Month: November 2022

In 2022,Wu, Yimin; Zhang, Ling; Ma, Fudong; Ding, Tao; Obolda, Ablikim published an article in Designed Monomers and Polymers. The title of the article was 《Synthesis of carbazole-based dendritic conjugated polymer: dual channel optical probe for detection of iodine (-) and mercury (2+)》.Recommanded Product: 6825-20-3 The author mentioned the following in the article:

A new type of carbazole-based blue-emitting dendritic conjugated polymer, poly[(9,9-dioctyl)-2,7-fluorene-co-4,4′,4”-triphenylamine-co-9-(4-(9H-carbazol-9-yl)butyl)-3,6-carbazole](P), was successfully synthesized by Suzuki coupling reaction. Chem. structures of monomers and polymer were verified by FI-IR and 1HNMR characterizations. We found that polymer showed a special selectivity and high sensitivity for I-. With the addition of I-, the fluorescent polymer solution was obviously quenched. The polymer showed a special detection effect on I-. However, the fluorescent polymer was obviously restored when Hg2+ was added to the P/I- system due to the large complexation between I- and Hg2+. The anti-interference experiments of probe P/I- showed that other background cations have a slight influence on detecting Hg2+, and the calculated detection limit of Hg2+ reached 9.7 x 10-8 M, which could be a potential application for a two-channel cyclic detection of I- and Hg2+. Addnl., it was found that the theor. values were in agreement with the exptl. data. In the experiment, the researchers used many compounds, for example, 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Recommanded Product: 6825-20-3)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a reagent in the synthesis of P7C3-A20 which is a potent neuroprotective agent. And it has been used in the preparation of N-(2-hydroxyethyl)-3,6-dibromocarbazole.Recommanded Product: 6825-20-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhu, Jinwei; Lou, Xiaoyu; Wang, Yubing; Xiong, Zhuo; Chen, Jie; Yan, Wei published an article in Chemical Engineering Science. The title of the article was 《Conjugated microporous poly(aniline)s for removal of low-concentration formaldehyde》.Electric Literature of C18H12Br3N The author mentioned the following in the article:

Removal of indoor formaldehyde is important but challenging due to the low concentration Here, we showed the applicability of a new class of conjugated microporous poly(aniline)s (CMPAs) in this formaldehyde capture. The unique properties of rich ultramicroporosity and benzenoid amine (-NH-) groups made the resulting CMPAs ideal platforms for the efficient low-concentration formaldehyde adsorption, through the interaction between benzenoid amine groups and formaldehyde via Mannich reaction and H-bond in the ultramicropore. They therefore exhibited ultrafast adsorption, receiving > 80% removal efficiency for ca 0.7 ppm formaldehyde within 60 min, and benchmarking storage capacity, achieving ∼2679.68 mg·g-1 for CMPA-2. Our CMPAs also worked well in a self-assembled air clean unit, keeping kinetically reducing average 98% of formaldehyde after treatment of 4000 BV polluted air (with ∼25 ppm formaldehyde) without break-through. Outcomes highlighted the potential of CMPAs for the clean-up of airborne formaldehyde for human health protection in next generation. In the experiment, the researchers used Tris(4-bromophenyl)amine(cas: 4316-58-9Electric Literature of C18H12Br3N)

In other references, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Electric Literature of C18H12Br3N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Tajimi, Yuka; Nachi, Yasuhiro; Inada, Ryoko; Hashimoto, Ryoga; Yamawaki, Mugen; Ohkubo, Kei; Morita, Toshio; Yoshimi, Yasuharu published an article in Journal of Organic Chemistry. The title of the article was 《9-Cyano-10-methoxycarbonylanthracene as a Visible Organic Photoredox Catalyst in the Two-Molecule Photoredox System》.Name: 9,10-Dibromoanthracene The author mentioned the following in the article:

Visible-light-induced decarboxylative and deboronative reactions using two-mol. organic photoredox catalysts, namely, phenanthrene (Phen) and biphenyl (BP), as electron donors and 9-cyano-10-methoxycarbonylanthracene 1a as an electron acceptor were achieved. The high solubility of 1a significantly improved the reaction efficiency and product yield. In addition, the facile tuning of the oxidation potential of the electron-donor mol. via the replacement of Phen with BP enabled the application of the two-mol. photoredox system to a wide range of substrates. The experimental process involved the reaction of 9,10-Dibromoanthracene(cas: 523-27-3Name: 9,10-Dibromoanthracene)

9,10-Dibromoanthracene(cas: 523-27-3) is synthesized by the bromination of anthracene. The bromination reaction is carried out at room temperature using carbon tetrachloride as a solvent. Using 80-85% anthracene as raw material, adding bromine to react for half an hour, the yield is 83-88%.Name: 9,10-Dibromoanthracene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Wang, Zhifan; Yang, Beiqi; Yang, Qi; Wang, Yuanhua published an article in Organic Chemistry Frontiers. The title of the article was 《C(sp3)-H 1,3-diamination of cumene derivatives catalyzed by a dirhodium(II) catalyst》.Safety of 1-Bromo-3,4,5-trimethoxybenzene The author mentioned the following in the article:

The simultaneous and direct amination of multiple inert Csp3-H bonds is a challenging method for C-N bond formation. Here, a radical sequential reaction mediated by a dirhodium(II) catalyst was developed for the successful one-step synthesis of 1,3-diamines via the interaction of cumene derivatives with N-fluorobenzenesulfonimide (NFSI). Mechanistic studies revealed that the reaction underwent an iterative radical polar crossover and desaturation activation procedure to achieve the activation of three adjacent C-H bonds. The synthesized diamine compounds were converted into useful functional mols. by further removal of phenylsulfonyl groups. In the experiment, the researchers used many compounds, for example, 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Safety of 1-Bromo-3,4,5-trimethoxybenzene)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Safety of 1-Bromo-3,4,5-trimethoxybenzene1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhong, Qidi; Wang, Yinxin; Lan, Hanyang; Zhu, Hao; Fan, Qiangwen published an article in Journal of Organic Chemistry. The title of the article was 《Construction of 3,12-Diazatetracyclododecane-dienes through Unexpected Visible-Light-Induced Radical Cascade Cyclization》.Application In Synthesis of (Bromomethyl)cyclopropane The author mentioned the following in the article:

A novel visible-light-induced cascade radical cyclization reaction of 3-cyano-4-aryl-1,4-dihydropyridines I (R1 = cyclopropylmethyl, benzyl, 4-chlorobenzyl, naphthalen-2-ylmethyl, etc.; R2 = Ph, 4-chlorophenyl, 3-methylphenyl, 2-fluorophenyl, etc.) for the construction of 3,12-diazatetracyclododecane-diene derivatives II is reported for the first time. In the presence of 410 nm blue LED lamp as the light source and ethanol as the solvent, the reactions proceed smoothly to afford photocyclization products in good yields. The process is carried out through the breaking of original C=C double bonds and the formation of three new single bonds in one pot and proved to be able to tolerate different substituents. The experimental process involved the reaction of (Bromomethyl)cyclopropane(cas: 7051-34-5Application In Synthesis of (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Application In Synthesis of (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Wang, Lucia; Lin, Shengjia; Santos, Emmanuel; Pralat, Jenna; Spotton, Kaylyn; Sharma, Abhishek published an article in Journal of Organic Chemistry. The title of the article was 《Boron-Promoted Deprotonative Conjugate Addition: Geminal Diborons as Soft Pronucleophiles and Acyl Anion Equivalents》.Recommanded Product: 7051-34-5 The author mentioned the following in the article:

The 1,4-addition of α,α-diboryl carbanions generated via deprotonation of the corresponding geminal diborons R1CH(Bpin)2 (R1 = prop-2-en-1-yl, thiophen-3-ylmethyl, cyclopropylmethyl, etc.) has been reported. The methodol. provided a general route to highly substituted and synthetically useful γ,γ-diboryl ketones R1C(Bpin)2CH(R3)C(O)R2 (R2 = C6H5, 4-ClC6H4, cyclohexyl, etc.; R3 = Me, Ph, Et, etc.). The development of geminal diborons as soft pronucleophiles also enabled their use as acyl anion equivalent via a one-pot tandem conjugate addition-oxidation sequence. The results came from multiple reactions, including the reaction of (Bromomethyl)cyclopropane(cas: 7051-34-5Recommanded Product: 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Recommanded Product: 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Abdellaoui, O.; Chraibi, M.; Skalli, M. K.; Haoudi, A.; Fikri-Benbrahim, K.; Rodi, Y. Kandri; Mazzah, A.; Senhaji, O. published an article in Asian Journal of Chemistry. The title of the article was 《Synthesis and antibacterial evaluation of three quaternary ammonium surfactants based on isatin》.Safety of 1,6-Dibromohexane The author mentioned the following in the article:

In present study, several isatin-derived quaternary ammonium surfactants I [n = 3, 6, 12] with different carbon chain lengths were designed and synthesized. They were synthesized by alkylation of indoline-2,3-dione with various dibromo-alkanes, then quaternization with trimethylamine. Further, the critical micelle concentrations (CMC) value of surfactants I synthesized was determined in an aqueous solution using elec. conductivity The synthesized surfactants I had CMC ranging from 0.01 to 0.012 mol/L. The antibacterial activity of the titer compounds I was evaluated against gram-neg. bacteria (P. aeruginosa and E. coli), as well as gram-pos. bacteria (S. aureus). The surfactant with a long hydrocarbon chain I [n = 12] showed activity against all bacteria tested (min. inhibitory concentration = 1.25-2.5 mg/mL), whereas those with a short hydrocarbon chain proved to be inactive. After reading the article, we found that the author used 1,6-Dibromohexane(cas: 629-03-8Safety of 1,6-Dibromohexane)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.Safety of 1,6-Dibromohexane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Choi, Hosam; Choi, Joohee; Han, Jongyeol; Lee, Kiyoun published an article in Journal of Organic Chemistry. The title of the article was 《Divergent Total Syntheses of Gymnothelignan N, Beilschmin A, and Eupomatilones 1, 3, 4, and 7》.Reference of 1-Bromo-3,4,5-trimethoxybenzene The author mentioned the following in the article:

A seven-step asym. total synthesis of gymnothelignan N is detailed in the current report. The approach is based on an early-stage one-carbon homologative lactonization reaction, which we recently revisited and modified to construct the core γ-butyrolactone motif with the requisite β,γ-vicinal stereogenic centers. By design, the utilization of the same chiral γ-butyrolactone intermediate permitted the rapid and effective divergent assembly of optically active eupomatilones 1, 3, 4, and 7 in five or six steps from com. available materials. This represents one of the shortest and highest-yielding syntheses reported to date. In the experiment, the researchers used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Reference of 1-Bromo-3,4,5-trimethoxybenzene)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Reference of 1-Bromo-3,4,5-trimethoxybenzene1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Ma, Chun-Hua; Zhao, Lu; He, Xing; Jiang, Yu-Qin; Yu, Bing published an article in Organic Chemistry Frontiers. The title of the article was 《Visible-light-induced direct 3-ethoxycarbonylmethylation of 2-aryl-2H-indazoles in water》.COA of Formula: C9H9BrO2 The author mentioned the following in the article:

A visible-light-driven rhodamine B-catalyzed transition-metal-free 3-ethoxycarbonylmethylation of 2-aryl-2H-indazoles and imidazo[1,2-a]pyridines (40 examples) using com. available α-bromoesters was realized in water. This protocol features sustainability, operational simplicity, mild reaction conditions, and remarkable substrate scope. Importantly, α-bromoamides are also appropriate substrates for affording 3-carbamylmethylation products. It could be used for the synthesis of the drug zolpidem and the late-stage modification of natural products. In the experiment, the researchers used Benzyl 2-bromoacetate(cas: 5437-45-6COA of Formula: C9H9BrO2)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is an aromatic chemical, usually appearing as a clear liquid with a moderate sweet-jasmine fragrance. This compound appears as a component of some of our fragrance blends.COA of Formula: C9H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Category: bromides-buliding-blocksIn 2019 ,《Discovery of Novel Dual Histone Deacetylase and Mammalian Target of Rapamycin Target Inhibitors as a Promising Strategy for Cancer Therapy》 appeared in Journal of Medicinal Chemistry. The author of the article were Chen, Yong; Yuan, Xue; Zhang, Wanhua; Tang, Minghai; Zheng, Li; Wang, Fang; Yan, Wei; Yang, Shengyong; Wei, Yuquan; He, Jun; Chen, Lijuan. The article conveys some information:

In the present study, a series of novel dual-target histone deacetylase (HDAC) and mammalian target of rapamycin (mTOR) inhibitors were designed and synthesized using pyrimidine-pyrazolyl pharmacophore to append HDAC recognition cap and hydroxamic acid as a zinc-binding motif. Among them, I was the optimal lead compound with potent inhibition activities against mTOR and HDAC1 with half-maximal inhibitory concentration of 1.2 and 0.19 nM, resp. Western blot confirmed that I could upregulate acetylation of H3 and α-tubulin and downregulate mTOR-related downstream mediators. I could also stimulate cell cycle arrest in G0/G1 phase and induce tumor cell apoptosis. I showed comparable antitumor activity with the combination medication in MM1S xenograft model with a tumor growth inhibitory rate of 72.5%, without causing significant loss of body weight and toxicity. All of the results indicated that I could be a promising dual target inhibitor for treating hematol. malignancies. The experimental process involved the reaction of Ethyl 3-bromopropanoate(cas: 539-74-2Category: bromides-buliding-blocks)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In contrast, terrestrial plants account only for a few bromine-containing compounds.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary