Month: November 2022

Related Products of 76006-33-2In 2020 ,《Nickel-catalyzed dual C(sp2)-H activation of arenes: a new route to diaryl ethers》 appeared in Organic Chemistry Frontiers. The author of the article were Lv, Ningning; Chen, Zhengkai; Yu, Shuling; Liu, Zhanxiang; Zhang, Yuhong. The article conveys some information:

Diaryl ethers were synthesized directly from simple arenes for the first time through dual C(sp2)-H activation with the aid of a bidentate auxiliary by nickel catalysis. The anion of the additive is crucial to the transformation, and the control experiments revealed that the acyloxylated benzamide was the key intermediate. The results came from multiple reactions, including the reaction of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Related Products of 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. Related Products of 76006-33-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 5437-45-6In 2021 ,《Enantioselective Rauhut-Currier Reaction with β-Substituted Acrylamides Catalyzed by N-Heterocyclic Carbenes》 appeared in Organic Letters. The author of the article were Pitchumani, Venkatachalam; Breugst, Martin; Lupton, David W.. The article conveys some information:

β-Substituted acrylamides have low electrophilicity and are yet to be exploited in the enantioselective Rauhut-Currier reaction. Exploiting electron-withdrawing protection of the amide, and moderate nucleophilicity N-heterocyclic carbenes (NHCs), such substrates have been converted to enantioenriched quinolones. The reaction proceeds with complete diastereoselectivity, good yield, and modest enantioselectivity. Derivatizations are reported, as are computational studies, supporting decreased amide bond character with electron-withdrawing protection of the nitrogen. The experimental part of the paper was very detailed, including the reaction process of Benzyl 2-bromoacetate(cas: 5437-45-6Application of 5437-45-6)

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.Application of 5437-45-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of C12H7Br2NIn 2022 ,《Effects of 3,6-Dibromocarbazole on Soil Health-Based on Soil Enzymes and the Biolog-ECO Test》 was published in Water, Air, & Soil Pollution. The article was written by Du, Zhongkun; Zhang, Ji; Cheng, Chao; Shi, Baihui; Zhu, Lusheng; Wang, Jun; Wang, Jinhua; Li, Bing. The article contains the following contents:

Polyhalogenated carbazoles (PHCZs) are a kind of emerging contaminants with doxin-like toxicity, potential bioaccumulation capability, and persistence. Data about the risks of PHCZs on soil ecosystem are scarce to date, although PHCZs have been detected with high concentrations in the soil. The present study performed a preliminary investigation of 3,6-dibromocarbazole (36-DBCZ, a PHCZ with a high detection rate, and concentration in the environment) at concentrations of 0.1, 1.0, 10, and 100 mg/kg on the soil health, based on soil enzyme test and Biolog-ECO assay. Results showed that 36-DBCZ could inhibit the activity and diversity of soil microbes, even at the environment-relevant concentration (0.1 mg/kg). But, the inhibition lasted only about 10 days. As time passed, slight increases in microbe activity and diversity were found in 36-DBCZ-treated groups. We hypothesized that the degradation products of 36-DBCZ provided extra nutrients to the soil microbes, which required further verification. Activities of urease, β-glucosidase, and acid phosphatase were increasingly increased, in contrast to the microbial activity. The present study provides valuable data on the effects of PHCZs on the soil ecosystem, and we suggest that the degradation of PHCZs, as well as their influences on the structure and functions of the soil microbial community, should be investigated in future studies. In the experiment, the researchers used many compounds, for example, 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Synthetic Route of C12H7Br2N)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used in the preparation of N-(2-hydroxyethyl)-3,6-dibromocarbazole.Synthetic Route of C12H7Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetateIn 2019 ,《Synthesis and characterization of stanozolol N-glucuronide metabolites》 was published in Monatshefte fuer Chemie. The article was written by Kratena, Nicolas; Enev, Valentin; Gmeiner, Guenter; Gaertner, Peter. The article contains the following contents:

The preparation, separation, and anal. of two regioisomeric N-glucuronides of the common doping agent stanozolol are described in this manuscript. Glucuronidation was carried out using modified Koenigs-Knorr conditions developed specifically for pyrazoles. After preparative HPLC separation both isomers could be isolated in a pure form. Global cleavage of protecting groups furnished the putative human phase II metabolites STN1 and STN2 which were compared with human excretion studies. The results came from multiple reactions, including the reaction of (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3Recommanded Product: (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate)

(2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3) may be used for the synthesis of HMR1098-S-Glucuronide Methyl Ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.Recommanded Product: (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Name: Ethyltriphenylphosphonium bromideIn 2021 ,《Highly efficient and reversible low-concentration SO2 absorption in flue gas using novel phosphonium-based deep eutectic solvents with different substituents》 was published in Journal of Molecular Liquids. The article was written by Zhao, Yongqi; Dou, Jinxiao; Wei, Aoran; Khoshkrish, Salman; Yu, Jianglong. The article contains the following contents:

Four hydrogen bond acceptors (HBAs) with different carbon chain length substituents, including methyl-triphenyl phosphonium bromide (MTPB), ethyl-tri-Ph phosphonium bromide (ETPB), propyl-triphenyl phosphonium bromide (PTPB), and butyl-tri-Ph phosphonium bromide (BTPB), combined with ethylene glycol (EG) were developed to synthesize four low-viscosity deep eutectic solvents (DESs). In this study, the effect of different substituents in DESs on low-concentration SO2 absorption was systematically studied at 30-70°C. Exptl. results show that the EG-MTPB DES has a higher SO2 absorption capacity and a lower viscosity than other DESs. The reason for the higher SO2 absorption capacity of EG-MTPB DES was described by viscosity experiments and quantum chem. calculations It was shown that the strong polarization ability of the CH3- group promotes the absorption of SO2 by DESs. 1H NMR and FTIR results indicated that chem. interactions primarily exist between the S of SO2 and Br, and the O of SO2 and the H atom of EG form hydrogen bonds. The d. functional theory (DFT) results also confirm that the charge of the Br atom migrated to the S atom. Also, thermostability and regeneration experiments showed that the EG-MTPB DES exhibits good stability and can thus be used for industrial flue gas desulfurization. In the part of experimental materials, we found many familiar compounds, such as Ethyltriphenylphosphonium bromide(cas: 1530-32-1Name: Ethyltriphenylphosphonium bromide)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.Name: Ethyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of C9H11BrO3In 2021 ,《Synthesis of Thio-lignan Analogues, Bioequivalent Salvinal without Unfavored Aldehyde》 was published in Journal of Organic Chemistry. The article was written by Saito, Yohei; Kobayashi, Yukiko; Yoshida, Nanami; Goto, Masuo; Nakagawa-Goto, Kyoko. The article contains the following contents:

The oxygen in the benzofuran (BF) of three antiproliferative natural neolignans, salvinal, obovaten, and 2-[7-methoxy-2-(4-methoxyphenyl)-3-methylbenzofuran-5-yl]ethanol, was replaced with sulfur to form the new biol. scaffold benzothiophene (BT) thio-lignans. The synthesized derivatives were evaluated for antiproliferative activity against five human cancer cell lines, including a multidrug-resistant cell line. Thio-salvinal displayed significant antiproliferative effects with half-maximal inhibitory concentration (IC50) values of 0.57-0.95μM against all tested cell lines, except for the HER2 neg. breast cancer cell line MCF-7. This thio-lignan was 6.5-9.4 times more potent than the parent. However, the related thio-lignans showed much weaker antiproliferative effects and were less potent than the parent natural benzofuran lignans. Newly synthesized thio-lignan I affected cell cycle progression at 24 and 48 h in the G2/M transition and S phase, resp., as well as promoted sub-G1 induction by stimulating microtubule depolymerization and nuclear fragmentation. Since a highly reactive aldehyde in salvinal is generally not appropriate for drug development, we have successfully found nonaldehyde derivative I showing biol. activity similar to salvinal by replacing BF with BT and an aldehyde with 1,3-dioxolane. After reading the article, we found that the author used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Synthetic Route of C9H11BrO3)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Synthetic Route of C9H11BrO31-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Catalytic impact of twin headed geminis in study of ninhydrin with aspartic acid in an acetate buffer system》 was written by Kumar, Dileep; Rub, Malik Abdul; Bhattarai, Ajaya. SDS of cas: 629-03-8This research focused ontwin headed gemini surfactant ninhydrin aspartic acid reaction kinetics; Ruhemann’s purple. The article conveys some information:

Herein, catalytic impact of aqueous-micellar solution of twin headed 16-s-16 (s = spacer) gemini surfactants (GS) was measured in the study of ninhydrin (nin) with aspartic (Asp) amino acid. The study was performed over the different range of reactants’ concentration, temperature and pH. Reaction obeyed the order to be resp. fractional and unity in [nin] and [Asp]. The values of several quantities, viz., critical micellar concentration (cmc), thermodn. parameters, and binding parameters were calculated and described herewith. The exptl. outcomes depict that the reaction is catalyzed, significantly, by twin headed gemini surfactants and follow the order at all concentration as: GS-4 > GS-5 > GS-6. In the rate constant (kψ) vs. [GS] rate profiles, kψ intensifies even at below cmc values of surfactants (region I), and previously observe practically unchanged behavior (region II). Finally, a fast changes in kψ is detected (region III). Catalytic impact of twin headed GS achieved in this study is deduced by using a model called as micellar pseudo-phase in which rate constant depends on both the reactants. The numerous kinetic constants in twin headed geminis were evaluated and elaborated. An acceptable mechanism reliable with kinetics comprising the development of Ruhemanns’ purple between nin and Asp has been proposed. The experimental part of the paper was very detailed, including the reaction process of 1,6-Dibromohexane(cas: 629-03-8SDS of cas: 629-03-8)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of pyrrolo-tetrathiafulvalene molecular bridge (6PTTF6) to study redox switching behavior of single molecules; synthesis of water-soluble thermoresponsive polylactides.SDS of cas: 629-03-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis of steroid analogs of tubuloclustin, their cytotoxicity and effect on microtubules of A549 carcinoma cells》 was written by Nurieva, E. V.; Zefirov, N. A.; Mamaeva, A. V.; Wobith, B.; Kuznetsov, S. A.; Zefirova, O. N.. Reference of 8-Bromooctanoic acidThis research focused ontubuloclustin methoxyestradiol analog preparation antitumor microtubule lung carcinoma. The article conveys some information:

Synthesis of analogs of tubuloclustin (N-(7-adamant-2-yloxy-7-oxoheptanoyl)-N-deacetylcolchicine ) with the colchicine fragment replaced with 2-methoxyestradiol scaffold attached via phenolic hydroxy group was described. Esters 3a-c exhibit moderate cytotoxicity (EC50 = 5-6 μmol L-1) and exert a weak effect on the microtubule network in A549 human lung carcinoma cells similar to the clustering effect of tubuloclustin and its derivatives Conjugates 6a-c and 7a-c with the phenolic ester bond are low stable and compounds 7a-c are inactive to the microtubules of A549 cells, while compounds 6a-c cause an unusual effect of curling of the microtubules. In the experimental materials used by the author, we found 8-Bromooctanoic acid(cas: 17696-11-6Reference of 8-Bromooctanoic acid)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid.Reference of 8-Bromooctanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Vinyl Azides as Radical Acceptors in the Vitamin B12-Catalyzed Synthesis of Unsymmetrical Ketones》 was written by Dworakowski, Krzysztof R.; Pisarek, Sabina; Hassan, Sidra; Gryko, Dorota. Recommanded Product: 2969-81-5This research focused onunsym ketone preparation; vinyl azide alkyl bromide Vitamin B12 catalyst light irradiation. The article conveys some information:

Vitamin B12 catalyzed the reaction of vinyl azides with electrophiles under light irradiation to afforded unsym. carbonyl compounds R1C(O)CH2R2 [R1 = Ph, 4-t-BuC6H4, 4-ClC6H4, etc.; R2 = (CH2)3CN, (CH2)3Ph, (CH2)3C(O)OEt, etc.] in decent yields. Mechanistic studies revealed that alkyl radicals were key intermediates in this transformation. In the experimental materials used by the author, we found Ethyl 4-bromobutyrate(cas: 2969-81-5Recommanded Product: 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

HPLC of Formula: 401-55-8On November 28, 2020 ,《Recyclable Ruthenium Catalyst for Distal meta-C-H Activation》 appeared in Chemistry – A European Journal. The author of the article were Choi, Isaac; Mueller, Valentin; Wang, Yanhui; Xue, Kai; Kuniyil, Rositha; Andreas, Loren B.; Karius, Volker; Alauzun, Johan G.; Ackermann, Lutz. The article conveys some information:

The unprecedented hybrid-ruthenium catalysis for distal meta-C-H activation was disclosed. The hybrid-ruthenium catalyst was recyclable, as was proven by various heterogeneity tests, and fully characterized with various microscopic and spectroscopic techniques, highlighting the phys. and chem. stability. Thereby, the hybrid-ruthenium catalysis proved broadly applicable for meta-C-H alkylations of among others purine-based nucleosides and natural product conjugates. Addnl., its versatility was further reflected by meta-C-H activations through visible-light irradiation, as well as para-selective C-H activations.Ethylbromofluoroacetate(cas: 401-55-8HPLC of Formula: 401-55-8) was used in this study.

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.HPLC of Formula: 401-55-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary