Month: November 2022

Application of 2623-87-2In 2019 ,《Imprinting supramolecular chirality on silica from natural triterpenoid-regulated helical ribbons》 was published in Materials Chemistry Frontiers. The article was written by Gao, Yuxia; Hao, Jie; Liu, Jinguo; Liang, Yun; Du, Fengpei; Hu, Jun; Ju, Yong. The article contains the following contents:

Supramol. chirality has attracted significant attention because of its critical roles in the life and material sciences. In this study, a natural triterpenoid-tailored amphiphilic mol. C4-MOP was designed and synthesized, in which the pyridinium head group was modified on the skeleton of triterpenoid through an alkyl linker. The introduction of pyridinium not only offers a hydrophilic cation to promote the assembly process but also renders itself as the nucleation point to adsorb silica precursors. The results showed that by adjusting the solvent compositions and the concentration of C4-MOP, well-ordered helical nanoribbons with both right- and left-handedness were fabricated by the assembly of C4-MOP, where the hydrophilic pyridinium cations were helically displayed on the surface of ribbons. Subsequently, by taking advantage of electrostatic interactions between pyridinium and the silica precursor, the supramol. chirality of C4-MOP was successfully imprinted onto the silica nanostructures using the gel-sol mineralization process. Our work provides a simple yet useful strategy to prepare chiral silica, which could promote the applications of chiral natural products in material science. The experimental part of the paper was very detailed, including the reaction process of 4-Bromobutanoic acid(cas: 2623-87-2Application of 2623-87-2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Application of 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of C7H5BrOIn 2019 ,《Enantioselective Gold-Catalyzed Pictet-Spengler Reaction》 was published in Organic Letters. The article was written by Glinsky-Olivier, Nicolas; Yang, Shengwen; Retailleau, Pascal; Gandon, Vincent; Guinchard, Xavier. The article contains the following contents:

Cationic chiral Au(I) complexes catalyze asym. Pictet-Spengler reactions between tryptamines and arylaldehydes. The resulting tetrahydro-β-carbolines I (R1 = H, 5-Me, 5-OMe; R2 = Allyl, Bn, CH2Mes, etc.; R3 = Ph, 4-Et-C6H4, 2-CN-C6H4, 3ClC6H4, etc.)are obtained with wide functional group tolerance in high yield and with high enantioselectivities (up to 95%). Aldehydes bearing polar or protic functions are well tolerated. The reaction features a hitherto unknown C2-auration of the indole as the key step, supported by d. functional theory calculations The experimental part of the paper was very detailed, including the reaction process of o-Bromobenzaldehyde(cas: 6630-33-7Synthetic Route of C7H5BrO)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Synthetic Route of C7H5BrOIt is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Access to 12-membered cyclic ortho,meta-diarylheptanoids: total synthesis of Actinidione via Isomyricanone》 was written by Masse, Paul; Choppin, Sabine; Chiummiento, Lucia; Colobert, Francoise; Hanquet, Gilles. Synthetic Route of C9H11BrO3This research focused ontwelve membered cyclic ortho meta diarylheptanoid synthesis; Suzuki Miyaura coupling ring closing metathesis; Actinidione synthesis Isomyricanone. The article conveys some information:

We describe herein the first access to 12-membered cyclic[7,0]ortho,meta-diarylheptanoids. The key features of the synthesis include both a Suzuki-Miyaura coupling and a ring closing metathesis. Actinidione, a promising natural product, along with a bioactive tetracyclic derivative were obtained in 14 steps for the first time from cheap com. available substrates with an overall yield of 18-21%. Our modus operandi complies with the principles of the synthesis ideality by using notably strategic reactions. After reading the article, we found that the author used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Synthetic Route of C9H11BrO3)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Synthetic Route of C9H11BrO31-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Determining sub-cooled liquid vapor pressures and octanol-air partition coefficients for chlorinated and brominated polycyclic aromatic hydrocarbons based on gas chromatographic retention times: Application for gas/particle partitioning in air》 was written by Vuong, Quang Tran; Thang, Phan Quang; Ohura, Takeshi; Choi, Sung-Deuk. SDS of cas: 523-27-3This research focused onvapor pressure octanol air partition coefficient PAH GCRT partitioning. The article conveys some information:

Halogenated polycyclic aromatic hydrocarbons (Halo-PAHs) are a new group of PAH derivatives and are reported to be more toxic than their parent PAHs. However, limited research has been undertaken on their physicochem. properties. In this study, subcooled liquid vapor pressures (PL) and octanol-air partition coefficients (KOA) of 24 chlorinated and 11 brominated PAHs (ClPAHs and BrPAHs) were determined using the gas chromatog. retention time (GC-RT) technique. The temperature dependences of PL and KOA for the Halo-PAHs were determined by the slopes and intercepts of the linear regressions. The GC-RT method also provided the enthalpies of vaporization (ΔHL) and internal energies of phase transfer (ΔUOA) for all interested compounds The activity of Halo-PAHs in octanol (γoct) ranging from 18 to 87, indicated the non-ideal solution behavior. The number of the chlorine atoms in the PAH rings could influence the interaction of ClPAHs with the organic matter, whereas this interaction for BrPAHs could not be studied due to the limited number of target BrPAHs. The measured values of PL and KOA were applied to investigate the gas/particle partition behaviors of Halo-PAHs in Ulsan, South Korea. This study is so far the first one to report the linear regression coefficients, which can be used to estimate the PL and KOA values of Halo-PAHs at any temperature The experimental part of the paper was very detailed, including the reaction process of 9,10-Dibromoanthracene(cas: 523-27-3SDS of cas: 523-27-3)

9,10-Dibromoanthracene(cas: 523-27-3) is a dibrominated polycyclic aromatic hydrocarbon (PAH). 9,10-Dibromoanthracene is often used as an energy acceptor and activator in reactions that produce chemiluminescence.SDS of cas: 523-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Significant Enhancement of Two-Photon Excited Fluorescence in Water-Soluble Triphenylamine-Based All-Organic Compounds》 was written by Gong, Yu; Bi, Xiangdong; Chen, Nikki; Forconi, Marcello; Kuthirummal, Narayanan; Teklu, Alem; Gao, Bo; Koenemann, Jacob; Harris, Nico; Brennan, Christian; Thomas, Marisa; Barnes, Taylor; Hu, Ming. Reference of Tris(4-bromophenyl)amineThis research focused ontwo photon absorption fluorescence triphenylamine protein complex. The article conveys some information:

Understanding water-soluble and environmentally friendly two-photon absorption (TPA) mols. benefits the design of superior organic complexes for biomedical, illumination, and display applications. The authors designed two triphenylamine-based all-organic compounds and explored the mechanism of enhanced TP fluorescence in water solutions for potential applications. Exptl., adding protein into the authors′ TPA mol. solution can drastically boost the TP fluorescence. Numerical simulations reveal that the TPA mols. prefer to dock inside the protein complex. The authors hypothesize that the interaction between the authors′ triphenylamine-based all-organic compounds and H2O mols. lead to nonradiative decay processes, which prevent strong TP fluorescence in the water solution Therefore, the protection by, for example, protein mols. from such interactions can be a universal strategy for superior functioning of organic TPA mols. Further experiments and numerical simulations support the authors′ hypothesis. The present study may facilitate the design of superior water-soluble and environmentally friendly superior organic complexes. After reading the article, we found that the author used Tris(4-bromophenyl)amine(cas: 4316-58-9Reference of Tris(4-bromophenyl)amine)

In general, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Reference of Tris(4-bromophenyl)amine

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis of Novel Vindoline-Chrysin Hybrids》 was written by Mayer, Szabolcs; Nagy, Nora; Keglevich, Peter; Szigetvari, Aron; Dekany, Miklos; Szantay, Csaba Junior; Hazai, Laszlo. COA of Formula: C4H7BrO2This research focused onvindoline chrysin doxorubicin cisplatin ciglitazone diphenylamine 10 chloroacetamidovindoline anticancer; anticancer effect; chrysin; hybrid molecule; reaction mechanism; vindoline. The article conveys some information:

Vinca alkaloids are well-known microtubule targeting agents, which are used against some types of cancer. Vindoline is one of the monomeric Vinca alkaloids which does not have anti-tumor effect, although its derivatives have serious impact on the field of these indole alkaloids. Chrysin is a secondary plant metabolite, which has broad-spectrum biol. activity, among others anticancer activity. Chrysin had shown synergic effect with several antiproliferative compounds (e. g., doxorubicin, cisplatin and ciglitazone), therefore, we attempted the synthesis of a novel vindoline-chrysin hybrid mol. However, in the first case a diphenylamine structure was isolated. The mechanism of the unexpected reaction was studied, and then the originally targeted hybrid was synthesized by a reverse route coupling. A further hybrid was produced using a different site of the mol. The antitumor activities were determined against 60 human tumor cell lines (NCI60), where the aimed hybrid showed low micromolar GI50 values on most of the cell lines. In addition to this study using 4-Bromobutanoic acid, there are many other studies that have used 4-Bromobutanoic acid(cas: 2623-87-2COA of Formula: C4H7BrO2) was used in this study.

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).COA of Formula: C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《The impact of an isoreticular expansion strategy on the performance of iodine catalysts supported in multivariate zirconium and aluminum metal-organic frameworks》 was published in Dalton Transactions in 2019. These research results belong to Tahmouresilerd, Babak; Moody, Michael; Agogo, Louis; Cozzolino, Anthony F.. Formula: C6H5BrO2 The article mentions the following:

Iodine functionalized variants of DUT-5 (Al) and UiO-67 (Zr) were prepared as expanded-pore analogs of MIL-53 (Al) and UiO-67 (Zr). They were prepared using a combination of multivariate and isorecticular expansion strategies. Multivariate MOFs with a 25% iodine-containing linker was chosen to achieve an ideal balance between a high d. of catalytic sites and sufficient space for efficient diffusion. Changes to the oxidation potential of the catalyst as a result of the pore-expansion strategy led to a decrease in activity with electron rich substrates. On the other hand, these larger frameworks proved to be more efficient catalysts for substrates with higher oxidation potentials. Recyclability tests for these larger MOFs showed sustained catalytic activity over multiple recycles. In the experiment, the researchers used many compounds, for example, 2-Bromobenzene-1,4-diol(cas: 583-69-7Formula: C6H5BrO2)

2-Bromobenzene-1,4-diol(cas: 583-69-7) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Formula: C6H5BrO2 Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Three-component coupling reaction for the synthesis of fully substituted triazoles: reactivity control of Cu-acetylide toward alkyl azides and diazo compounds》 was written by Chen, Fa-Jie; Mamidipalli, Phani; Sabbasani, Venkata Reddy; Liu, Huaqing; Xia, Yuanzhi; Lee, Daesung. Formula: C9H9BrO2This research focused ontriazole preparation; alkyne alkyl azide diazo compound multicomponent coupling copper catalyst. The article conveys some information:

Herein, a Cu-catalyzed three-component coupling reaction of alkynes, azides, and diazo compounds for the synthesis of fully substituted triazoles I [R = n-Bu, CH2OH, CO2Et, etc.; R1 = CH2SiMe3, Bn, 4-MeC6H4CH2, etc.; R2 = Et, n-hexyl, Bn, 2-adamantyl] was reported. The reactivities of alkyl azides and diazo compounds toward Cu-acetylide were controlled by the introduction of a ligand and the stoichiometry of azide and diazo compounds to suppress the undesired protonation or the alkyne-diazo coupling, maximizing the selectivity for the three-component coupling. Besides, the use of aliphatic alkynes was crucial for achieving high selectivity for the three-component coupling reaction. This method featured mild reaction conditions, broad substrate scope, and good functional group tolerance. A variety of fully substituted triazoles and ring-fused triazoles were synthesized by this method in moderate to good yields. The experimental process involved the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6Formula: C9H9BrO2)

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.Formula: C9H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Visible-light reversible photopolymerization: insights via online photoflow – electrospray ionization – mass spectrometry》 was written by Van De Walle, Matthias; Petit, Charlotte; Blinco, James P.; Barner-Kowollik, Christopher. Reference of Ethyl 4-bromobutyrateThis research focused onvisible light reversible photopolymerization electrospray ionization mass spectrometry. The article conveys some information:

Light as a non-invasive and clean external stimulus provides a facile route towards macromol. design. Herein, we demonstrate the scalable synthesis of catalyst-free, visible-light mediated photo-oligomers and -polymers via a step-growth mechanism. Both a batch approach and a continuous photoflow setup are employed to investigate the degree of polymerization and scalability. Violet blue light at 415 nm triggers [2 + 2]-cycloadditions of a pyrene-chalcone derivative to grow linear step-growth polymers, while subsequent UV-B light irradiation triggers the depolymerization The process was monitored online via a photoflow – high resolution electrospray ionization mass spectrometry setup (ESI-MS). Size exclusion chromatog. provides addnl. off-line anal. of both the polymerization and photodegradation over time. By changing the color of light, photopolymers can be recycled and reshaped, allowing these macromol. precursors to be applied to reversible and photodegradable material design. In addition to this study using Ethyl 4-bromobutyrate, there are many other studies that have used Ethyl 4-bromobutyrate(cas: 2969-81-5Reference of Ethyl 4-bromobutyrate) was used in this study.

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Reference of Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Name: 3,3”,5,5”-Tetrabromo-5′-(3,5-dibromophenyl)-1,1′:3′,1”-terphenylOn March 31, 2002, Palomero, Juan; Mata, Jose A.; Gonzalez, Florenci; Peris, Eduardo published an article in New Journal of Chemistry. The article was 《Facile synthesis of first generation ferrocene dendrimers by a convergent approach using ditopic conjugated dendrons》. The article mentions the following:

A facile synthesis of new conjugated ferrocenyl-based dendrimers is reported and the compounds obtained have been fully characterized. The synthetic method consists of a two-step procedure, which combines olefination by the Wittig procedure and Pd-mediated C-C coupling, leading to high yields of first generation dendrimers with 3, 6 and 12 peripheral ferrocene units. The crystal structure of the conjugated ditopic ferrocenyl dendron and its aldehyde precursor are also described. In the experiment, the researchers used many compounds, for example, 3,3”,5,5”-Tetrabromo-5′-(3,5-dibromophenyl)-1,1′:3′,1”-terphenyl(cas: 29102-67-8Name: 3,3”,5,5”-Tetrabromo-5′-(3,5-dibromophenyl)-1,1′:3′,1”-terphenyl)

3,3”,5,5”-Tetrabromo-5′-(3,5-dibromophenyl)-1,1′:3′,1”-terphenyl(cas: 29102-67-8) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Name: 3,3”,5,5”-Tetrabromo-5′-(3,5-dibromophenyl)-1,1′:3′,1”-terphenylSome of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary