Month: November 2022

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate, Electric Literature of 4897-84-1

Zhang, Xinyu;Sivaguru, Paramasivam;Zanoni, Giuseppe;Han, Xinyue;Tong, Minghui;Bi, Xihe research published 《 Catalytic Asymmetric C(sp³)-H Carbene Insertion Approach to Access Enantioenriched 3-Fluoroalkyl 2,3-Dihydrobenzofurans》, the research content is summarized as follows. A rhodium-catalyzed enantioselective intramol. carbene insertion into ether α-C(sp³)-H bonds under mild conditions using the operationally safe and easily decomposable fluoroalkyl N-triftosylhydrazones 2-OCH₂R-4-R¹-5-R¹C₆H₂C(=NNHTfs)CF₂R³ [R = cyclopropyl, CN, 4-fluorophenyl, etc.; R¹ = H, OMe; R² = H, Me, Br, NO₂, etc.; R³ = F, CF₃, COOEt] as the carbene source was reported. This method enables the efficient synthesis of a range of previously inaccessible chiral fluoroalkyl 2,3-dihydrobenzofuran derivatives I in good to high yield with excellent diastereoselectivity and high enantioselectivity. The usefulness of this transformation is exemplified in the straightforward synthesis of several CF₃-analogs of natural products and bioactive mols. DFT calculations provide insights into the underlying stepwise pathway and the origin of enantioselectivity.

Electric Literature of 4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Formula: C7H5BrO2.

Zhang, Xing Xing;Diao, Liang Zhuo;Chen, Liu Zeng;Ma, Duo;Wang, Yu Meng;Jiang, Han;Ruan, Ban Feng;Liu, Xin Hua research published 《 Discovery of 4-((E)-3,5-dimethoxy-2-((E)-2-nitrovinyl)styryl)aniline derivatives as potent and orally active NLRP3 inflammasome inhibitors for colitis》, the research content is summarized as follows. A series of pterostilbene derivatives I [R¹ = tert-Bu, Ph, 2-furyl, etc] were designed and synthesized based on previous SAR, leading to discovery of new effective NLRP3 inflammasome inhibitors with metabolic stability. Among them, the most effective compound I [R¹ = 2-furyl] showed high inhibitory efficacy (against IL-1 β: IC₅₀ = 1.23μM) and almost no toxicity (against IL-1 b: IC₅₀ > 100μM). Further mechanism studies have showed that compound I [R¹ = 2-furyl] directly targets the NLRP3 and affects the assembly of inflammasomes to inhibit the activation of NLRP3 inflammasomes. More importantly, in vitro experiments show that compound I [R¹ = 2-furyl] has a significant therapeutic effect on DSS-induced colitis in mice with good metabolic stability to liver microsomes (t_1/2 = 138.6 min). This research encourages the further development of more effective NLRP3 inflammasome inhibitors based on this chem. scaffold.

Formula: C7H5BrO2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Product Details of C6H7BrN2.

Zhang, Xiao;Li, Jiao-Yang;Zhang, Kai;Ding, Lei;Wang, Chuan-Kui;Fung, Man-Keung;Fan, Jian research published 《 Highly efficient thermally activated delayed fluorescence emitters with suppressed energy loss and a fast reverse intersystem crossing process》, the research content is summarized as follows. Thermally activated delayed fluorescence (TADF) emitters with low non-radiative decay and a fast reverse intersystem crossing (RISC) process are highly desirable for achieving efficient organic light-emitting diodes (OLEDs). This work revealed the excited-state structural relaxation induced emission behavior of the frequently used donor unit, spiro[acridine-9,9′-fluorene] (spAc). This structural change at the excited state from bent conformation to planar conformation was suppressed greatly by doping the emitter in a solid matrix, thus avoiding the non-radiative energy loss and enhancing the utilization of excitons. Furthermore, the spAc-based emitters achieved small ΔE(¹CT-³CT) and ΔE(³LE-³CT) with the aid of the robust configuration design, thus promoting a fast RISC process up to 1.69 x 10⁶ s^-1. As a result, these TADFs demonstrated excellent photoluminescence quantum yields (PLQYs) in the range of 91.0-98.2%. OLEDs based on BPCN-spAc showed a state-of-the-art efficiency with an external quantum efficiency (EQE) of nearly 30% and power efficiency (PE) over 80 lm W^-1 at 592 nm. This study deepened the understanding of the luminescent behavior of robust TADF emitters in solution and in the solid state, which could provide helpful guidance for the design of efficient TADF materials.

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Product Details of C6H7BrN2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Application of C4H7BrO2.

Zhang, Xiaheng;Smith, Russell T.;Le, Chip;McCarver, Stefan J.;Shireman, Brock T.;Carruthers, Nicholas I.;MacMillan, David W. C. research published 《 Copper-mediated synthesis of drug-like bicyclopentanes》, the research content is summarized as follows. Multicomponent reactions are relied on in both academic and industrial synthetic organic chem. owing to their step- and atom-economy advantages over traditional synthetic sequences¹. Recently, bicyclo[1.1.1]pentane (BCP) motifs have become valuable as pharmaceutical bioisosteres of benzene rings, and in particular 1,3-disubstituted BCP moieties have become widely adopted in medicinal chem. as para-Ph ring replacements². These structures are often generated from [1.1.1]propellane via opening of the internal C-C bond through the addition of either radicals or metal-based nucleophiles^3-13. The resulting propellane-addition adducts are then transformed to the requisite polysubstituted BCP compounds via a range of synthetic sequences that traditionally involve multiple chem. steps. Although this approach was effective so far, a multicomponent reaction that enables single-step access to complex and diverse polysubstituted drug-like BCP products would be more time efficient compared to current stepwise approaches. Here the authors report a one-step three-component radical coupling of [1.1.1]propellane to afford diverse functionalized bicyclopentanes using various radical precursors and heteroatom nucleophiles via a metallaphotoredox catalysis protocol. This copper-mediated reaction operates on short timescales (five minutes to one hour) across multiple (more than ten) nucleophile classes and can accommodate a diverse array of radical precursors, including those that generate alkyl, α-acyl, trifluoromethyl and sulfonyl radicals. This method was used to rapidly prepare BCP analogs of known pharmaceuticals, one of which is substantially more metabolically stable than its com. progenitor.

5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., Application of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 20469-65-2, formula is C8H9BrO2, Name is 1-Bromo-3,5-dimethoxybenzene. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. COA of Formula: C8H9BrO2.

Zhang, Song;Feng, Zhenghuai;Jiang, Chunhui;Yu, Xiaojun;Pan, Jianke;Du, Juan;Jiang, Zhiyu;Chen, Yuan;Wang, Tianli research published 《 Highly Enantioselective Synthesis of Phosphorus-Containing ε-Benzosultams by Bifunctional Phosphonium Salt-Promoted Hydrophosphonylation》, the research content is summarized as follows. ε-Benzosultam derivatives are potential drug candidates with diverse biol. activities. A series of chiral ε-benzosultams bearing phosphorus functionalities was synthesized by catalytic asym. hydrophosphonylation in the presence of a bifunctional phosphonium salt catalyst. The desired hydrophosphonylation products were obtained in good yields with high enantioselectivities, and scale-up reactions and further derivations were successfully accomplished. Some control experiments were also conducted to elucidate the plausible reaction mechanism of this chem. transformation.

20469-65-2, 1-Bromo-3,5-dimethoxybenzene, also known as 1-Bromo-3,5-dimethoxybenzene, is a useful research compound. Its molecular formula is C8H9BrO2 and its molecular weight is 217.06 g/mol. The purity is usually 95%.
1-Bromo-3,5-dimethoxybenzene is used as an intermediate in the synthetic preparation of pharmaceutical inhibitors via cross-coupling reactions.
1-Bromo-3,5-dimethoxybenzene can be synthesized by using 1,3-dimethoxybenzene via iridium-catalyzed arene borylation.
1-Bromo-3,5-dimethoxybenzene (1BDMB) is a synthetic molecule that can be used as an electron acceptor in organic photovoltaic cells. 1BDMB is a salt of the sodium salt of resorcylic acid and 1,3-dibromo-5,5-dimethoxybenzene. It has been shown to have a radical mechanism for the generation of free radicals. The radical mechanism is initiated by light absorption by the ruthenium complex at the center of the molecule which induces photoinduced electron transfer from the ruthenium to 1BDMB. This process results in electron transfer from the donor to an acceptor molecule, such as oxygen or nitrogen. The pharmacokinetic properties of this compound are not well known; however, it has been demonstrated that it can be synthesized through a cross-coupling reaction with other aromatic compounds such as stemofuran., COA of Formula: C8H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Synthetic Route of 2576-47-8.

Zhang, Shuying;Wang, Jiaomei;Liu, Xiangxue;Wang, Ke;Zhang, Chao;Song, Hongbing;Guo, Zhenmei;Lv, Zhiguo research published 《 Synthesis of 2,2,4-trimethyl-1, 3-pentaerediol monoisobutyrate catalyzed by homogeneous catalysis-liquid/liquid separation catalytic system based on Bibasic sites Ionic Liquids》, the research content is summarized as follows. Herein a novel homogeneous catalysis-liquid/liquid separation catalytic system based on 1,8-diazabicyclo-[5.4.0]undec-7-ene (DBU)-functionalized, 1,1,3,3-tetra-Me guanidine-functionalized and imidazolium-functionalized bibasic sites ionic liquids (BSILs) ([HDBU]IM, [Aemim]IM, [TMG]IM, [Aemim]Pro, [Aemim]Gly, [HDBU]Pro and [HDBU]Gly) with a room temperature liquid/liquid phase transition characteristic were reported. And for the first time, this novel catalytic system was employed for the synthesis of 2,2,4-trimethyl-1,3-pentanediol 1-isobutyrate, achieving homogeneous catalysis, easy recycling and long service-life of the catalyst. Addnl., the mechanism of homogeneous catalysis-biphasic separation was explained by the solubility of reactant and product in BSILs/H₂O catalytic system and the existence H-bonding between BSILs and H₂O. Bibasic sites were confirmed by two endothermic peaks on the TG-DCS curve of [Aemim]IMC (the CO₂ captured by [Aemim]IM).

Synthetic Route of 2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., 2576-47-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 823-78-9, formula is C7H6Br2, Name is 1-Bromo-3-(bromomethyl)benzene. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Application In Synthesis of 823-78-9.

Zhang, Shuai;Xiao, Jun-Zhao;Li, Yan-Bo;Shi, Chang-Yun;Yin, Liang research published 《 Copper(I)-Catalyzed Asymmetric Alkylation of Unsymmetrical Secondary Phosphines》, the research content is summarized as follows. A Cu(I)-catalyzed asym. alkylation of HPAr¹Ar² with alkyl halides is uncovered, which provides an array of P-stereogenic phosphines in generally high yield and enantioselectivity. The electrophilic alkyl halides enjoy a broad substrate scope, including allyl bromides, propargyl bromide, benzyl bromides, and alkyl iodides. Also, 11 unsym. diarylphosphines (HPAr¹Ar²) serve as competent pronucleophiles. The present methodol. is also successfully applied to catalytic asym. double and triple alkylation, and the corresponding products were obtained in moderate diastereo- and excellent enantioselectivities. Some ³¹P NMR experiments indicate that bulky HPPhMes exhibits weak competitively coordinating ability to the Cu(I)-bisphosphine complex, and thus the presence of stoichiometric HPAr¹Ar² does not affect the enantioselectivity significantly. Therefore, the high enantioselectivity in this reaction is attributed to the high performance of the unique Cu(I)-(R,R_P)-TANIAPHOS complex in asym. induction. Finally, one monophosphine and two bisphosphines prepared by the present reaction are employed as efficient chiral ligands to afford three structurally diversified Cu(I) complexes, which demonstrates the synthetic utility of the present methodol.

Application In Synthesis of 823-78-9, 3-Bromobenzyl bromide undergoes reduction with diethylzinc in the presence of Pd(PPh3)4 to yield corresponding hydrocarbon.

3-Bromobenzyl bromide is a useful research compound. Its molecular formula is C7H6Br2 and its molecular weight is 249.93 g/mol. The purity is usually 95%.

3-Bromobenzyl bromide is a molecule that has been synthesized and shown to have anticancer activity. It inhibits the activity of cancer cells by binding to amines in these cells and preventing the formation of hydrogen bonds between these molecules. 3-Bromobenzyl bromide has also been shown to selectively inhibit the activity of NS5B polymerase, an enzyme that is important in the replication of the hepatitis C virus. The synthetic nature of this molecule makes it an attractive target for analytical methods such as nuclear magnetic resonance spectroscopy. This molecule also shows significant cytotoxicity against cancer cell lines in vitro, as well as inducing tumor necrosis factor-alpha (TNF-α) production in lps-stimulated murine macrophages., 823-78-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 823-78-9, formula is C7H6Br2, Name is 1-Bromo-3-(bromomethyl)benzene. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Electric Literature of 823-78-9.

Zhang, Rongyi;Li, Qigang;Xie, Qiqiang;Ni, Chuanfa;Hu, Jinbo research published 《 Difluorocarbene-Induced Ring-Opening Difluoromethylation-Halogenation of Cyclic (Thio)Ethers with TMSCF₂X (X=Br, Cl)》, the research content is summarized as follows. The ring-opening difluoromethylation-halogenation of cyclic (thio)ethers is reported through a simple strategy relying on carbon-chalcogen bond activation with difluorocarbene. The reaction proceeds through in situ protonation of the previously little-known difluoromethylene oxonium or sulfonium ylide intermediate followed by ring-opening with halide ion to afford halogenated acyclic difluoromethyl (thio)ethers that can then be employed for further elaboration. TMSCF₂X (X=Br, Cl) are unique reagents to achieve this synthetic purpose, which serve as both the difluorocarbene source and the halide ion source.

Electric Literature of 823-78-9, 3-Bromobenzyl bromide undergoes reduction with diethylzinc in the presence of Pd(PPh3)4 to yield corresponding hydrocarbon.

3-Bromobenzyl bromide is a useful research compound. Its molecular formula is C7H6Br2 and its molecular weight is 249.93 g/mol. The purity is usually 95%.

3-Bromobenzyl bromide is a molecule that has been synthesized and shown to have anticancer activity. It inhibits the activity of cancer cells by binding to amines in these cells and preventing the formation of hydrogen bonds between these molecules. 3-Bromobenzyl bromide has also been shown to selectively inhibit the activity of NS5B polymerase, an enzyme that is important in the replication of the hepatitis C virus. The synthetic nature of this molecule makes it an attractive target for analytical methods such as nuclear magnetic resonance spectroscopy. This molecule also shows significant cytotoxicity against cancer cell lines in vitro, as well as inducing tumor necrosis factor-alpha (TNF-α) production in lps-stimulated murine macrophages., 823-78-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Safety of (2-Bromophenyl)boronic acid.

Zhang, Qiaohong;Wang, Huibin;Hu, Wenkang;Xu, Xiaqing;Xu, Zhaojun;Chen, Chen;Wang, Dawei research published 《 The Cascade C-H functionalization with sequential hydroxylation and oxidation through heterogeneous BINAP-copper on hydrotalcite》, the research content is summarized as follows. A cascade C-H hydroxylation and further oxidation process, 2-sulfanylphenols 6-OH-R¹C₆H₃S(R² C₆H₄) (R¹ = H, 2-Br, 3-Br, 4-CF₃, etc.; R² = H, 2-OMe, 3-OMe, 4-F, etc.) and arylthioquinones I (R³ = H, 2,6-Cl₂, 3-Br, 4-tBu, etc.) use the heterogeneous catalyst [Cu(binap)I]₂@HT. The catalytic system was tolerant to various substituents including alkyl, alkoxy, ester, halogen or trifluoromethyl on the Ph ring of the thiophenols R¹C₆H₄SH/3-R⁴OC₆H₄SH (R⁴ = H, Me) or arylboronic acids R⁵B(OH)₂ (R⁵ = Ph, 4-ethoxyphenyl, 2,6-dichlorophenyl, etc.). In addition to electron-donating groups, the products with strong electron-withdrawing groups, such as Me formylate and trifluoromethyl also were achieved with good yields at 90°C for 12h (68% and 66%, resp.). Repeated experiment results showed that the catalyst could be reused at least five times without obvious decrease in catalytic activity.

Safety of (2-Bromophenyl)boronic acid, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Computed Properties of 402-49-3.

Zhang, Qiao;Wang, Simin;Zhang, Qian;Xiong, Tao research published 《 Radical Addition-Triggered Remote Migratory Isomerization of Unactivated Alkenes to Difluoromethylene-Containing Alkenes Enabled by Bimetallic Catalysis》, the research content is summarized as follows. A fascinating alkene remote migratory isomerization engendered by carbon radical addition to C=C bond in alkenes Ar(CH₂)_nCH=CH₂ (Ar = C₆H₅, 4-FC₆H₄, 2-pyridyl, etc.; n = 2, 4, 5, 6, 7) via bimetallic catalysis has been disclosed. A diverse array of alkenes bearing distantly incorporated the difluoromethylene ArCH=CH(CH₂)_mCF₂C(O)R (m = 1, 4, 5, 6, 9; R = OMe, OEt, morpholin-4-yl, etc.) functionality have been expediently obtained. The retainment of C=C bonds in products could serve as an useful synthetic platform furnishing otherwise difficult to access value-added densely functionalized difluoromethylene containing mols. In addition, some exptl. studies have been implemented to shed light on the probable mechanism.

Computed Properties of 402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., 402-49-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary