Month: November 2022

In 2019,Nature Communications included an article by He, Zhi-Tao; Hartwig, John F.. SDS of cas: 7073-94-1. The article was titled 《Palladium-catalyzed α-arylation for the addition of small rings to aromatic compounds》. The information in the text is summarized as follows:

A generally applicable approach to attach small rings to a wide range of aromatic compounds by palladium-catalyzed α-arylation of cyclopropyl, cyclobutyl and azetidinyl esters was reported. The direct α-arylation of cyclopropyl esters and cyclobutyl esters was achieved in high yield by ensuring that rate of coupling exceeded rate of Claisen condensation. The α-arylation of azetidines was achieved without ring opening of strained saturated heterocycle by conducting reactions with an azetidine derivative bearing a benzyl protecting group on nitrogen. Mechanistic studies showed that α-arylation of small rings was challenging because of the weak acidity of α C-H bond (cyclopropanes), strong sensitivity of strained esters to Claisen condensation (cyclobutatanes), or facile decomposition of enolates (azetidinyl esters). In the experiment, the researchers used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1SDS of cas: 7073-94-1)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. SDS of cas: 7073-94-1 Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Tetrahedron Letters included an article by Wang, Hai-Xia; Li, Wen-Peng; Xia, Chao; Xie, Ming-Sheng; Qu, Gui-Rong; Guo, Hai-Ming. Quality Control of Benzyl 2-bromoacetate. The article was titled 《Enantioselective synthesis of chiral carbocyclic pyrimidine nucleosides via asymmetric cyclopropanation》. The information in the text is summarized as follows:

An efficient method to construct chiral cyclopropyl pyrimidine carbocyclic nucleoside analogs bearing a quaternary center was developed via asym. Michael-initiated cyclopropanation. The axis chirality was observed in cyclopropyl pyrimidine carbocyclic nucleoside analogs for the first time, which was caused by the rotationally restricted N-C bond in N-COPh moiety. Using (DHQD)2AQN as the organocatalyst, diverse cyclopropyl pyrimidine carbocyclic nucleoside analogs were generated in 76-93% yields and 73-96% ee. In addition to this study using Benzyl 2-bromoacetate, there are many other studies that have used Benzyl 2-bromoacetate(cas: 5437-45-6Quality Control of Benzyl 2-bromoacetate) was used in this study.

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is an aromatic chemical, usually appearing as a clear liquid with a moderate sweet-jasmine fragrance. This compound appears as a component of some of our fragrance blends.Quality Control of Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Nickel-Catalyzed Selective Reduction of Carboxylic Acids to Aldehydes》 were Iosub, Andrei V.; Moravcik, Stefan; Wallentin, Carl-Johan; Bergman, Joakim. And the article was published in Organic Letters in 2019. Product Details of 17696-11-6 The author mentioned the following in the article:

The direct reduction of carboxylic acids to aldehydes is a fundamental transformation in organic synthesis. The combination of an air-stable Ni precatalyst, di-Me dicarbonate as an activator, and silane reductant effects this reduction for a wide variety of substrates, including pharmaceutically relevant structures, in good yields and with no overredn. to alcs. Moreover, this methodol. is scalable, allows access to deuterated aldehydes, and is also compatible with one-pot use of the aldehyde products.8-Bromooctanoic acid(cas: 17696-11-6Product Details of 17696-11-6) was used in this study.

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Product Details of 17696-11-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《A Protocol for the Ortho-Deuteration of Acidic Aromatic Compounds in D2O Catalyzed by Cationic RhIII》 were Garreau, Alyssa L.; Zhou, Hanyang; Young, Michael C.. And the article was published in Organic Letters in 2019. Recommanded Product: 586-76-5 The author mentioned the following in the article:

Methods to catalytically introduce deuterium in synthetically useful yields ortho to a carboxylic acid directing group on arenes typically requires D2 or high catalyst loadings, which makes using these approaches cost prohibitive for large-scale synthesis (equipment and reagent costs resp.). Herein, we present a simplified approach using low catalyst loadings of cationic RhIII and D2O as both deuterium source and solvent and show its application to H/D exchange on various carboxylic acid substrates. The results came from multiple reactions, including the reaction of 4-Bromobenzoic acid(cas: 586-76-5Recommanded Product: 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Recommanded Product: 586-76-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Tailored Polymers with Complement Activation Ability To Improve Antitumor Immunity》 were Li, Chenxi; Lu, Yue; Chen, Qing; Hu, Haiyang; Zhao, Xiuli; Qiao, Mingxi; Chen, Dawei. And the article was published in Molecular Pharmaceutics in 2019. Safety of Ethyl 3-bromopropanoate The author mentioned the following in the article:

The complement system plays an important role in host innate immunity, and its activation can be exploited as a potential strategy for vaccine adjuvants. Herein, a pH-responsive micellar vaccine platform (COOH-NPs) was developed using a carboxyl-modified diblock copolymer of poly(2-ethyl-2-oxazoline)-poly(D,L-lactide) (COOH-PEOz-PLA). The copolymer self-assembled into micelles with hydroxyl groups shielding on the surface, which activated the complement system for the enhanced immune responses. Compared with the control nanoparticles (OCH3-NPs), COOH-NPs significantly enhanced lymph node-resident dendritic cell maturation, antigen-specific IgG production, antigen-specific CD4+ and CD8+ T-cell activation, and the amount of memory T-cell generation in vivo. Furthermore, immunization with COOH-NPs/OVA in E.G7-OVA tumor-bearing mice not only remarkably inhibited tumor growth but also prolonged the survival of tumor-bearing mice. These results indicated that COOH-NPs with the capability of complement activation efficiently boosted the immune responses for the antitumor effect. The study demonstrated the significance of taking advantage of a complement-activating vaccine platform for cancer immunotherapy.Ethyl 3-bromopropanoate(cas: 539-74-2Safety of Ethyl 3-bromopropanoate) was used in this study.

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Safety of Ethyl 3-bromopropanoateSome of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《The high performance of polyaniline-gel network modified electrode in 3-(2,2,6,6-tetramethyl-piperidiynl-1-oxyl)-1-methylylimidazoliumbromide biredox electrolyte used for supercapacitor》 were Wang, Kui; Wang, Jixiao; Zhao, Song; Wang, Zhi; Wang, Shichang. And the article was published in Journal of Power Sources in 2019. SDS of cas: 623-24-5 The author mentioned the following in the article:

Improving energy d. while maintaining power d. and cycle stability is the most serious challenge for supercapacitors. The solid active electrode material might possess a higher redox species d. compared with its traditional counterpart, however, its electrochem. reaction kinetics is several magnitude orders lower in solids than that in liquids, leading to a deterioration of power d. Thus, a new approach based on 3-TEMPO-1-methylylimidazolium bromide (MIm+-TEMPO• Br-) biredox electrolyte, and a PANI-gel network modified carbon paper (PNcp) electrode for supercapacitor were developed. The biredox electrolyte possesses a high energy d. comparable to solid redox materials and a fast kinetics of liquid redox reaction, while the cross-diffusion of ions leads to a serious voltage drop which presents an inherent self-discharge problem. Fortunately, the PNcp prepared by a millisecond photo-thermal process makes up for this shortcoming. On one hand, its unique PANI-gel network structure protects the biredox electrolyte from cross-diffusion phenomenon, however, the combination of doping/dedoping process of PANI and redox process of MIm+-TEMPO• Br- provides an extra effect to prevent the self-discharge and attain a synergetic electrochem. performance. This method explores an avenue to pursue for battery level energy d. meanwhile maintains good power d. In addition to this study using 1,4-Bis(bromomethyl)benzene, there are many other studies that have used 1,4-Bis(bromomethyl)benzene(cas: 623-24-5SDS of cas: 623-24-5) was used in this study.

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. SDS of cas: 623-24-5 Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Catalytic radical generation of π-allylpalladium complexes》 was published in Nature Catalysis in 2020. These research results belong to Huang, Huan-Ming; Koy, Maximilian; Serrano, Eloisa; Pflueger, Philipp Miro; Schwarz, J. Luca; Glorius, Frank. Application of 1779-49-3 The article mentions the following:

A radical approach for the generation of π-allylpalladium complexes by employing N-hydroxyphthalimide esters e.g., I as bifunctional reagents in combination with 1,3-dienes RCH=CHCH=CH2 (R = H, Me, 2-phenylethyl, cyclohexyl, etc.) and 1,3-cyclohexadiene was shown. Using this strategy, 1,4-aminoalkylation of dienes were reported. The remarkable scope and functional group tolerance of this redox-neutral and mild protocol were demonstrated across >60 examples e.g., II. The utility of this strategy was further demonstrated in radical cascade reactions and in the late-stage modification of drugs and natural products. The experimental process involved the reaction of Methyltriphenylphosphonium bromide(cas: 1779-49-3Application of 1779-49-3)

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is used for methylenation through the Wittig reaction. It is utilized in the synthesis of an enyne and 9-isopropenyl -phenanthrene by using sodium amide as reagent. Application of 1779-49-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Formal Bromine Atom Transfer Radical Addition of Nonactivated Bromoalkanes Using Photoredox Gold Catalysis》 was published in Organic Letters in 2020. These research results belong to Zidan, Montserrat; McCallum, Terry; Swann, Rowan; Barriault, Louis. SDS of cas: 7051-34-5 The article mentions the following:

Organic transformations mediated by photoredox catalysis have been at the forefront of reaction discovery. Recently, it has been demonstrated that binuclear Au(I) bisphosphine complexes, such as [Au2(μ-dppm)2]X2, are capable of mediating electron transfer to nonactivated bromoalkanes for the generation of a variety of alkyl radicals. The transfer reactions of bromine, derived from nonactivated bromoalkanes, are largely unknown. Therefore, we propose that unique metal-based mechanistic pathways are at play, as this binuclear gold catalyst has been known to produce Au(III) Lewis acid intermediates. The scope and proposed mechanistic overview for the formal bromine atom transfer reaction of nonactivated bromoalkanes mediated by photoredox Au(I) catalysis is presented. The methodol. presented afforded good yields and a broad scope which include examples using bromoalkanes and iodoarenes. In the experiment, the researchers used (Bromomethyl)cyclopropane(cas: 7051-34-5SDS of cas: 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.SDS of cas: 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Catalytic enantioselective synthesis of carbocyclic and heterocyclic spiranes via a decarboxylative aldol cyclization》 was published in Chemical Science in 2020. These research results belong to Inanaga, Kazato; Wollenburg, Marco; Bachman, Shoshana; Hafeman, Nicholas J.; Stoltz, Brian M.. Related Products of 14660-52-7 The article mentions the following:

The synthesis of a variety of enantioenriched 1,3-diketospiranes from the corresponding racemic allyl β-ketoesters via an interrupted asym. allylic alkylation is disclosed. Substrates possessing pendant aldehydes undergo decarboxylative enolate formation in the presence of a chiral Pd catalyst and subsequently participate in an enantio- and diastereoselective, intramol. aldol reaction to furnish spirocyclic β-hydroxy ketones which may be oxidized to the corresponding enantioenriched diketospiranes. Addnl., this chem. has been extended to α-allylcarboxy lactam substrates leading to a formal synthesis of the natural product (-)-isonitramine. The experimental process involved the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Related Products of 14660-52-7)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Related Products of 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Hapten Synthesis and the Development of an Ultrasensitive Indirect Competitive ELISA for the Determination of Diethylstilbestrol in Food Samples》 was written by Yang, Xingdong; Wang, Yinbiao; Song, Chunmei; Hu, Xiaofei; Wang, Fangyu; Zeng, Xianyin. Recommanded Product: 2969-81-5 And the article was included in Scientific Reports in 2020. The article conveys some information:

An ultrasensitive indirect competitive ELISA (ic ELISA) using monoclonal antibodies (mAbs) was developed for the specific detection of diethylstilbestrol (DES) residues. To establish an ELISA based on mAbs, hapten diethylstilbestrol mono-carboxypropyl-ether (DES-MCPE) was chem. synthesized and then conjugated to bovine serum albumin (BSA) for immunization in mice. This ic ELISA was further optimized for DES determination The sensitivity of the ic ELISA was found to be 0.49μg/kg and the limit of detection was 0.075μg/kg. DES residues in salmon meat and pork were tested with the recovery range from 74.0 to 85.2% and the coefficient of variation (CV) was less than 10%. Parallel anal. of DES samples from salmon meat showed comparable results from the ic ELISA with high-performance liquid chromatog. The ic ELISA provides a useful screening method for the quant. detection of DES residues in animal-derived food. In the experiment, the researchers used Ethyl 4-bromobutyrate(cas: 2969-81-5Recommanded Product: 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Recommanded Product: 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary