Month: November 2022

Ma, Yucheng; Zhuang, Zeyan; Xing, Longjiang; Li, Jianqing; Yang, Zhiwen; Ji, Shaomin; Hu, Rong; Zhao, Zujin; Huo, Yanping; Tang, Ben Zhong published an article in 2021. The article was titled 《The AIE-Active Dual-Cationic Molecular Engineering: Synergistic Effect of Dark Toxicity and Phototoxicity for Anticancer Therapy》, and you may find the article in Advanced Functional Materials.Product Details of 4316-58-9 The information in the text is summarized as follows:

The development of anticancer therapy is significant to human health but remains a huge challenge. Photodynamic therapy (PDT), inducing the synergistic mitochondrial dysfunction in cancer cells is a promising approach but suffer from the low efficiency in hypoxic microenvironment and deep-seated tumors. Herein, to improve the outcomes of PDT for cancer treatment, a series of red fluorophores consisting of dual-cationic triphenylphosphonium-alkylated pyridinium and (substituted) triphenylamine are prepared as organelle-targeting antitumor photosensitizers (PSs) with aggregation-induced emission characteristics. These PSs can selectively accumulate at the mitochondria or lysosomes of cancer cells with both dark- and photo-cytotoxicity, making them possess excellent killing effect on cancer cells and efficient inhibition of tumor growth in living mice. This study brings about new insight into the development of powerful cancer treatment. The results came from multiple reactions, including the reaction of Tris(4-bromophenyl)amine(cas: 4316-58-9Product Details of 4316-58-9)

In other references, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Product Details of 4316-58-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Liyan; Jin, Tengda; Guo, Yingjie; Martin, A. C.; Sun, Keju; Dudley, Gregory B.; Yang, Jingyue published an article in 2021. The article was titled 《Synthesis of gem-Dimethylcyclopentane-Fused Arenes with Various Topologies via TBD-Mediated Dehydro-Diels-Alder Reaction》, and you may find the article in Journal of Organic Chemistry.Reference of 2,5-Dibromothiophene The information in the text is summarized as follows:

The development of efficient methods for the synthesis of substituted polycyclic arenes with various topologies is in high demand due to their excellent elec. and optical properties. In this work, a series of gem-dimethylcyclopentane-fused arenes with more than ten topologies were synthesized via a 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD)-mediated dehydro-Diels-Alder reaction with moderate to good yields. The introduction of the near-planar gem-dimethylcyclopentane moiety not only impacts the mol. conjugative system but also regulates the intermol. π-π interactions and crystal packing, which are critical for the photoelec. performance of arenes. The photophys. properties, mol. geometry, mol. packing of these compounds, and electrochem. properties were investigated by UV-vis absorption, fluorescence emission spectra, DFT calculations, single-crystal X-ray structure anal., and cyclic voltammetry study. In the experimental materials used by the author, we found 2,5-Dibromothiophene(cas: 3141-27-3Reference of 2,5-Dibromothiophene)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used as starting reagent for the synthesis of α,α′-didecylquater-, -quinque- and -sexi-thiophenes.Reference of 2,5-Dibromothiophene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Yao, Chengbo; Williams, Alana D. N.; Gu, Yiting; Norton, Jack R. published an article in Journal of Organic Chemistry. The title of the article was 《Isomerization of Aziridines to Allyl Amines via Titanium and Chromium Cooperative Catalysis》.Safety of Ethyltriphenylphosphonium bromide The author mentioned the following in the article:

A Ti/Cr cooperative catalyst isomerized aziridines to allyl amines under mild conditions. The reaction tolerated a broad range of aziridines with various nitrogen substituents. The titanium catalyst was most successful in opening 1,2-disubstituted aziridines, forming radical intermediates in a highly regioselective manner. The chromium catalyst appears to abstract an H• from these radical intermediates and then return the H• to the titanium system in the form of an H+ and an electron. The reaction was complementary to previous reports on the isomerization of aziridines to allyl amines. After reading the article, we found that the author used Ethyltriphenylphosphonium bromide(cas: 1530-32-1Safety of Ethyltriphenylphosphonium bromide)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. It is also used as catalysts in the synthesis of certain organic compounds and as a pharmaceutical intermediate.Safety of Ethyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Parsutkar, Mahesh M.; Moore, Curtis E.; RajanBabu, T. V. published an article in Dalton Transactions. The title of the article was 《Activator-free single-component Co(I)-catalysts for regio- and enantioselective heterodimerization and hydroacylation reactions of 1,3-dienes. New reduction procedures for synthesis of [L]Co(I)-complexes and comparison to in situ generated catalysts》.SDS of cas: 13465-09-3 The author mentioned the following in the article:

Although cobalt(I) bis-phosphine complexes have been implicated in many selective C-C bond-forming reactions, until recently relatively few of these compounds have been fully characterized or have been shown to be intermediates in catalytic reactions. In this paper we present a new practical method for the synthesis and isolation of several cobalt(I)-bis-phosphine complexes and their use in Co(I)-catalyzed reactions. We find that easily prepared (in situ generated or isolated) bis-phosphine and (2,6-N-aryliminoethyl)pyridine (PDI) cobalt(II) halide complexes are readily reduced by 1,4-bis-trimethylsilyl-1,4-dihydropyrazine or com. available lithium nitride (Li3N), leaving behind only innocuous volatile byproducts. Depending on the structures of the bis-phosphines, the cobalt(I) complex crystallizes as a phosphine-bridged species [(P-P)(X)CoI[μ-(P-P)]CoI(X)(P-P)] or a halide-bridged species [(P-P)CoI[μ-(X)]2CoI(P-P)]. Because the side-products are innocuous, these methods can be used for the in situ generation of catalytically competent Co(I) complexes for a variety of low-valent cobalt-catalyzed reactions of even sensitive substrates. These complexes are also useful for the synthesis of rare cationic [(P-P)CoI-η4-diene]+[X-] or [(P-P)CoI-η6-arene]+[X-] complexes, which are shown to be excellent single-component catalysts for the following regioselective reactions of dienes: heterodimerizations with ethylene or Me acrylate, hydroacylation and hydroboration. The reactivity of the single-component catalysts with the in situ generated species are also documented.Indium(III) bromide(cas: 13465-09-3SDS of cas: 13465-09-3) was used in this study.

Indium(III) bromide(cas: 13465-09-3) is used in organic synthesis as a water tolerant Lewis acid. It efficiently catalyzes the three-component coupling of β-keto esters, aldehydes and urea (or thiourea) to afford the corresponding dihydropyrimidinones.SDS of cas: 13465-09-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Li, Wanjiang; Chen, Longbin; Dong, Jiao; Feng, Yancong; Wang, Yao; Li, Hao; Zhou, Guofu published an article in ACS Applied Polymer Materials. The title of the article was 《Water- and Heat-Induced Crack-Healing of UCST-Type Poly(acrylamide-co-acrylonitrile) with Intrinsic Controllability and Reversibility》.Application of 623-24-5 The author mentioned the following in the article:

Autonomic crack-healing technol. has become a common option for reconstructing polymer networks against mech. degradation, structure mismatch, material fatigue, and even performance failure, but how to precisely and easily trigger this healing process on the crack interfaces is still a huge challenge. Here, we first found an autonomic physicochem. crack-healing behavior featuring intrinsic controllability and reversibility, based on nonionic poly(acrylamide-co-acrylonitrile) [P(AAm-co-AN)] with an upper critical solution temperature (UCST). Under the fast synergistic action between extrinsic deionized water and heat, the scratched P(AAm-co-AN) layer fully returned to the original flat form and was reworked at least five times. Meanwhile, their corresponding optical and mech. performances also recovered almost 100%. In particular, the intrinsic thermoresponsiveness of P(AAm-co-AN) takes a leading role in this crack-healing process, in which both interchain transition and topol. entanglement come into play. It provides a facile, rapid, precise, green, and autonomic crack-healing strategy for improving polymer durability. The results came from multiple reactions, including the reaction of 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Application of 623-24-5)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Application of 623-24-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Liu, Jie; Xu, Xinxin; Wu, Aihong; Song, Shanshan; Xu, Liguang; Xu, Chuanlai; Kuang, Hua; Liu, Liqiang published an article in LWT–Food Science and Technology. The title of the article was 《Immunochromatographic assay for the rapid and sensitive detection of etoxazole in orange and grape samples》.Name: Ethyl 4-bromobutyrate The author mentioned the following in the article:

Etoxazole, a novel organofluorine pesticide, has been widely used against various mites in fruits and vegetables. In this study, we designed an etoxazole-hapten and produced a highly sensitive monoclonal antibody (mAb) against etoxazole with a half-maximal inhibitory concentration of 4.04 ng/mL. Based on the mAb, we developed an immunochromatog. assay (ICA) for the detection of etoxazole in orange and grape samples. In the qual. detection, the visible limit of detection (vLOD) and cut-off value were 10 and 100 ng/g (fresh weight), resp. In the quant. detection, the LOD value was 2.03 ng/g (fresh weight) in orange and 2.52 ng/g (fresh weight) in grape samples. The recovery rates ranged from 94.7 ± 4.0% to 103.3 ± 3.8%, with CVs of 3.7-4.2% and 96.4 ± 3.4% to 106.1 ± 5.5%, with CVs of 3.5-5.2% for etoxazole in grape and orange samples, resp. The ICA results were similar to those of LC-MS/MS. Therefore, our developed ICA is a rapid, sensitive, and simple tool for screening etoxazole residues in fruits and vegetables. In addition to this study using Ethyl 4-bromobutyrate, there are many other studies that have used Ethyl 4-bromobutyrate(cas: 2969-81-5Name: Ethyl 4-bromobutyrate) was used in this study.

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Name: Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Jiao, Nianming; Yuan, Yanyan; Yao, Yuan; Liu, Long; Zhang, Yanqiang published an article in Fuel Processing Technology. The title of the article was 《Strained carbocycle based hypergolic ionic fuels with the improved energy capacity》.Product Details of 7051-34-5 The author mentioned the following in the article:

Different from the previous nitrogenous groups, we present a new strategy of improving the ionic liquids (ILs) energy capacity by introducing the strained carbocycles. The ILs with three- and/or four-member carbocycles were prepared, and their physicochem. properties as rocket fuels were studied. The ignition tests show that all of these ILs have the expected hypergolic reactivity with the oxidizer (white fuming HNO3). In virtue of the strained cyclopropane and cyclobutane substituents, the resulting hypergolic ILs possess better energy properties (heats of formation 0.784-1.968 kJ g-1; specific impulses 313.0-315.7 s) and densities (1.03-1.15 g cm-3) than the corresponding ILs with n-alkyl substituents. This strategy of introducing strained ring groups into hypergolic ILs gives a new approach to improve energy properties of hypergolic ILs. The experimental part of the paper was very detailed, including the reaction process of (Bromomethyl)cyclopropane(cas: 7051-34-5Product Details of 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Product Details of 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Wu, Lipeng; Zhang, Kaiming; Shi, Jiaoyan; Wu, Fan; Zhu, Xufei; Dong, Wei; Xie, Aming published an article in Composites, Part B: Engineering. The title of the article was 《Metal/nitrogen co-doped hollow carbon nanorods derived from self-assembly organic nanostructure for wide bandwidth electromagnetic wave absorption》.HPLC of Formula: 523-27-3 The author mentioned the following in the article:

Converting carbonaceous material into heteroatom-doped hollow nanomaterial is a promise route to realize lightweight and high-performance electromagnetic wave absorption (EMA). In this work, a series of metal/nitrogen co-doped hollow carbon nanorods (M-NHCRs, M represent as Fe, Co, Ni) were successfully fabricated via a facile self-assembly template strategy, which refers to self-assembling of 9,10-dibromoanthracene (DBA), surficial modification with polydopamine (PDA) and metal ions, and controlled pyrolysis. Among these M-NHCRs, Co-NHCR exhibits remarkable EMA performance, where the optimal reflection loss (RL) reaches -58.6 dB at a loading ratio of 5 wt%. Moreover, the effective absorption bandwidth (EAB) gets to 7.65 GHz. It is considered that the high-performance EMA should be attributed to the unique hollow structure, excellent conductance loss and improved polarization relaxation. This research not only provides a new idea for the design of lightweight electromagnetic absorbents with broadband efficient absorption, but also broadens the way of synthesizing hollow nanomaterials.9,10-Dibromoanthracene(cas: 523-27-3HPLC of Formula: 523-27-3) was used in this study.

9,10-Dibromoanthracene(cas: 523-27-3) is synthesized by the bromination of anthracene. The bromination reaction is carried out at room temperature using carbon tetrachloride as a solvent. Using 80-85% anthracene as raw material, adding bromine to react for half an hour, the yield is 83-88%.HPLC of Formula: 523-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhu, Hong; Liu, Zhichao; Xu, Chenbo; Chen, Caiqi; Wen, Jinxuan; Yang, Keqin; Chen, Suqin; Pan, Yuexiao published an article in Journal of Alloys and Compounds. The title of the article was 《Large red shift from blue to green in the photoluminescence of pure CsPbBr3 nanoplatelets triggered by the cooperative effect of ligands combination》.Recommanded Product: 4-Bromobutanoic acid The author mentioned the following in the article:

A viable design strategy toward cubic CsPbBr3 (CPB) nanoplatelet (NPs) with blue emission at 450-467 nm and a large red shift to the green region at 500-512 nm occurs was developed through a cooperative effect of the ligands 4-bromobutyric acid (BBA) and oleylamine (OLA). The influence of the mol. ratio of BBA/OLA, reaction time and temperature on the transformation from blue to green was studied systematically. The red shift in the PL of CPB NPs is ascribed to the growth of the crystals with decreased quantum confinement. The luminescence quantum yields (PLQYs) of the blue and green luminescence of the obtained CPB NPs reach 94.4 and 84.4%, resp. This proposed strategy not only exptl. fabricates size-adjustable CPB NPs but also helps to reveal in depth the mechanisms of the large variation of quantum confinement in pure cubic CPB NPs. The results came from multiple reactions, including the reaction of 4-Bromobutanoic acid(cas: 2623-87-2Recommanded Product: 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Recommanded Product: 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 21085-72-3In 2021 ,《Tandem-Cleavage Linkers Improve the In Vivo Stability and Tolerability of Antibody-Drug Conjugates》 appeared in Bioconjugate Chemistry. The author of the article were Chuprakov, Stepan; Ogunkoya, Ayodele O.; Barfield, Robyn M.; Bauzon, Maxine; Hickle, Colin; Kim, Yun Cheol; Yeo, Dominick; Zhang, Fangjiu; Rabuka, David; Drake, Penelope M.. The article conveys some information:

Although peptide motifs represent the majority of cleavable linkers used in clin.-stage antibody-drug conjugates (ADCs), the sequences are often sensitive to cleavage by extracellular enzymes, such as elastase, which leads to systemic release of the cytotoxic payload. This action reduces the therapeutic index by causing off-target toxicities that can be dose-limiting. For example, a common side-effect of ADCs made using peptide-cleavable linkers is myelosuppression, including neutropenia. Only a few reports describe methods for optimizing peptide linkers to maintain efficient and potent tumor payload delivery while enhancing circulating stability. Herein, the authors address these critical limitations through the development of a tandem-cleavage linker strategy, where two sequential enzymic cleavage events mediate payload release. The authors prepared dipeptides that are protected from degradation in the circulation by a sterically encumbering glucuronide moiety. Upon ADC internalization and lysosomal degradation, the monosaccharide is removed and the exposed dipeptide is degraded, which liberates the attached payload inside the target cell. The authors used CD79b-targeted monomethyl auristatin E (MMAE) conjugates as the model system and compared the stability, efficacy, and tolerability of ADCs made with tandem-cleavage linkers to ADCs made using standard technol. with the vedotin linker. The results, where rat studies showed dramatically improved tolerability in the hematopoietic compartment, highlight the role that linker stability plays in efficacy and tolerability and also offer a means of improving an ADC’s therapeutic index for improved patient outcomes. The experimental part of the paper was very detailed, including the reaction process of (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3Application of 21085-72-3)

(2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3) may be used for the synthesis of HMR1098-S-Glucuronide Methyl Ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.Application of 21085-72-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary