Month: November 2022

Han, Yanning; Zhang, Tong; Chen, Qiao; Chen, Xinyu; Xue, Pengchong published an article in 2021. The article was titled 《π-Stacking Conversion and Enhanced Force-Stimuli Response of a Divinylanthracene Derivative in a Hydrogen-Bonded Framework》, and you may find the article in Crystal Growth & Design.Related Products of 523-27-3 The information in the text is summarized as follows:

Hydrogen bond-induced π-stacking conversion was used to achieve an enhanced force-stimuli response of 9,10-bis(2-(pyridin-4-yl)vinyl)anthracene (BP4VA). In BP4VA crystals, the mols. adopted a J-aggregate pattern, and no overlap between the central anthracene planes was observed Trimesic acid (TA) as a hydrogen bond donor could promote the transformation of the π-stacking type of BP4VA as a hydrogen bond acceptor. It was found that TA and BP4VA mols. formed two-dimensional lamellar hydrogen-bonded frameworks with large windows, which were filled by BP4VA mols. belonging to other layers. Within such three-dimensional packing, J-aggregate stacking type of BP4VA converted into a mixture of J-type and H-type dimers. Moreover, BP4VA adopted a highly twisted conformation, and π-π interaction between them was very weak. So, the hydrogen-bonded complex emitted a short wavelength fluorescence. More importantly, the yellow hydrogen-bonded complex turned into red solids under force stimuli, and its fluorescence had a fairly large shift of more than 110 nm. This is in contrast with a spectral shift of 43 nm from the sheared neat BP4VA crystals. Quantum chem. calculation and spectral observations implied that the planarization, shortened π-distance, and large overlap between anthracene units should be responsible for the large spectral shift. The results imply that the appropriate acid as a hydrogen bond donor might help distyrylanthracene derivatives possess outstanding functions. Hydrogen bond-induced π-stacking conversion was used to achieve an enhanced force-stimuli response of 9,10-bis(2-(pyridin-4-yl)vinyl)anthracene. Trimesic acid (TA) and BP4VA formed three-dimensional frameworks, in which the J-aggregate stacking type converted into a mixture of J-type and H-type dimers. Moreover, the yellow complex turned into red solids under force stimuli, and its fluorescence had a shift of more than 110 nm. In the experiment, the researchers used 9,10-Dibromoanthracene(cas: 523-27-3Related Products of 523-27-3)

9,10-Dibromoanthracene(cas: 523-27-3) is synthesized by the bromination of anthracene. The bromination reaction is carried out at room temperature using carbon tetrachloride as a solvent. Using 80-85% anthracene as raw material, adding bromine to react for half an hour, the yield is 83-88%.Related Products of 523-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chakraborty, Mithun; Mahesh, Gaddam; Nakel, Omkar R.; Chavda, Gautamee; Anusha, Susarla; Sudhakar, Gangarajula published an article in 2021. The article was titled 《A Facile Approach to Access Multi-Substituted Indenes via Nazarov Cyclization of Aryl, Vinyl and Alkyl/Aryl Carbinols》, and you may find the article in ChemistrySelect.Related Products of 2675-79-8 The information in the text is summarized as follows:

A divergent approach to highly substituted functionalized indenes I [R1 = H, Me, Ph, etc.; R2 = H, Me; R3 = Me, Et, Ph; R4 = 6-OMe, 5,7-(OMe)2, 5,6,7-(OMe)3, etc.; R5 = CH2-CO2Et, 4-MeOC6H4, 2-FC6H4, etc.] was developed. The two-step reaction involved nucleophilic addition reaction of aryl vinyl ketone, an ideal intermediate with aryl or alkyl nucleophilic reagent, followed by electrocyclic reaction (Nazarov cyclization) in the presence of Lewis acid catalyst afforded indene derivatives I in good to excellent yield. After reading the article, we found that the author used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Related Products of 2675-79-8)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Related Products of 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ma, Tao; Hua, Jiawei; Bian, Mixue; Qin, Hong; Lin, Xinxin; Yang, Xiaobing; Liu, Chengkou; Yang, Zhao; Fang, Zheng; Guo, Kai published an article in 2022. The article was titled 《Visible light-promoted aerobic oxidative cleavage and cyclization of olefins to access 3-hydroxy-isoindolinones》, and you may find the article in Organic Chemistry Frontiers.Quality Control of Ethyltriphenylphosphonium bromide The information in the text is summarized as follows:

A convenient and environmentally friendly synthetic route from 2-vinylbenzimides to 3-hydroxy-isoindolinones through visible light-promoted transformations via iron/disulfide catalysis and mol. oxygen oxidation was developed. A range of 3-hydroxy-isoindolinones were obtained in moderate to good yields, which exhibited excellent functional group compatibility and broad substrate scope. Further mechanistic investigations proved that dioxetane might be a key intermediate being involved in the reaction. After reading the article, we found that the author used Ethyltriphenylphosphonium bromide(cas: 1530-32-1Quality Control of Ethyltriphenylphosphonium bromide)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. It is also used as catalysts in the synthesis of certain organic compounds and as a pharmaceutical intermediate.Quality Control of Ethyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhang, Chang-Sheng; Shao, Ya-Ping; Zhang, Fu-Min; Han, Xue; Zhang, Xiao-Ming; Zhang, Kun; Tu, Yong-Qiang published an article in Chemical Science. The title of the article was 《Cu(II)/SPDO complex catalyzed asymmetric Baeyer-Villiger oxidation of 2-arylcyclobutanones and its application for the total synthesis of eupomatilones 5 and 6》.Reference of 1-Bromo-3,4,5-trimethoxybenzene The author mentioned the following in the article:

A novel classical kinetic resolution of 2-aryl-substituted or 2,3-disubstituted cyclobutanones of Baeyer-Villiger oxidation catalyzed by a Cu(II)/SPDO complex is reported for the first time, producing normal lactones in excellent enantioselectivities (up to 96% ee) and regioselectivities (up to >20/1), along with unreacted ketones in excellent enantioselectivities (up to 99% ee). The current transformation features a wide substrate scope. Moreover, catalytic asym. total syntheses of natural eupomatilones 5 and 6 are achieved in nine steps from com. available 3-methylcyclobutan-1-one. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Reference of 1-Bromo-3,4,5-trimethoxybenzene)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Reference of 1-Bromo-3,4,5-trimethoxybenzene1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize symmetric 3,3′,4,4′,5,5′-hexamethoxydiphenylacetylene via Stille-type coupling with bis-(tributylstannyl)acetylene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Liu, Sen; Shen, Can; Jiang, Dongsheng; Qian, Cheng; Yang, Zhongmei; Wang, Jianquan; Ye, Wei published an article in Macromolecular Bioscience. The title of the article was 《Cascade Tumor Therapy Platform for Sensitized Chemotherapy and Penetration Enhanced Photothermal Therapy》.Recommanded Product: Bromopentacarbonylmanganese(I) The author mentioned the following in the article:

As a stand-alone therapy strategy may not be sufficient for effective cancer treatment and a combination of chemotherapy with other therapies is a main trend in cancer treatment. A combination of chemotherapy and photothermal therapy (PTT) is reported here to achieve the goal of cascade multistage cancer treatment. A thermally responsive amphiphilic copolymer is designed and then a CuS nanoparticles (NPs)-based carbon monoxide (CO) photoinduced release system and doxorubicin (Dox) are encapsulated to construct the nanomedicine. The large-sized nanomedicine can accumulate in tumors after long circulation in vivo and will generate heat to act as a photothermal therapeutic agent by near IR (NIR) light. Moreover, synergically release of CO and Dox is achieved and acted as a sensitized chemotherapeutic agent. The combination of PTT and chemotherapy sensitization can effectively eliminate active tumor cells in the periphery of the tumor. CuS NPs are also released after the degradation of nanomedicine and small-sized CuS NPs possess better tumor penetration and achieve penetration-enhanced PTT by further NIR irradiation, thereby effectively eliminating tumor cells inside solid tumors. Hence, cascade multistage cancer treatment of “”combined PTT and chemotherapy sensitization””-“”penetration-enhanced PTT”” is achieved, and tumor cells are comprehensively and effectively eliminated. The results came from multiple reactions, including the reaction of Bromopentacarbonylmanganese(I)(cas: 14516-54-2Recommanded Product: Bromopentacarbonylmanganese(I))

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Recommanded Product: Bromopentacarbonylmanganese(I)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Hanning; Yang, Yang; Jing, Xu; He, Cheng; Duan, Chunying published an article in 2021. The article was titled 《Multi-Component Metal-Organic Frameworks Significantly Boost Visible-Light-Driven Hydrogen Production Coupled with Selective Organic Oxidation》, and you may find the article in Chemistry – An Asian Journal.Recommanded Product: Tris(4-bromophenyl)amine The information in the text is summarized as follows:

Visible-light-driven hydrogen production coupled with selective organic oxidation has attracted increasing attention, as it not only provides clean and renewable energy, but also utilizes the other half reaction to achieve some value-added organic chems. Metal-organic frameworks based on metal clusters and organic ligands self-assembly give a perspective on the formation of multifunctional heterogeneous photocatalyst to significantly boost visible-light photocatalytic activities under mild conditions. By incorporating two types of photoactive units, tricarboxytriphenylamine (H3TCA) and tris(4-(pyridinyl)phenyl)amine (NPy3), into a single metal-organic frameworks, a multi-component MOF Co-MIX was obtained. With the redox active metal centers enabling the photoexcitation reduction of protons into hydrogen and the photogenerated holes promoting considerable oxidation of substrates, the resulting Co-MIX exhibits high catalytic activity for the photocatalytic hydrogen production coupled with selective oxidation of benzylamine or 1,2,3,4-tetrahydroisoquinoline. Importantly, the photocatalytic experiments of single-component Co-TCA and Co-NPy3 verified the pos. synergistic effects on stability and photocatalytic ability of the two ligands (H3TCA and NPy3) in one single MOF, revealing that the multi-component strategy is very important for the efficient charge separation and excellent photocatalytic activity of the catalyst. In the part of experimental materials, we found many familiar compounds, such as Tris(4-bromophenyl)amine(cas: 4316-58-9Recommanded Product: Tris(4-bromophenyl)amine)

In other references, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Recommanded Product: Tris(4-bromophenyl)amine

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kuribara, Takahito; Nakajima, Masaya; Nemoto, Tetsuhiro published an article in 2022. The article was titled 《A visible-light activated secondary phosphine oxide ligand enabling Pd-catalyzed radical cross-couplings》, and you may find the article in Nature Communications.Safety of (Bromomethyl)cyclopropane The information in the text is summarized as follows:

A secondary phosphine oxide ligand bearing a visible-light sensitization moiety and apply it to Pd-catalyzed radical cross-coupling reactions was reported. The tautomeric phosphinous acid coordinates to palladium in-situ, allowing for pseudo-intramol. single-electron transfer between the ligand and palladium. Mol. design of the metal complexes aided by time-dependent d. functional theory calculations enables the involvement of allyl radicals from π-allyl palladium(II) complexes, and alkyl and aryl radicals from the corresponding halides and palladium(0) complex. This complex enables radical cross-couplings by ligand-to-Pd(II) and Pd(0)-to-ligand single-electron transfer under visible-light irradiation After reading the article, we found that the author used (Bromomethyl)cyclopropane(cas: 7051-34-5Safety of (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Safety of (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Meng, Shuai; Hettiarachchi, Ishani Lakshika; Bhetuwal, Bishwa Raj; Thapa, Prakash; Zhu, Jianglong published an article in Journal of Organic Chemistry. The title of the article was 《Stereoselective Synthesis of β-D-Manno-heptopyranoside via Cs2CO3-Mediated Anomeric O-Alkylation: Synthesis of a Tetrasaccharide Repeating Unit of Bacillus thermoaerophilus Surface-Layer Glycoprotein》.Formula: C19H18BrP The author mentioned the following in the article:

Stereoselective synthesis of D-glycero- and L-glycero-β-D-mannoheptosides has been achieved by cesium carbonate-mediated β-selective anomeric O-alkylation of the corresponding D-mannoheptoses. In addition, this method has been utilized in the total synthesis of a tetrasaccharide repeat unit of Bacillus thermoaerophilus surface-layer glycoprotein. The results came from multiple reactions, including the reaction of Methyltriphenylphosphonium bromide(cas: 1779-49-3Formula: C19H18BrP)

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is used for methylenation through the Wittig reaction. It is utilized in the synthesis of an enyne and 9-isopropenyl -phenanthrene by using sodium amide as reagent. Formula: C19H18BrP

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhang, Can; Hu, Jinnuo; Song, Jingya; Wu, Maotong; Zhang, Zhen published an article in ACS Food Science & Technology. The title of the article was 《Development of ic-ELISAs for the Detection of Bisphenol A Diglycidyl Ether and Its Derivatives in Canned Luncheon Meats》.Name: Ethyl 4-bromobutyrate The author mentioned the following in the article:

Canned foods are widely consumed because of their convenience, hygiene, and nutrition. Bisphenol A diglycidyl ether (BADGE), an industrial product of epichlorohydrin and bisphenol A, widely exists in the inner coating of canned foods. A hydrolysis or chlorination reaction of BADGE can occur in the process of storage, forming a variety of derivatives such as bisphenol A (2,3-dihydroxypropyl) glycidyl ether (BADGE·H2O), bisphenol A (3-chloro-2-hydroxypropyl) glycidyl ether (BADGE·HCl), and bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) glycidyl ether (BADGE·HCl·H2O), which seriously threaten consumer′s health. In this research, two haptens were successfully synthesized, and antibodies were obtained by the s.c. immunization of New Zealand rabbits. Indirect competitive enzyme-linked immunosorbent assays (ic-ELISAs) were established for the detection of BADGE, BADGE·H2O, BADGE·HCl, and BADGE·HCl·H2O, and the IC15 values (concentrations at an inhibition rate of 15%) were determined as 0.73, 0.39, 0.78, and 1.45 ng/mL, resp. The recovery of BADGE and its derivatives at various spiking levels in canned luncheon meat samples ranged from 76.70 to 98.35%. The results detected by the proposed ic-ELISAs were also validated by HPLC anal., which showed a good agreement (R2 = 0.9861). In the experiment, the researchers used Ethyl 4-bromobutyrate(cas: 2969-81-5Name: Ethyl 4-bromobutyrate)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Name: Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Si, Min; Yan, Jiaqi; Ding, Yongzheng; Huang, Hanmin published an article in Organic & Biomolecular Chemistry. The title of the article was 《Pd-Catalyzed carbonylative lactonization of 2-halidearomatic aldehydes with H2O as a nucleophile》.Name: o-Bromobenzaldehyde The author mentioned the following in the article:

A palladium-catalyzed carbonylative cyclization reaction of 2-halidebenzaldehydes with H2O was described, which provided a strategy for the synthesis of diversely substituted 3,3′-oxyphthalides. Notably, the obtained 3,3′-oxyphthalide could be easily transformed into 3-aryl and alkyl phthalides with excellent efficiency using organozinc reagents under mild reaction conditions. The experimental process involved the reaction of o-Bromobenzaldehyde(cas: 6630-33-7Name: o-Bromobenzaldehyde)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Name: o-BromobenzaldehydeSynthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary