Month: November 2022

Organic compounds having carbon bonded to bromine are called organic bromides. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application In Synthesis of 244205-40-1.

Zhang, Meng-Yuan;Liang, Xiao;Ni, Dan-Ning;Liu, Di-Hong;Peng, Qian;Zhao, Cui-Hua research published 《 2-(Dimesitylboryl)phenyl-Substituted [2.2]Paracyclophanes Featuring Intense and Sign-Invertible Circularly Polarized Luminescence》, the research content is summarized as follows. A new type of [2.2]paracyclophanes that contain a 2-(dimesitylboryl)phenyl and a N,N-disubstituted amino groups at 2 different Ph rings is disclosed. They show intense circularly polarized luminescence combining high fluorescence efficiency (Φ_F) and luminescence dissymmetry factor (|g_lum|), which are ≤0.93 and ≤1.73 × 10^-2, resp. The pseudo-meta derivatives display solvent-induced CPL sign inversion owing to the solvent-dependent excited-state dynamics.

244205-40-1, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., Application In Synthesis of 244205-40-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 20469-65-2, formula is C8H9BrO2, Name is 1-Bromo-3,5-dimethoxybenzene, Formula: C8H9BrO2

Zhang, Lei;Liu, Chengyu;Yang, Lei;Cao, Liming;Liang, Chaoming;Sun, Maolin;Ma, Yueyue;Cheng, Ruihua;Ye, Jinxing research published 《 Synthesis of triarylphosphines from arylammonium salts via one-pot transition-metal-free C-P coupling》, the research content is summarized as follows. Reductive arylation of secondary diarylphosphine oxides Ar₂P(O)H was achieved by one-pot reaction with DIBAL-H and arylammonium salts [Ar¹NMe₃][OTf] in the presence of KO^tBu base and transition metal-free conditions affording triarylphosphines Ar₂PAr¹ with high yields. A nucleophilic aromatic substitution (S_NAr) reaction that allowed transition-metal-free C-P bond construction via C-N bond cleavage was developed. The coupling between aryltrimethylammonium salts and secondary phosphines from the in situ reduction of diarylphosphine oxides led to the formation of diverse triarylphosphines with various functional groups. This one-pot process was not only a pertinent S_NAr precedent but also a favorable transition-metal-free alternative for C-P coupling.

20469-65-2, 1-Bromo-3,5-dimethoxybenzene, also known as 1-Bromo-3,5-dimethoxybenzene, is a useful research compound. Its molecular formula is C8H9BrO2 and its molecular weight is 217.06 g/mol. The purity is usually 95%.
1-Bromo-3,5-dimethoxybenzene is used as an intermediate in the synthetic preparation of pharmaceutical inhibitors via cross-coupling reactions.
1-Bromo-3,5-dimethoxybenzene can be synthesized by using 1,3-dimethoxybenzene via iridium-catalyzed arene borylation.
1-Bromo-3,5-dimethoxybenzene (1BDMB) is a synthetic molecule that can be used as an electron acceptor in organic photovoltaic cells. 1BDMB is a salt of the sodium salt of resorcylic acid and 1,3-dibromo-5,5-dimethoxybenzene. It has been shown to have a radical mechanism for the generation of free radicals. The radical mechanism is initiated by light absorption by the ruthenium complex at the center of the molecule which induces photoinduced electron transfer from the ruthenium to 1BDMB. This process results in electron transfer from the donor to an acceptor molecule, such as oxygen or nitrogen. The pharmacokinetic properties of this compound are not well known; however, it has been demonstrated that it can be synthesized through a cross-coupling reaction with other aromatic compounds such as stemofuran., Formula: C8H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Name: 4-Bromobenzene-1,2-diamine.

Zhang, Kaiyue;Wang, Lanzhi research published 《 p-Toluenesulfonic acid catalyzed multi-component reaction to synthesize 1,5-benzodiazepine compounds containing indole ring》, the research content is summarized as follows. In this paper, five new 1,5-dihydrospiro[benzo[b][1,4]diazepine-2,3′-indoline] compounds with multi-ring systems and functional groups containing indolin, ester groups were obtained via three-component tandem reaction (michael addition, nucleophilic addition, dehydration, cyclization, proton transfer, etc.). These reactions were achieved by reaction of substituted o-phenylenediamine, Et propiolate and isatin with p-toluenesulfonic acid as catalyst in EtOH, which realized the construction of one new seven-membered ring and four new chem. bonds (one C-C, two C-N, one C=C) in one-pot. The advantages of this method consist of green reaction process, mild reaction conditions, short reaction time and good yields of products.

Name: 4-Bromobenzene-1,2-diamine, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., 1575-37-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid. Organic compounds having carbon bonded to bromine are called organic bromides. Application of C6H11BrO2.

Zhang, Jun;Zheng, Mengmeng;Yan, Jiayan;Deng, Zixin;Zhu, Dongqing;Qu, Xudong research published 《 A Permissive Medium Chain Acyl-CoA Carboxylase Enables the Efficient Biosynthesis of Extender Units for Engineering Polyketide Carbon Scaffolds》, the research content is summarized as follows. The selective incorporation of new-to-nature extender units into polyketide synthesis is a highly effective way to engineer their carbon scaffolds. Currently, most atypical extender units are biosynthesized via reductive carboxylation of α,β-unsaturated thioesters catalyzed by crotonyl-CoA reductase/carboxylases or thioesterification of malonates by malonyl-CoA ligases followed by epimerase catalyzed enantiomerization. In this study, we identified an unusual β-subunit (Arm13) of the acyl-CoA carboxylase (ACCase) from the biosynthesis of armeniaspirols. This β-subunit is permissive to the α- and ε-subunits of propionyl-CoA carboxylase to form a fully active ACCase. Distinct from the other regular ACCases in substrate specificity, this ACCase can directly carboxylate medium chain acyl-CoAs ranging from C6 to C9 either with or without terminal substituents, e.g., alkyne or Ph groups, to produce corresponding alkylmalonyl-CoAs with high catalytic efficiency. By harnessing the power of this ACCase in extender unit biosynthesis, we introduced structural variation into the carbon scaffold of armeniaspirols by feeding corresponding carboxylate precursors. These findings not only enrich the knowledge of the medium chain-specific ACCases but also provide an important biocatalyst for diversifying building blocks, which will greatly facilitate polyketide engineering.

4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., Application of C6H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Recommanded Product: 2-Bromo-4,5-dimethoxybenzaldehyde.

Zhang, Jitan;Xu, Qiaoqiao;Fan, Jian;Zhou, Lan;Liu, Nannan;Zhu, Li;Wu, Jiaping;Xie, Meihua research published 《 Pd(II)-Catalyzed enantioconvergent twofold C-H annulation to access atropisomeric aldehydes: a platform for diversity-oriented-synthesis》, the research content is summarized as follows. Herein, the first Pd(II)-catalyzed atroposelective dual C-H annulative strategy for the assembly of axially chiral aldehyde frameworks such as I [R = Me, Et, i-Pr] using com. available amino acid as the transient auxiliary and chiral pool was presented. This reaction accommodated a broad substrate scope to give atropisomeric aldehydes bearing both C-C and N-C chiral axes in good yields (up to 95%) with excellent enantioinduction (up to 99%). The utility of this synthetic methodol. was testified by various practical late-stage transformations, thereby accomplishing diversity-oriented synthesis of structurally diverse biaryl atropisomers and several functionalized axially chiral species such as bifunctional organocatalysts. Moreover, a series of mechanistic studies had provided more details for this catalytic transformation.

Recommanded Product: 2-Bromo-4,5-dimethoxybenzaldehyde, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Quality Control of 4224-70-8.

Zhang, Jian-Xin;Shu, Wei research published 《 Ni-Catalyzed Reductive 1,2-Cross-Dialkylation of Unactivated Alkenes with Two Alkyl Bromides》, the research content is summarized as follows. Herein, a Ni-catalyzed reductive 1,2-dialkylation of unactivated aliphatic alkenes had been developed using two different alkyl bromides to gave (cyanoethyl)-alkyl-aryl-propanamides R¹CH₂CHR²CH₂C(O)NHAr [R¹ = cyanomethyl, H₂CCO₂Et, (2-oxotetrahydrofuran-3-yl); R² = Et, n-Pr, 3-phenylpropyl, etc.; Ar = Ph, 4-MeC₆H₄, 3-MeOC₆H₄, etc.]. The reaction proceeded smoothly under mild conditions to install two Csp³-Csp³ bonds onto directed aliphatic alkenes, demonstrating excellent chemo- and regioselectivity with good functional group tolerance.

Quality Control of 4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Synthetic Route of 4897-84-1.

Zhang, Hualin;Xie, Ruliang;AI-furas, Hawaa;Li, Yupeng;Wu, Qingxia;Li, Jian;Xu, Fang;Xu, Tianfeng research published 《 Design, Synthesis, and Biological Evaluation of Novel EGFR PROTACs Targeting Del19/T790M/C797S Mutation》, the research content is summarized as follows. The tertiary epidermal growth factor receptor (EGFR) C797S mutation predominates in the acquired mutational resistance in cancer patients to third-generation EGFR inhibitors. Small-mol. inhibitors targeting the EGFR C797S mutation have been developed with good efficiency. However, these compounds may still induce new EGFR mutations to evade the inhibition pathway. One EGFR protein degrader based on an allosteric inhibitor has shown some benefits of degrading the EGFR L858R/T790M/C797S triple mutant. However, the degrader of the other important triple EGFR mutation Del19/T790M/C797S has not been reported. Here we present the design and synthesis of a series of EGFR proteolysis-targeting chimeras (PROTACs) that can rapidly and potently induce EGFR degradation in Ba/F3 cells expressing the EGFR^{Del19/T790M/C797S} mutant. One representative compound 6h time- and dose-dependently induced EGFR degradation with a DC₅₀ of 8 nM. It also showed good antiproliferation activity (IC₅₀ = 0.02μM) against Ba/F3-EGFR^{Del19/T790M/C797S} cells. 6h may serve as a lead compound to develop therapeutic agents for the treatment of resistant non-small cell lung cancer patients with EGFR C797S mutants.

Synthetic Route of 4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde, Application of C9H9BrO3

Zhang, Fulin;Zhao, Ruihua;Zhu, Lei;Yu, Yinghua;Liao, Saihu;Wang, Zhi-Xiang;Huang, Xueliang research published 《 Divergent isoindolinone synthesis through palladium-catalyzed isocyanide bridging C-H activation》, the research content is summarized as follows. An isocyanide-bridging C-H activation through the formation of a five-membered palladacycle was reported. As such, a proximal C-H bond in aldehyde moiety is activated selectively. The subsequent palladium shift and intramol. C=N bond insertion construct a valuable isoindolinone framework. Compared with conventional isocyanide-promoted C-H bond activation, both carbon and nitrogen atoms in isocyanide are engaged in new bond formations. Three types of isoindolinones I [R = t-Bu, cyclohexyl, Bn, etc.; R¹ = H, CN; R² = H, Bn, 2H-1,3-benzodioxol-5-ylmethyl, etc.; R³ = H, F, OMe, etc.; R⁴ = H, Cl, NH₂, etc.; R⁵ = H, Me, OTs, etc.; -R₄R₅– = -OCH₂O-; -R₅R₆– = -(CH)₄-; R⁶ = H, OMe, etc.] can be obtained selectively by variations of the reaction conditions. Mechanistic studies shed light on the reaction pathways. The synthetic potential of current methodol. is demonstrated by providing concise routes to key intermediates of indoprofen, indobufen, aristolactams, lennoxamine, and falipamil.

Application of C9H9BrO3, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide. Organic compounds having carbon bonded to bromine are called organic bromides. Application In Synthesis of 2576-47-8.

Zhang, Dongyu;Qu, Rong;Zhang, Haining;Zhang, Fangfang research published 《 Differentiation of Chemisorption and Physisorption of Carbon Dioxide on Imidazolium-type Poly(ionic liquid) Brushes》, the research content is summarized as follows. Amine-functionalized imidazolium-based poly(ionic liquid) brushes on mesoporous silica were synthesized via “grafting through” technique and were applied as model sorbents to understand physisorption and chemisorption of carbon dioxide mols. The exptl. results reveal that the total adsorption capacity of model sorbents derived from temperature programmed desorption (TPD) approach reaches 1.72 mmol·g-1 that is much higher than the sum of adsorption capacity of bare mesoporous silica and free polymers at 25°C under carbon dioxide partial pressure of 0.2 bar. The proposed phys. adsorption and chem. adsorption of carbon dioxide mols. in TPD response curves were validated by volumetric desorption measurement. It is also observed that phys. adsorption is completely reversible and chem. adsorption is irreversible. The results demonstrate that the temperature programmed desorption technique is an effective approach to differentiate chemisorption and physisorption of gaseous species on solid sorbents, which is beneficial for understanding of adsorption mechanism and materials design.

2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., Application In Synthesis of 2576-47-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. COA of Formula: C6H6BBrO2.

Zhang, Dejiang;Le, Liyuan;Qiu, Renhua;Wong, Wai-Yeung;Kambe, Nobuaki research published 《 Nickel- and Palladium-Catalyzed Cross-Coupling Reactions of Organostibines with Organoboronic Acids》, the research content is summarized as follows. A strategy for the formation of antimony-carbon bond was developed by nickel-catalyzed cross-coupling of halostibines. This method has been applied to the synthesis of various triaryl- and diarylalkylstibines from the corresponding cyclic and acyclic halostibines. This protocol showed a wide substrate scope (72 examples) and was compatible to a wide range of functional groups such as aldehyde, ketone, alkene, alkyne, haloarenes (F, Cl, Br, I), and heteroarenes. A successful synthesis of one arylated stibine in a scale of 34.77 g demonstrates high synthetic potential of this transformation. The formed stibines (R₃Sb) were then used for the palladium-catalyzed carbon-carbon bond forming reaction with aryl boronic acids [R-B(OH)₂], giving biaryls with high selectivity, even the structures of two organomoieties (R and R’) are very similar. Plausible catalytic pathways were proposed based on control experiments

COA of Formula: C6H6BBrO2, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary