Month: November 2022

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Organic compounds having carbon bonded to bromine are called organic bromides. SDS of cas: 5392-10-9.

Yu, Yinghua;Chakraborty, Pushkin;Song, Jinshuai;Zhu, Lei;Li, Chunsen;Huang, Xueliang research published 《 Easy access to medium-sized lactones through metal carbene migratory insertion enabled 1,4-palladium shift》, the research content is summarized as follows. Herein, a valuable strategy for medium-sized lactones e.g., dibenzo[b,e]oxepin-6(11H)-one synthesis by accomplishing site-selective C-H bond functionalization via a palladium carbene migratory insertion enabled 1,4-palladium shift was described. The overall process achieves the formal dimerization of two readily available benzaldehyde derivatives RCHO (R = 6-bromo-1,3-dihydro-2-benzofuran-5-yl, 1-bromonaphthalen-2-yl, 2-iodophenyl, etc.), providing value-added products medium-sized lactones. The method is amenable to late-stage modification of approved drugs and other complex mols. Mechanistic studies including deuterium-labeling experiments and DFT calculation shed light on the reaction pathways.

SDS of cas: 5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Recommanded Product: 2-Bromo-4,5-dimethoxybenzaldehyde.

Yu, Yinghua;Ma, Liyao;Xia, Jiajin;Xin, Luoting;Zhu, Lei;Huang, Xueliang research published 《 A Modular Approach to Dibenzo-fused ε-Lactams: Palladium-Catalyzed Bridging-C-H Activation》, the research content is summarized as follows. Tricyclic ring systems possessing a dibenzo structure joined to a seven-membered heterocyclic ring frequently show important biol. activities. However, a modular approach to these mols. based on efficient intermol. reaction of readily available chems. is lacking. Herein, an unprecedented palladium-catalyzed formal [4+3] annulation for modular construction of these tricyclic systems is described. This reaction features easily accessible reactants (o-haloarylaldehydes and N-tosylhydrazones), broad substrate scope, and excellent functional group compatibility. The synthetic potential is demonstrated by the easy scale-up reactions, late-stage modification of complex mols., and collective synthesis of bioactive mols. and approved drugs.

Recommanded Product: 2-Bromo-4,5-dimethoxybenzaldehyde, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Electric Literature of 70-23-5.

Yu, Ya’nan;Han, Yuqiao;Zhang, Fupo;Gao, Zhenmei;Zhu, Tong;Dong, Suzhen;Ma, Mingliang research published 《 Design, Synthesis, and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel PI3K/mTOR Dual Inhibitors》, the research content is summarized as follows. A series of imidazo[1,2-a]pyridine derivatives I [X = 2,4-F₂C₆H₃SO₂NH; R¹ = Me₂NCH₂CH₂, 2-HOC₆H₄, 2-(pyrrolidin-1-yl)ethyl, etc.], II [X as above; R² = Me₂NCH₂CH₂, 2-(4-methylpiperazin-1-yl)ethyl, 2-(morpholin-4-yl)ethyl, 3-(morpholin-4-yl)propyl] and III [R³ = Me₂NCH₂CH₂, 3-HO₂CC₆H₄, 2-thienyl, etc.; R⁴ = H, Cl, OMe; R⁵ = NH₂, NHSO₂Me, 2,4-F₂C₆H₃SO₂NH, etc.] was synthesized as phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors and subjected to pharmacokinetics, pharmacodynamics, mol. docking and antitumor activity assessment in vitro and in vivo. Result showed that, the compound III [R³ = 2-(4-methylpiperazin-1-yl)ethyl; R⁴ = OMe; R⁵ = 2,4-F₂C₆H₃SO₂NH] proved to be a potent PI3K/mTOR dual inhibitor with excellent mTOR kinase selectivity, modest plasma clearance and acceptable oral bioavailability. Furthermore, this compound displayed significant inhibition of tumor growth in HCT116 and HT-29 xenografts without obvious effect on body weight

70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., Electric Literature of 70-23-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Recommanded Product: 2-Bromo-4,5-dimethoxybenzaldehyde.

Yu, Shu-Yan;Gao, Li-Hong;Wu, Jing-Xin;Lan, Hong-Bing;Ma, Yi;Yin, Zhi-Gang research published 《 Regio- and stereoselective intramolecular hydroalkoxylation of aromatic alkynols: an access to dihydroisobenzofurans under transition-metal-free conditions》, the research content is summarized as follows. An efficient, transition-metal-free method to synthesize dihydroisobenzofuran derivatives via intramol. hydroalkoxylation of aromatic alkynols with the promotion of cesium carbonate has been developed. The reaction proceeds regioselectively with exclusive formation of 5-exo-dig product, and only Z-isomer of the new generated double bond is observed This new protocol features with milder reaction conditions, more convenient operation and satisfactory selectivities.

Recommanded Product: 2-Bromo-4,5-dimethoxybenzaldehyde, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Formula: C7H5BrO2.

Yu, Min;Wu, Chaolong;Zhou, Li;Zhu, Li;Yao, Xiaoquan research published 《 Aerobic Oxidation of Aldehydes to Carboxylic Acids Catalyzed by Recyclable Ag/C₃N₄ Catalyst》, the research content is summarized as follows. A simple, efficient and recyclable protocol for aerobic oxidation of aldehydes to carboxylic acid RCOOH [R = Ph, 4-ClC₆H₄, 1-naphthyl, etc.] by using C₃N₄ supported silver nanoparticles (Ag/C₃N₄) as a catalyst in aqueous solution under mild conditions was reported. Under standard conditions, the corresponding carboxylic acids could be obtained in good to excellent yields. In addition, Ag/C₃N₄ was convenient for recovery and could be reused three times with satisfactory yields.

Formula: C7H5BrO2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine, Related Products of 1575-37-7

Yu, Hanbo;Song, Xiaoxian;Xie, Ning;Wang, Jiaxuan;Li, Chenglong;Wang, Yue research published 《 Reversible Crystal-to-Crystal Phase Transitions with High-Contrast Luminescent Alterations for a Thermally Activated Delayed Fluorescence Emitter》, the research content is summarized as follows. Merging thermally activated delayed fluorescence (TADF) and mechanochromic luminescence (MCL) into one single mol. is a promising strategy for developing multifunctional organic materials. Herein, a unique multifunctional mol. TPA-DQP, comprising a large π-conjugated diquinoxalino[2,3-a:2′,3′-c]phenazine (DQP) as the acceptor and triphenylamine (TPA) as the donor, is designed and synthesized. TPA-DQP possesses polymorphism, efficient TADF emission as well as MCL property with high-contrast in emission colors from 576 to 706 nm. Reversible crystal-to-crystal phase transitions in response to external stimuli such as vapor fuming and heating are realized on the basis of the two polymorphs of TPA-DQP. The distinct crystal-to-crystal phase transition is attributed ultimately to the change of packing arrangements and intermol. interactions of the two polymorphs under stimuli. Furthermore, TPA-DQP-based organic light emitting diode (OLED) device achieves external quantum efficiency as high as 18.3% at 676 nm, which represents the best performance for deep-red OLEDs based on MCL-active TADF emitters. This study reports a novel MCL-active TADF material that exhibits crystal-to-crystal phase transition and brings insight into the underlying relationship between mol. packing modes and the photoluminescent behavior.

Related Products of 1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., 1575-37-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Product Details of C5H7BrO3.

Yu, Bin;Zhou, Shuang;Cao, Lixin;Hao, Zesheng;Yang, Dongyan;Guo, Xiaofeng;Zhang, Nailou;Bakulev, Vasiliy A.;Fan, Zhijin research published 《 Design, Synthesis, and Evaluation of the Antifungal Activity of Novel Pyrazole-Thiazole Carboxamides as Succinate Dehydrogenase Inhibitors》, the research content is summarized as follows. Succinate dehydrogenase (SDH) is regarded as a promising target for fungicide discovery. To continue our ongoing studies on the discovery of novel SDH inhibitors as fungicides, novel pyrazole-thiazole carboxamides were designed, synthesized, and evaluated for their antifungal activity. The results indicated that compounds 9ac, 9bf, and 9cb showed excellent in vitro activities against Rhizoctonia cerealis with EC₅₀ values from 1.1 to 4.9 mg/L, superior to that of the com. fungicide thifluzamide (EC₅₀ = 23.1 mg/L). Compound 9cd (EC₅₀ = 0.8 mg/L) was far more active than thifluzamide (EC₅₀ = 4.9 mg/L) against Sclerotinia sclerotiorum. Compound 9ac exhibited promising in vivo activity against Rhizoctonia solani (90% at 10 mg/L), which was better than that of thifluzamide (80% at 10 mg/L). The field experiment showed that compound 9ac had 74.4% efficacy against Rhizoctonia solani on the 15th day after two consecutive sprayings at an application rate of 4.80 g a.i./667 m², which was close to that of thifluzamide (83.3%). Furthermore, mol. docking explained the possible binding mode of compound 9ac in the RcSDH active site. Our studies indicated that the pyrazole-thiazole carboxamide hybrid is a new scaffold of SDH inhibitors.

70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., Product Details of C5H7BrO3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate, COA of Formula: C5H7BrO3

Yu, Bin;Zhao, Bin;Hao, Zesheng;Chen, Lei;Cao, Lixin;Guo, Xiaofeng;Zhang, Nailou;Yang, Dongyan;Tang, Liangfu;Fan, Zhijin research published 《 Design, synthesis and biological evaluation of pyrazole-aromatic containing carboxamides as potent SDH inhibitors》, the research content is summarized as follows. To continue studies on discovery of new potent antifungal leads, 43 novel pyrazole-aromatic containing carboxamides were rationally designed and synthesized. Bioassays indicated that most target compounds displayed good in vitro antifungal activities against Botrytis cinerea, Rhizoctonia cerealis and Sclerotinia sclerotiorum and in vivo antifungal activity against R. solani. Compound I exhibited the most significant in vitro activity against R. cerealis (EC₅₀ = 0.93μg/mL) with about 2-fold more potent than a previously reported lead compound N-(3-bromophenyl)-2-[3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl]-4-thiazolecarboxamide (EC₅₀ = 2.01μg/mL), and about 11-fold more potent than the pos. control/com. succinate dehydrogenase inhibitor thifluzamide (EC₅₀ = 23.09μg/mL). Structure-activity relationship anal. and mol. docking simulations indicated that the presence of difluoromethyl pyrazole-(m-benzene)carboxamide scaffold obviously increased the antifungal activity. The further enzymic bioassay showed that both thifluzamide and compound I displayed excellent SDH inhibitory effects, and fluorescence quenching anal. suggested that they may share the same target SDH.

COA of Formula: C5H7BrO3, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Quality Control of 5392-10-9.

Yu, Bangkui;Yu, Houjian;Huang, Hanmin research published 《 Palladium-Catalyzed Chemoselective Aminomethylative Cyclization and Aromatizing Allylic Amination: Access to Functionalized Naphthalenes》, the research content is summarized as follows. A palladium-catalyzed chemoselective aminomethylative cyclization and aromatizing allylic amination of enyne-tethered allylic alcs. with aminals is described. Under the reaction conditions, the cationic vinyl allylpalladium species undergoes selective migratory insertion of alkenes rather than reductive elimination with nucleophiles. This strategy provides an efficient and unique approach to the construction of functionalized naphthalenes, which are important building blocks in synthetic organic chem. Mechanistic studies have revealed that the selective sequential migratory insertion of enyne and alkene is crucial for the cyclization.

5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., Quality Control of 5392-10-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 20469-65-2, formula is C8H9BrO2, Name is 1-Bromo-3,5-dimethoxybenzene. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Reference of 20469-65-2.

Yoshioka, Shota;Wen, Ke;Saito, Susumu research published 《 Development of Effective Bidentate Diphosphine Ligands of Ruthenium Catalysts toward Practical Hydrogenation of Carboxylic Acids》, the research content is summarized as follows. Hydrogenation of carboxylic acids (CAs) to alcs. represents one of the most ideal reduction methods for using abundant CAs as alternative C and energy sources. However, systematic studies on the effects of metal-to-ligand relations on the catalytic activity of metal complex catalysts are scarce. The authors previously demonstrated a rational methodol. for CA hydrogenation, in which CA-derived cationic metal carboxylate [(PP)M(OCOR)]+ (M = Ru and Re; P = one P coordination) served as the catalyst prototype for CA self-induced CA hydrogenation. Herein, the authors report systematic trial-and-error studies on how the authors could achieve higher catalytic activity by modifying the structure of bidentate diphosphine (PP) ligands of mol. Ru catalysts. C chains connecting two P atoms as well as Ar groups substituted on the P atoms of PP ligands were intensively varied, and the induction of active Ru catalysts from precatalyst Ru(acac)₃ was surveyed extensively. As a result, the activity and durability of the (PP)Ru catalyst substantially increased compared to those of other mol. Ru catalyst systems, including the authors’ original Ru catalysts. The results validate the authors’ approach for improving the catalyst performance, which would benefit further advancement of CA self-induced CA hydrogenation.

Reference of 20469-65-2, 1-Bromo-3,5-dimethoxybenzene, also known as 1-Bromo-3,5-dimethoxybenzene, is a useful research compound. Its molecular formula is C8H9BrO2 and its molecular weight is 217.06 g/mol. The purity is usually 95%.
1-Bromo-3,5-dimethoxybenzene is used as an intermediate in the synthetic preparation of pharmaceutical inhibitors via cross-coupling reactions.
1-Bromo-3,5-dimethoxybenzene can be synthesized by using 1,3-dimethoxybenzene via iridium-catalyzed arene borylation.
1-Bromo-3,5-dimethoxybenzene (1BDMB) is a synthetic molecule that can be used as an electron acceptor in organic photovoltaic cells. 1BDMB is a salt of the sodium salt of resorcylic acid and 1,3-dibromo-5,5-dimethoxybenzene. It has been shown to have a radical mechanism for the generation of free radicals. The radical mechanism is initiated by light absorption by the ruthenium complex at the center of the molecule which induces photoinduced electron transfer from the ruthenium to 1BDMB. This process results in electron transfer from the donor to an acceptor molecule, such as oxygen or nitrogen. The pharmacokinetic properties of this compound are not well known; however, it has been demonstrated that it can be synthesized through a cross-coupling reaction with other aromatic compounds such as stemofuran., 20469-65-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary