-Xuan; Feng, Yi-Si; Fan, Shilu published an article in Organic Letters. The title of the article was 《Regioselective Alkylpolyfluoroarylation of Styrenes by Copper-Catalyzed C(sp3)-H and C(sp2)-H Double Activation》.Recommanded Product: 2635-13-4 The author mentioned the following in the article:

A novel dehydrogenative dicarbofunctionalization of vinyl arenes ArCH=CHR (Ar = Ph, thiophen-2-yl, 2H-1,3-benzodioxol-5-yl, etc.; R = H, Me) with polyfluoroarenes I (R1 = F, OMe, Ph, etc.) and inactivated alkanes such as cyclohexane, cyclopentane, cycloheptane, etc. enabled by copper catalysis has been accomplished under mild conditions. This transformation provides a regioselective route to highly functionalized polyfluoroaryl compds II (R2 = cyclopentyl, cyclohexyl, cycloheptyl, etc.) that occur as structural scaffolds in a variety of pharmaceuticals and materials. Preliminary mechanistic studies indicate that the carbon-based radical and copper intermediate are involved in the reaction, and the reaction pathway is dominated by the bond dissociation energy (BDE) of C(sp3)-H bonds. In the part of experimental materials, we found many familiar compounds, such as 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Recommanded Product: 2635-13-4)

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Recommanded Product: 2635-13-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Product Details of 623-24-5In 2021 ,《Well-defined cyclic polymer synthesis via an efficient etherification-based bimolecular ring-closure strategy》 appeared in Polymer Chemistry. The author of the article were Sharma, Sandeep; Ntetsikas, Konstantinos; Ladelta, Viko; Bhaumik, Saibal; Hadjichristidis, Nikos. The article conveys some information:

The synthesis of cyclic polymers on a large scale is a challenging task for polymer scientists due to the requirement of ultra-high dilution conditions. In this paper, we demonstrate an alternative method to prepare cyclic polymers with moderate dilution and up to 1 g scale. We employed a simple Williamson etherification reaction to prepare cyclic polymers with a good solvent/non-solvent combination. In this way, various polystyrene (PS) and polyethylene glycol (PEG) cyclic homopolymers were synthesized. Anionic polymerization using high vacuum techniques combined with the postpolymn. reaction was used to generate linear dihydroxy PS precursors. The synthesized linear and cyclic homopolymers were fully characterized using various spectroscopic and anal. techniques, such as size exclusion chromatog. (SEC), matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy (MALDI-TOF-MS), and differential scanning calorimetry (DSC). Detailed NMR spectroscopic studies were also performed to obtain the complete structural information of the synthesized polymers. In addition to this study using 1,4-Bis(bromomethyl)benzene, there are many other studies that have used 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Product Details of 623-24-5) was used in this study.

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Product Details of 623-24-5 The most pervasive is the naturally produced bromomethane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Product Details of 586-76-5In 2020 ,《A recyclable, metal-free mechanochemical approach for the oxidation of alcohols to carboxylic acids》 appeared in Molecules. The author of the article were Denlinger, Kendra Leahy; Carr, Preston; Waddell, Daniel C.; Mack, James. The article conveys some information:

The oxidation of primary alcs. under mechanochem. conditions in a Spex8000M Mixer/Mill was investigated. To facilitate ease of separation and recyclability, a polystyrene-bound version of a TEMPO catalyst was employed. When paired with Oxone in a stainless-steel vial with a stainless-steel ball, several primary alcs. were successfully oxidized to the corresponding carboxylic acids. The product was isolated using gravity filtration, which also allowed for the polystyrene-bound TEMPO catalyst to be recovered and reused in subsequent oxidation reactions. Furthermore, it was demonstrated that the size and steric hindrance of the primary alc. does not hinder the rate of the reaction. Finally, the aldehyde was selectively obtained from a primary alc. under ball milling conditions by using a combination of non-supported TEMPO with a copper vial and copper ball. In the part of experimental materials, we found many familiar compounds, such as 4-Bromobenzoic acid(cas: 586-76-5Product Details of 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Product Details of 586-76-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary