Month: November 2022

Kreyenschmidt, Friedrich; Koszinowski, Konrad published an article in 2018, the title of the article was Low-Valent Ate Complexes Formed in Cobalt-Catalyzed Cross-Coupling Reactions with 1,3-Dienes as Additives.Related Products of 83152-22-1 And the article contains the following content:

The combination of CoCl2 and 1,3-dienes is known to catalyze challenging alkyl-alkyl cross-coupling reactions between Grignard reagents and alkyl halides, but the mechanism of these valuable transformations remains speculative. Herein, electrospray-ionization mass spectrometry is used to identify and characterize the elusive intermediates of these and related reactions. The vast majority of detected species contain low-valent cobalt(I) centers and diene mols. Charge tagging, deuterium labeling, and gas-phase fragmentation experiments elucidate the likely origin of these species and show that the diene not only binds to Co as a π ligand, but also undergoes migratory insertion reactions into Co-H and Co-R bonds. The resulting species have a strong tendency to form anionic cobalt(I) ate complexes, the superior nucleophilicity of which should render them highly reactive toward electrophilic substrates and, thus, presumably is the key to the high catalytic efficiency of the system under investigation. Upon the reaction of the in situ formed cobalt(I) ate complexes with organyl halides, only the final cross-coupling product could be detected, but no cobalt(III) species. This finding implies that this reaction step proceeds in a direct manner without any intermediate or, alternatively, that it involves an intermediate with a very short lifetime. The experimental process involved the reaction of (6-Bromohexyl)triphenylphosphonium bromide(cas: 83152-22-1).Related Products of 83152-22-1

The Article related to low valet cobalt complex cross coupling reaction diene reaction, cobalt diene electrospray ionization mass spectrometry intermediate preparation, ate complexes, cobalt, cross-coupling, mass spectrometry, reactive intermediates and other aspects.Related Products of 83152-22-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jiang, Jian-An; Chen, Cheng; Huang, Jian-Gang; Liu, Hong-Wei; Cao, Song; Ji, Ya-Fei published an article in 2014, the title of the article was Cu(OAc)2-catalyzed remote benzylic C(sp3)-H oxyfunctionalization for C=O formation directed by the hindered para-hydroxyl group with ambient air as the terminal oxidant under ligand- and additive-free conditions.Synthetic Route of 185345-46-4 And the article contains the following content:

A hindered para-hydroxyl group-directed remote benzylic C(sp3)-H oxyfunctionalization has been developed for the straightforward transformation of 2,6-disubstituted 4-cresols, 4-alkylphenols, 4-hydroxybenzyl alcs. and 4-hydroxybenzyl alkyl ethers into various aromatic carbonyl compounds The ligand- and additive-free Cu(OAc)2-catalyzed atm. oxidation-mediated by ethylene glycol unlocks a facile, atom-economical, and environmentally benign C=O formation for the functionalization of primary and secondary benzyl groups. Due to the pharmaceutical importance of 4-hydroxybenzaldehydes and 4-hydroxyphenones, the methodol. is expected to be of significant value for both fundamental research and practical applications. The experimental process involved the reaction of 3-Bromo-5-fluoro-4-hydroxybenzaldehyde(cas: 185345-46-4).Synthetic Route of 185345-46-4

The Article related to cresol alkylphenol hydroxybenzyl alc ether copper catalyzed benzylic oxyfunctionalization, hindered phenol oxidation air ethylene glycol ligand additive free, hydroxybenzaldehyde hydroxyphenone environmentally benign preparation and other aspects.Synthetic Route of 185345-46-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On February 1, 2020, Sun, Nannan; Ma, Xiaojun; Zhou, Kaifeng; Zhu, Chen; Cao, Zhonglian; Wang, Yonghui; Xu, Jun; Fu, Wei published an article.Reference of 4-(Bromomethyl)-1,1′-biphenyl The title of the article was Discovery of novel N-sulfonamide-tetrahydroquinolines as potent retinoic acid receptor-related orphan receptor γt inverse agonists for the treatment of autoimmune diseases. And the article contained the following:

In this study, authors designed and synthesized a series of N-sulfonamide-tetrahydroquinolines by mol. modeling and scaffold hopping strategy, aiming at improving the metabolic stabilities. Detailed SAR exploration led to identification of potent RORγt inverse agonists such as compound II with moderate binding affinity and inhibitory activity of Th17 cell differentiation. Binding mode of compound II with RORγt-LBD was revealed by mol. docking. Moreover, compound II showed lower intrinsic clearance in mouse liver microsomes compared with compound I and potent in-vivo efficacy and safety in psoriasis models, which can be used as a good starting point for the further optimization. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Reference of 4-(Bromomethyl)-1,1′-biphenyl

The Article related to sulfonamido tetrahydroquinoline preparation rror inverse agonist sar safety, inverse agonists, metabolic stability, n-sulfonamide-tetrahydroquinolines, psoriasis, retinoic acid receptor-related orphan receptor γt (rorγt), th17 cells and other aspects.Reference of 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Islam, M. Q.; Hill, W. E.; Webb, T. R. published an article in 1989, the title of the article was Synthesis and characterization of long chain unsymmetrical diphosphines.Safety of (6-Bromohexyl)triphenylphosphonium bromide And the article contains the following content:

The long-chain unsym. diphosphines, R2P(CH2)nPPh2 (R = Me, Et; n = 6, 8) have been synthesized and characterized by their 31P and 1H NMR spectra. The purity of product is strictly dependent on the reaction condition. Attempted preparation of the diphosphines with same substituents on P but a longer chain length (10 and 12 methylene bridge) was unsuccessful because of possible disubstitution in the first of the four step synthesis giving mixed products (sym. and unsym. diphosphines). The experimental process involved the reaction of (6-Bromohexyl)triphenylphosphonium bromide(cas: 83152-22-1).Safety of (6-Bromohexyl)triphenylphosphonium bromide

The Article related to diphosphine unsym long chain, dibromoalkane reaction triorganophosphine, oxidation diphosphonium dibromide unsym, bromoalkylphosphonium bromide preparation reaction triorganophosphine, quaternization triorganophosphine dibromoalkane and other aspects.Safety of (6-Bromohexyl)triphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nakayama, Kaii; Kamiya, Hidehiro; Okada, Yohei published an article in 2022, the title of the article was Radical cation Diels-Alder reactions of arylidene cycloalkanes.Name: (6-Bromohexyl)triphenylphosphonium bromide And the article contains the following content:

TiO2 photoelectrochem. and electrochem. radical cation Diels-Alder reactions of arylidene cycloalkanes are described, leading to the construction of spiro ring systems. Although the mechanism remains an open question, arylidene cyclobutanes are found to be much more effective in the reaction than other cycloalkanes. Since the reaction is completed with a substoichiometric amount of electricity, a radical cation chain pathway is likely to be involved. The experimental process involved the reaction of (6-Bromohexyl)triphenylphosphonium bromide(cas: 83152-22-1).Name: (6-Bromohexyl)triphenylphosphonium bromide

The Article related to spiro compound preparation photoelectrochem electrochem reaction, arylidene cycloalkane dimethyl butadiene diels alder reaction, diels–alder reaction, arylidene cycloalkane, radical cation, single-electron transfer, spiro ring system and other aspects.Name: (6-Bromohexyl)triphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On May 26, 1987, Haga, Toru; Nagano, Hideyoshi; Okuda, Hiroki; Takase, Masayuki published a patent.Computed Properties of 111010-07-2 The title of the patent was Preparation of 5-bromo-4-chloro-2-fluoroaniline as intermediate for tetrahydrophthalimide herbicides. And the patent contained the following:

The title compound (I), useful as an intermediate for herbicidal tetrahydrophthalimides II (R = H, alkyl, Ph) were prepared by reduction of 1-bromo-2-chloro-4-fluoro-5-nitrobenzene (III). A mixture of 14 g III and 20 g Fe powder in AcOH 20, EtOAc 30, and 5% aqueous AcOH 50 mL was refluxed at 60-80° for 3 h to give 10.4 g I. The experimental process involved the reaction of 5-Bromo-4-chloro-2-fluoroaniline(cas: 111010-07-2).Computed Properties of 111010-07-2

The Article related to aniline trihalo preparation herbicide intermediate, herbicide intermediate bromochlorofluoroaniline preparation, phthalimide tetrahydro herbicide intermediate trihaloaniline, bromochlorofluoroaniline intermediate herbicide preparation and other aspects.Computed Properties of 111010-07-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Varano, Flavia; Catarzi, Daniela; Vigiani, Erica; Vincenzi, Fabrizio; Pasquini, Silvia; Varani, Katia; Colotta, Vittoria published an article in 2020, the title of the article was Piperazine- and piperidine-containing thiazolo[5,4-d]pyrimidine derivatives as new potent and selective adenosine A2A receptor inverse agonists.Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione And the article contains the following content:

The therapeutic use of A2A adenosine receptor (AR) antagonists for the treatment of neurodegenerative disorders, such as Parkinson and Alzheimer diseases, is a very promising approach. Moreover, the potential therapeutic role of A2A AR antagonists to avoid both immunoescaping of tumor cells and tumor development is well documented. Herein, authors report on the synthesis and biol. evaluation of a new set of piperazine- and piperidine- containing 7-amino-2-(furan-2-yl)thiazolo[5,4-d]pyrimidine derivatives designed as human A2A AR antagonists/inverse agonists. Binding and potency data indicated that a good number of potent and selective hA2A AR inverse agonists were found. Amongst them, the compound I exhibited the highest A2A AR binding affinity (Ki = 8.62 nM) as well as inverse agonist potency (IC50 = 7.42 nM). The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione

The Article related to piperazinyl piperidinyl thiazolopyrimidine preparation in silico adme prediction, adenosine a2a receptor inverse agonist human, g protein-coupled receptors, adenosine a2a receptor ligands, adenosine receptors, thiazolo[5,4-d]pyrimidines and other aspects.Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On May 13, 2004, Bit, Rino Antonio; Giblin, Gerard Martin Paul; Hall, Adrian; Hurst, David Nigel; Kilford, Ian Reginald; Miller, Neil Derek; Scoccitti, Tiziana published a patent.Application In Synthesis of Ethyl 2-bromo-6-fluorobenzoate The title of the patent was Preparation of benzoic acids and related compounds as EP1 receptor antagonists for the treatment of prostaglandin mediated diseases.. And the patent contained the following:

Title compounds I [A = (un)substituted aryl, 5 or 6-membered heterocyclyl ring, bicyclic heterocyclyl; B = Ph, pyridyl; Z = O, S, SO, etc.; R1 = CO2R4, CN, CONR5R6, etc.; R2a, R2b = H, halogen, (un)substituted alkyl, etc.; Rx = (un)substituted alkyl, CQaQb-heterocyclyl, CQaQb-bicyclic heterocyclyl, etc.; R4, R5 = H, (un)substituted alkyl; R6 = H, (un)substituted alkyl, heteroaryl, etc.; R8, R9 = H, Cl, F, etc.; Qa, Qb = H, CH3] and their pharmaceutically acceptable derivatives were prepared For example, the Suzuki coupling of Et 2′-bromobiphenyl-3-carboxylate and 2-benzyloxy-5-chlorophenylboronic acid, e.g., prepared from 3-ethoxycarbonylphenylboronic acid, followed by hydrolysis afforded compound I [A-R1 = 3-carboxyphenyl; Z = O; R2a = H, R2b = 5-Cl; R8, R9 = H] in 39% overall yield. In human prostanoid EP1 receptor binding assays, 90-examples of compounds I exhibited pIC50 values ranging from 6.0->9.0 at the EP1 receptor and pIC50 values of <6.0 at the EP3 receptor. Of note, no toxicol. effects are indicated/expected (sic) when the compounds I are administered at the assay concentration of 3 nM. Compounds I are claimed useful for the treatment of prostaglandin mediated diseases, e.g., inflammation, pain, etc. The experimental process involved the reaction of Ethyl 2-bromo-6-fluorobenzoate(cas: 1214362-62-5).Application In Synthesis of Ethyl 2-bromo-6-fluorobenzoate

The Article related to benzoic acid derivative preparation ep1 receptor antagonist prostaglandin disease, antiinflammatory agent benzoic acid derivative preparation ep1 receptor antagonist, analgesic benzoic acid derivative preparation ep1 receptor antagonist and other aspects.Application In Synthesis of Ethyl 2-bromo-6-fluorobenzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On March 1, 2022, Meng, Depei; Lyu, Yichong; Ni, Chuanfa; Zhou, Min; Li, Yang; Hu, Jinbo published an article.Electric Literature of 2567-29-5 The title of the article was S-(Trifluoromethyl)Benzothioate (TFBT): A KF-Based Reagent for Nucleophilic Trifluoromethylthiolation. And the article contained the following:

S-(Trifluoromethyl)benzothioate (TFBT) was developed as an inexpensive, bench-stable and user-friendly trifluoromethylthiolation reagent which was easily synthesized by using KF as the only fluorine source. By using TFBT, trifluoromethylthiolates with various counterions was readily obtained. The synthetic application of TFBT was demonstrated by trifluoromethylthiolation-halogenation of arynes, bis(trifluoromethylthiolation)-halogenation of 1,2-benzdiynes, nucleophilic substitution of alkyl halides, deoxytrifluoromethylthiolation of alcs., and cross-coupling with aryl and vinyl boronic acids. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Electric Literature of 2567-29-5

The Article related to trifluoromethyl benzothioate preparation aryne halogenation trifluoromethylthiolation, halo trifluoromethylthio arene preparation, s-(trifluoromethyl)benzothioate, aryne, multifunctionalization, potassium fluoride, trifluoromethylthiolation and other aspects.Electric Literature of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On August 5, 2020, Sidhu, Jagpreet Singh; Raj, Pushap; Pandiyan, Thangarasu; Singh, Narinder published an article.Formula: C10H8BrNO2 The title of the article was Synthesis of Nickel(II) Complexes of Novel Naphthalimide Based Heterodipodal Schiff Base Ligands, Structure, Characterization and Application for Degradation of Pesticides. And the article contained the following:

To degrade the highly toxic pesticide into less harmful components, authors have synthesized four nickel complexes of naphthalimide based organic ligands. These complexes catalyze the hydrolysis of phosphorothioate bonds of organophosphates in an aqueous medium. The metal complexes {[Ni(L1)2]-[Ni(L4)2]} were synthesized by the electrochem. method and characterized using single-crystal x-ray crystallog. and mass spectrometry. Anal. techniques revealed that complexes are mononuclear and possess octahedral geometry. The rate of degradation of chlorpyriphos and parathion Me was evaluated using 31P NMR and LC-MS chromatogram. The byproduct of chlorpyriphos upon catalytic degradation with complex was confirmed from mass spectrometry. It was found that chlorpyriphos degrade into 3,5,6-trichloropyridin-2-ol after 50 min of incubation with catalyst. However, parathion Me took only 20 min to hydrolyze into its byproduct. Moreover, the inhibition assay of acetylcholinesterase was performed for pesticides in the presence of metal complex and the interesting outcome was recorded. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Formula: C10H8BrNO2

The Article related to nickel naphthalimide heterodipodal schiff base preparation degrade pesticide, crystal mol structure naphthalimide heterodipodal schiff base, phosphorothioate organophosphate hydrolysis catalyst naphthalimide heterodipodal schiff base nickel and other aspects.Formula: C10H8BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary