Month: November 2022

On February 15, 2017, Du, Shunfu; Ji, Chunqing; Xin, Xuelian; Zhuang, Mu; Yu, Xuying; Lu, Jitao; Lu, Yukun; Sun, Daofeng published an article.Synthetic Route of 41819-13-0 The title of the article was Syntheses, structures and characteristics of four alkaline-earth metal-organic frameworks (MOFs) based on benzene-1,2,4,5-tetracarboxylic acid and its derivative ligand. And the article contained the following:

Two new pillar-layered Ba(II)-based 3D frameworks and two new Ca(II)-based 3D supramol. frameworks, [Ba2(dbtec)(H2O)2]n (1), [Ca2(dbtec)(H2O)8]n (2), {[Ba2(H2btec)·H2O]·0.5H2O}n (3) and [Ca(H2btec)·H2O]n (4) (H4dbtec = 3,6-dibromobenzene-1,2,4,5-tetracarboxylic acid; H4btec = benzene-1,2,4,5-tetracarboxylic acid), were synthesized under similar reaction conditions and stoichiometry. Single crystal x-ray diffraction study reveals axial-orientation Br···π supramol. interactions exist in the crystal structure of 1, which keeps an 3D binodal network with the (32.412.510.62.72)(32.46.56.6)2 topol. Whereas in 2, intramol. and intermol. H-bonding interactions with the ligated water mols. promote the formation of 3D supramol. frameworks network. For 3, a new 3D 3-nodal network occurs in the structure and some rare coordination modes for the H4btec are observed There is a 2D double layer with the thickness of 7.60 Å in 4. In addition, besides the high thermal stability, the FTIR spectra, PXRD patterns and the photoluminescent of these compounds are also discussed. The experimental process involved the reaction of 3,6-Dibromobenzene-1,2,4,5-tetracarboxylic acid(cas: 41819-13-0).Synthetic Route of 41819-13-0

The Article related to preparation crystal structure calcium barium dibromobenzenetetracarboxylate benzenetetracarboxylate mof, luminescence thermal stability calcium barium dibromobenzenetetracarboxylate benzenetetracarboxylate mof and other aspects.Synthetic Route of 41819-13-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On January 31, 2020, Dato, Florian M.; Neudoerfl, Joerg-Martin; Guetschow, Michael; Goldfuss, Bernd; Pietsch, Markus published an article.Reference of 2-(2-Bromoethyl)isoindoline-1,3-dione The title of the article was ω-Quinazolinonylalkyl aryl ureas as reversible inhibitors of monoacylglycerol lipase. And the article contained the following:

The serine hydrolase monoacylglycerol lipase (MAGL) is involved in a plethora of pathol. conditions, in particular pain and inflammation, various types of cancer, metabolic, neurol. and cardiovascular disorders, and is therefore a promising target for drug development. Although a large number of irreversible-acting MAGL inhibitors have been discovered over the past years, there are only few compounds known so far which inhibit the enzyme in a reversible manner. Therefore, much effort is put into the development of novel chem. entities showing reversible inhibitory behavior, which is thought to cause less undesired side effects. To explore a wide range of chem. structures as MAGL binders, we have applied a virtual screening approach by docking small mols. into the crystal structure of human MAGL (hMAGL) and envisaged a library of 45 selected compounds which were then synthesized. Biochem. investigations included the determination of the inhibitory potency on hMAGL and two related hydrolases, i.e. human fatty acid amide hydrolase (hFAAH) and murine cholesterol esterase (mCEase). The most promising candidates from theses analyses, i.e. three ω-quinazolinonylalkyl aryl ureas bearing alkyl spacers of three to five methylene groups, exhibited IC50 values of 20-41μM and reversible, detergent-insensitive behavior towards hMAGL. Among these compounds, the inhibitor 1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-(4-oxo-3,4-dihydroquinazolin-2-yl)butyl)urea (96) was selected for further kinetic characterization, yielding a dissociation constant Ki = 15.4μM and a mixed-type inhibition with a pronounced competitive component (α = 8.94). This mode of inhibition was further supported by a docking experiment, which suggested that the inhibitor occupies the substrate binding pocket of hMAGL. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Reference of 2-(2-Bromoethyl)isoindoline-1,3-dione

The Article related to quinazolinonylalkyl aryl urea inhibitor monoacylglycerol lipase, cholesterol esterase, enzyme kinetics, fatty acid amide hydrolase, inhibitors, monoacylglycerol lipase, promiscuous inhibition, serine hydrolases and other aspects.Reference of 2-(2-Bromoethyl)isoindoline-1,3-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On April 30, 2019, Xie, Ruliang; Mei, Xiangdong; Ning, Jun published an article.Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione The title of the article was Design, synthesis and insecticide activity of novel acetylcholinesterase inhibitors: triazolinone and phthalimide heterodimers. And the article contained the following:

A new series of 1,2,4-triazolin-3-one and phthalimide heterodimers I [X = (CH2)n; n = 1, 2, 9, etc.] was synthesized and evaluated for their insecticidal and acetylcholinesterase inhibitory activities. Most of the synthesized compounds I showed good in vitro inhibitory activities against both Drosophila melanogaster acetylcholinesterase (DmAChE) and Musca domestica acetylcholinesterase (MdAChE). Among them, compound I (n = 7) was found to be most potent AChE inhibitor (IC50 = 8.07 μM to DmAChE, IC50 = 32.24 μM to MdAChE), whose activities were 2.31- and 1.35-fold more active than the pos. control ethion (CP, IC50 = 18.62 μM to DmAChE, IC50 = 43.56 μM to MdAChE). The docking model study revealed that compound I (n = 7) possessed fitted spatial structure and bound to central pocket and peripheral site of DmAChE. Moreover, most of the compounds I demonstrated high insecticidal activity to Lipaphis erysimi and Tetranychus cinnabarinus at concentration of 300 mg/L. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione

The Article related to triazolyl isoindoline dione preparation insecticide acetylcholinesterase inhibitor mol docking, acetylcholinesterase, acetylcholinesterase inhibiting potency, dual binding site, heterodimer, insecticidal activity and other aspects.Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On January 17, 2020, Gonzalez-Rodriguez, Jorge; Soto, Martin; Soengas, Raquel G.; Rodriguez-Solla, Humberto published an article.Category: bromides-buliding-blocks The title of the article was SmI2-promoted cross coupling reaction of N-2-bromoethylphthalimide and carbonyl compounds: Synthesis of α-aryl-α’-hydroxy ketones. And the article contained the following:

In this paper, the SmI2-mediated carbonyl-imide reductive cross coupling between N-2-bromoethylphthalimide and different aldehydes and ketones in the presence of anhydrous catalytic NiI2 was disclosed. This methodol. provided an effective tool to prepare α-aryl-α’-hydroxy ketones I [R1 = n-C7H15, 4-ClC6H4, C6H4CH=CH, etc; R1 = R2 = Et; R1R2 = (CH2)4, (CH2)5] under mild conditions which could be applied to various functionalized, aliphatic and aromatic aldehydes and ketones. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Category: bromides-buliding-blocks

The Article related to aryl alpha hydroxy ketone preparation chemoselective, bromoethylphthalimide aldehyde reductive cross coupling samarium iodide mediated, ketone bromoethylphthalimide reductive cross coupling samarium iodide mediated and other aspects.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On September 30, 2022, Ekinci, Orhan; Akkoc, Mitat; Khan, Siraj; Yasar, Sedat; Guerses, Canbolat; Noma, Samir; Balcioglu, Sevgi; Sen, Betuel; Ayguen, Muhittin; Yilmaz, Ismet published an article.Application In Synthesis of 2-(2-Bromoethyl)isoindoline-1,3-dione The title of the article was Synthesis and biological evaluation of Au-NHC complexes. And the article contained the following:

New seven Au-N-heterocyclic carbene (NHC) complexes were synthesized via transmetalation from Ag-NHC complexes. NHC salts, Ag-NHC, and Au-NHC complexes were fully characterized by widely used spectroscopic techniques. The mol. and crystal structures of 3b and 3f Au-NHC complexes were clarified through the single-crystal x-ray diffraction method. According to x-ray diffraction anal. results, the coordination geometry around Au(I) atoms in the complexes are revealed to be almost linear with C-Au-Cl angle. Anticancer activity, DNA binding, xanthine oxidase (XO) inhibitory activity studies, and mol. docking studies were evaluated for all Au-NHC complexes to explore the binding mechanism at the active site. The IC50 value of Au-NHC complexes against human colorectal cancer (Caco-2) and breast cancer (MCF-7) cell lines was defined by MTT assay. The IC50 values for MCF-7 in the range of 5.2 ± 2 to 152.4 ± 1μM and Caco-2 5.2 ± 1 to 152.7 ± 2μM showed that 3a, 3b, 3c, 3d, and 3g have better anticancer activity than Cisplatin incredibly complex 3a against both cancer cell line. All Au-NHC complexes showed excellent antimicrobial activity against different bacteria and fungi. 3a was the complex that exhibited the best antimicrobial activity here as well. The XO inhibitory activity exptl. results indicated that all gold complexes showed remarkable inhibition activity against XO compared to the generally used standard, allopurinol. The range of IC50 value was determined from 0.407 to 2.681μM. 3d complex showed the lowest IC50 value at 0.407μM. DNA binding experiments were performed using agarose gel electrophoresis to observe the ability of synthesized Au-NHC complexes to interact with the supercoiled pUC19 plasmid DNA. Mol. docking studies were performed to determine the binding mode of all active compounds against the XO enzyme, antibacterial, antifungal, and MCF-7 cell lines. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Application In Synthesis of 2-(2-Bromoethyl)isoindoline-1,3-dione

The Article related to silver gold heterocyclic carbene complex halo preparation crystal structure, antitumor human silver gold heterocyclic carbene complex halo, antibacterial antifungal silver gold heterocyclic carbene complex halo dna and other aspects.Application In Synthesis of 2-(2-Bromoethyl)isoindoline-1,3-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On April 22, 2022, Wang, Hui; Yang, Ren-Yin; Xu, Bo published an article.Application In Synthesis of 4-(Bromomethyl)-1,1′-biphenyl The title of the article was Synthesis of Cyclopropenes and Fluorinated Cyclopropanes via Michael Initiated Ring Closure of Alkyl Triflones. And the article contained the following:

A facile synthesis of cyclopropenes and fluorinated cyclopropanes from readily available alkyl triflones was developed. The reaction, regardless of electronic effect, gave products in good to excellent yields and moderate diastereoselectivity. The mechanism may involve tandem Michael addition of triflones/intramol. nucleophilic cyclization (elimination of -SO2CF3)/elimination of fluoride. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Application In Synthesis of 4-(Bromomethyl)-1,1′-biphenyl

The Article related to cyclopropene fluorinated cyclopropane preparation diastereoselective, alkyl triflone chalcone michael initiated ring closure, michael initiated ring closure, alkyl triflones, cyclopropenes, fluorinated cyclopropanes and other aspects.Application In Synthesis of 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On April 24, 2013, Zhang, Liang-Liang; Guo, Yu; Wei, Yan-Hui; Guo, Jie; Wang, Xing-Po; Sun, Dao-Feng published an article.Recommanded Product: 41819-13-0 The title of the article was Crystal structure and temperature-dependent fluorescent property of a 2D cadmium (II) complex based on 3,6-dibromobenzene-1,2,4,5-tetracarboxylic acid. And the article contained the following:

A new Cd (II) organic coordination polymers [Cd(dbtec)0.5(H2O)3]·H2O (1), was constructed based on 3,6-dibromobenzene-1,2,4,5-tetracarboxylic acid (H4dbtec), and characterized by elemental anal. (EA), IR spectroscopy (IR), powder x-ray diffraction (PXRD), and single crystal X-ray diffraction. In 1, μ2-η1:η1 and μ4-η2:η2 dbtec ligands link four heptacoordinated CdII ions to form a 2-dimensional 44 topol. layer structure, which is further connected into an interesting 3-dimensional network by H bond and Br···O halogen bond. Also, the thermal stabilities, solid UV spectroscopy and temperature-dependent fluorescent properties of 1 were studied. The experimental process involved the reaction of 3,6-Dibromobenzene-1,2,4,5-tetracarboxylic acid(cas: 41819-13-0).Recommanded Product: 41819-13-0

The Article related to preparation cadmium bromobenzenetetracarboxylate coordination polymer, crystal structure cadmium bromobenzenetetracarboxylate coordination polymer, fluorescence cadmium bromobenzenetetracarboxylate coordination polymer and other aspects.Recommanded Product: 41819-13-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cresp, T. M.; Sargent, M. V.; Elix, J. A.; Murphy, D. P. H. published an article in 1973, the title of the article was Formylation and bromination ortho to the hydroxy-group of 2-carbonyl-substituted phenols in the presence of titanium(IV) chloride.Name: Methyl 5-bromo-2-methoxy-4-methylbenzoate And the article contains the following content:

Formylation with Cl2CHOMe-TiCl4 of Me 2,4-dihydroxybenzoate, Me 2-hydroxy-4-methoxybenzoate, Et 2-hydroxy-4-methoxy-6-methylbenzoate, Me 2-hydroxy-4-methylbenzoate, and 2-hydroxy-4-methoxyacetophenone gave the 3-formyl derivatives as the major products. Bromination in the presence of TiCl4 gave similar results. Formation of a six-membered ring Ti complex (e.g., I) induces selective substitution ortho to the OH group. The experimental process involved the reaction of Methyl 5-bromo-2-methoxy-4-methylbenzoate(cas: 39503-58-7).Name: Methyl 5-bromo-2-methoxy-4-methylbenzoate

The Article related to selective formylation phenol derivative, formylation hydroxybenzoate titanium chloride, phenol carboxy formylation titanium, bromination hydroxybenzoate titanium chloride, chloromethyl ether formylation phenol derivative and other aspects.Name: Methyl 5-bromo-2-methoxy-4-methylbenzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On May 31, 2022, Zhang, Naichen; Ye, Yuanzhi; Bai, Lu; Liu, Jingjing; Wang, Han; Luan, Xinjun published an article.Safety of 4-(Bromomethyl)-1,1′-biphenyl The title of the article was Transition metal-free dearomatization of halonaphthols with C(sp3)-electrophiles. And the article contained the following:

The first intermol. electrophilic dearomatization of halonaphthols I (R1 = H, 7-MeO, 6-Me3Si, 3-Cl, etc.) with benzyl/allyl bromides R2Br (R2 = PhCH2, PhCHMe, 4-MeO2CC6H4CH2, H2C:CHCH2, PhCH:CH, etc.) is described. Halonaphthols are used as carbon nucleophiles in dearomatization to form three-dimensional cyclic enones II with excellent chemoselectivity, in which etherification of phenolic hydroxyl group could be restrained by using cesium carbonate as the base. A wide range of cyclic enones was directly prepared from various substituted benzyl/allyl bromides and halonaphthols. Mechanistic investigations suggest a direct SN2 reaction pathway. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Safety of 4-(Bromomethyl)-1,1′-biphenyl

The Article related to allylic bromide fluoronaphthol chemoselective electrophilic allylation dearomatization, allyl benzyl fluoro naphthalenone preparation, fluoronaphthol chemoselective electrophilic benzylation benzyl bromide dearomatization and other aspects.Safety of 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On October 10, 2022, Wang, Yanwei; Zhao, Zhiwei; Pan, Deng; Wang, Siyi; Jia, Kangping; Ma, Dengke; Yang, Guoqing; Xue, Xiao-Song; Qiu, Youai published an article.Product Details of 2567-29-5 The title of the article was Metal-Free Electrochemical Carboxylation of Organic Halides in the Presence of Catalytic Amounts of an Organomediator. And the article contained the following:

Herein, an electroreductive carboxylation of organic carbon-halogen bonds (X=Br and Cl) promoted by catalytic amounts of naphthalene as an organic mediator is reported. This transformation proceeds smoothly under mild conditions with a broad substrate scope of 59 examples, affording the valuable and versatile carboxylic acids in moderate to excellent yields without the need of costly transition metal, wasted stoichiometric metal reductants, or sacrificial anodes. Further late-stage carboxylations of natural product and drug derivatives demonstrate its synthetic utility. Mechanistic studies confirmed the activation of carbon-halogen bonds via single-electron transfer and the key role of naphthalene in this reaction. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Product Details of 2567-29-5

The Article related to carboxylic acid aryl alkyl preparation, aryl chloride bromide carbon dioxide electroreductive carboxylation naphthalene catalyst, co2 utilization, carboxylation, electroreduction, organic halides, organic reductive mediator and other aspects.Product Details of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary