Month: November 2022

Bhat, Sachin A.; Rao, D. S. Shankar; Prasad, S. Krishna; Yelamaggad, Channabasaveshwar V. published their research in Nanoscale Advances in 2021. The article was titled 《Chiral plasmonic liquid crystal gold nanoparticles: self-assembly into a circular dichroism responsive helical lamellar superstructure》.Application In Synthesis of 4-Bromobutanoic acid The article contains the following contents:

Owing to their proven and promising potential in various technol. endeavors ranging from catalysis and sensing to invisibility cloaks made from metamaterials, chiral plasmonic superstructures resulting from the directed self-assembly of optically active metal nanoparticles (MNPs) have been pursued intensively in recent years. Several strategic efforts have emerged especially to accomplish advanced nanomaterials assembling into liquid crystalline (LC) helical structures, where MNPs are regularly packed in fluid/frozen arrays/layers or wires (columns). While the helical fluid columnar arrays (mol. wires) showing CD (CD) have been realized, the discovery of fluid chiral lamellar ordering, where the dielec. and conducting regimes are arranged alternatively, has hitherto remained highly elusive. Herein we report the first examples of monodisperse LC-gold NPs (LC-GNPs) self-assembling into a fluid/frozen lamellar structure exhibiting CD activity. Notably, these new, exceptional LC-GNPs have been realized by simple, hassle-free protocols that involve the room temperature addition of LC dimer-like arylamines to Au(III), where the amines not only reduce Au(III) to Au(0) but also bind strongly to the central GNP scaffold. Their mol. structure, mesomorphism, and ability to interact with circularly polarized light have been evidenced unambiguously and could play an important role in realizing metamaterials in the visible region. In the experiment, the researchers used many compounds, for example, 4-Bromobutanoic acid(cas: 2623-87-2Application In Synthesis of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Application In Synthesis of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ibrahim, Tarek S.; Malebari, Azizah M.; Mohamed, Mamdouh F. A. published an article in 2021. The article was titled 《Design, Synthesis, In Vitro Anticancer Evaluation and Molecular Modelling Studies of 3,4,5-Trimethoxyphenyl-Based Derivatives as Dual EGFR/HDAC Hybrid Inhibitors》, and you may find the article in Pharmaceuticals.Category: bromides-buliding-blocks The information in the text is summarized as follows:

Recently, combining histone deacetylase (HDAC) inhibitors with chemotherapeutic drugs or agents, in particular epidermal growth factor receptor (EGFR) inhibitors, is considered to be one of the most encouraging strategy to enhance the efficacy of the antineoplastic agents and decrease or avoid drug resistance. Therefore, in this work, based on introducing 3,4,5-trimethoxy Ph group as a part of the CAP moiety, in addition to incorporating 4-6 aliphatic carbons linker and using COOH or hydroxamic acid as ZBG, 12 novel EGFR/HDAC hybrid inhibitors 2a-c, 3a-c, 4a-c and 5a-c were designed, constructed, and evaluated for their anticancer activities against 4 cancer cell lines (HepG2, MCF-7, HCT116 and A549). Among all, hybrids with hydroxamic acid 4a-c and 5a, exhibited the highest inhibition against all cancer cell lines with IC50 ranging from 0.536 to 4.892 μM compared to Vorinostat (SAHA) with IC50 ranging from 2.43 to 3.63 μM and Gefitinib with IC50 ranging from 1.439 to 3.366 μM. Mechanistically, the most potent hybrids 4a-c and 5a were further tested for their EGFR and HDACs inhibitory activities. The findings disclosed that hybrid 4b displayed IC50 = 0.063 μM on the target EGFR enzyme which is slightly less potent than the standard Staurosporine (IC50 = 0.044 μM). Furthermore, hybrid 4b showed less HDAC inhibitory activity IC50 against HDAC1 (0.148), 2 (0.168), 4 (5.852), 6 (0.06) and 8 (2.257) than SAHA. In addition, the investigation of apoptotic action of the most potent hybrid 4b showed a significant increase in Bax level up to 3.75-folds, with down-regulation in Bcl2 to 0.42-fold, compared to the control. Furthermore, hybrid 4b displayed an increase in the levels of Caspases 3 and 8 by 5.1 and 3.15 folds, resp. Addnl., the cell cycle anal. of hybrid 4b revealed that it showed programmed cell death and cell cycle arrest at G1/S phase. Moreover, all these outcomes together with the mol. docking study recommended the rationalized target hybrids 4a-c and 5a, particularly 4b, may be considered to be promising lead candidates for discovery of novel anticancer agents via dual inhibition of both EGFR/HDAC enzymes. In addition to this study using Ethyl 5-bromovalerate, there are many other studies that have used Ethyl 5-bromovalerate(cas: 14660-52-7Category: bromides-buliding-blocks) was used in this study.

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Di; Lin, Liming; Xie, Yunji; Pang, Jinhui; Jiang, Zhenhua published an article in 2021. The article was titled 《Anion exchange membrane based on poly(arylene ether ketone) containing long alkyl densely quaternized carbazole derivative pendant》, and you may find the article in Journal of Membrane Science.SDS of cas: 629-03-8 The information in the text is summarized as follows:

A series of poly(arylene ether ketone) copolymers (PAEK-HQACz-x) containing long alkyl densely quaternized carbazole derivative pendant was designed and synthesized for anion exchange membrane. It was found that constructing long alkyl chain between hydrophobic polymer backbone and hydrophilic densely functionalized hydrophilic pendant effective promoted the formation of well-defined microscopic phase separation morphol., in turn enabling high hydroxide conduction and confined dimensional variation. The PAEK-HQACz-0.7 membrane exhibited the hydroxide conductivity of 98.1 mS cm-1 at 80°C, while the swelling ratio was only 13.5%. The toughness and alk. stability of PAEK-HQACz-x membranes were also significantly improved by attaching the long alkyl chain onto the quaternized carbazole derivative pendant. The PAEK-HQACz-0.7 membrane was selected for membrane electrode assembly and showed acceptable results. These properties demonstrated such membranes to be promising anion exchange membrane candidates. In the experiment, the researchers used 1,6-Dibromohexane(cas: 629-03-8SDS of cas: 629-03-8)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of pyrrolo-tetrathiafulvalene molecular bridge (6PTTF6) to study redox switching behavior of single molecules; synthesis of water-soluble thermoresponsive polylactides.SDS of cas: 629-03-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Xu, Kaidi; Zhang, Zhi-Yuan; Zhou, Zihao; Li, Chunju published an article in Chinese Chemical Letters. The title of the article was 《Prospering the biphen[n]arenes family by tailoring reaction modules》.Application In Synthesis of 1-Bromo-3,4,5-trimethoxybenzene The author mentioned the following in the article:

Reported here is the comprehensive investigation on the formation of biphen[n]arenes by tailoring reaction modules. Five new macrocyclic arenes and four oligomers were synthesized by the condensation of monomers possessing different multimethoxyphenyl reaction modules and paraformaldehyde. We proved that the number and sites of methoxy on reaction modules greatly affected the reaction activity, shape, and connection mode of macrocycles. Moreover, the triangular and saddle-shaped configuration of macrocycles were revealed by single crystal structures. The results provided a typical and fundamental guidance in designing new macrocyclic arenes. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Application In Synthesis of 1-Bromo-3,4,5-trimethoxybenzene)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Application In Synthesis of 1-Bromo-3,4,5-trimethoxybenzene1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Singh, Varinder; Abudayyeh, Abdullah M.; Robb, Matthew G.; Brooker, Sally published an article in Dalton Transactions. The title of the article was 《Mono-copper far more active than analogous di-copper complex for electrocatalytic hydrogen evolution》.Recommanded Product: 623-24-5 The author mentioned the following in the article:

The di-copper(II) analog, [CuII2(bis-LEt)](BF4)2 (2), of the previously reported mono-copper(II) complex [CuIILEt]BF4 (1) which resulted in long lived electrocatalytic hydrogen evolution reaction (HER), has been prepared, characterised and tested for HER. The new bis-macrocycle, bis-HLEt, was formed from two HLEt Schiff base macrocycles (prepared by 1 + 1 condensation of 2,2′-iminobisbenzaldehyde and diethylenetriamine) being connected by selective alkylation of the less sterically hindered secondary alkyl amine group (NH) of each, using α,α′-dibromo-para-xylene to form a linker between them. The desired dicopper(II) complex, [Cu2II(bis-LEt)](BF4).4H2O (2.4H2O), was readily prepared, as a yellowish brown solid in 82% yield. SCXRD on yellow-brown crystals of [CuII2(bis-LEt)](BF4)2.2MeCN (2.2MeCN) revealed both copper(II) centers are square planar with a very similar copper(II) coordination environment to that of square planar 1. Although dicopper(II) complex 2 is easier to reduce than the analogous monocopper(II) complex 1 in MeCN (E1/2(ΔE): 2 -1.20(0.12) V, 1 -1.39(0.09) V, vs. 0.01 M AgNO3/Ag), electrocatalytic HER testing of dicopper complex 2·4H2O, in MeCN with 80 equiv of acetic acid, revealed it was inactive, in stark contrast to the high and ongoing activity of 1 under the same conditions. So two is definitely not better than one metal ion in this case. Rather, it may be that the presence of an NH group in the macrocycle of 1, but absent in the bis-macrocycle of 2 (due to alkylating that NH to link the two macrocycles), may be key to the HER activity seen for 1. In the experimental materials used by the author, we found 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Recommanded Product: 623-24-5)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Recommanded Product: 623-24-5 Organobromine compounds have fallen under increased scrutiny for their environmental impact.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Hartman, Tomas; Konecny, Jan; Mazanek, Vlastimil; Sturala, Jiri; Sofer, Zdenek published an article in Inorganic Chemistry. The title of the article was 《A Decade of Germananes: Four Approaches to Their Functionalization》.Name: Methyl 3-bromopropanoate The author mentioned the following in the article:

Since the 1st synthesis of germanane (GeH) reported in 2013, two-dimensional Ge-based materials were intensively studied. Over the past decade, several methodologies for the functionalization of germanane were introduced. The 1st approach used exfoliation of Zintl phase CaGe2 with alkyl halides. Liu’s solvothermal method was used for the synthesis of Me germanane. Another methodol. used Ge-H activation with Na naphthalenide and its subsequent alkylation. All of these methods provide functionalized germananes; thus, a comparison of these methods is needed. Such a comparison of current synthetic approaches towards alkyl germananes is reported, and addnl., a new method for Ge-H activation using a NaK equimolar alloy is presented as a 4th approach. For this purpose, eight alkyl reagents were chosen representing reactive benzyl bromides as well as linear esters and nitriles because they contain easily trackable functional groups. The materials were characterized using FTIR spectroscopy, Raman spectroscopy, XPS, and TGA, and the data were compared. The comparison of all methods revealed not only some drawbacks for each method but also their advantages. The method using Na naphthalenide provided the lowest degree of surface coverage, whereas the solvothermal method seemed to provide materials with the highest degree of functionalization; unfortunately, the functionalization was also accompanied by a high degree of surface oxidation, i.e., (Ge-OH/Ge = O) formation. The highest degree of surface coverage accompanied by the lowest degree of surface oxidation was achieved employing Goldberger’s phase transfer direct exfoliation of CaGe2 as well as Ge-H activation using the NaK alloy with subsequent alkylation. The results came from multiple reactions, including the reaction of Methyl 3-bromopropanoate(cas: 3395-91-3Name: Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Name: Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Liu, Genyan; Zhou, Congwei; Zhang, Zhisong; Wang, Chenchen; Luo, Xiaogang; Ju, Xiulian; Zhao, Chunqing; Ozoe, Yoshihisa published an article in Pest Management Science. The title of the article was 《Novel insecticidal 1,6-dihydro-6-iminopyridazine derivatives as competitive antagonists of insect RDL GABA receptors》.SDS of cas: 539-74-2 The author mentioned the following in the article:

BACKGROUND : The ionotropic γ-aminobutyric acid (GABA) receptor (iGABAR) is an important target for insecticides and parasiticides. Our previous studies showed that competitive antagonists (CAs) of insect iGABARs have the potential to be used for developing novel insecticides and that the structural modification of gabazine (a representative CA of mammalian iGABARs) could lead to the identification of novel CAs of insect iGABARs. RESULTS : In the present study, a novel series of 1,3-di- and 1,3,5-trisubstituted 1,6-dihydro-6-iminopyridazines (DIPs) was designed using a versatile strategy and synthesized using facile methods. Electrophysiol. studies showed that several target DIPs (30μM) exhibited excellent antagonistic activities against common cutworm and housefly iGABARs consisting of RDL subunits. The IC50 values of 3-(4-methoxyphenyl), 3-(4-trifluoromethoxyphenyl), 3-(4-biphenylylphenyl), 3-(2-naphthyl), 3-(3,4-methylenedioxyphenyl), and 3,5-(4-methoxyphenyl) analogs ranged from 2.2 to 24.8μM. Addnl., several 1,3-disubstituted DIPs, especially 3-(4-trifluoromethoxyphenyl) and 3-(3,4-methylenedioxyphenyl) analogs, exhibited moderate insecticidal activity against common cutworm larvae, with >60% mortality at a concentration of 100 mg kg-1. Mol. docking studies showed that the oxygen atom on the three-substituted aromatic ring could form a hydrogen bond with Arg254, which may enhance the activity of these DIPs against housefly iGABARs. CONCLUSION : This systematic study indicated that the presence of a carboxyl side chain shorter by one methylene than that of gabazine at the 1-position of the pyridazine ring is effective for maintaining the stable binding of these DIPs in insect iGABARs. Our study provides important information for the design of novel insect iGABAR CAs. 2022 Society of Chem. Industry. In the part of experimental materials, we found many familiar compounds, such as Ethyl 3-bromopropanoate(cas: 539-74-2SDS of cas: 539-74-2)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In contrast, terrestrial plants account only for a few bromine-containing compounds.SDS of cas: 539-74-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Tandekar, Kesar; Tripathi, Anjali; Prasad, Muvva D.; Supriya, Sabbani published an article in Materials Advances. The title of the article was 《Keggin based self-assembled mesoporous materials for capture of selective guest molecules》.Quality Control of Ethyltriphenylphosphonium bromide The author mentioned the following in the article:

A series of self-assembled mesoporous materials, compounds 1-9, of the type [RPPh3]n[XM12O40] (R = Ph, Me, Et; n = 3 or 4; X = P, Si; M = Mo, W) composed of Keggin anions and phosphonium cations have been fabricated and characterized. These thermally stable hybrid materials show selective reversible uptake of non-polar mols. such as iodine and carbon disulfide under ambient conditions. The resultant porosity is attributed to the self-assembling of the cations on the surface of the Keggin anion such that the pores are lined with the phosphonium cations rendering them hydrophobhic. The present work explores the spontaneous self-assembly process of POM integrated mesoporous compounds stabilized via non-covalent interactions and their potential applications as adsorbing materials. In the experimental materials used by the author, we found Ethyltriphenylphosphonium bromide(cas: 1530-32-1Quality Control of Ethyltriphenylphosphonium bromide)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.Quality Control of Ethyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhou, Xuechen; Zheng, Mengzhu; Zhao, Na; Hu, Yixin; Yang, Kaiyin; Huo, Junfeng; Liu, Guangyuan; Huang, Jiangeng; Chen, Lixia; Zhou, Yirong; Li, Hua published an article in Bioorganic Chemistry. The title of the article was 《Discovery of linear unnatural peptides as potent mutant isocitrate dehydrogenase 1 inhibitors by Ugi reaction》.HPLC of Formula: 2623-87-2 The author mentioned the following in the article:

Isocitrate dehydrogenases 1 (IDH1) catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutaric acid (α-KG). It is the most frequently mutated metabolic gene in human cancer and its mutations interfere with cell metabolism and epigenetic regulation, thus promoting tumorigenesis. In order to discover potent new mutant IDH1 inhibitors, based on the structure of marketed inhibitor AG-120 (Ivosidenib), we designed, synthesized and evaluated a series of linear unnatural peptide analogs via Ugi reaction, as potential mutant IDH1 inhibitors. All these compounds were evaluated for their inhibition on mutant IDH1 enzyme activity. The structure-activity relationship was discussed on the basis of exptl. data, with an attempt to pave the way for future studies. Among them, 43 exhibited potent and selective enzyme inhibitory activity, and showed strong binding affinity with mutant IDH1. It can decrease the cellular concentration of 2-HG, and suppress the proliferation of HT1080 and IDH1 mutant-U-87 cells by selectively inhibiting the activity of mutant IDH1. The results came from multiple reactions, including the reaction of 4-Bromobutanoic acid(cas: 2623-87-2HPLC of Formula: 2623-87-2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).HPLC of Formula: 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Liu, Haichao; Lau, Vincent Ho Man; Xu, Pan; Chan, Tsz Hin; Huang, Zhongxing published an article in Nature Communications. The title of the article was 《Diverse synthesis of α-tertiary amines and tertiary alcohols via desymmetric reduction of malonic esters》.Electric Literature of C9H11Br The author mentioned the following in the article:

While conventional methods towards these motifs often rely on enantioselective carbon-carbon or carbon-heteroatom bond formation reactions, a desym. method was developed here by selectively hydrosilylating one of the esters of easily accessible α-substituted α-amino- and -oxymalonic esters. The desymmetrization was enabled by a suite of dinuclear zinc catalysts with pipecolinol-derived tetradentate ligands and could accommodate a diverse panel of heteroatom substituents, including secondary amides, tertiary amines and ethers of different sizes. The polyfunctionalized reduction products, in return, had provided expeditious approaches to enantioenriched nitrogen- and oxygen-containing mols., including dipeptides, vitamin analogs, and natural metabolites. The experimental process involved the reaction of 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Electric Literature of C9H11Br)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Electric Literature of C9H11Br The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary