Month: November 2022

Kim, Hyoung-Juhn published their research in Korean Membrane Journal on December 31 ,2003. The article was titled 《Sulfonated dendrimers for the application of fuel cell membranes 1. Synthesis and characterization of sulfonated dendrimers》.COA of Formula: C24H12Br6 The article contains the following contents:

1,3,5-Substituted polyphenylene type dendrimers were synthesized. The dendrimer was heated in concentrate H2SO4 at 120°C. The reaction mixture was precipitated to ether after simple filtration to get para-sulfonated dendrimer as the chief product. To give mech. properties to the sulfonated dendrimer, it was partially cross-linked with Ph ether in the medium of P2O5 and CH3SO3H. After reading the article, we found that the author used 3,3”,5,5”-Tetrabromo-5′-(3,5-dibromophenyl)-1,1′:3′,1”-terphenyl(cas: 29102-67-8COA of Formula: C24H12Br6)

3,3”,5,5”-Tetrabromo-5′-(3,5-dibromophenyl)-1,1′:3′,1”-terphenyl(cas: 29102-67-8) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. COA of Formula: C24H12Br6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhou, Quan; Snider, Barry B. published their research in Journal of Organic Chemistry on December 3 ,2010. The article was titled 《Synthesis of Hexacyclic Parnafungin A and C Models》.Category: bromides-buliding-blocks The article contains the following contents:

Unstable hexacyclic parnafungin A and C models isoxazolophenanthridones I (R = R1 = H; R = MeO, R1 = H; R = H, R1 = MeO) and benzopyranoisoxazolophenanthridinediones II (R2 = H, Me) were prepared using Suzuki coupling reactions, reductive cyclizations of o-nitrobenzoates to benzisoxazolones and the cyclocondensations of hydroxymethylarylbenzisoxazolones to fused isoxazoloquinolines as key steps. Iodoxanthones III (R2 = H, Me) were prepared in four or five steps and 33-50% overall yields from Me salicylate and either 5-Me or 5-(hydroxymethyl)resorcinol; Suzuki-Miyaura coupling of III (R2 = H, Me) with an excess of readily available 3-carbomethoxy-2-nitrophenyl pinacolboronate (prepared in three steps from 3-methyl-2-nitro-1-bromobenzene) afforded the hindered highly functionalized (methoxycarbonyl)nitrophenyl-substituted xanthones in 53-58% yields. Zinc reduction of the (methoxycarbonyl)nitrophenyl-substituted xanthones gave benzisoxazolinones that were treated with MsCl and then with base to generate the unstable hexacyclic parnafungin A and C models II (R = H) and II (R = Me) in 13% overall yield for 8 steps and in 8% overall yield for 9 steps, resp. Analogously to the parnafungins, II (R2 = Me) decomposes to a phenanthridine with a half-life of 2 d in CDCl3. The experimental part of the paper was very detailed, including the reaction process of 3-Bromo-2-nitrobenzoic acid(cas: 116529-61-4Category: bromides-buliding-blocks)

3-Bromo-2-nitrobenzoic acid(cas: 116529-61-4) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Basak, Akash; Abouelhassan, Yasmeen; Norwood, Verrill M. IV; Bai, Fang; Nguyen, Minh Thu; Jin, Shouguang; Huigens, Robert W. III published 《Synthetically Tuning the 2-Position of Halogenated Quinolines: Optimizing Antibacterial and Biofilm Eradication Activities via Alkylation and Reductive Amination Pathways》.Chemistry – A European Journal published the findings.Synthetic Route of C6H5Br2N The information in the text is summarized as follows:

Agents capable of eradicating bacterial biofilms are of great importance to human health as biofilm-associated infections are tolerant to our current antibiotic therapies. We have recently discovered that halogenated quinoline (HQ) small mols. are: (1) capable of eradicating methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphylococcus epidermidis (MRSE) and vancomycin-resistant Enterococcus faecium (VRE) biofilms, and (2) synthetic tuning of the 2-position of the HQ scaffold has a significant impact on antibacterial and antibiofilm activities. Here, we report the chem. synthesis and biol. evaluation of 39 HQ analogs that have a high degree of structural diversity at the 2-position. We identified diverse analogs that are alkylated and aminated at the 2-position of the HQ scaffold and demonstrate potent antibacterial (MIC≤0.39 μM) and biofilm eradication (MBEC 1.0-93.8 μM) activities against drug-resistant Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecium strains while demonstrating <5 % haemolysis activity against human red blood cells (RBCs) at 200 μM. In addition, these HQs demonstrated low cytotoxicity against HeLa cells. Halogenated quinolines are a promising class of antibiofilm agents against Gram-pos. pathogens that could lead to useful treatments against persistent bacterial infections. In the experiment, the researchers used many compounds, for example, 3,5-Dibromoaniline(cas: 626-40-4Synthetic Route of C6H5Br2N)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Synthetic Route of C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Journal of Organic Chemistry included an article by Shin, Jung-Ah; Kim, Jiheon; Lee, Hongsoo; Ha, Sura; Lee, Hee-Yoon. Computed Properties of C4H7BrO2. The article was titled 《Cu(OTf)2-Promoted 1,4-Addition of Alkyl Bromides to Dehydroalanine》. The information in the text is summarized as follows:

Zn/Cu(OTf)2 mediated addition of alkyl bromides to dehydroalanine (Dha) derivatives including dipeptides and tripeptides in high yields under aqueous medium was developed. This protocol allows selective and biocompatible access to various amino acid units from Dha derivatives In the experiment, the researchers used many compounds, for example, Methyl 3-bromopropanoate(cas: 3395-91-3Computed Properties of C4H7BrO2)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Computed Properties of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,ChemistrySelect included an article by de Oliveira, Adeildo Junior; Souza, Isis Torres; Bernardo, Vanderson Barbosa; Santos, Larissa C.; de Lima, Maria Raquel Ferreira; Goulart, Henrique Fonseca; Goulart Santana, Antonio Euzebio. Formula: C6H12Br2. The article was titled 《Monobromination of α,ω-Diols: Highly Efficient Preparation of Synthetic Intermediates》. The information in the text is summarized as follows:

The present work aimed to evaluate different conditions to perform monobromination reactions of α,ω-diols HOCH2(CH2)nCH2OH (n = 4, 5, 6, 8) using HBr. Three solvents such as, toluene, isooctane, 1,2-dichloroethane were tested in two distinct molar proportions between 1,8-octanediol and HBr (1:1 and 1:2 equiv). All reactions occurred under reflux. After establishing the best reactional conditions, assays with four sym. α,ω-diols, 1,6-hexanediol; 1,7-heptanediol; 1,8-octanediol; and 1,10-decanediol, with 2 equivalent HBr in 1,2-dichloroethane, were conducted. Using toluene as solvent lead to the best reaction yields (81-95%), producing the least amount of unwanted dibrominated product BrCH2(CH2)nCH2Br. Reactions in 1,2-dichloroethane gave similar results to the ones with toluene when 2 equivalent HBr were used. The lowest reactional efficiency registered in these assays occurred in isooctane, forming the highest amount of dibromide. Diols 1,7-heptanediol and 1,8-octanediol showed the best results under the conditions studied, in 1,2-dichloroethane. In the experiment, the researchers used many compounds, for example, 1,6-Dibromohexane(cas: 629-03-8Formula: C6H12Br2)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.Formula: C6H12Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Advanced Synthesis & Catalysis included an article by Zhang, Heng; Yu, Yinghua; Huang, Shenlin; Huang, Xueliang. Synthetic Route of C7H5BrO. The article was titled 《Palladium-Catalyzed Cascade Reaction of o-Bromobenzaldehydes with N-Sulfonylhydrazones: An Efficient Approach to the Naphthalene Skeleton》. The information in the text is summarized as follows:

A new strategy for the construction of the naphthalene backbone was described. The reaction essentially started from two simple aldehydes. The key step was enabled by a palladium-carbene migratory insertion. After that, a sequence of reversible allylic alkylation and intramol. condensation took place to give the substituted naphthalene derivatives Addnl. manipulations on the sulfonyl group in the product via palladium-catalyzed Kumada coupling were also investigated.o-Bromobenzaldehyde(cas: 6630-33-7Synthetic Route of C7H5BrO) was used in this study.

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Synthetic Route of C7H5BrOSynthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Journal of Medicinal Chemistry included an article by Lee, Taekyu; Christov, Plamen P.; Shaw, Subrata; Tarr, James C.; Zhao, Bin; Veerasamy, Nagarathanam; Jeon, Kyu Ok; Mills, Jonathan J.; Bian, Zhiguo; Sensintaffar, John L.; Arnold, Allison L.; Fogarty, Stuart A.; Perry, Evan; Ramsey, Haley E.; Cook, Rebecca S.; Hollingshead, Melinda; Davis Millin, Myrtle; Lee, Kyung-min; Koss, Brian; Budhraja, Amit; Opferman, Joseph T.; Kim, Kwangho; Arteaga, Carlos L.; Moore, William J.; Olejniczak, Edward T.; Savona, Michael R.; Fesik, Stephen W.. Application of 1129-28-8. The article was titled 《Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer》. The information in the text is summarized as follows:

Overexpression of myeloid cell leukemia-1 (Mcl-1) in cancers correlates with high tumor grade and poor survival. Addnl., Mcl-1 drives intrinsic and acquired resistance to many cancer therapeutics, including B cell lymphoma 2 family inhibitors, proteasome inhibitors, and antitubulins. Therefore, Mcl-1 inhibition could serve as a strategy to target cancers that require Mcl-1 to evade apoptosis. Herein, we describe the use of structure-based design to discover a novel compound (42) that robustly and specifically inhibits Mcl-1 in cell culture and animal xenograft models. Compound 42 binds to Mcl-1 with picomolar affinity and inhibited growth of Mcl-1-dependent tumor cell lines in the nanomolar range. Compound 42 also inhibited the growth of hematol. and triple neg. breast cancer xenografts at well-tolerated doses. These findings highlight the use of structure-based design to identify small mol. Mcl-1 inhibitors and support the use of 42 as a potential treatment strategy to block Mcl-1 activity and induce apoptosis in Mcl-1-dependent cancers. After reading the article, we found that the author used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Application of 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application of 1129-28-8 Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Journal of Luminescence included an article by Majeed, Shereen A.; Nwaji, Njemuwa; Mack, John; Nyokong, Tebello; Makhseed, Saad. Computed Properties of C12H7Br2N. The article was titled 《Nonlinear optical responses of carbazole-substituted phthalocyanines conjugated to graphene quantum dots and in thin films》. The information in the text is summarized as follows:

Three different phthalocyanine complexes substituted with carbazoles were conjugated to graphene quantum dots (GQDs) through π-π stacking. The morphologies, sizes, and crystallinities of the nanoconjugates were determined using Raman spectroscopy, energy dispersive X-ray spectroscopy, transmission electron microscopy, and X-ray diffraction. The nonlinear optical (NLO) properties of the metallophthalocyanines alone and when conjugated to the GQD nanomaterial in different solvents, as well as after having been embedded in thin films, were studied. The effects of the different substituents and solvents on the NLO properties of the metallophthalocyanines were evaluated. Enhancements in the photophys. properties of the complexes upon conjugation with the nanomaterial were observed Fluorescence quantum yields, fluorescence lifetimes, triplet quantum yields, and triplet lifetimes were measured for the complexes, and for their conjugates in DMSO. The results came from multiple reactions, including the reaction of 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Computed Properties of C12H7Br2N)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used as a reagent in the synthesis of P7C3-A20 which is a potent neuroprotective agent.Computed Properties of C12H7Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Reactive & Functional Polymers included an article by Zhang, Shuai; Zhu, Xiuling; Jin, Cuihong; Hu, Huilan. HPLC of Formula: 629-03-8. The article was titled 《Pyridinium-functionalized crosslinked anion exchange membrane based on multication side chain tethered elastomeric triblock poly(styrene-b-(ethylene-co-butylene)-b-styrene)》. The information in the text is summarized as follows:

Hydroxide ion conductivity and long-term chem. stability play an important role in the development of anion exchange membranes (AEMs) for application of alk. anion exchange membrane fuel cells (AAEMFCs). Herein, the high alk. stable elastomeric triblock copolymer, poly(styrene-b-(ethylene-co-butylene)-b-styrene) (SEBS) with pendent multi-cation side chain and 4,4-bipyridine was develop for AEMs. The three cations in a side chain were tethered to the SEBS backbone and the length of the spacer between cations was six methylene (-CH2-) groups (TNQN). More importantly, the 4,4-bipridine was introduced to the membranes as the crosslinker and functional groups, which exhibited the significant improvement in hydroxide ion conductivity of the membranes. The hydroxide conductivity of the cross-linked quaternized SEBS (TNQN-SEBS-Bpy) membranes was 30.41-69.04 mS·cm-1 from 30°C to 80°C, which could be ascribed to well micromorphol. and more functional groups. Compared to the uncross-linked TNQN-SEBS, the TNQN-SEBS-Bpy membranes showed higher mech. property and thermal stability. All the membranes exhibited good alk. stability which the hydroxide conductivity maintained above 90% of the original ionic conductivity after 300 h of alk. treatment (1 M aqueous NaOH) at 80°C. Based on these outstanding properties, the cross-linked membranes show great potential application as alk. anion exchange membranes. In the experimental materials used by the author, we found 1,6-Dibromohexane(cas: 629-03-8HPLC of Formula: 629-03-8)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of pyrrolo-tetrathiafulvalene molecular bridge (6PTTF6) to study redox switching behavior of single molecules; synthesis of water-soluble thermoresponsive polylactides.HPLC of Formula: 629-03-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,New Journal of Chemistry included an article by Kobra, Khadijatul; Li, Yuxuan; Sachdeva, Rakesh; McMillen, Colin D.; Pennington, William T.. Recommanded Product: Methyltriphenylphosphonium bromide. The article was titled 《New polymorphism and structural sensitivity in triphenylmethylphosphonium trihalide salts》. The information in the text is summarized as follows:

In the course of our ongoing study of halogen bonding in cocrystals of organoiodine mols. with triiodide salts, we have isolated three of the four known polymorphs of triphenylmethylphosphonium triiodide (PPh3MeI3) and found that one of the tetramorphs exhibits a low temperature phase transition not previously described in the literature. Variable temperature crystallog. studies coupled with differential scanning calorimetry were used to determine the transition temperature and solid-state single crystal to single crystal reversibility of the phase change. To monitor the effect of the size of the anion, bromine was introduced to the reaction mixtures to produce trihalide salts (PPh3MeX3) having varying degrees of mixed iodine and bromine content. The resulting modification of anion size led to structural perturbations beyond those previously observed for the PPh3MeI3 polymorphs, giving three different structure types with similar but not identical packing arrangements of the ions. In addition to providing insight into the effect of subtle changes to crystal packing, the mixed trihalides offer structural and electronic tuning to the applicability of rod-shaped trihalides and functional halogen bonding acceptors. In addition to this study using Methyltriphenylphosphonium bromide, there are many other studies that have used Methyltriphenylphosphonium bromide(cas: 1779-49-3Recommanded Product: Methyltriphenylphosphonium bromide) was used in this study.

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is an organophosphorus compound, with potential use as a precursor and a solvent in organic synthesis. And it is used widely for methylenation via the Wittig reaction.Recommanded Product: Methyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary