Month: November 2022

In 2019,Journal of Organic Chemistry included an article by Empel, Claire; Patureau, Frederic W.; Koenigs, Rene M.. HPLC of Formula: 6825-20-3. The article was titled 《Visible Light Induced Metal-Free Carbene N-Carbazolation》. The information in the text is summarized as follows:

Metal-free N-H functionalization reactions represent an important strategy for sustainable C-N coupling reactions. In this report, we describe the visible light photolysis of aryl diazoacetates in the presence of some N-heterocycles that enables mild, metal-free N-H functionalization reactions of carbazole and azepine heterocycles (15 examples, up to 83% yield). After reading the article, we found that the author used 3,6-Dibromo-9H-carbazole(cas: 6825-20-3HPLC of Formula: 6825-20-3)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used as a reagent in the synthesis of P7C3-A20 which is a potent neuroprotective agent.HPLC of Formula: 6825-20-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Synergistic cooperation of bi-active hydrogen atoms in protic carboxyl imidazolium ionic liquids to push cycloaddition of CO2 under benign conditions》 were Wang, Tengfei; Zhu, Xinrui; Mao, Lemin; Liu, Yi; Ren, Tiegang; Wang, Li; Zhang, Jinglai. And the article was published in Journal of Molecular Liquids in 2019. Formula: C6H11BrO2 The author mentioned the following in the article:

Nine protic carboxyl imidazolium ionic liquids were synthesized. Then, they were employed to catalyze the chem. fixation of carbon dioxide (CO2) and propylene oxide leading to propylene carbonate in the absence of co-catalyst and organic solvent. HCPImBr presents the best catalytic activity with the product yield of 92% under reaction temperature 120°C, CO2 initial pressure 1.5 MPa, catalyst amount 0.5 mol%, and reaction time 2.0 h. Even if the reaction temperature and CO2 initial pressure are decreased to 80°C and 1.0 MPa, resp., the 85% of product yield would be kept with the 1.0% catalyst dosage along with 12.0 h. With the exception of the most optimal reaction conditions, generality, and recyclability of HCPImBr are also investigated. More importantly, the reaction mechanism is investigated by the d. functional theory, which is the first time to report the mechanism for protic carboxyl imidazolium ionic liquids The catalytic activity of ionic liquids would be further improved with the reasonable combination of cation and anion. In the part of experimental materials, we found many familiar compounds, such as Ethyl 4-bromobutyrate(cas: 2969-81-5Formula: C6H11BrO2)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Formula: C6H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Synthesis and characterization of analogues of glycine-betaine ionic liquids and their use in the formation of aqueous biphasic systems》 were Pereira, Matheus M.; Pedro, Sonia N.; Gomes, Joana; Sintra, Tania E.; Ventura, Sonia P. M.; Coutinho, Joao A. P.; Freire, Mara G.; Mohamadou, Aminou. And the article was published in Fluid Phase Equilibria in 2019. Product Details of 2969-81-5 The author mentioned the following in the article:

A series of novel analogs of glycine-betaine ionic liquids (AGB-ILs), viz. 1-(4-ethoxy-4-oxobutyl)-1-methylpyrrolidin-1-ium, N,N,N-tri(n-butyl)(4-ethoxy-4-oxobutyl)-1-phosphonium and N,N,N-trialkyl(4-ethoxy-4-oxobutyl)-1-aminium cations with Et, Pr and Bu alkyl chains, combined with the bromide anion, have been synthesized and characterized. Their synthesis and characterization by spectroscopic methods and elemental anal. is here reported. These ILs were further characterized in what concerns their thermal properties and ecotoxicity against Allvibrio fischeri, and compared with the com. tetra(n-butyl)ammonium and tetra(n-butyl)phosphonium bromide. The novel AGB-ILs described in this work have low m.ps., below 100°C, display high degradation temperatures (180-310°C), and low toxicity as shown by being harmless or practically harmless towards the marine bacteria Allvibrio fischeri. Finally, the ability of the synthesized AGB-ILs to form aqueous biphasic systems with potassium citrate/citric acid (at pH 7) was evaluated, and the resp. ternary phase diagrams were determined It is shown that the increase of the cation alkyl chain length facilitates the creation of ABS, and that phosphonium-based ILs present a slightly better separation performance in presence of aqueous solutions of the citrate-based salt. In the experiment, the researchers used Ethyl 4-bromobutyrate(cas: 2969-81-5Product Details of 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Product Details of 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Alkynyl-functionalized chain-extended PCL for coupling to biological molecules》 was published in European Polymer Journal in 2020. These research results belong to Izraylit, Victor; Hommes-Schattmann, Paul J.; Neffe, Axel T.; Gould, Oliver E. C.; Lendlein, Andreas. Computed Properties of C8H15BrO2 The article mentions the following:

Chem. functionalization of poly(ε-caprolactone) (PCL) enables a mol. integration of addnl. function. Here, the authors report an approach to incorporate reactive alkynyl side-groups by synthesizing a chain-extended PCL, where the reactive site is introduced through the covalently functionalizable chain extender 3-(prop-2-yn-1-yloxy)propane-1,2-diol (YPD). Chain-extended PCL with Mw of 101 to 385 kg·mol-1 were successfully synthesized in a one-pot reaction from PCL-diols with various molar masses, L-lysine Et ester diisocyanate (LDI) or trimethyl(hexamethylene)diisocyanate (TMDI), and YPD, in which the d. of functionalizable groups and spacing between them can be controlled by the composition of the polymer. The employed diisocyanate compounds and YPD possess an asym. structure and form a non-crystallizable segment leaving the PCL crystallites to dominate the material′s mech. properties. The mixed glass transition temperature Tg = -60 to -46° of the PCL/polyurethane amorphous phase maintains the synthesized materials in a highly elastic state at ambient and physiol. conditions. Reaction conditions for covalent attachment in copper(I)-catalyzed azide-alkyne-cycloaddition reactions (CuAAC) in solution were optimized in a series of model reactions between the alkyne moieties of the chain-extended PCL and benzyl azide, reaching conversions over 95% of the alkyne moieties and with yields of up to 94% for the purified functionalized PCL. This methodol. was applied for reaction with the azide-functionalized cell adhesion peptide GRGDS. The required modification of the peptide provides selectivity in the coupling reactions. The obtained results suggest that YPD could potentially be employed as versatile mol. unit for the creation of a variety of functionalizable polyesters as well as polyurethanes and polycarbonates offering efficient and selective click-reactions. In the experiment, the researchers used 8-Bromooctanoic acid(cas: 17696-11-6Computed Properties of C8H15BrO2)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid.Computed Properties of C8H15BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Thiocyanation and 2-Amino-1,3-thiazole Formation in Water Using Recoverable and Reusable Glycosylated Resorcin[4]arene Cavitands》 was published in Journal of Organic Chemistry in 2020. These research results belong to Husain, Ali A.; Bisht, Kirpal S.. Safety of Ethyl 3-bromopropanoate The article mentions the following:

A family of three spatially directional resorcin[4]arene cavitand glycoconjugates (RCGs) have been applied as efficient recoverable and reusable inverse phase transfer catalysts for eco- and environmentally friendly thiocyanation and 2-amino-1,3-thiazole formation reactions in water. The results show that RCGs (1 mol %) were capable of hosting and catalyzing various water-insoluble bromo/thiocyanato substrates in water without the use of any co-organic solvents. The recoverability and reusability of RCG catalytic systems, i.e., RCG1 and RCG3, were also examined upon a simple extraction of the desired products using DCM or Et acetate, followed by subjecting the recovered aqueous solution containing the RCG catalysts to the next reaction cycles. The experimental process involved the reaction of Ethyl 3-bromopropanoate(cas: 539-74-2Safety of Ethyl 3-bromopropanoate)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Safety of Ethyl 3-bromopropanoate Organobromine compounds have fallen under increased scrutiny for their environmental impact.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Solid-Phase Synthesis of Sequence-Defined Informational Oligomers》 was published in Journal of Organic Chemistry in 2020. These research results belong to Strom, Kyle R.; Szostak, Jack W.. Name: 3,5-Dibromoaniline The article mentions the following:

Genetic biopolymers utilize defined sequences and monomer-specific mol. recognition to store and transfer information. Synthetic polymers that mimic these attributes using reversible covalent chem. for base-pairing pose unique synthetic challenges. Here, we describe a solid-phase synthesis methodol. for the efficient construction of ethynyl benzene oligomers with specific sequences of aniline and benzaldehyde subunits. Handling these oligomers is complicated by the fact that they often exhibit multiple conformations because of intra- or intermol. pairing. We describe conditions that allow the dynamic behavior of these oligomers to be controlled so that they may be manipulated and characterized without needing to mask the recognition units with protecting groups. The results came from multiple reactions, including the reaction of 3,5-Dibromoaniline(cas: 626-40-4Name: 3,5-Dibromoaniline)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Name: 3,5-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Structure-Activity Relationship of Antischistosomal Ozonide Carboxylic Acids》 was published in Journal of Medicinal Chemistry in 2020. These research results belong to Wu, Jianbo; Wang, Xiaofang; Chiu, Francis C. K.; Haberli, Cecile; Shackleford, David M.; Ryan, Eileen; Kamaraj, Sriraghavan; Bulbule, Vivek J.; Wallick, Alexander I.; Dong, Yuxiang; White, Karen L.; Davis, Paul H.; Charman, Susan A.; Keiser, Jennifer; Vennerstrom, Jonathan L.. Reference of Ethyl 5-bromovalerate The article mentions the following:

Semisynthetic artemisinins and other bioactive peroxides are best known for their powerful antimalarial activities, and they also show substantial activity against schistosomes-another Hb-degrading pathogen. Building on this discovery, we now describe the initial structure-activity relationship (SAR) of antischistosomal ozonide carboxylic acids OZ418 (2) and OZ165 (3). Irresp. of lipophilicity, these ozonide weak acids have relatively low aqueous solubilities and high protein binding values. Ozonides with para-substituted carboxymethoxy and N-benzylglycine substituents had high antischistosomal efficacies. It was possible to increase solubility, decrease protein binding, and maintain the high antischistosomal activity in mice infected with juvenile and adult Schistosoma mansoni by incorporating a weak base functional group in these compounds In some cases, adding polar functional groups and heteroatoms to the spiroadamantane substructure increased the solubility and metabolic stability, but in all cases decreased the antischistosomal activity. In the part of experimental materials, we found many familiar compounds, such as Ethyl 5-bromovalerate(cas: 14660-52-7Reference of Ethyl 5-bromovalerate)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Reference of Ethyl 5-bromovalerate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Molecular modeling insights in the extraction of benzene from hydrocarbon stream using deep eutectic solvent》 was published in Journal of Molecular Liquids in 2020. These research results belong to Kumar, Nikhil; Naik, Papu Kumar; Banerjee, Tamal. Application In Synthesis of Methyltriphenylphosphonium bromide The article mentions the following:

The present study aims to elucidate the mol. insights into the extraction of benzene from hydrocarbon mixture using a phosphonium based deep eutectic solvent (DES). The prepared DES consists of the hydrogen bond acceptor (HBA; methyltriphenylphosphonium bromide, MTPB) and hydrogen bond donor (HBD; ethylene glycol) at a molar ratio of 1:4. The at.-level classical mol. dynamic (MD) simulation technique is then employed to investigate the equilibrium phase behavior of the DES + benzene + hexane ternary system with respect to solvent rich and hydrocarbon-rich phases. To observe the effect of feed concentration, three different concentrations were considered from the reported exptl. runs, which gave high selectivity and distribution coefficient values. The non-bonded interaction energies of different species and the structural properties such as radial distribution functions, spatial distribution functions (SDFs), and the average number of hydrogen bonds are then computed. It is found that the cation within the HBA, namely, MTP, initiates interactions with benzene when compared to HBD or its anion (Br). MTP and ethylene glycol both are seen to contribute to the hydrogen bonding with benzene, which results in a higher exptl. solubility value. The calculations of SDFs further reveal the fact that the benzene mols. are evenly distributed around the active sites of the MTP mol., whereas hexane mols. are found to be distributed around the non-active sites of the DES. In order to validate the simulation procedure, the concentration in both the phases was compared with the existing LLE exptl. results. In the penultimate part, 2D 1H-13C Heteronuclear Multiple Bond Correlation (HMBC) NMR is performed for investigating and confirming the hydrogen bonding interactions among components of DES and benzene. The results came from multiple reactions, including the reaction of Methyltriphenylphosphonium bromide(cas: 1779-49-3Application In Synthesis of Methyltriphenylphosphonium bromide)

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is used for methylenation through the Wittig reaction. It is utilized in the synthesis of an enyne and 9-isopropenyl -phenanthrene by using sodium amide as reagent. Application In Synthesis of Methyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Cobalt-Salen-Based Porous Ionic Polymer: The Role of Valence on Cooperative Conversion of CO2 to Cyclic Carbonate》 was published in ACS Applied Materials & Interfaces in 2020. These research results belong to Li, Jing; Han, Yulan; Lin, Han; Wu, Nanhua; Li, Qinkun; Jiang, Jun; Zhu, Jiahua. Recommanded Product: 1,4-Bis(bromomethyl)benzene The article mentions the following:

Cobalt-salen-based porous ionic polymers, which are composed of cobalt and halogen anions decorated on the framework, effectively catalyze the CO2 cycloaddition reaction of epoxides to cyclic carbonates under ambient conditions. The cooperative effect of bifunctional active sites of cobalt as the Lewis acidic site and the halogen anion as the nucleophile responds to the high catalytic performance. Moreover, d. functional theory results indicate that the cobalt valence state and the corresponding coordination group influence the rate-determining step of the CO2 cycloaddition reaction and the nucleophilicity of halogen anions. In addition to this study using 1,4-Bis(bromomethyl)benzene, there are many other studies that have used 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Recommanded Product: 1,4-Bis(bromomethyl)benzene) was used in this study.

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. Recommanded Product: 1,4-Bis(bromomethyl)benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis and Spectroscopy of Emissive, Surface-Modified, Copper-Doped Indium Phosphide Nanocrystals》 was published in ACS Materials Letters in 2020. These research results belong to Mundy, M. Elizabeth; Eagle, Forrest W.; Hughes, Kira E.; Gamelin, Daniel R.; Cossairt, Brandi M.. Computed Properties of Br3In The article mentions the following:

Aminophosphine precursors were used to synthesize Cu-doped InP nanocrystals (NCs) via direct doping in a slow-injection bottom-up method and postsynthetic cation exchange. By both methods, the amount of Cu incorporated into the NCs could be tuned simply by varying the molar ratio during synthesis. Common postsynthetic surface modifications such as Lewis acid treatment and Zn chalcogenide shelling were performed on these samples, resulting in an enhancement of the Cu-based emission from 10% to 40%. For samples with thick shells, the Cu-based luminescence quantum yield reached over 60%, a record value for doped InP NCs. Time-resolved luminescence spectroscopy showed increasing carrier lifetimes after surface treatments concurrent with the disappearance of a 2 ns decay process previously attributed to surface trapping in native InP NCs, showing the broad applicability and consistent impacts of the surface treatments. In this way, a route to obtain high-quality near-IR emitters using less toxic alternatives to the popular Pb- and Cd-containing materials was developed. In the experiment, the researchers used Indium(III) bromide(cas: 13465-09-3Computed Properties of Br3In)

Indium(III) bromide(cas: 13465-09-3) is used in organic synthesis as a water tolerant Lewis acid. It efficiently catalyzes the three-component coupling of β-keto esters, aldehydes and urea (or thiourea) to afford the corresponding dihydropyrimidinones.Computed Properties of Br3In

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary