Month: November 2022

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Organic compounds having carbon bonded to bromine are called organic bromides. Product Details of C6H7BrN2.

Zhou, L.-H.;Jin, Y.-J.;Ma, L.-F.;Huang, W.-H.;Wu, Y. research published 《 Highly Efficient and Catalyst-Free Synthesis of Benzimidazoles in Aqueous Media》, the research content is summarized as follows. A convenient and highly efficient, catalysts-free synthesis of benzimidazoles in an aqueous medium were developed. The conditions of the synthesis were optimized and its scope was successfully extended to various substrates with good to excellent yields. The exptl. procedure was simple and the products were isolated by filtration followed by recrystallization from water.

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Product Details of C6H7BrN2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 70-23-5, formula is C5H7BrO3, The most pervasive is the naturally produced bromomethane. HPLC of Formula: 70-23-5

Zhou, Kehan;Geng, Jingyao;Wang, Dongjie;Zhang, Jingyu;Zhao, Yingsheng research published 《 An Indirect Strategy for Trifluoromethylation via an Iridium Catalyst: Approach to Generate Isocoumarin Skeletons in Bioactive Molecules》, the research content is summarized as follows. 3-Bromo-1,1,1-trifluoroacetone was first disclosed as an effective indirect trifluoromethylation reagent to construct the important 3-trifluoromethyl isocoumarin skeleton. The reaction proceeds through a ligand-promoted, iridium-catalyzed ortho-selective C-H alkylation of benzoic acid and an intermol. cyclization reaction promoted by silver acetate. A wide range of 3-trifluoromethyl isocoumarins can be easily obtained in moderate to good yields. Importantly, the isocoumarin skeleton can be easily formed in bioactive compounds, highlighting the importance of this reaction.

70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., HPLC of Formula: 70-23-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 1575-37-7, formula is C6H7BrN2, The most pervasive is the naturally produced bromomethane. Quality Control of 1575-37-7

Zhou, Jie;Yu, Tao;Li, Ke;Zeng, Kai;Yang, Guo-Ping;Hu, Chang-Wen research published 《 Two U(VI)-Containing Silicotungstates with Sandwich Structures: Lewis Acid-Base Synergistic Catalyzed Synthesis of Benzodiazepines and Pyrazoles》, the research content is summarized as follows. Two new U(VI)-containing silicotungstates with similar sandwiched polyanions but different space structures, two-dimensional (2D) Na_10.5H_3.5(H₂O)₃₆[Na(UO₂)(α-SiW₉O₃₄)]₂·2.5H₂O (1) and three-dimensional (3D) Na₁₄(H₂O)₃₆[Na(UO₂)(α-SiW₉O₃₄)]₂·4H₂O (2), were synthesized by the reactions of UO₂(OAc)₂ and Na₁₀[α-SiW₉O₃₄]·18H₂O in aqueous solution with different pH. Structure analyses demonstrated that different reaction conditions may provide different self-assembly condition and result in the different coordination environments of Na(I)-H₂O clusters with different disorders, which are the keys for the differences between 1 and 2. Compound 2 was demonstrated to show excellent catalytic activity for the synthesis of 3H-benzo[b][1,4]diazepines and pyrazoles via the intermol. cyclization reactions, and the yields of desired products were up to 99%. This work represents a case of the catalytic properties for U(VI)-containing POMs.

Quality Control of 1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., 1575-37-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 19111-87-6, formula is C18H11Br, Name is 2-Bromotriphenylene. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Electric Literature of 19111-87-6.

Zhou, Hui;Bae, Han Yong;Leutzsch, Markus;Kennemur, Jennifer L.;Becart, Diane;List, Benjamin research published 《 The Silicon-Hydrogen Exchange Reaction: A Catalytic σ-Bond Metathesis Approach to the Enantioselective Synthesis of Enol Silanes》, the research content is summarized as follows. The use of chiral enol silanes in fundamental transformations such as Mukaiyama aldol-, Michael-, and Mannich reactions, as well as Saegusa-Ito dehydrogenations, has enabled the chem. synthesis of enantiopure natural products and valuable pharmaceuticals. However, accessing these intermediates in high enantiopurity has generally required the use of either stoichiometric chiral precursors or stoichiometric chiral reagents. The authors now describe a catalytic approach in which strongly acidic and confined imidodiphosphorimidates (IDPi) catalyze highly enantioselective interconversions of ketones and enol silanes. These Si-H exchange reactions enable access to enantiopure enol silanes via tautomerizing σ-bond metatheses, either in a deprotosilylative desymmetrization of ketones with allyl silanes as the Si source, or in a protodesilylative kinetic resolution of racemic enol silanes with a carboxylic acid as the silyl acceptor.

19111-87-6, 2-Bromotriphenylene is a useful research compound. Its molecular formula is C18H11Br and its molecular weight is 307.2 g/mol. The purity is usually 95%.
2-Bromotriphenylene is a brominating agent that has the ability to react with sodium carbonate and emit light. The luminescence of 2-bromotriphenylene can be used as an indicator of the degree of dilution, or how much water is present in a solution. It also emits light when it reacts with chloride ions in a reaction solution. 2-Bromotriphenylene can be used as a polymer matrix to form polymeric films, which are then used as catalysts for organic reactions. The luminescence properties of 2-bromotriphenylene make it suitable for use in functional theory experiments. This chemical compound is relatively low cost, and has been shown to have high yield in catalysis., Electric Literature of 19111-87-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Formula: C7H5BrO2.

Zhou, Guanyu;Huang, Zhibin;Xu, Xu;Fang, Zhang;Huang, Pengcheng;Deng, Zefeng;Li, Bao;Zhao, Yingsheng research published 《 Rhodium(III)-Catalyzed Synthesis of Quinazolin-4(3H)-ones with N-Methoxyamides as Synthesis Reagents》, the research content is summarized as follows. A practical method to synthesize quinoxalinones I [R = H, 6-Me, 7-Et, etc.; R¹ = H, 3-Br, 3-MeO, etc.] via intra/intermol. amination using rhodium as the catalyst was developed. A wide variety of quinoxalinones I were prepared from N-methoxybenzamides in moderate to excellent yields. Gram-scale reactions were also achieved, highlighting the synthetic importance of this new transformation.

Formula: C7H5BrO2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Recommanded Product: 4-Bromo-N-methylaniline.

Zhou, Cong;Li, Miao;Sun, Jianwei;Cheng, Jiang;Sun, Song research published 《 Photoredox-Catalyzed α-Aminomethyl Carboxylation of Styrenes with Sodium Glycinates: Synthesis of γ-Amino Acids and γ-Lactams》, the research content is summarized as follows. A visible-light photoredox-catalyzed reductive α-aminomethyl carboxylation of styrenes and 1,1-diarylalkenes with sodium N-arylglycinates and CO₂ has been developed to synthesize a series of α,α-disubstituted γ-amino acids such as MePhNCH₂CH₂CPh₂CO₂H and γ-lactams such as 1,3,3-triphenyl-2-pyrrolidinone with high efficiency and regioselectivity. Notably, CO₂ released from the decarboxylation step can be reused for the subsequent carboxylation. Distinct from the previous reactions with the same type of substrates leading to simple decarboxylation and olefin hydroalkylation, this process involves addnl. CO₂ sequestration, thus leading to olefin α-aminomethyl carboxylation. These findings not only provide new access to α,α-disubstituted γ-amino acids and γ-lactams but also serve as a proof of concept for CO₂ reutilization in decarboxylation reactions.

6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., Recommanded Product: 4-Bromo-N-methylaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Application of C7H8BrN.

Zhou, Chao-Zheng;Zhao, Yu-Rou;Tan, Fang-Fang;Guo, Yan-Jun;Li, Yang research published 《 Utilization of renewable formic acid from lignocellulosic biomass for the selective hydrogenation and/or N-methylation》, the research content is summarized as follows. Herein, the utilization of renewable formic acid from lignocellulosic biomass as a hydrogen source and a carbon source for the selective hydrogenation and further N-methylation of various quinolines and the derivatives I (Y = CH, N; R = H, 6-Br, 2,3-(Me)₂, 6-Cl, etc.), 1,10-phenanthroline, 2,9-dimethyl-1,10-phenanthroline and 2,7-dimethyl-pyrido[2,3-g]quinoline, various indoles II (R¹ = 2-Me, 5-Br, 6-F, etc.) under mild conditions in high efficiencies were developed. N-methylation of various anilines R²C₆H₄NHCH₃ (R² = H, 2-Cl, 3-Me, 4-OMe, etc.) and R²C₆H₄NH₂ is also developed. Mechanistic studies indicate that the hydrogenation occurs via a transfer hydrogenation pathway.

6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., Application of C7H8BrN

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Product Details of C6H6BBrO2.

Zhong, Jing;Zhou, Wuxin;Yan, Xufei;Xia, Ying;Xiang, Haifeng;Zhou, Xiangge research published 《 Selective Activation of Unstrained C(O)-C Bond in Ketone Suzuki-Miyaura Coupling Reaction Enabled by Hydride-Transfer Strategy》, the research content is summarized as follows. A Rh(I)-catalyzed ketone Suzuki-Miyaura coupling reaction of benzylacetone with arylboronic acids RB(OH)₂ (R = Ph, 4-methoxyphenyl, naphthalen-2-yl, etc.) is developed. Selective C(O)-C bond activation, which employs aminopyridine as temporary directing group (TDG) and Et vinyl ketone as hydride acceptor, occurs on the alkyl chain containing β-position hydrogen. A series of acetophenone products CH₃C(O)R was obtained in yields up to 75%.

Product Details of C6H6BBrO2, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Synthetic Route of 5392-10-9.

Zhong, Jiankai;Hu, Rui;Sang, Jingjing;Rao, Weidong research published 《 Gold(I)-catalyzed intramolecular [4 + 2] cycloaddition of ortho-(N-tethered 1,6-diynyl)benzaldehydes to 3,4-dihydrobenzo[f]isoquinolin-1(2H)-ones》, the research content is summarized as follows. An efficient synthetic method to prepare 3,4-dihydrobenzo[f]isoquinolin-1(2H)-ones such as I [R¹ = H, F, Ph, etc.; R² = H, Me, Cl, etc.; R³ = H, OMe, Ph; R⁴ = Ts, Bs; R⁵ = H, Me, octyl, etc.; R¹R² = OCH₂O] through gold(I)-catalyzed intramol. [4 + 2] benzannulation of ortho-(N-tethered 1,6-diynyl)benzaldehydes at a low catalyst loading of 2 mol% was described. The product of 3,4-dihydrobenzo[f]isoquinolin-1(2H)-ones I could be easily transformed to benzo[f]isoquinolin-1-ols by simply treating with phenylmagnesium bromide under mild conditions. The structures of compounds I [R¹ = H, R² = H, R³ = H, R⁴ = Ts, R⁵ = Me] and I [R¹ = H, R² = H, R³ = Ph, R⁴ = Ts, R⁵ = H] were also ascertained by X-ray crystallog. anal.

Synthetic Route of 5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Organobromine compounds have fallen under increased scrutiny for their environmental impact., COA of Formula: C5H9BrO2.

Zhong, Dayou;Wu, Di;Zhang, Yan;Lu, Zhiwu;Usman, Muhammad;Liu, Wei;Lu, Xiuqiang;Liu, Wen-Bo research published 《 Synthesis of Sultams and Cyclic N-Sulfonyl Ketimines via Iron-Catalyzed Intramolecular Aliphatic C-H Amidation》, the research content is summarized as follows. Cyclic sulfonamides (sultams) play a unique role in drug discovery and synthetic chem. A direct synthesis of sultams by an intramol. C(sp³)-H amidation reaction using an iron complex in situ derived from Fe(ClO₄)₂ and aminopyridine ligand is reported. This strategy features a readily available catalyst and tolerates a broad variety of substrates as demonstrated by 22 examples (up to 89% yield). A one-pot iron-catalyzed amidation/oxidation procedure for the synthesis of cyclic N-sulfonyl ketimines is also realized with up to 92% yield (eight examples). The synthetic utility of the method is validated by a gram-scale reaction and derivatization of the products to ring-fused sultams.

4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., COA of Formula: C5H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary