Month: November 2022

Zhou, Han-Qi; Gu, Xing-Wei; Zhou, Xiao-Hua; Li, Li; Ye, Fei; Yin, Guan-Wu; Xu, Zheng; Xu, Li-Wen published an article in 2021, the title of the article was Enantioselective palladium-catalyzed C(sp2)-C(sp2) σ bond activation of cyclopropenones by merging desymmetrization and (3+2) spiroannulation with cyclic 1,3-diketones.Application of 2567-29-5 And the article contains the following content:

Herein, an unprecedented palladium-catalyzed (3+2) spiro-annulation merging C(sp2)-C(sp2) σ bond activation and click desymmetrization to form synthetically versatile and value-added oxaspiro products I [R1 = Me, Et; R2 = n-Pr, but-2-yn-1-yl, naphthalen-2-ylmethyl, thiophen-2-ylmethyl, etc.; R3 = n-Pr, Ph, 4-fluorophenyl, 3-methylphenyl, etc.; R4 = i-Pr, n-Pr, Ph, 4-fluorophenyl, etc.] have been presented. The operationally straightforward and enantioselective palladium-catalyzed atom-economic annulation process exploits a TADDOL-derived bulky P-ligand bearing a large cavity to control enantioselective spiro-annulation that converts cyclopropenones II and cyclic 1,3-diketones III, 2′,3′-dihydrospiro[cyclopentane-1,1′-inden]-3-ene-2,5-dione and 5-((tert-butyldimethylsilyl)oxy)naphthalene-1,4-dione into chiral oxaspiro cyclopentenone-lactone scaffolds I with good diastereo- and enantio-selectivity. The click-like reaction is a successful methodol. with a facile construction of two vicinal carbon quaternary stereocenters and can be used to deliver addnl. stereocenters during late-state functionalization for the synthesis of highly functionalized or more complex mols. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Application of 2567-29-5

The Article related to oxaspiro cyclopentenone lactone preparation regioselective diastereoselective enantioselective, cyclopropenone cyclic diketone bond activation desymmetrization spiroannulation palladium catalyst and other aspects.Application of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On November 5, 2021, Tak, Raj K.; Noda, Hidetoshi; Shibasaki, Masakatsu published an article.Category: bromides-buliding-blocks The title of the article was Ligand-enabled, copper-catalyzed electrophilic amination for the asymmetric synthesis of β-amino acids. And the article contained the following:

Catalytic asym. nitrene transfer has emerged as a reliable method for the synthesis of nitrogen-containing chiral compounds Herein, we report the copper-catalyzed intramol. asym. electrophilic amination of aromatic rings. The reactive intermediate is a copper-alkyl nitrene generated from isoxazolidin-5-ones. Copper catalysis promotes three classes of asym. transformations, namely, asym. desymmetrization, parallel kinetic resolution, and kinetic resolution, expanding the repertoire of alkyl nitrene transfer and providing various cyclic and linear β-amino acids in their enantioenriched forms. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Category: bromides-buliding-blocks

The Article related to amino acid beta cyclic linear enantioselective synthesis solvent effect, electrophilic amination copper catalyst isoxazolidinone nitrene, asym desymmetrization kinetic resolution nitrene transfer and other aspects.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sisto, Francesca; Carradori, Simone; Guglielmi, Paolo; Spano, Mattia; Secci, Daniela; Granese, Arianna; Sobolev, Anatoly P.; Grande, Rossella; Campestre, Cristina; Marcantonio, Maria Carmela Di; Mincione, Gabriella published an article in 2021, the title of the article was Synthesis and evaluation of thymol-based synthetic derivatives as dual-action inhibitors against different strains of H. pylori and AGS cell line.Related Products of 2567-29-5 And the article contains the following content:

Herein, the synthesis of a new series of thymol-based ethers I [R = Me, H2C:CH, CN, EtO2C, Ph, 2-BrC6H4, etc.] and their microbiol. screening against eight strains of H. pylori and the cytotoxic activity against human gastric adenocarcinoma (AGS) cells are reported. Structural anal. comprehended elemental anal. and 1H/13C/19F NMR spectra. The anal. of structure-activity relationships within this mol. library of these structurally-related compounds showed that some chem. modifications of the OH group of thymol led to broad-spectrum growth inhibition on all isolates. Preferred substitutions were benzyl groups compared to alkyl chains and the specific presence of functional groups at para position of the benzyl moiety such as 4-CN and 4-Ph endowed the most anti-H. pylori activity toward all the strains with min. inhibitory concentration (MIC) values up to 4μg/mL. Poly-substitution on the benzyl ring was not essential. Moreover, several compounds characterized by the lowest min. inhibitory concentration/min. bactericidal concentration (MIC/MBC) values against H. pylori were also tested in order to verify a cytotoxic effect against AGS cells with respect to 5-fluorouracil and carvacrol. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Related Products of 2567-29-5

The Article related to thymol ether preparation helicobacter pylori antibacterial gastric adenocarcinoma, ags cells, helicobacter pylori, drug resistance, dual-action agents, antimicrobial activity, semi-synthesis, thymol and other aspects.Related Products of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kwon, Ye-Mi; Kim, Sou Hyun; Jung, Young-Suk; Kwak, Jae-Hwan published an article in 2021, the title of the article was Synthesis and Biological Evaluation of (S)-2-(Substituted arylmethyl)-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-3-carboxamide Analogs and Their Synergistic Effect against PTEN-Deficient MDA-MB-468 Cells.Reference of 4-(Bromomethyl)-1,1′-biphenyl And the article contains the following content:

A series of twenty-six compounds of furfuryl or benzyl tetrahydropyrazino[1,2-a]indole analogs were synthesized and evaluated for cytotoxic activity against the estrogen receptor (ER)-pos. breast cancer cell line (MCF-7) and the epidermal growth factor receptor (EGFR) over-expressed triple-neg. breast cancer cell line (MDA-MB-468). Among them, compounds 2b, 2f and 2i showed more potent activity and selectivity against MDA-MB-468 cells than gefitinib, as an EGFR- tyrosine kinase inhibitor. In addition, it was confirmed by means of isobologram anal. of combinational treatment with gefitinib that they have a synergistic effect, especially compounds 2b and 2f, which inhibit Akt T308 phosphorylation. Moreover, it was confirmed that 2-benzyl-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-3-carboxamide analogs (2b, 2f, and Ref 2) tend to selectively inhibit PI3Kβ, which is involved in the phosphorylation of Akt. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Reference of 4-(Bromomethyl)-1,1′-biphenyl

The Article related to arylmethyl tetrahydropyrazinoindole carboxamide analog synergistic effect pten cancer cell, egfr-tki resistance, pten-deficient cancer cells, anti-tnbc, pyrazinoindolone scaffold, synergistic effects and other aspects.Reference of 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On May 1, 2020, Varano, Flavia; Catarzi, Daniela; Vincenzi, Fabrizio; Pasquini, Silvia; Pelletier, Julie; Lopes Rangel Fietto, Juliana; Espindola Gelsleichter, Nicolly; Sarlandie, Marine; Guilbaud, Audrey; Sevigny, Jean; Varani, Katia; Colotta, Vittoria published an article.Recommanded Product: 574-98-1 The title of the article was Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A2A receptor as potential antitumor agents. And the article contained the following:

Adenosine pathway, including its generating enzyme (CD73) and its receptors represents a key target for cancer immunotherapy. Here we aimed to search for novel compounds able to co-target the CD73 and the A2A adenosine receptor (A2A AR) as dual-blockers of adenosine generation and activity. The design project was to combine in the same mol. the thiazolo[5,4-d]pyrimidine core, an essential pharmacophoric feature to block the A2A AR, with a benzenesulfonamide group which is a characteristic group of CD73 inhibitors. Most of the reported compounds resulted in inverse agonists of the human (h) A2A AR endowed with high affinity, selectivity and potency. However they were weak inhibitors of CD73 enzyme. Nevertheless, this study can be considered as a starting point to develop more active compounds The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Recommanded Product: 574-98-1

The Article related to cancer immunotherapy a2aar inverse agonists cd37 inhibitor antitumor agents, adenosine a(2a) receptor inverse agonists, antitumor agents, cd73 inhibitors, cancer immunotherapy, thiazolo[5,4-d]pyrimidine and other aspects.Recommanded Product: 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shu, Chenglin; Liu, Caiping; Wu, Mingyan; Chen, Cheng; Hong, Maochun published an article in 2021, the title of the article was Simultaneous fluorescence and phosphorescence in Zn(II)-zwitterionic coordination polymers with tunable colors.SDS of cas: 2567-29-5 And the article contains the following content:

Three similar ionic-type ligands which can provide ligand-centered charge transfer (LCCT) have been employed to synthesize three isostructural complexes, resp. Due to the coordination of the ligands to the metal centers, all of the above mentioned complexes feature fluorescence and phosphorescence properties simultaneously. The mechanism of the luminous process is ligand-centered charge transfer (LCCT) combined with metal-to-ligand charge transfer (MLCT) processes. More interestingly, one compound manifests tunable colors from yellow to blue emissions involving white emission by varying the temperature and/or excitation wavelength directly. Exptl. and computational results indicate that the differences in luminous properties originate from the ligand distortion combined with different electron states. Thus, this study provides a facile method to synthesize new single-component tunable-color luminescent coordination polymers with simultaneous fluorescence and phosphorescence. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).SDS of cas: 2567-29-5

The Article related to bipyridylmethyl azidobipyridylmethyl carboxylatobipyridylmethyl pyridyldicarboxylate zinc coordination polymer preparation structure, fluorescence phosphorescence zinc zwitterionic polymer tunable color and other aspects.SDS of cas: 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Grollier, Kevin; Taponard, Alexis; De Zordo-Banliat, Arnaud; Magnier, Emmanuel; Billard, Thierry published an article in 2020, the title of the article was Metal-free nucleophilic trifluoromethylselenolation via an iodide-mediated umpolung reactivity of trifluoromethylselenotoluenesulfonate.Related Products of 2567-29-5 And the article contains the following content:

Herein, a practical method to generate CF3Se- (and RFSe-) anions from shelf-stable reagents under iodide activation was reported. Metal-free nucleophilic trifluoromethylselenolations have been then performed with this in situ-generated anion. Perfluoroalkylselenolations have also been described. The umpolung reactivity of trifluoromethylselenotoluenesulfonates 4-CH3C6H4S(O)2SeR (R = trifluoromethyl, 1,1,2,2,2-pentafluoroethyl, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluorohexyl) can be performed under reductive or oxidative conditions with alkyl halides R1X (R1 = dodecyl, Bn, (5-nitrofuran-2-yl)methyl, etc.; X = Br, Cl) to give desired products R1SeR. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Related Products of 2567-29-5

The Article related to selenide preparation, trifluoromethyl selenotoluenesulfonate alkyl halide perfluoroalkylselenolation, fluorine, nucleophilic substitution, perfluoroalkylselenolation, selenium, trifluoromethylselenolation and other aspects.Related Products of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On August 7, 2018, Orteca, Giulia; Tavanti, Francesco; Bednarikova, Zuzana; Gazova, Zuzana; Rigillo, Giovanna; Imbriano, Carol; Basile, Valentina; Asti, Mattia; Rigamonti, Luca; Saladini, Monica; Ferrari, Erika; Menziani, Maria Cristina published an article.Reference of 2-(2-Bromoethyl)isoindoline-1,3-dione The title of the article was Curcumin derivatives and Aβ-fibrillar aggregates: An interactions’ study for diagnostic/therapeutic purposes in neurodegenerative diseases. And the article contained the following:

Several neurodegenerative diseases, like Alzheimer’s (AD), are characterized by amyloid fibrillar deposition of misfolded proteins, and this feature can be exploited for both diagnosis and therapy design. In this paper, structural modifications of curcumin scaffold were examined in order to improve its bioavailability and stability in physiol. conditions, as well as its ability to interfere with β-amyloid fibrils and aggregates. The acid-base behavior of curcumin derivatives, their pharmacokinetic stability in physiol. conditions, and in vitro ability to interfere with Aβ fibrils at different incubation time were investigated. The mechanisms governing these phenomena have been studied at at. level by means of mol. docking and dynamic simulations. Finally, biol. activity of selected curcuminoids has been investigated in vitro to evaluate their safety and efficiency in oxidative stress protection on hippocampal HT-22 mouse cells. Two aromatic rings, π-conjugated structure and H-donor/acceptor substituents on the aromatic rings showed to be the sine qua nonstructural features to provide interaction and disaggregation activity even at very low incubation time (2 h). Computational simulations proved that upon binding the ligands modify the conformational dynamics and/or interact with the amyloidogenic region of the protofibril facilitating disaggregation. Significantly, in vitro results on hippocampal cells pointed out protection against glutamate toxicity and safety when administered at low concentrations (1 μM). On the overall, in view of its higher stability in physiol. conditions with respect to curcumin, of his rapid binding to fibrillar aggregates and strong depolymerizing activity, phthalimide derivative K2F21 appeared a good candidate for both AD diagnostic and therapeutic purposes. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Reference of 2-(2-Bromoethyl)isoindoline-1,3-dione

The Article related to curcumin neurodegenerative disease antialzheimer alzheimer diagnosis, alzheimer’s disease, amyloid β fibrillar aggregates, curcumin-derivatives, hippocampal ht-22 mouse cells, molecular dynamics simulations and other aspects.Reference of 2-(2-Bromoethyl)isoindoline-1,3-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Asadi, Mehdi; Ebrahimi, Mostafa; Mohammadi-Khanaposhtani, Maryam; Azizian, Homa; Sepehri, Saghi; Nadri, Hamid; Biglar, Mahmood; Amanlou, Massoud; Larijani, Bagher; Mirzazadeh, Roghieh; Edraki, Najmeh; Mahdavi, Mohammad published an article in 2019, the title of the article was Design, synthesis, molecular docking, and cholinesterase inhibitory potential of phthalimide-dithiocarbamate hybrids as new agents for treatment of Alzheimer’s disease.Product Details of 574-98-1 And the article contains the following content:

A novel series of phthalimide-dithiocarbamate hybrids was synthesized and evaluated for in vitro inhibitory potentials against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The anti-cholinesterase results indicated that among the synthesized compounds, the compounds 7g and 7h showed the most potent anti-AChE and anti-BuChE activities, resp. Mol. docking and dynamic studies of the compounds 7g and 7h, resp., in the active site of AChE and BuChE revealed that these compounds as well interacted with studied cholinesterases. These compounds also possessed drug-like properties and were able to cross the BBB. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Product Details of 574-98-1

The Article related to synthesis docking cholinesterase inhibitor phthalimide dithiocarbamate hybrid antialzheimer, alzheimer’s disease, acetylcholinesterase, butyrylcholinesterase, dithiocarbamate, inhibitory activity, phthalimide and other aspects.Product Details of 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

McGrory, Rochelle; Faggyas, Reka J.; Sutherland, Andrew published an article in 2021, the title of the article was One-pot synthesis of N-substituted benzannulated triazoles via stable arene diazonium salts.HPLC of Formula: 574-98-1 And the article contains the following content:

A mild and effective one-pot synthesis of benzothiatriazine-1,1(2H)-dioxides I [R = Me, Bn, Ph, etc.] and 1,2,3-benzotriazin-4(3H)-ones II [R1 = H, 5-F, 7-CF3, etc.; R2 = H, cyclohexyl, Ph, etc.] was developed. The method involved the diazotization and subsequent cyclization of 2-aminobenzamides and 2-aminobenzenesulfonamides via stable diazonium salts, prepared using a polymer-supported nitrite reagent and p-tosic acid. The transformation was compatible with a wide range of aryl functional groups and amide/sulfonamide-substituents and was used for the synthesis of pharmaceutically important targets. The synthetic utility of the one-pot diazotizaton-cyclization process was further demonstrated with the preparation of an α-amino acid containing 1,2,3-benzotriazin-4(3H)-one. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).HPLC of Formula: 574-98-1

The Article related to benzotriazinone preparation, aminobenzamide polymer supported nitrite diazotizaton cyclization, benzothiatriazine dioxide preparation, aminobenzenesulfonamide polymer supported nitrite diazotizaton cyclization and other aspects.HPLC of Formula: 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary