Month: November 2022

In 2022,Liu, Aifeng; Zheng, Minggang; Qiu, Ying; Hua, Yi; Li, Ying; Jiang, Yuqing; Ning, Ke; Hu, Shanmin; Wang, Ling published an article in Environmental Research. The title of the article was 《Study of the scavenger and vector roles of microplastics for polyhalocarbazoles under simulated gastric fluid conditions》.Related Products of 6825-20-3 The author mentioned the following in the article:

Microplastics entering the digestive system of living organisms can serve as a carrier of hydrophobic organic pollutants (HOPs), increasing their exposure levels and the health risks they pose to both humans and animals. The desorption kinetics of six polyhalocarbazoles (PHCZs) from 5 mm and 0.15 mm polypropylene (PP) and polyvinyl chloride (PVC) microplastic particles were assessed using a combined microplastics and food system, representing the gastric system of vertebrates and invertebrates. Results showed that the chem. transfer of PHCZs is biphasic and reversible, with rapid exchange occurring within 2-48 h, followed by a period of slow transfer, which continues for weeks to months. The desorption capacity of PHCZs loaded on 0.15 mm microplastic particles was greater than that of 5 mm particles. The bioavailability percentage of PHCZ congeners for PP (24.2%-65.3%) and PVC (43.5%-57.2%) in the vertebrate fluid system were all lower than those in the invertebrate system (34.2%-70.7% for PP and 56.3%-72.7% for PVC, resp.). These findings indicate that physiol. conditions, such as polarity, ingestion fluid, and microplastic affect the desorption of PHCZs from microplastics. In addition, desorption from PP was inhibited by the presence of foodstuff loaded with PHCZs due to competition, while desorption from PVC was not significantly affected by the presence of PHCZs contaminant food. Microplastics could provide a cleaning function in gastric fluid systems containing contaminated foodstuff, especially PP, which was capable of competitive adsorption of PHCZs from food. Few investigations have focused on the adverse effects of microplastic ingestion on human health, particularly in their role as vectors for HOPs, compared to other routes of exposure and transport. Therefore, these findings provide valuable insight into the health risks associated with dietary intake of microplastics and HOPs. In addition to this study using 3,6-Dibromo-9H-carbazole, there are many other studies that have used 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Related Products of 6825-20-3) was used in this study.

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used in the preparation of N-(2-hydroxyethyl)-3,6-dibromocarbazole.Related Products of 6825-20-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Computed Properties of Br3InIn 2021 ,《Indium bromide (InBr3): A versatile and efficient catalyst in organic synthesis》 appeared in Synthetic Communications. The author of the article were Yu, Ying; Kazemi, Mosstafa. The article conveys some information:

A review. Indium compounds are versatile and efficient materials for catalysis in chem. science, especially in organic synthesis. Amongst indium compounds, indium bromide (InBr3) is widely employed in many chem. reactions. The present review focuses on the developments in the catalytic application of indium bromide (InBr3) for chem. reactions. The review is aimed at researchers, graduate students, and synthetic chemists at all levels in academia and industry, for the utilization of indium bromide (InBr3) as a catalyst in chem. transformations. In the experiment, the researchers used many compounds, for example, Indium(III) bromide(cas: 13465-09-3Computed Properties of Br3In)

Indium(III) bromide(cas: 13465-09-3) is used as a catalyst to produce dithioacetals when unactivated alkynes react with thiols and fields such as optics and microelectronics that utilize semiconductor technology have wide uses for indium in high-performing solar cells.Computed Properties of Br3In

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 3141-27-3In 2022 ,《Stable room temperature ferroelectricity in hydrogen-bonded supramolecular assemblies of ambipolar π-systems》 was published in Chemical Science. The article was written by Mukherjee, Anurag; Barman, Shubhankar; Ghosh, Anupam; Chakraborty, Saptarshi; Datta, Ayan; Datta, Anuja; Ghosh, Suhrit. The article contains the following contents:

This article reports H-bonding driven supramol. polymerization of naphthalimide (A)-thiophene (D)-naphthalimide (A) (ADnA, n = 1-4) conjugated ambipolar π-systems and its remarkable impact on room temperature ferroelectricity. Electrochem. studies confirm the ambipolar nature of these ADnA mols. with the HOMO-LUMO gap varying between 2.05 and 2.29 eV. Electron d. mapping from ESP calculations reveals intra-mol. charge separation as typically observed in ambipolar systems. In the aggregated state, AD1A and AD2A exhibit bathochromically shifted absorption bands while AD3A and AD4A show typical H-aggregation with a hypsochromic shift. Polarization vs. elec. field (P-E) measurements reveal stable room temperature ferroelectricity for these supramol. assemblies, most prominent for the AD2A system, with a Curie temperature (Tc) ∼ 361 K and saturation polarization (Ps) of ∼2μC cm-2 at a rather low coercive field of ∼2 kV cm-1. Control mols., lacking either the ambipolar chromophore or the amide functionality, do not show any ferroelectricity, vindicating the present mol. and supramol. design. Computational studies enable structural optimization of the stacked oligomer(s) of AD2A mols. and reveal a significant increase in the macro-dipole moment (in the range of 10-12 Debye) going from the monomer to the oligomer(s), which provides the rationale for the origin of ferroelectricity in these supramol. polymers. In the experimental materials used by the author, we found 2,5-Dibromothiophene(cas: 3141-27-3Related Products of 3141-27-3)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene polymerizes by debromination with magnesium catalyzed by nickel compounds to form poly(2,5- thienylene) .Related Products of 3141-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Category: bromides-buliding-blocksIn 2021 ,《Design and synthesis of novel tacrine-dipicolylamine dimers that are multiple-target-directed ligands with potential to treat Alzheimer′s disease》 was published in Bioorganic Chemistry. The article was written by Zhang, Panpan; Wang, Ze; Mou, Chenye; Zou, Jiamei; Xie, Yanfei; Liu, Zhiwen; Benjamin Naman, C.; Mao, Yuechun; Wei, Jiaxin; Huang, Xinghan; Dong, Jiahui; Yang, Mengxiang; Wang, Ning; Jin, Haixiao; Liu, Fufeng; Lin, Dongdong; Liu, Hao; Zhou, Fei; He, Shan; Zhang, Bin; Cui, Wei. The article contains the following contents:

Alzheimer′s disease (AD) is a prevalent neurodegenerative disorder that has multiple causes. Therefore, multiple-target-directed ligands (MTDLs), which act on multiple targets, have been developed as a novel strategy for AD therapy. In this study, novel drug candidates were designed and synthesized by the covalent linkings of tacrine, a previously used anti-AD acetylcholinesterase (AChE) inhibitor, and dipicolylamine, an β-amyloid (Aβ) aggregation inhibitor. Most tacrine-dipicolylamine dimers potently inhibited AChE and Aβ1-42 aggregation in vitro, and 13a exhibited nanomolar level inhibition. Mol. docking anal. suggested that 13a could interact with the catalytic active sites and the peripheral anion site of AChE, and bind to Aβ1-42 pentamers. Moreover, 13a effectively attenuated Aβ1-42 oligomers-induced cognitive dysfunction in mice by activating the cAMP-response element binding protein/brain-derived neurotrophic factor signaling pathway, decreasing tau phosphorylation, preventing synaptic toxicity, and inhibiting neuroinflammation. The safety profile of 13a in mice was demonstrated by acute toxicity experiments All these results suggested that novel tacrine-dipicolylamine dimers, especially 13a, have multi-target neuroprotective and cognitive-enhancing potentials, and therefore might be developed as MTDLs to combat AD.Methyl 3-bromopropanoate(cas: 3395-91-3Category: bromides-buliding-blocks) was used in this study.

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 7073-94-1In 2018 ,《Au-Catalyzed Oxidative Arylation: Chelation-Induced Turnover of ortho-Substituted Arylsilanes》 was published in ACS Catalysis. The article was written by Robinson, Matthew P.; Lloyd-Jones, Guy C.. The article contains the following contents:

Ortho-Substituted aryl silanes have previously been found to undergo much slower Au-catalyzed intermol. arylation than their m,p-substituted isomers, with many examples failing to undergo turnover at all. A method to indirectly quantify the rates of C-Si auration of o-substituted aryl silanes, under conditions of turnover, has been developed. All examples are found to undergo very efficient C-Si auration, indicative that it is the subsequent C-H auration that is inhibited by the ortho substituent. A simple Ar-Au conformational model suggests that C-H auration can be accelerated by chelation. A series of ortho-functionalized aryl silanes are shown to undergo efficient arylation. In the experimental materials used by the author, we found 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Recommanded Product: 7073-94-1)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Recommanded Product: 7073-94-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《A chiral uranyl-Kemp’s tricarboxylate cubic framework: structure-directing effect of counter ions with three-fold rotational symmetry》 was written by Thuery, Pierre; Harrowfield, Jack. Related Products of 1779-49-3This research focused onuranyl carboxylate coordination polymer preparation Hirshfeld surface; crystal structure uranyl carboxylate coordination polymer. The article conveys some information:

In the presence of PPh3Me+ cations, Kemp’s tricarboxylate (kta3-) complexes the uranyl cation to give [PPh3Me][UO2(kta)] (1), a triperiodic framework with cubic symmetry and srs topol. The PPh3Me+ cation is held by weak interactions into cavities with matching three-fold rotational symmetry. Comparison with the diperiodic hemi-hydrate polymorph previously reported points to the disrupting role of OH···O hydrogen bonds in the latter.Methyltriphenylphosphonium bromide(cas: 1779-49-3Related Products of 1779-49-3) was used in this study.

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is a lipophilic molecule with a cation allowing for it to be used to deliver molecules to specific cell components. Also considered an antineoplastic agent.Related Products of 1779-49-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Alkyl vs. aryl modifications: a comparative study on modular modifications of triphenylphosphonium mitochondrial vectors》 was written by Ong, How Chee; Coimbra, Joao T. S.; Kwek, Germain; Ramos, Maria J.; Xing, Bengang; Fernandes, Pedro A.; Garcia, Felipe. Application In Synthesis of Ethyltriphenylphosphonium bromideThis research focused ontriphenylphosphonium mitochondrial vector alkyl aryl modification lipophilicity. The article conveys some information:

Triphenylphosphonium (TPP+) moieties are commonly conjugated to drug mols. to confer mitochondrial selectivity due to their pos. charge and high lipophilicity. Although optimization of lipophilicity can be achieved by modifying the length of the alkyl linkers between the TPP+ moiety and the drug mol., it is not always possible. While methylation of the TPP+ moiety is a viable alternative to increase lipophilicity and mitochondrial accumulation, there are no studies comparing these two sep. modular approaches. Thus, we have systematically designed, synthesized and tested a range of TPP+ mols. with varying alkyl chain lengths and degree of aryl methylation to compare the two modular methodologies for modulating lipophilicity. The ability of aryl/alkyl modified TPP+ to deliver cargo to the mitochondria was also evaluated by confocal imaging with a TPP+-conjugated fluorescein-based fluorophore. Furthermore, we have employed mol. dynamics simulations to understand the translocation of these mols. through biol. membrane model systems. These results provide further insights into the thermodn. of this process and the effect of alkyl and aryl modular modifications. In the part of experimental materials, we found many familiar compounds, such as Ethyltriphenylphosphonium bromide(cas: 1530-32-1Application In Synthesis of Ethyltriphenylphosphonium bromide)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.Application In Synthesis of Ethyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Discovery of triazole-based uracil derivatives bearing amide moieties as novel dipeptidyl peptidase-IV inhibitors》 was written by Deng, Xiaoyan; Han, Li; Zhou, Jinpei; Zhang, Huibin; Li, Qing. SDS of cas: 3395-91-3This research focused ontriazole amide uracil preparation dipeptidyl peptidase IV inhibitor antidiabetic; Amide; DPP-4 inhibitor; T2DM; Triazole; Uracil derivatives. The article conveys some information:

Dipeptidyl peptidase-IV (DPP-4) is a validated target for T2DM treatment. The authors previously reported a novel series of triazole-based uracil derivatives bearing aliphatic carboxylic acids with potent DPP-4 inhibitory activities in vitro, but these compounds showed poor hypoglycemic effects in vivo. Herein the authors further optimized the triazole moiety by amidation of the carboxylic acid to improve in vivo activities. Two series of compounds 3a-f and 4a-g were designed and synthesized. By screening in DPP-4, compound 4c ((R)-2-(4-((4-(3-aminopiperidin-1-yl)-3-(but-2-yn-1-yl)-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)methyl)-1H-1,2,3-triazol-1-yl)-N,N-dimethylacetamide hydrochloride) was identified as a potent DPP-4 inhibitor with the IC50 value of 28.62 nM. Docking study revealed compound 4c has a favorable binding mode and interpreted the SAR of these analogs. DPP-8 and DPP-9 tests indicated compound 4c had excellent selectivity over DPP-8 and DPP-9. Further in vivo evaluations revealed that compound 4c showed more potent hypoglycemic activity than its corresponding carboxylic acid in ICR mice and dose-dependently reduced glucose levels in type 2 diabetic C57BL/6 mice. The overall results have shown that compound 4c could be a promising lead for further development of novel DPP-4 agents treating T2DM. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-bromopropanoate(cas: 3395-91-3SDS of cas: 3395-91-3)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.SDS of cas: 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity》 was written by Bian, Jinlei; Ren, Jie; Li, Yongren; Wang, Jubo; Xu, Xi; Feng, Yifan; Tang, Hui; Wang, Yajing; Li, Zhiyu. Application of 17696-11-6This research focused onWogonin PROTAC CDK9 antitumor click chem; Antitumor; CDK9; Click Chemistry; PROTAC; Wogonin. The article conveys some information:

Wogonin is a natural product isolated from the Scutellaria baicalensis and has been proved to be a potent and selective inhibitor of CDK9. Using this scaffold, we designed and synthesized a series of proteolysis targeting chimeras (PROTACs) targeting CDK9 by recruiting ubiquitin E3 ligase cereblon (CRBN). For constructing diverse Wogonin-based PROTACs, a “”click chem.”” approach was employed for the synthesis of CDK9-targeting PROTACs. The results of western blotting assays showed that compounds containing triazole group in the linker could selectively downregulate the intracellular CDK9 level. Among these compounds, 11c could selectively degrade CDK9 in a concentration-dependent manner. In addition, the application of the proteasome inhibitor MG132 and CRBN siRNA silencing confirmed that 11c could promote the proteasome-dependent and CRBN-dependent degradation Consistent with the degradation of the CDK9 protein, 11c selectively inhibits proliferation of CDK9-overexpressed cancer cells. Thus, our Wogonin-based PROTAC would be an efficient probe that induces the degradation of CDK9. The results came from multiple reactions, including the reaction of 8-Bromooctanoic acid(cas: 17696-11-6Application of 17696-11-6)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Application of 17696-11-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Functionalization of triblock copolymer elastomers by cross-linking the end blocks via trans-N-alkylation-based exchangeable bonds》 was written by Hayashi, Mikihiro; Chen, Lei. Category: bromides-buliding-blocksThis research focused ontriblock copolymer elastomer crosslinking alkylation preparation property. The article conveys some information:

We demonstrate the functionalization of ABA triblock copolymer-based materials by introducing dynamic covalent bonded cross-links. The bond-exchange via trans-N-alkylation was operated in the domains of poly(4-vinylpyridine) end blocks, cross-linked by quaternization with dibromo cross-linkers, thus exhibiting vitrimer-like properties (e.g., softening and great stress relaxation) and other useful functions, such as re-processability, recyclability, and self-adhesion. The results came from multiple reactions, including the reaction of 1,6-Dibromohexane(cas: 629-03-8Category: bromides-buliding-blocks)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of pyrrolo-tetrathiafulvalene molecular bridge (6PTTF6) to study redox switching behavior of single molecules; synthesis of water-soluble thermoresponsive polylactides.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary