Month: November 2022

《Nucleophilic fluoroalkylation of terminal vinyl triflones with SO2CF3 as a removable activating group》 was written by Tian, Ping-ping; Xiao, Hong-qing; Wang, Lu; Yu, Yingxin; Huang, Yangen. Quality Control of Ethylbromofluoroacetate And the article was included in Tetrahedron Letters on April 11 ,2019. The article conveys some information:

Terminal vinyl triflones served as excellent Michael addition acceptors which readily reacted with difluoromethylene phosphabetaine and di- or mono-fluoroalkyl bromides to afford compounds containing CF2 or CF groups. This fluoroalkylation was characterized by mild reaction conditions, ready availability of reagents and excellent functional-group tolerance.Ethylbromofluoroacetate(cas: 401-55-8Quality Control of Ethylbromofluoroacetate) was used in this study.

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Quality Control of Ethylbromofluoroacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Visible-Light-Mediated [2+2+1] Carbocyclization Reactions of 1,7-Enynes with Bromofluoroacetate to Form Fused Monofluorinated Cyclopenta[c]quinolin-4-ones》 was written by Qu, Yi; Xu, Wentao; Zhang, Jingjing; Liu, Yuxiu; Li, Yongqiang; Song, Hongjian; Wang, Qingmin. Application In Synthesis of Ethylbromofluoroacetate And the article was included in Journal of Organic Chemistry on April 17 ,2020. The article conveys some information:

Herein, we describe a new protocol for photoinduced radical [2+2+1] carbocyclization reactions of 1,7-enynes with bromofluoroacetate. These reactions, which proceed via a cascade involving fluoroalkylation, 6-exo-dig and 5-endo-trig cyclizations, H-transfer step, and oxidative dehydrogenation, provide an efficient and general route to a variety of fused monofluorinated cyclopenta[c]quinolin-4-one derivatives In addition to this study using Ethylbromofluoroacetate, there are many other studies that have used Ethylbromofluoroacetate(cas: 401-55-8Application In Synthesis of Ethylbromofluoroacetate) was used in this study.

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Application In Synthesis of Ethylbromofluoroacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Formula: C10H16Br3NOn March 2, 2021, Williams, Sierra J.; Hwang, Clare S.; Prescher, Jennifer A. published an article in Biochemistry. The article was 《Orthogonal bioluminescent probes from disubstituted luciferins》. The article mentions the following:

Bioluminescence imaging with luciferase-luciferin pairs is routinely used to monitor cellular functions. Multiple targets can be visualized in tandem using luciferases that process unique substrates, but only a handful of such orthogonal probes are known. Multiplexed studies require addnl. robust, light-emitting mols. In this work, we report new luciferins for orthogonal imaging that comprise disubstituted cores. These probes were found to be bright emitters with various engineered luciferases. The unique patterns of light output also provided insight into enzyme-substrate interactions necessary for productive emission. Screening studies identified mutant luciferases that could preferentially process the disubstituted analogs, enabling orthogonal imaging with existing bioluminescent reporters. Further mutational analyses revealed the origins of substrate selectivity. Collectively, this work provides insights into luciferase-luciferin features relevant to bioluminescence and expands the number of probes for multicomponent tracking. The results came from multiple reactions, including the reaction of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide(cas: 111865-47-5Formula: C10H16Br3N)

Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide(cas: 111865-47-5) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In contrast, terrestrial plants account only for a few bromine-containing compounds.Formula: C10H16Br3N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Computed Properties of C15H12BrNO2SOn May 8, 2006 ,《Synthesis of fused imidazo-pyridine and -azepine derivatives by sequential van Leusen/Heck reactions》 appeared in Tetrahedron Letters. The author of the article were Beebe, Xenia; Gracias, Vijaya; Djuric, Stevan W.. The article conveys some information:

Fused imidazo-pyridine and -azepine derivatives were synthesized using a sequential van Leusen/intramol. Heck protocol. The combination of a multicomponent reaction followed by an intramol. carbon-carbon bond forming reaction generates heterocycles of significant mol. complexity from readily available starting materials in just two steps. In addition to this study using a-Tosyl-(2-bromobenzyl) isocyanide, there are many other studies that have used a-Tosyl-(2-bromobenzyl) isocyanide(cas: 936548-16-2Computed Properties of C15H12BrNO2S) was used in this study.

a-Tosyl-(2-bromobenzyl) isocyanide(cas: 936548-16-2) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Computed Properties of C15H12BrNO2S

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kaplan, Justin M.; Hruszkewycz, Damian P.; Strambeanu, Iulia I.; Nunn, Christopher J.; VanGelder, Kelsey F.; Dunn, Anna L.; Wozniak, Derek I.; Dobereiner, Graham E.; Leitch, David C. published an article on January 14 ,2019. The article was titled 《Scalable and Chemoselective Synthesis of γ-Keto Esters and Acids via Pd-Catalyzed Carbonylation of Cyclic β-Chloro Enones》, and you may find the article in Organometallics.HPLC of Formula: 76283-09-5 The information in the text is summarized as follows:

The Pd-catalyzed carbonylation of cyclic β-chloro enones using simple phosphine ligands is described. Screening identified P(Me)(t-Bu)2 as the most general ligand for an array of chloro enone electrophiles. The reaction scope was evaluated on a milligram scale across 80 examples, with excellent reactivity observed in nearly every case. Carbonylation can be achieved even in the presence of potentially sensitive or inhibitory functional groups, including basic nitrogens as well as aryl chlorides or bromides. Twenty examples were run on a gram scale, demonstrating scalability and practical utility. Using P(Me)(t-Bu)2, the reaction rate depends on both nucleophile and electrophile identity, with completion times varying between 3 and >18 h under a standard set of conditions. Switching to P(t-Bu)3 for the carbonylation of 3-chlorocyclohex-2-enone with MeOH results in a dramatic rate increase, enabling effective catalysis with kinetics consistent with rate-limiting mass transfer. Stoichiometric oxidative addition of 3-chlorocyclohex-2-enone and 3-oxocyclohex-1-enecarbonyl chloride to both Pd[P(t-Bu)3]2 and Pd(PCy3)2 has enabled characterization and isolation of several potential catalytic intermediates, including Pd-vinyl and Pd-acyl species supported by P(t-Bu)3 and PCy3 ligands. Monitoring the oxidative addition of 3-chlorocyclohex-2-enone to Pd(PCy3)2 by NMR spectroscopy indicates that coordination of the alkene precedes oxidative addition As a result of these studies, Me 3-oxocyclohex-1-enecarboxylate was synthesized via Pd-catalyzed carbonylation of 3-chlorocyclohex-2-enone in 90% yield on a 60 g scale with only 0.5 mol % catalyst loading.4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5HPLC of Formula: 76283-09-5) was used in this study.

4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. HPLC of Formula: 76283-09-5 The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Riente, Paola; Fianchini, Mauro; Llanes, Patricia; Pericas, Miquel A.; Noel, Timothy published their research in Nature Communications on December 31 ,2021. The article was titled 《Shedding light on the nature of the catalytically active species in photocatalytic reactions using Bi2O3 semiconductor》.HPLC of Formula: 401-55-8 The article contains the following contents:

The importance of discovering the true catalytically active species involved in photocatalytic systems allows for a better and more general understanding of photocatalytic processes, which eventually may help to improve their efficiency. Bi2O3 has been used as a heterogeneous photocatalyst and is able to catalyze several synthetically important visible-light-driven organic transformations. However, insight into the operative catalyst involved in the photocatalytic process is hitherto missing. Herein, we show through a combination of theor. and exptl. studies that the perceived heterogeneous photocatalysis with Bi2O3 in the presence of alkyl bromides involves a homogeneous BinBrm species, which is the true photocatalyst operative in the reaction. Hence, Bi2O3 can be regarded as a precatalyst which is slowly converted in an active homogeneous photocatalyst. This work can also be of importance to mechanistic studies involving other semiconductor-based photocatalytic processes. In addition to this study using Ethylbromofluoroacetate, there are many other studies that have used Ethylbromofluoroacetate(cas: 401-55-8HPLC of Formula: 401-55-8) was used in this study.

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.HPLC of Formula: 401-55-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Mawad, Damia; Artzy-Schnirman, Arbel; Tonkin, Joanne; Ramos, Jose; Inal, Sahika; Mahat, Muzamir M.; Darwish, Nadim; Zwi-Dantsis, Limor; Malliaras, George G.; Gooding, J. Justin; Lauto, Antonio; Stevens, Molly M. published 《Electroconductive Hydrogel Based on Functional Poly(Ethylenedioxy Thiophene)》.Chemistry of Materials published the findings.Product Details of 3395-91-3 The information in the text is summarized as follows:

Poly(ethylene dioxythiophene) with functional pendant groups bearing double bonds is synthesized and employed for the fabrication of electroactive hydrogels with advantageous characteristics; covalently crosslinked porous 3D scaffolds with notable swelling ratio, appropriate mech. properties, electroactive in physiol. conditions, and suitable for pro-liferation and differentiation of C2C12 cells. This is a new approach for the fabrication of conductive engineered constructs. The results came from multiple reactions, including the reaction of Methyl 3-bromopropanoate(cas: 3395-91-3Product Details of 3395-91-3)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Product Details of 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,ChemPlusChem included an article by Mohamed, Mohamed Gamal; El-Mahdy, Ahmed F. M.; Ahmed, Mahmoud M. M.; Kuo, Shiao-Wei. Quality Control of 3,6-Dibromo-9H-carbazole. The article was titled 《Direct Synthesis of Microporous Bicarbazole-Based Covalent Triazine Frameworks for High-Performance Energy Storage and Carbon Dioxide Uptake》. The information in the text is summarized as follows:

In this study a series of bicarbazole-based covalent triazine frameworks (Car-CTFs) were synthesized under ionothermal conditions from [9,9′-bicarbazole]-3,3′,6,6′-tetracarbonitrile (Car-4CN) in the presence of molten zinc chloride. Thermogravimetric and Brunauer-Emmett-Teller analyses revealed that these Car-CTFs possessed excellent thermal stabilities and high sp. surface areas (ca. 1400 m2/g). The electrochem. performances of this Car-CTF series, investigated by using cyclic voltammetry, showed a highest capacitance of (545 F/g at 5 mV/s), which also exhibited excellent columbic efficiencies of 96.1% after 8000 cycles at 100μA/0.5 cm2. The other Car-CTF samples displayed similar efficiencies. Furthermore, based on CO2 uptake measurements, one of the series showed the highest CO2 uptake capacities: 3.91 and 7.60 mmol/g at 298 and 273 K, resp. These results suggest a simple method for the preparation of CTF materials that provide excellent electrochem. and CO2 uptake performance. In the experiment, the researchers used many compounds, for example, 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Quality Control of 3,6-Dibromo-9H-carbazole)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a reagent in the synthesis of P7C3-A20 which is a potent neuroprotective agent. And it has been used in the preparation of N-(2-hydroxyethyl)-3,6-dibromocarbazole.Quality Control of 3,6-Dibromo-9H-carbazole

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Chinese Chemical Letters included an article by Zhang, Ding; Sha, Min; Pan, Renming; Lin, Xiangyang; Xing, Ping; Jiang, Biao. Application In Synthesis of 1,4-Bis(bromomethyl)benzene. The article was titled 《Design and synthesis of the novel branched fluorinated surfactant intermediates with CF3CF2CF2C(CF3)2 group》. The information in the text is summarized as follows:

Perfluorooctanoic acid (PFOA) or perfluorooctane sulfonate (PFOS) was one of the most prominent fluorosurfactants and applied widely in fire-fighting and daily chem., etc. However, these surfactants have recently been identified as toxic and undegradability in the environment. Developing an efficient approach to environment-friendly fluorosurfactants is essential. A fluorocarbon branched chain strategy was adopted to develop /PFOS substitutes. A series of intermediates of novel branched fluorinated surfactants with CF3CF2CF2C(CF3)2 group were synthesized from perfluoro-2-methyl-2-pentene. All the steps were mild, easy-handled and cheap. It is expected to be a very significant direction for the development of non-bioaccumulable alternatives of PFOA or PFOS. In the experiment, the researchers used 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Application In Synthesis of 1,4-Bis(bromomethyl)benzene)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis. Application In Synthesis of 1,4-Bis(bromomethyl)benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Nature Communications included an article by Zhang, Wenjia; Hu, Xianglong; Shen, Qi; Xing, Da. Category: bromides-buliding-blocks. The article was titled 《Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy》. The information in the text is summarized as follows:

Cancer cells exhibit slightly elevated levels of reactive oxygen species (ROS) compared with normal cells, and approx. 90% of intracellular ROS is produced in mitochondria. In situ mitochondrial ROS amplification is a promising strategy to enhance cancer therapy. Here we report cancer cell and mitochondria dual-targeting polyprodrug nanoreactors (DT-PNs) covalently tethered with a high content of repeating camptothecin (CPT) units, which release initial free CPT in the presence of endogenous mitochondrial ROS (mtROS). The in situ released CPT acts as a cellular respiration inhibitor, inducing mtROS upregulation, thus achieving subsequent self-circulation of CPT release and mtROS burst. This mtROS amplification endows long-term high oxidative stress to induce cancer cell apoptosis. This current strategy of endogenously activated mtROS amplification for enhanced chemodynamic therapy overcomes the short lifespan and action range of ROS, avoids the penetration limitation of exogenous light in photodynamic therapy, and is promising for theranostics. The experimental process involved the reaction of 4-Bromobutanoic acid(cas: 2623-87-2Category: bromides-buliding-blocks)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary