Month: November 2022

Arno, Maria C. published the artcileExploiting the role of nanoparticle shape in enhancing hydrogel adhesive and mechanical properties, Computed Properties of 55788-44-8, the publication is Nature Communications (2020), 11(1), 1420, database is CAplus and MEDLINE.

The ability to control nanostructure shape and dimensions presents opportunities to design materials in which their macroscopic properties are dependent upon the nature of the nanoparticle. Although particle morphol. has been recognized as a crucial parameter, the exploitation of the potential shape-dependent properties has, to date, been limited. Herein, we demonstrate that nanoparticle shape is a critical consideration in the determination of nanocomposite hydrogel properties. Using translationally relevant calcium-alginate hydrogels, we show that the use of poly(L-lactide)-based nanoparticles with platelet morphol. as an adhesive results in a significant enhancement of adhesion over nanoparticle glues comprised of spherical or cylindrical micelles. Furthermore, gel nanocomposites containing platelets showed an enhanced resistance to breaking under strain compared to their spherical and cylindrical counterparts. This study opens the doors to a change in direction in the field of gel nanocomposites, where nanoparticle shape plays an important role in tuning mech. properties.

Nature Communications published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Computed Properties of 55788-44-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Alghamdi, Abdulaziz Ali B. published the artcileSynthesis and characterization of novel thiophene and carbazole-based polymers – optical and electrochemical characterization, Computed Properties of 52431-30-8, the publication is International Journal of Electrochemical Science (2016), 11(6), 5111-5127, database is CAplus.

A donor/acceptor series of carbazole copolymers, composed of alternating 2,7-linked 3,6-difluoro-9-(1-octyl-nonyl)-carbazole units and bithiophene repeated units [P1], 5,7-bis(5-bromothiophen-2-yl)-2,3-bis(4-(2-ethylhexyloxy) phenyl) thieno[3,4-b]pyrazine repeated units [P2] and bithiophene mixed with 5,7-bis(5-bromothiophen-2-yl)-2,3-bis(4-(2-ethylhexyloxy) phenyl) thieno[3,4-b]pyrazine repeated units [P3] have been prepared following Suzuki polymerization procedures. The route of synthesis and characterization techniques of this novel class of materials, together with their photophys. and electrochem. properties are presented in this study. The polymers were characterized by 1H NMR, 13C NMR and Elemental Anal. Mol. weights were estimated using gel permeation chromatog. (GPC). The thermal stability behavior for polymers was investigated using thermogravimetric anal. (TGA) and differential scanning calorimetry (DSC). The electronic and photo-phys. properties were investigated by use of cyclic voltammetry (CV) and UV-Vis spectroscopy, resp.

International Journal of Electrochemical Science published new progress about 52431-30-8. 52431-30-8 belongs to bromides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 2,5-Dibromo-3,4-dinitrothiophene, and the molecular formula is C4Br2N2O4S, Computed Properties of 52431-30-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Iwamoto, Hiroaki published the artcileComputational design of high-performance ligand for enantioselective Markovnikov hydroboration of aliphatic terminal alkenes, Computed Properties of 76283-09-5, the publication is Nature Communications (2018), 9(1), 1-10, database is CAplus.

Finding optimal chiral ligands for transition-metal-catalyzed asym. reactions using trial-and-error methods is often time-consuming and costly, even if the details of the reaction mechanism are already known. Although modern computational analyses allow the prediction of the stereoselectivity, there are only very few examples for the attempted design of chiral ligands using a computational approach for the improvement of the stereoselectivity. Herein, authors report a systematic method for the design of chiral ligands for the enantioselective Markovnikov hydroboration of aliphatic terminal alkenes based on a computational and exptl. evaluation sequence. Authors also developed a three-hindered-quadrant P-chirogenic bisphosphine ligand that was designed in accordance with the design guidelines derived from this method, which allowed the Markovnikov hydroboration to proceed with high enantioselectivity (up to 99% ee).

Nature Communications published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Computed Properties of 76283-09-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Matsunaga, Yoichiro published the artcileReactions of 3-isopropenyl- and 3-acetyltropolone with quaternary ammonium tribromides, Related Products of bromides-buliding-blocks, the publication is Bulletin of the Chemical Society of Japan (1992), 65(1), 295-7, database is CAplus.

Treatments of 3-isopropenyltropolone (I) with quaternary ammonium tribromides in THF afforded 3-methyl-8H-cyclohepta[b]furan-8-one (II). The reactions in methanol-dichloromethane gave 7-bromo-3-methyl-8H-cyclohepta[b]furan-8-one. Bromination of 3-acetyltropolone with the tribromides in THF produced 3-(bromoacetyl)tropolone, whereas the reaction in the methanolic solvent gave 7-bromo- and 5,7-dibromo-substituted 3-acetyltropolones. The brominations of 4′-hydroxyacetophenone were also carried out.

Bulletin of the Chemical Society of Japan published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Doba, Takahiro published the artcileIron-catalysed regioselective thienyl C-H/C-H coupling, Computed Properties of 303734-52-3, the publication is Nature Catalysis (2021), 4(7), 631-638, database is CAplus.

Regioselective thienyl-thienyl coupling is arguably one of the most important transformations for organic electronic materials. A prototype of ideal organic synthesis to couple two thienyl groups by cutting two C-H bonds requires formal removal of two hydrogen atoms with an oxidant, which often limits the synthetic efficiency and versatility for oxidation-sensitive substrates (for example, donor and hole-transporting materials). Here, we found that di-Et oxalate, used together with AlMe3, acts as a two-electron acceptor in an iron-catalyzed C-H activation. We describe the regioselective thienyl C-H/C-H coupling with an iron(III) catalyst, a trisphosphine ligand, AlMe3 and di-Et oxalate under mild conditions. The efficient catalytic system accelerated by ligand optimization polymerizes thiophene-containing monomers into homo- and copolymers bearing a variety of electron-donative π motifs. The findings suggest the versatility of iron catalysis for the synthesis of functional polymers, for which the potential of this ubiquitous metal has so far not been fully appreciated.

Nature Catalysis published new progress about 303734-52-3. 303734-52-3 belongs to bromides-buliding-blocks, auxiliary class Thiophene,Bromide, name is 2-Bromo-3-(2-ethylhexyl)thiophene, and the molecular formula is C12H19BrS, Computed Properties of 303734-52-3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Liu, Juncheng published the artcileInvestigation on the solubilization of organic dyes and micro-polarity in AOT water-in-CO₂ microemulsions with fluorinated co-surfactant by using UV-Vis spectroscopy, SDS of cas: 518-67-2, the publication is Journal of Supercritical Fluids (2004), 32(1-3), 97-103, database is CAplus.

It was found that the dyes thymol blue, dimidium bromide, and methyl orange, which are not soluble in pure supercritical CO₂, could be conveniently solubilized in AOT water-in-CO₂ reverse microemulsions with 2,2,3,3,4,4,5,5-octafluoro-1-pentanol as co-surfactant. The solubilities of the dyes in the microemulsions were measured successfully by using a UV-visible spectroscopy method newly established in our laboratory; besides that, for a given temperature, a critical micelle pressure at which formation of AOT water-in-CO₂ reverse micelles starts, was determined in term of the effect of pressure on the absorption intensity of the dyes in the microemulsions. Furthermore, the micro-polarity environment of the AOT water-in-CO₂ reverse microemulsions was investigated systematically according to the shift of the solvatochromic probes methyl orange and dimidium bromide with varying water content by using UV-visible spectroscopy.

Journal of Supercritical Fluids published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, SDS of cas: 518-67-2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Oh, Soo-Jin published the artcileMONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1, Name: 1,3-Dibromonaphthalene, the publication is Molecular Pharmacology (2013), 84(5), 726-735, database is CAplus and MEDLINE.

Transmembrane protein with unknown function 16/anoctamin-1 (ANO1) is a protein widely expressed in mammalian tissues, and it has the properties of the classic calcium-activated chloride channel (CaCC). This protein has been implicated in numerous major physiol. functions. However, the lack of effective and selective blockers has hindered a detailed study of the physiol. functions of this channel. In this study, we have developed a potent and selective blocker for endogenous ANO1 in Xenopus laevis oocytes (xANO1) using a drug screening method we previously established. We have synthesized a number of anthranilic acid derivatives and have determined the correlation between biol. activity and the nature and position of substituents in these derived compounds A structure-activity relationship revealed novel chem. classes of xANO1 blockers. The derivatives contain a -NO₂ group on position 5 of a naphthyl group-substituted anthranilic acid, and they fully blocked xANO1 chloride currents with an IC₅₀ < 10 μM. The most potent blocker, N-((4-methoxy)-2-naphthyl)-5-nitroanthranilic acid (MONNA), had an IC₅₀ of 0.08 μM for xANO1. Selectivity tests revealed that other chloride channels such as bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator were not appreciably blocked by 10∼30 μM MONNA. The potent and selective blockers for ANO1 identified here should permit pharmacol. dissection of ANO1/CaCC function and serve as potential candidates for drug therapy of related diseases such as hypertension, cystic fibrosis, bronchitis, asthma, and hyperalgesia.

Molecular Pharmacology published new progress about 52358-73-3. 52358-73-3 belongs to bromides-buliding-blocks, auxiliary class Bromide,Naphthalene, name is 1,3-Dibromonaphthalene, and the molecular formula is C10H6Br2, Name: 1,3-Dibromonaphthalene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

He, Yali published the artcilePyrazol-1-yl-propanamides as SARD and Pan-Antagonists for the Treatment of Enzalutamide-Resistant Prostate Cancer, Related Products of bromides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2020), 63(21), 12642-12665, database is CAplus and MEDLINE.

We report herein the design, synthesis, and pharmacol. characterization of a library of novel aryl pyrazol-1-yl-propanamides as selective androgen receptor degraders (SARDs) and pan-antagonists that exert broad-scope AR antagonism. Pharmacol. evaluation demonstrated that introducing a pyrazole moiety as the B-ring structural element in the common A-ring-linkage-B-ring nonsteroidal antiandrogens’ general pharmacophore allowed the development of a new scaffold of small mols. with unique SARD and pan-antagonist activities even compared to our recently published AF-1 binding SARDs such as UT-155 and UT-34. Novel B-ring pyrazoles exhibited potent AR antagonist activities, including promising distribution, metabolism, and pharmacokinetic properties, and broad-spectrum AR antagonist properties, including potent in vivo antitumor activity. I was able to induce an 80% tumor growth inhibition of xenografts derived from the enzalutamide-resistant (Enz-R) VCaP cell line. These results represent an advancement toward the development of novel AR antagonists for the treatment of Enz-R prostate cancer.

Journal of Medicinal Chemistry published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Williams, Sierra J. published the artcileOrthogonal bioluminescent probes from disubstituted luciferins, COA of Formula: C10H16Br3N, the publication is Biochemistry (2021), 60(8), 563-572, database is CAplus and MEDLINE.

Bioluminescence imaging with luciferase-luciferin pairs is routinely used to monitor cellular functions. Multiple targets can be visualized in tandem using luciferases that process unique substrates, but only a handful of such orthogonal probes are known. Multiplexed studies require addnl. robust, light-emitting mols. In this work, we report new luciferins for orthogonal imaging that comprise disubstituted cores. These probes were found to be bright emitters with various engineered luciferases. The unique patterns of light output also provided insight into enzyme-substrate interactions necessary for productive emission. Screening studies identified mutant luciferases that could preferentially process the disubstituted analogs, enabling orthogonal imaging with existing bioluminescent reporters. Further mutational analyses revealed the origins of substrate selectivity. Collectively, this work provides insights into luciferase-luciferin features relevant to bioluminescence and expands the number of probes for multicomponent tracking.

Biochemistry published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C6H6N2O, COA of Formula: C10H16Br3N.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wan, Honghe published the artcileBenzo[d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)-Hit to Lead studies, Synthetic Route of 53484-26-7, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(17), 5063-5066, database is CAplus and MEDLINE.

Hit to Lead optimization and SAR development led to the identification of the potent and selective benzo[d]imidazole inhibitor (17b)(I) of Co-activator Associated Arginine Methyltransferase (CARM1).

Bioorganic & Medicinal Chemistry Letters published new progress about 53484-26-7. 53484-26-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Nitro Compound,Amine,Benzene, name is 4-Bromo-N-methyl-2-nitroaniline, and the molecular formula is C6H7BFNO2, Synthetic Route of 53484-26-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary