Month: November 2022

《Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 2. Ketone Linked Analogs》 was written by Carter, David S.; Jacobs, Robert T.; Freund, Yvonne R.; Berry, Pamela W.; Akama, Tsutomu; Easom, Eric E.; Lunde, Christopher S.; Rock, Fernando; Stefanakis, Rianna; McKerrow, James; Fischer, Chelsea; Bulman, Christina A.; Lim, Kee Chong; Suzuki, Brian M.; Tricoche, Nancy; Sakanari, Judy A.; Lustigman, Sara; Plattner, Jacob J.. Synthetic Route of C8H7BrO2 And the article was included in ACS Infectious Diseases in 2020. The article conveys some information:

The optimization of a series of benzimidazole-benzoxaborole hybrid mols. linked via a ketone that exhibit good activity against Onchocerca volvulus, a filarial nematode responsible for the disease onchocerciasis, also known as river blindness, is described. The lead identified in this series, 21 (AN15470), was found to have acceptable pharmacokinetic properties to enable an evaluation following oral dosing in an animal model of onchocerciasis. Compound 21was effective in killing worms implanted in Mongolian gerbils when dosed orally as a suspension at 100 mg/kg/day for 14 days but not when dosed orally at 100 mg/kg/day for 7 days. In the experimental materials used by the author, we found 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Synthetic Route of C8H7BrO2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. Synthetic Route of C8H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Deoxyfluorination of Carboxylic, Sulfonic, Phosphinic Acids and Phosphine Oxides by Perfluoroalkyl Ether Carboxylic Acids Featuring CF2O Units》 was written by Zhao, Shiyu; Guo, Yong; Su, Zhaoben; Wu, Chengying; Chen, Wei; Chen, Qing-Yun. COA of Formula: C8H15BrO2 And the article was included in Chinese Journal of Chemistry in 2021. The article conveys some information:

The synthesis of acyl fluorides RCOF [R = Br(CH2)6CH2, Ph, 1-naphthyl, etc.], sulfonyl fluorides R1SO2F [R1 = Ph, 4-MeC6H4, 4-ClC6H4, etc.] and phosphoric fluorides R2PO(F)R3 [R2 = Ph, 4-MeC6H4, 2-naphthyl, etc.; R3 = Me, F, Ph, etc.] could be realized via carbonic difluoride (COF2) generated in situ from thermal degradation of the PFECA salt. The use of potassium salts of perfluoroalkyl ether carboxylic acids (PFECA) was reported featuring CF2O units as deoxyfluorination reagents, which were generated mainly as byproducts in the manufacture of hexafluoropropene oxide (HFPO). After reading the article, we found that the author used 8-Bromooctanoic acid(cas: 17696-11-6COA of Formula: C8H15BrO2)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.COA of Formula: C8H15BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Luomo; Hilt, Gerhard published their research in Chemistry – A European Journal in 2021. The article was titled 《Indium Tribromide-Catalysed Transfer-Hydrogenation: Expanding the Scope of the Hydrogenation and of the Regiodivergent DH or HD Addition to Alkenes》.Recommanded Product: Indium(III) bromide The article contains the following contents:

The transfer-hydrogenation as well as the regioselective and regiodivergent addition of H-D from regiospecific deuterated dihydroarom. compounds to a variety of 1,1-di- and trisubstituted alkenes was realized with InBr3 in dichloro(m)ethane. In comparison with the previously reported BF3·Et2O-catalyzed process, electron-deficient aryl-substituents was applied reliably and thereby several restrictions would be lifted, and new types of substrates would be transformed successfully in hydrodeuterogenation as well as deuterohydrogenation transfer-hydrogenation reactions. The experimental process involved the reaction of Indium(III) bromide(cas: 13465-09-3Recommanded Product: Indium(III) bromide)

Indium(III) bromide(cas: 13465-09-3) is used as a catalyst to produce dithioacetals when unactivated alkynes react with thiols and fields such as optics and microelectronics that utilize semiconductor technology have wide uses for indium in high-performing solar cells.Recommanded Product: Indium(III) bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Sien; He, Bangyue; Li, Hongyi; Zhang, Xiaofeng; Shang, Yaping; Su, Weiping published their research in Chemistry – A European Journal in 2021. The article was titled 《Facile Synthesis of Alkylidene Phthalides by Rhodium-Catalyzed Domino C-H Acylation/Annulation of Benzamides with Aliphatic Carboxylic Acids》.Related Products of 76006-33-2 The article contains the following contents:

Facile synthesis of alkylidene phthalides I [R1 = H, Me, Ph, etc.; R2 = H, 3-Me, 3-Ph, etc.; R3 = H, Me, Et, etc.; R4 = Et, i-Pr, n-Bu, etc; R3R4 = CH2(CH2)2CH2, CH2(CH2)4CH2] by rhodium-catalyzed domino C-H acylation/annulation of benzamides with aliphatic carboxylic acids. The Rh-catalyzed ortho-C(sp2)-H functionalization of 8-aminoquinoline-derived benzamides with aliphatic acyl fluorides generated in situ from the corresponding acids was developed. This reaction initiated with 8-aminoquinoline-directed ortho-C(sp2)-H acylation, which was accompanied by subsequent intramol. nucleophilic acyl substitution of amide group to produce alkylidene phthalides. This approach exhibited high stereo-selectivity for Z-isomer products and tolerates a variety of functional groups as well as aliphatic carboxylic acids with diverse structural scaffolds. After reading the article, we found that the author used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Related Products of 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In contrast, terrestrial plants account only for a few bromine-containing compounds.Related Products of 76006-33-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tian, Yanxin; He, Yulin; Liu, Pan; Zhang, Hui; Zheng, Qiuying; Liu, Jialiang; Xiao, Linghan; Wang, Xibin; Ao, Yuhui; Li, Ming published their research in Journal of Materials Science in 2021. The article was titled 《Mild and in situ photo-crosslinking of anthracene-functionalized poly(aryl ether ketone) for enhancing temporal stability of organic NLO materials》.Quality Control of 4-Bromobutanoic acid The article contains the following contents:

Developing a mild and efficient method to simultaneously enhance poling efficiency and temporal stability is meaningful and challenging for organic second-order nonlinear optical materials. In this paper, a new poly(aryl ether ketone) and chromophores functionalized with anthracene groups have been designed and prepared Poling and crosslinking process could be separated by the mild and photo-initiated cycloaddition of anthracene group. As the UV-Vis spectrum, DSC and TGA curves, the networks had formed by 30-min irradiation of the lower-power UV light which led little decomposition of dipolar chromophores. The maximum electro-optic coefficient (r33) of these polymers is 28.5 pm V-1 (at 1.3μm), and the order parameter reaches 0.22. Moreover, the depolarization temperature of α peak, related to the dipole relaxation, has been increased to 129°C after crosslinking, which is 17°C higher than uncrosslinked ones. All these results indicated that the photo-crosslinking of anthracene exhibited promising potential for improving alignment stability and NLO activity at the same time. After reading the article, we found that the author used 4-Bromobutanoic acid(cas: 2623-87-2Quality Control of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Quality Control of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hong, Haitao; Wu, Ni; Han, Mingxi; Guo, Zhiyong; Zhan, Hongbing; Du, Shaowu; Chen, Banglin published their research in Materials Chemistry Frontiers in 2021. The article was titled 《An anthracene based conjugated triazine framework as a luminescent probe for selective sensing of p-nitroaniline and Fe(III) ions》.SDS of cas: 523-27-3 The article contains the following contents:

Covalent triazine frameworks (CTFs), as a burgeoning type of porous organic material, have attracted increasing attention in a lot of research fields, including gas separation, heterogeneous catalysis, etc. In particular, stemming from their heteroatom effect (HAE), incorporated with the merits of π-conjugated frameworks, electron-rich triazine units and extraordinary chem. stability, they exhibit prospective potential applications in chem. sensing. In this paper, a triazine-based conjugated porous organic polymer (DPA-CTF) containing anthracene units was used to study the sensing effects on nitroarom. compounds and metal ions. Intriguingly, DPA-CTF showed sensitive detection performance towards nitroarom. explosives, especially p-nitroaniline (p-NA). Besides, it also exhibited high sensitivity toward Fe3+ ions compared to other metal ions. A series of characterization studies and computational simulations were used to explain the mechanism of the luminescence quenching effect. These results manifest that the new synthesized CTF is a promising candidate as a chem. sensor for p-NA and Fe3+ ions. In addition to this study using 9,10-Dibromoanthracene, there are many other studies that have used 9,10-Dibromoanthracene(cas: 523-27-3SDS of cas: 523-27-3) was used in this study.

9,10-Dibromoanthracene(cas: 523-27-3) can be sublimated and oxidized to generate anthraquinone. Soluble in hot benzene and hot toluene, slightly soluble in alcohol, ether and cold benzene, insoluble in water.SDS of cas: 523-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Guang-Ya; Ruan, Sun-Hong; Li, Yan-Yun; Gao, Jing-Xing published their research in Chinese Chemical Letters in 2021. The article was titled 《Manganese catalyzed asymmetric transfer hydrogenation of ketones》.Safety of Bromopentacarbonylmanganese(I) The article contains the following contents:

The asym. transfer hydrogenation (ATH) of a wide range of ketones catalyzed by manganese complex as well as chiral PxNy-type ligand under mild conditions was investigated. Using 2-propanol as hydrogen source, various ketones could be enantioselectively hydrogenated by combining cheap, readily available [MnBr(CO)5] with chiral, 22-membered macrocyclic ligand (R,R,R’,R’)-CyP2N4 I with 2 mol% of catalyst loading, affording highly valuable chiral alcs. with up to 95% ee. The results came from multiple reactions, including the reaction of Bromopentacarbonylmanganese(I)(cas: 14516-54-2Safety of Bromopentacarbonylmanganese(I))

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Safety of Bromopentacarbonylmanganese(I)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Chang-Cheng; Zhang, Guo-Xiang; Zuo, Zhi-Wei; Zeng, Rong; Zhai, Dan-Dan; Liu, Feng; Shi, Zhang-Jie published their research in Science China: Chemistry in 2021. The article was titled 《Photo-induced deep aerobic oxidation of alkyl aromatics》.Synthetic Route of C7H5BrO2 The article contains the following contents:

In this report, e.g., photo-induced deep aerobic oxidation of (poly)alkyl benzene toluene to benzene (poly)carboxylic acids e.g., benzoic acid was developed. CeCl3 was proved to be an efficient HAT (hydrogen atom transfer) catalyst in the presence of alc. as both hydrogen and electron shuttle. Dioxygen (O2) was found as a sole terminal oxidant. In most cases, pure products were easily isolated by simple filtration, implying large-scale implementation advantages. The reaction provides an ideal protocol to produce valuable fine chems. from naturally abundant petroleum feedstocks. The results came from multiple reactions, including the reaction of 4-Bromobenzoic acid(cas: 586-76-5Synthetic Route of C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Synthetic Route of C7H5BrO2 It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hu, Hongmei; Zhao, Meirong; Jin, Hangbiao published their research in Journal of Separation Science in 2021. The article was titled 《Determination of polyhalogenated carbazoles in waters at low nanogram-per-liter concentrations with solid-phase disk extraction》.SDS of cas: 6825-20-3 The article contains the following contents:

Polyhalogenated carbazoles, a class of emerging contaminants with persistence and dioxin-like toxicity, have received increasing attention in recent years. In this study, a simple, rapid, sensitive, and high throughput method based on solid-phase disk extraction and gas chromatog.-mass spectrometry was described for the determination of polyhalogenated carbazoles in low nanogram-per-liter range in water samples. The proposed solid-phase disk extraction method was initially optimized, and the optimum exptl. conditions found were 1 L water sample (pH 6-9) extracted and enriched by Empore 3-stn octadecyl disk at flow rate of 5 to 50 mL/min and eluted by 5 mL of acetone and 3 x 10 mL methylene dichloride. The linearity of the method ranged from 0.2 to 50 ng/L for carbazole and 11 polyhalogenated carbazoles, with correlation coefficients ranging from 0.9951 to 0.9996. The limits of detection were in the low nanogram per L level, ranging from 0.018 to 0.12 ng/L. Finally, the optimized method was applied for determining trace levels of carbazole and 11 polyhalogenated carbazoles in tap water and seawater samples with good recovery of 86.6-112.8%. Carbazole and 3-7 polyhalogenated carbazoles were detected, and 3,6-dichlorocarbazole was the predominant congener both in tap water and seawater. In the part of experimental materials, we found many familiar compounds, such as 3,6-Dibromo-9H-carbazole(cas: 6825-20-3SDS of cas: 6825-20-3)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used as a reagent in the synthesis of P7C3-A20 which is a potent neuroprotective agent.SDS of cas: 6825-20-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pu, Mingrui; Chen, Hui; Chao, Pengjie; Zhu, Yulin; Zheng, Nan; Lai, Hanjian; Zhao, Tingxing; He, Feng published their research in ACS Applied Polymer Materials in 2021. The article was titled 《Chlorinated Random Terpolymers with Efficient Solar Conversion and Low Batch-to-Batch Variation》.Electric Literature of C4H2Br2S The article contains the following contents:

The strategy of random terpolymn. has been shown to be a flexible and effective method with which to construct state-of-the-art polymer donors, and chlorination has frequently been utilized to fine-tune material properties in these polymers with the aim of improving the solar conversion efficiency. Herein, three random terpolymers consisting of BDT, BDD, and Th-Cl monomers in the optimized ratio of 1:0.85:0.15 were synthesized in parallel in an effort to understand the effect of chlorination in terpolymer systems and the chlorine-containing derviatives (named PBDB-Th15, PBDB-ThCl15, and PBDB-Th2Cl15). Among these three polymers, PBDB-ThCl15 shows a low-lying HOMO level, the most balanced hole and electron mobility, and enhanced aggregation behavior in blend film as a result of the introduction of one chlorine atom. When blended with a small mol. acceptor Y6, the resulting PBDB-ThCl15:Y6-based device showed the highest PCE of 15.63% of the three polymers. The PBDB-Th15- and PBDB-Th2Cl15-based devices present relatively poor conversion efficiencies of 14.91% and 12.62%. Interestingly, the terpolymer PBDB-ThCl15 was repeatedly prepared by random terpolymn. under the same conditions, and a low batch-to-batch variation was observed with a PCE of 1̃5.50%. These results indicate that the synergy of chlorination with random terpolymn. promises to contribute to the preparation of stable and high-performance solar cell polymers. In the experimental materials used by the author, we found 2,5-Dibromothiophene(cas: 3141-27-3Electric Literature of C4H2Br2S)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used in the preparation of soluble α,ω-diformyl-a-oligothiophenes.Electric Literature of C4H2Br2S

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary