Month: November 2022

On July 31, 2018, Rafiq, Kiran; Saify, Zafar Saied; Nesar, Shagufta; Faiyaz, Ambreen; Muhammad, Iyad Naeem published an article.HPLC of Formula: 574-98-1 The title of the article was Some novel piperidine analogues having strong alpha glucosidase inhibition. And the article contained the following:

In the present work some hydroxy piperidine analogs have been synthesized and analyzed for their hypoglycemic effect through glucosidase inhibition owing to the structural resemblance with nojirimycin. The activity was done by spectral absorbance anal. using acarbose as standard Two analogs 1-(1”-phenoxypropyl)-4-phenyl-4-hydroxy piperidinium hydrobromide and 1-(1”-adamantan acyl)-4-(4′-bromophenyl)-4-hydroxy piperidinium hydrobromide were found to pose excellent activity having 87.4 and 54.7% inhibition resp., hence strengthening the idea of studying piperidine analogs as glucosidase inhibitors due to structural similarity with nojirimycin. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).HPLC of Formula: 574-98-1

The Article related to piperidine derivative preparation alpha glucosidase inhibitor, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.HPLC of Formula: 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On June 15, 2022, Wang, Tingting; Dong, Jianhao; Yu, Na; Tang, Weiqin; Jin, Yaping; Xu, Yixin; Yang, Jingshuai published an article.Safety of 4-(Bromomethyl)-1,1′-biphenyl The title of the article was Synthesis and properties of a new ether-free poly(bis-alkylpiperidinium) polymer for the anion exchange membrane. And the article contained the following:

Developing anion exchange membranes (AEMs) with high performance and excellent alk. stability is a huge challenge to the fuel cell. Herein, a new bispiperidinium compound is synthesized through a nucleophilic reaction between 4,4′-trimethylenebis (1-Me piperidine) and 4-bromomethylbiphenyl. Subsequently, a novel poly(bis-alkylpiperidinium) polymer (i.e. Tmmp-Bmb-TFAc) is synthesized through the Friedel-Crafts polycondensation of bispiperidinium monomer and 1,1,1-trifluoroacetone. The synthesized ether-free Tmmp-Bmb-TFAc contains two piperidinium cations per polymer repeat unit in the main chain, which thus is employed as the AEM. The obtained AEM exhibits high ionic exchange capacity of 2.25 mmol g-1, low volume swelling of 13.6% and moderate tensile strength of 12.3 MPa in Br- form simultaneously. Meanwhile, the Tmmp-Bmb-TFAc membrane achieves a high conductivity of 45.0 mS cm-1 at 80 °C and possesses an excellent alk. stability in 1 mol L-1 KOH at 60°C within 480 h. Furthermore, no degradation of the polymer backbone is detected by 1H NMR spectra when immersing the membrane in 1 mol L-1 KOH at 80°C. This work provides a gentle and facile approach on the design and preparation of ether-free AEMs with cations in the polymer main chain. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Safety of 4-(Bromomethyl)-1,1′-biphenyl

The Article related to bisalkylpiperidinium polymer preparation anion exchange membrane thermomech morphol property, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Safety of 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On July 21, 2022, Chehardoli, Gholamabbas; Gholamhoseini, Pooriya; Ebadi, Ahmad; Ziaei, Maral; Akbarzadeh, Tahmineh; Saeedi, Mina; Mahdavi, Mohammad; Khoshneviszadeh, Mehdi; Najafi, Zahra published an article.COA of Formula: C10H8BrNO2 The title of the article was 6-Methoxy-1-tetralone Derivatives Bearing an N-Arylpyridinium Moiety as Cholinesterase Inhibitors: Design, Synthesis, Biological Evaluation, and Molecular Docking Study. And the article contained the following:

A novel series of 6-methoxy-1-tetralone derivatives bearing N-aryl pyridinium moiety I (Ar = C6H5, 2-FC6H4, 3-ClC6H4, etc.; n = 1, 2, 3, 4, 5; X = Cl, Br) were designed, synthesized, and evaluated as acetyl and butyrylcholinesterase inhibitors. The designed derivatives inhibited acetylcholinesterase (AChE) with IC50 values of 0.025-23.743μM and butyrylcholinesterase (BChE) with IC50 values of 0.716-20.588μM. The synthesized compounds were divided into two series. Derivatives containing N-benzyl moieties generally were more potent anti-AChE and anti-BChE agents than compounds with N-alkylphthalimide groups. Among them, the compound I (Ar = C6H5; n = 1; X = Br) and compound I (Ar = 3-ClC6H4; n = 1; X = Br) exhibited significant inhibitory activity against AChE and BChE with IC50 values of 0.025 and 0.716μM in comparison to donepezil as a reference drug (0.029 and 0.948μM, resp.). The results of kinetic and mol. modeling studies demonstrated that the synthesized compounds I (Ar = C6H5; n = 1; X = Br) and I (Ar = 3-ClC6H4; n = 1; X = Br) derivatives can act as mixed and dual binding inhibitors, and bind to both CAS and PAS of AChE and BChE enzymes. Among the assessed compounds, the compound I (Ar = C6H5; n = 1; X = Br) indicated significant neuroprotection against H2O2-induced cell death in PC12 cells. So, these findings indicate the therapeutic potential of 6-methoxy-1-tetralone derivatives bearing N-aryl pyridinium moiety derivatives as anti-AD agents. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).COA of Formula: C10H8BrNO2

The Article related to methoxy tetralone aryl pyridinium preparation, mol docking adme inhibitor physicochem property, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.COA of Formula: C10H8BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On October 29, 2015, Takahashi, Taichi; Umino, Akinori; Iijima, Daisuke; Takamatsu, Hisayuki published a patent.Product Details of 1160653-94-0 The title of the patent was Novel 2-aminopyridine and 2-aminopyrimidine derivatives and medicinal use thereof. And the patent contained the following:

Provided are compounds that exhibit an excellent autotaxin (ATX) inhibitory effect, etc. and are efficacious as a prophylactic or therapeutic agent for diseases in which ATX participates. Compounds represented by general formula I [ring A = cycloalkyl, heterocyclyl, etc.; Z1-Z4 = C, N; R1 = halo, (halo)alkyl, (halo)alkoxy, aryl, etc.; R2, R3 = H, halo, (halo)alkyl, (halo)alkoxy, aryl; R4 = H, alkyl, halo; R5, R6 = H, OH, halo, etc., (linked via O, CO, etc.); L1 = bond, linear alkylene, cycloalkylene, etc] have an excellent ATX inhibitory effect and are useful as a prophylactic or therapeutic agent for ATX-associated diseases, e.g., tumor, obesity, and inflammation. The experimental process involved the reaction of 3-Bromo-2-fluoro-6-methoxybenzaldehyde(cas: 1160653-94-0).Product Details of 1160653-94-0

The Article related to aminopyridine aminopyrimidine preparation autotaxin inhibitor antitumor antiobesity antiinflammation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Product Details of 1160653-94-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On December 31, 1994, Ding, Ming-Wu; Shi, De-Qing; Xiao, Wen-Jing; Huang, Wen-Fang published an article.Computed Properties of 83152-22-1 The title of the article was Studies on the Wittig reaction. XV: A direct preparation of ω-unsaturated bromides via solid/liquid transfer Wittig reactions of ω-bromoalkyltriphenylphosphonium salts with aldehydes. And the article contained the following:

ω-Unsaturated bromides RCH:CH(CH2)n-1Br (n = 4, 6, 8, 10; R = Ph or substituted Ph, 2-furyl) were prepared by solid-liquid transfer Wittig reactions between ω-bromoalkyltriphenylphosphonium salts Ph3P+(CH2)nBr Br-and aldehydes RCHO. The experimental process involved the reaction of (6-Bromohexyl)triphenylphosphonium bromide(cas: 83152-22-1).Computed Properties of 83152-22-1

The Article related to alkenyl bromides aryl, arylalkenyl bromides, wittig aldehyde bromoalkyltriphenylphosphonium solid liquid, Aliphatic Compounds: Halides and Halonium Compounds and other aspects.Computed Properties of 83152-22-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On December 29, 2021, Kang, Kai; Loud, Nathan L.; DiBenedetto, Tarah A.; Weix, Daniel J. published an article.SDS of cas: 574-98-1 The title of the article was A General, Multimetallic Cross-Ullmann Biheteroaryl Synthesis from Heteroaryl Halides and Heteroaryl Triflates. And the article contained the following:

A new, general approach to biheteroaryls: the Ni- and Pd-catalyzed multimetallic cross-Ullmann coupling of heteroaryl halides with triflates. An array of 5-membered, 6-membered and fused heteroaryl bromides and chlorides, as well as aryl triflates derived from heterocyclic phenols proved to be viable substrates in this reaction (62 examples, 63 ± 17% average yield). The generality of this approach to biheteroaryls were further demonstrated in 96-well plate format at 10μmol scale. An array of 96 possible products provided >90% hit rate under a single set of conditions. Further, low-yielding combinations was rapidly optimized with a single “Toolbox Plate” of ligands, additives and reductants. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).SDS of cas: 574-98-1

The Article related to pyridyl trifluoromethanesulfonate heteroaryl halide nickel palladium catalyst ullmann coupling, heteroaryl pyridine preparation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.SDS of cas: 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On May 19, 2022, Grollier, Kevin; Ghiazza, Clement; Tlili, Anis; Billard, Thierry; Medebielle, Maurice; Vantourout, Julien C. published an article.Computed Properties of 2567-29-5 The title of the article was Electrochemical Trifluoromethylselenolation of Activated Alkyl Halides. And the article contained the following:

A practical electrochem. method for the generation of CF3Se- anion from a shelf-stable reagent (TsSeCF3) is reported allowing the metal-free trifluoromethylselenolation of activated alkyl halides RCH2X (X = Br, Cl; R = 4-F-Ph, pyridin-2-yl, 5-nitrofuran-2-yl, undecyl, etc.). Trifluoromethylselenolated compounds RCH2SeCF3 have been obtained in modest to excellent yields under the optimized reaction conditions. Finally, cyclic voltammetric and 19F NMR studies are presented and allowed to gain insight into the reaction mechanism. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Computed Properties of 2567-29-5

The Article related to trifluoromethylselenolate preparation electrochem, trifluoromethyltolueneselenosulfonate alkyl halide trifluoromethylselenolation, Aliphatic Compounds: (This Subsection Discontinued) and other aspects.Computed Properties of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On November 29, 2001, Astles, Peter C.; Eastwood, Paul R.; Houille, Olivier; Levell, Julian; Pauls, Heinz; Czekaj, Mark; Liang, Guyan; Gong, Yong; Pribish, James; Neuenschwander, Kent published a patent.Name: 2-Bromo-4-(bromomethyl)-1-methylbenzene The title of the patent was Preparation of (hetero)arylacyl-piperidinyl-benzylamines for use as tryptase inhibitors. And the patent contained the following:

Title compounds I [Ar = (hetero)aryl, where the two groups on the Ar ring are β to each other; R1-2 = H, alkyl; R3 = (un)substituted(hetero)aryl, arylalkenyl, cycloalkenyl, cycloalkyl, etc.; R4 = H, acyl, alkoxy, alkyloxycarbonyl, carboxy, CN, halo, etc.; n = 0 – 4] were prepared Over 300 synthetic examples were disclosed. For instance, 3-bromobenzylbromide was converted in two steps to boronate II. II was coupled to the triflate ester derivative of the enol of 4-oxo-N-benzyloxycarbonylpiperidine (DMF, K2CO3, PdCl2(dppf)•CH2Cl2, 80°C, 18 h) to give the corresponding bicyclic intermediate. This intermediate was deprotected and reduced to the piperidine (EtOH, 10% Pd-C/H2, room temperature, 5 h) and coupled to 5-phenethylthiophene-2-carboxylic acid (DMF, HAPyU, iPr2NEt, room temperature, 18 h) to give III. III had Ki = 50 nM for tryptase. I are useful in the treatment of e.g., asthma and inflammatory diseases. The experimental process involved the reaction of 2-Bromo-4-(bromomethyl)-1-methylbenzene(cas: 259231-26-0).Name: 2-Bromo-4-(bromomethyl)-1-methylbenzene

The Article related to piperidinylbenzylamine tryptase inhibitor preparation, pyridine quinoline thiophene furan indole piperidine tryptase inhibitor preparation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Name: 2-Bromo-4-(bromomethyl)-1-methylbenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On July 17, 2014, Li, Yun-Long; Burns, David M.; Feng, Hao; Xue, Chu-Biao; Wang, Anlai; Pan, Jun published a patent.HPLC of Formula: 1196157-51-3 The title of the patent was Preparation of bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors for treating proliferative and immune disorders. And the patent contained the following:

The present disclosure describes bicyclic aromatic carboxamide derivatives of formula I (wherein Cy is (un)substituted C3-7 cycloalkyl or (un)substituted 4-10 membered heterocycloalkyl; A1 is N or (un)substituted CH; R2 is H, halogen, C1-6 alkyl, etc.; or A1 and R2 together form part of a ring; R3 is H, halogen or NH2; R4 is H or halogen; and A5-A8 are independently N or (un)substituted CH, with provisos), as well as their compositions and methods of use as Pim kinase inhibitors for treating cancer and other diseases. Synthetic procedures for preparing I are exemplified. Example compound II was prepared in a 6-step synthesis that involved reaction of intermediate III with benzyl [(3S)-1-(3-aminopyridin-4-yl)piperidin-3-yl]carbamate followed by deprotection of the intermediate formed to give II. In Pim kinase inhibitory assays in vitro, II had IC50 values of ≤100 nM for Pim1 and Pim3 and an IC50 value between 100 nM and 1000 nM for Pim2 kinase. The experimental process involved the reaction of 2-Amino-6-bromonicotinic acid(cas: 1196157-51-3).HPLC of Formula: 1196157-51-3

The Article related to preparation bicyclic aromatic carboxamide compound pim kinase inhibitor therapy, proliferative immune disorder treatment bicyclic aromatic carboxamide compound, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.HPLC of Formula: 1196157-51-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On November 1, 2008, Ju-Nam, Yon; Allen, David W.; Gardiner, Philip H. E.; Bricklebank, Neil published an article.Electric Literature of 83152-22-1 The title of the article was ω-Thioacetylalkylphosphonium salts: Precursors for the preparation of phosphonium-functionalised gold nanoparticles. And the article contained the following:

Two new ω-thioacetylalkylphosphonium salts that function as masked cationic alkanethiolate ligands for the stabilization of gold nanoparticles were prepared Both (3-thioacetylpropyl)triphenylphosphonium bromide and (6-thioacetylhexyl)triphenylphosphonium bromide form water-soluble gold nanoparticles of ∼5-10 nm in size that are stable for up to six months. The related (3-thioacetylpropyl)diphenylphosphine oxide was also prepared but did not act as a stabilizing ligand in gold nanoparticle formation. The experimental process involved the reaction of (6-Bromohexyl)triphenylphosphonium bromide(cas: 83152-22-1).Electric Literature of 83152-22-1

The Article related to phosphonium functionalized gold nanoparticle, Surface Chemistry and Colloids: Solid-Liquid Systems and other aspects.Electric Literature of 83152-22-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary