Month: November 2022

On September 30, 2022, Takao, Go; Hakozaki, Tomohiro; Miura, Keisuke; Urushibara, Yusuke; Fuchibe, Kohei; Ichikawa, Junji published an article.Electric Literature of 2567-29-5 The title of the article was Construction of Substituted [4]Acene Frameworks Based on Double Cationic Cyclizations of Fluoroalkenes. And the article contained the following:

5-Substituted and 5,6-disubstituted [4]acenes were synthesized by the double cationic cyclization of fluoroalkenes. (a) After being treated with Me2AlCl (1.2 equiv), 2-trifluoromethyl-1-alkenes bearing two aryl groups underwent domino Friedel-Crafts-type cyclization (two-ring construction) followed by dehydrogenation to generate 5-fluorinated [4]acenes. The same (trifluoromethyl)alkenes were treated with both Me2AlCl (1.2 equiv) and Me3Al (1.0 equiv), resulting in selective one-ring construction and the creation of bicyclic 1,1-difluoro-1-alkenes. (b) When treated with triflic acid, the bicyclic difluoroalkenes underwent regioselective protonation to generate CF2 cations; Friedel-Crafts-type cyclization of these cations provided tetracyclic ketones. The obtained ketones act as an appropriate platform for the introduction of substituents at the 5-position of [4]acenes. (c) When treated with DDQ/H+, the bicyclic difluoroalkenes underwent oxidative generation of allylic CF2 cations; Friedel-Crafts-type cyclization of these cations produced tetracyclic enones. The enones were subjected to double addition of carbanions to facilitate the introduction of two substituents at the 5- and 6-positions of dihydro[4]acenes. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Electric Literature of 2567-29-5

The Article related to trifluoromethyl alkene regioselective friedel crafts cyclization, polyacene preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Other Tricyclic and Multicyclic Six-Membered Ring Systems, Including Trypticenes and Helicenes and other aspects.Electric Literature of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On July 31, 2022, Xu, Ying; Chen, Peng; Tang, Lei; Zhang, Xiaojun; Shi, Feng; Ning, Xuyang; Bi, Jingli; Qu, Yang; Liu, Hongfei published an article.Electric Literature of 574-98-1 The title of the article was Hypoxia responsive and tumor-targeted mixed micelles for enhanced cancer therapy and real-time imaging. And the article contained the following:

Most chemotherapy agents have serious side effects due to lack of tumor targeting, which affects their clin. application. In addition, as an essential characteristic of malignant tumor, hypoxia is attracting exclusive research focus regarding its non-invasive real-time tracing in novel targeting delivery system. Herein, we designed a mixed micelle with tumor targeting and hypoxia responsiveness for tumor therapy and imaging. In particular, the dual-modified mix micelles were self-assembled by folic acid (FA) and 2-(2-nitroimidazole) ethylamine (NI) conjugated polymers, in which paclitaxel (PTX) and quantum dots (QDs) were co-loaded into the hydrophobic core. The drug loaded micelles showed satisfactory drug encapsulation, good storage stability, and sustained release properties. In vitro cell experiments showed that the mixed micelles exhibited enhanced cytotoxic effect and improved the cellular uptake, especially under hypoxic conditions, which was due to the FA mediated active targeting effect and NI induced hypoxic responsive release. In vivo experiments further proved that the mixed micelles possessed outstanding tumor targeting and hypoxia responsive properties. Furthermore, the drug loaded micelles showed excellent anti-tumor effect and can realize real-time in vivo imaging. This work demonstrates that the dual-modified mixed micelles co-loading with PTX and QDs might provide a novel approach for tumor therapy and imaging. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Electric Literature of 574-98-1

The Article related to folic acid nitroimidazoleethylamine polymer hypoxia tumor targeted micelle antitumor, hypoxia responsiveness, paclitaxel, quantum dots, real-time imaging, targeted deliver and other aspects.Electric Literature of 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On July 26, 2021, Ravula, Thirupathi; Ramamoorthy, Ayyalusamy published an article.Application In Synthesis of 4-(Bromomethyl)-1,1′-biphenyl The title of the article was Synthesis, Characterization, and Nanodisc Formation of Non-ionic Polymers. And the article contained the following:

Although lipid nanodiscs are increasingly used in the structural studies of membrane proteins, drug delivery and other applications, the interaction between the nanodisc belt and the protein to be reconstituted is a major limitation. To overcome this limitation and to further broaden the scope of nanodiscs, a family of non-ionic amphiphilic polymers synthesized by hydrophobic functionalization of fructo-oligosaccharides/inulin is reported. We show the stability of lipid nanodiscs formed by these polymers against pH and divalent metal ions, and their magnetic-alignment properties. The reported results also demonstrate that the non-ionic polymers extract membrane proteins with unprecedented efficiency. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Application In Synthesis of 4-(Bromomethyl)-1,1′-biphenyl

The Article related to nanodisc nonionic functionalization fructo oligosaccharide inulin nanodisc, membrane protein inulin functionalized, lipids, nanodiscs, non-ionic polymers, oligosaccharides and other aspects.Application In Synthesis of 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fonseca-Berzal, Cristina; Ibanez-Escribano, Alexandra; Vela, Nerea; Cumella, Jose; Nogal-Ruiz, Juan Jose; Escario, Jose Antonio; Bernardino da Silva, Patricia; Batista, Marcos Meuser; Soeiro, Maria de Nazare C.; Sifontes-Rodriguez, Sergio; Meneses-Marcel, Alfredo; Gomez-Barrio, Alicia; Aran, Vicente J. published an article in 2018, the title of the article was Antichagasic, Leishmanicidal, and Trichomonacidal Activity of 2-Benzyl-5-nitroindazole-Derived Amines.Recommanded Product: 574-98-1 And the article contains the following content:

Three different series of new 5-nitroindazole derivatives-1-(ω-aminoalkyl)-2-benzylindazolin-3-ones (series A; ten compounds), 3-(ω-aminoalkoxy)-2-benzylindazoles (series B; four compounds) and 3-alkylamino-2-benzylindazoles (series C; five compounds)-have been synthesized and evaluated against the protozoan parasites Trypanosoma cruzi, Leishmania amazonensis, and Trichomonas vaginalis: etiol. agents of Chagas disease, cutaneous leishmaniasis, and trichomoniasis, resp. Many indazoles of series A, B, and C were efficient against T. cruzi. Some compounds in series A, after successfully passing the preliminary screening for epimastigotes, exhibited activity values against amastigotes of several T. cruzi strains that were better than or similar to those shown by the reference drug benznidazole and displayed low nonspecific toxicity against mammalian cells. On the other hand, preliminary studies against promastigotes of L. amazonensis showed high leishmanicidal activity for some derivatives of series A and C. With regard to activity against T. vaginalis, some indazoles of series B and C were rather efficient against trophozoites of a metronidazole-sensitive isolate and showed low nonspecific toxicities toward Vero cell cultures. Addnl., some of these compounds displayed similar activity against metronidazole-sensitive and resistant isolates, showing the absence of cross-resistance between these derivatives and the reference drug. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Recommanded Product: 574-98-1

The Article related to benzyl nitroindazole amine antichagasic leishmanicidal trichomonacidal activity, antiprotozoal agents, leishmaniasis, nitrogen heterocycles, trichomoniasis, trypanosomiasis and other aspects.Recommanded Product: 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On April 1, 2021, Ibanez-Escribano, Alexandra; Reviriego, Felipe; Vela, Nerea; Fonseca-Berzal, Cristina; Nogal-Ruiz, Juan Jose; Aran, Vicente J.; Escario, Jose Antonio; Gomez-Barrio, Alicia published an article.Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione The title of the article was Promising hit compounds against resistant trichomoniasis: Synthesis and antiparasitic activity of 3-(ω-aminoalkoxy)-1-benzyl-5-nitroindazoles. And the article contained the following:

A series of 11 3-(ω-aminoalkoxy)-1-benzyl-5-nitroindazoles has been prepared starting from 1-benzyl-5-nitroindazol-3-ol, and evaluated against sensitive and resistant isolates of the sexually transmitted protozoan Trichomonas vaginalis. A variety of nitroindazoles demonstrate trichomonacidal profiles with IC50 < 20μM against the metronidazole-sensitive isolate. Moreover, all these compounds submitted to cytotoxicity assays against mammalian cells exhibited low non-specific cytotoxic effects, except two compounds I and II which displayed moderate cytotoxicity (CC50 = 74.7 and 59.1μM, resp.). Those compounds with trichomonacidal effect were also evaluated against a metronidazole-resistant culture. Special mention deserve compounds III and IV, which displayed better IC50 values (1.3 and 0.5μM resp.) than that of the reference drug (IC50 MTZ = 3.0μM). The high activity of these compounds against the resistant isolate reinforces the absence of cross-resistance with the reference drug. The remarkable trichomonacidal results against resistant T. vaginalis isolates suggest the interest of 3-(ω-aminoalkoxy)-1-benzyl-5-nitroindazoles to be considered as good prototypes to continue in the development of new drugs with enhanced trichomonacidal activity, aiming to increase the non-existent drugs to face clin. resistance efficiently for those patients in whom therapy with 5-nitroimidazoles is contraindicated. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione

The Article related to aminoalkoxy benzyl nitroindazole preparation antiparasitic resistant trichomoniasis, antiprotozoal agents, indazole, nitrogen heterocycles, resistance, trichomonas vaginalis and other aspects.Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Halik, Pawel K.; Lipinski, Piotr F. J.; Matalinska, Joanna; Kozminski, Przemyslaw; Misicka, Aleksandra; Gniazdowska, Ewa published an article in 2020, the title of the article was Radiochemical synthesis and evaluation of novel radioconjugates of neurokinin 1 receptor antagonist aprepitant dedicated for NK1R-positive tumors.Recommanded Product: 574-98-1 And the article contains the following content:

Aprepitant, a lipophilic and small mol. representative of neurokinin 1 receptor antagonists, is known for its anti-proliferative activity on numerous cancer cell lines that are sensitive to Substance P mitogen action. In the presented research, we developed two novel structural modifications of aprepitant to create aprepitant conjugates with different radionuclide chelators. All of them were radiolabeled with 68Ga and 177Lu radionuclides and evaluated in terms of their lipophilicity and stability in human serum. Furthermore, fully stable conjugates were examined in mol. modeling with a human neurokinin 1 receptor structure and in a competitive radioligand binding assay using rat brain homogenates in comparison to the aprepitant mol. This initial research is in the conceptual stage to give potential theranostic-like radiopharmaceutical pairs for the imaging and therapy of neurokinin 1 receptor-overexpressing cancers. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Recommanded Product: 574-98-1

The Article related to aprepitant radiopharmaceutical neurokinin receptor antagonist radionuclide chelator, aprepitant, neurokinin 1 receptor antagonist, radionuclide chelators, radiopharmaceuticals and other aspects.Recommanded Product: 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On March 15, 2022, Grant, Thomas M.; Rennison, David; Cervin, Gunnar; Pavia, Henrik; Hellio, Claire; Foulon, Valentin; Brimble, Margaret A.; Cahill, Patrick; Svenson, Johan published an article.Quality Control of 4-(Bromomethyl)-1,1′-biphenyl The title of the article was Towards eco-friendly marine antifouling biocides – Nature inspired tetrasubstituted 2,5-diketopiperazines. And the article contained the following:

Marine biofouling plagues all maritime industries at vast economic and environmental cost. Previous and most current methods to control biofouling have employed highly persistent toxins and heavy metals, including tin, copper, and zinc. These toxic methods are resulting in unacceptable environmental harm and are coming under immense regulatory pressure. Eco-friendly alternatives are urgently required to effectively mitigate the neg. consequence of biofouling without causing collateral harm. Amphiphilic micropeptides have recently been shown to exhibit excellent broad-spectrum antifouling activity, with a non-toxic mode of action and innate biodegradability. The present work focused on incorporating the pharmacophore derived from amphiphilic micropeptides into a 2,5-diketopiperazine (DKP) scaffold. This privileged structure is present in a vast number of natural products, including marine natural product antifoulants, and provides advantages of synthetic accessibility and adaptability. A novel route to sym. tetrasubstituted DKPs was developed and a library of amphiphilic 2,5-DKPs were subsequently synthesized. These biodegradable compounds were demonstrated to be potent marine antifoulants displaying broad-spectrum activity in the low micromolar range against a range of common marine fouling organisms. The outcome of planned coating and field trials will dictate the future development of the lead compounds The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Quality Control of 4-(Bromomethyl)-1,1′-biphenyl

The Article related to ciona undaria diketopiperazine marine antifouling biocides pharmacophore amphiphilic micropeptides, antifouling, broad-spectrum, diketopiperazine, marine, non-toxic, synthesis and other aspects.Quality Control of 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yang, Wu; Li, Yingzi; Zhu, Jiefeng; Liu, Wentan; Ke, Jie; He, Chuan published an article in 2020, the title of the article was Lewis acid-assisted Ir(III) reductive elimination enables construction of seven-membered-ring sulfoxides.COA of Formula: C13H11Br And the article contains the following content:

Iridium has played an important role in the evolution of C-H activation chem. over the last half century owing to its high reactivity towards stoichiometric C-H bond cleavage; however, the use of Ir(III) complexes in catalytic C-H functionalization/C-C bond formation appears to have fallen off significantly. The main problem lies in the reductive elimination step, as iridium has a tendency to form stable and catalytically inactive Ir(III) species. Herein, with a rationally designed Lewis acid assisted oxidatively induced strategy, the sluggish Ir(III) reductive elimination is successfully facilitated, enabling the facile C-C bond formation. The X-ray crystal structure of a silver salt adduct of iridacycle and DFT calculations demonstrate that the sulfoxide group acts as a key bridge connecting the Ir(III) metal center with the silver Lewis acid, which facilitates the reductive elimination of the Ir(III) metallacycle. Further identification of oxidants was carried out by performing stoichiometric reactions, which enables the development of catalytic construction of various highly functionalized seven-membered-ring sulfoxides e.g., 5,7-dihydrodibenzo[c,e]thiepine 6-oxide, that are of great interest in medicinal chem. and materials science. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).COA of Formula: C13H11Br

The Article related to dihydrodibenzothiepine oxide preparation chemoselective regioselective density functional theory, aralkyl sulfoxide oxidative reductive elimination lewis acid iridium catalyst and other aspects.COA of Formula: C13H11Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On September 2, 2005, Chow, Hak-Fun; Low, Kam-Hung; Wong, King Y. published an article.Safety of 2-Bromo-4-(bromomethyl)-1-methylbenzene The title of the article was An improved method for the regiospecific synthesis of polysubstituted [2.2]paracyclophanes. And the article contained the following:

4,16-Disubstituted, 4,7,12,15-tetrasubstituted, 4,8,12,16-tetrasubstituted and 4,5,7,8,12,13,15,16-octasubstituted [2.2]paracyclophanes can be prepared in significantly improved yields and excellent regiospecificities via the Winberg 1,6-elimination-dimerization reaction from substituted (4-methylbenzyl)trimethylammonium hydroxides. Using 2-chlorophenothiazine instead of phenothiazine as a polymerization inhibitor results in a doubling of product yields. The crystal structures of two of the products are available online. The experimental process involved the reaction of 2-Bromo-4-(bromomethyl)-1-methylbenzene(cas: 259231-26-0).Safety of 2-Bromo-4-(bromomethyl)-1-methylbenzene

The Article related to paracyclophane preparation crystal structure, bromoparacyclophane preparation crystal structure, methylbenzylmethylammonium hydroxide preparation winberg elimination dimerization and other aspects.Safety of 2-Bromo-4-(bromomethyl)-1-methylbenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On November 11, 2021, Yan, Si-Shun; Liu, Shi-Han; Chen, Lin; Bo, Zhi-Yu; Jing, Ke; Gao, Tian-Yu; Yu, Bo; Lan, Yu; Luo, Shu-Ping; Yu, Da-Gang published an article.Category: bromides-buliding-blocks The title of the article was Visible-light photoredox-catalyzed selective carboxylation of C(sp3)-F bonds with CO2. And the article contained the following:

A novel selective carboxylation of C(sp3)-F bonds with CO2 via visible-light photoredox catalysis. A variety of mono-, di-, and trifluoroalkylarenes as well as α,α-difluorocarboxylic esters and amides undergo such reactions to give important aryl acetic acids and α-fluorocarboxylic acids, including several drugs and analogs, under mild conditions. Notably, mechanistic studies and DFT calculations demonstrate the dual role of CO2 as an electron carrier and electrophile during this transformation. The fluorinated substrates would undergo single-electron reduction by electron-rich CO2 radical anions, which were generated in situ from CO2 via sequential hydride-transfer reduction and hydrogen-atom-transfer processes. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Category: bromides-buliding-blocks

The Article related to fluoroalkylarene 4czipn photocatalyst carboxylation, aryl acetic acid preparation, fluorocarboxylic ester 3dpafipn photocatalyst carboxylation, fluoro carboxylic acid preparation and other aspects.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary