Month: November 2022

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate, SDS of cas: 5445-17-0

Wu, Binglu;Jiang, Zhi-Jiang;Tang, Jianbo;Gao, Zhanghua;Liang, Hongze;Tang, Bencan;Chen, Jia;Lei, Kewei research published 《 Total synthesis study of rauvomines A and B: Construction of the pentacyclic core structure》, the research content is summarized as follows. A synthetic route has been developed for the core scaffold of rauvomines, which possess an abnormal sarpagine-type backbone without the C20-methylene substitution. The E-ring annulation was achieved by a TiCl₄-catalyzed Mukaiyama-Aldol reaction with a moderate yield of 70%.

SDS of cas: 5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., 5445-17-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Category: bromides-buliding-blocks.

Wu, Bin;Wang, Jianing;Liu, Xingchen;Zhu, Rong research published 《 Bicyclo[2.2.0]hexene derivatives as a proaromatic platform for group transfer and chemical sensing》, the research content is summarized as follows. Here the design, preparation, synthetic utility, and sensing application of a class of proarom. structures, namely bicyclo[2.2.0]hexene (BCHs) derivatives I [R = allyl, i-Pr, Bn, etc.] was reported. Building on a valence isomerism concept, they featured modular and easy synthesis as well as high thermal stability, and could be oxidatively activated under mild conditions. New alkyl transfer reactions using BCHs as a radical donor were developed to showcase the utility of their proaromaticity. Moreover, the redox-triggered valence isomerization of a quinoline-derived BCH led to colorimetric and fluorescent responses toward vapors of electrophilic reagents in solution and solid phase, resp. This optical response was showed to involved a 1,3-cyclohexadiene structure that possesses an intramol. charge transfer excited state with interesting aggregation induced emission (AIE) character. Thus, the potential of BCHs was demonstrated as a versatile platform for the development of new reagents and functional materials.

Category: bromides-buliding-blocks, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., 402-49-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 5392-10-9, formula is C9H9BrO3, The most pervasive is the naturally produced bromomethane. Reference of 5392-10-9

Worayuthakarn, Rattana;Suddee, Nattanit;Nealmongkol, Prattya;Ruchirawat, Somsak;Thasana, Nopporn research published 《 Copper-Mediated C-O/C-N Bond Formation: A Facile Synthesis of 3-Amidocoumarin, 3-Amidoazacoumarin, and N -Aroylindole Derivatives》, the research content is summarized as follows. Three different heterocyclic systems such as 3-amidocoumarins, 3-amidoazacoumarins I [R¹ = H, OMe; R² = H, OMe; R¹ = R² = H, OMe; X = CH, N; Y = CH, N; Ar = Ph, furan-3-yl, thiophene-2-yl, etc.; Z = N, O] and N-benzoylindol-2-carboxamides II [R = H, 6-OMe, 5-OMe, etc.] were synthesized via of copper-mediated C-O/C-N bond formation from azlactones under various heating conditions. The stereochem. of the double bond dictated the nature of the products. Microwave irradiation played an important role in the isomerization of the trisubstituted olefin leading to the formation of 3-amidocoumarins and 3-amidoazacoumarins. Three products showed promising-to-good cytotoxic activities against a panel of cancer cell lines, including HepG2 (hepatoblastoma) and MOLT-3 (T-lymphoblast acute lymphoblastic leukemia).

Reference of 5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 20469-65-2, formula is C8H9BrO2, Name is 1-Bromo-3,5-dimethoxybenzene. Organic compounds having carbon bonded to bromine are called organic bromides. Recommanded Product: 1-Bromo-3,5-dimethoxybenzene.

Woo-Jin, Choi;Jalani, Hitesh B.;Jeong, Jin-Hyun research published 《 Synthesis of selenopyrano[2,3-b]indol-4(9H)-ones and their C H arylation》, the research content is summarized as follows. Herein, authors disclose the synthesis of selenopyrano[2,3-b]indol-4(9H)-ones and their aryl derivatives using seleno-pyran ring formation via an in situ-generated selenide reacting directly with α-halo-β-ynones of substituted indoles providing selenopyrano[2,3-b]indol-4(9H)-ones. Subsequent direct CH arylation of the these compounds by palladium-catalyzed Heck reaction enables the incorporation of aryl substituents on the selenopyrano[2,3-b]indol-4(9H)-ones scaffolds with moderate yields. This new chemo-type incorporating an indole ring may be useful for the biol. screenings.

20469-65-2, 1-Bromo-3,5-dimethoxybenzene, also known as 1-Bromo-3,5-dimethoxybenzene, is a useful research compound. Its molecular formula is C8H9BrO2 and its molecular weight is 217.06 g/mol. The purity is usually 95%.
1-Bromo-3,5-dimethoxybenzene is used as an intermediate in the synthetic preparation of pharmaceutical inhibitors via cross-coupling reactions.
1-Bromo-3,5-dimethoxybenzene can be synthesized by using 1,3-dimethoxybenzene via iridium-catalyzed arene borylation.
1-Bromo-3,5-dimethoxybenzene (1BDMB) is a synthetic molecule that can be used as an electron acceptor in organic photovoltaic cells. 1BDMB is a salt of the sodium salt of resorcylic acid and 1,3-dibromo-5,5-dimethoxybenzene. It has been shown to have a radical mechanism for the generation of free radicals. The radical mechanism is initiated by light absorption by the ruthenium complex at the center of the molecule which induces photoinduced electron transfer from the ruthenium to 1BDMB. This process results in electron transfer from the donor to an acceptor molecule, such as oxygen or nitrogen. The pharmacokinetic properties of this compound are not well known; however, it has been demonstrated that it can be synthesized through a cross-coupling reaction with other aromatic compounds such as stemofuran., Recommanded Product: 1-Bromo-3,5-dimethoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 629-04-9, formula is C7H15Br, Name is 1-Bromoheptane. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. HPLC of Formula: 629-04-9.

Woodcock, Steven R.;Salvatore, Sonia R.;Freeman, Bruce A.;Schopfer, Francisco J. research published 《 Synthesis of 9- and 12-nitro conjugated linoleic acid: Regiospecific isomers of naturally occurring conjugated nitrodienes》, the research content is summarized as follows. Conjugated diene-containing fatty acids (rumenic and rumelenic acids) are major substrates for nitration under physiol. conditions. Their nitrated products are present in human urine. These nitrodiene-containing lipid electrophiles contain a strongly electron-withdrawing pair of conjugated double bonds amenable to nucleophilic attack in biol. milieu, which affords them pluripotent signaling capabilities. We report synthetic methods to obtain useful quantities of three main biol. nitrated fatty acids (9- and 12-nitro-conjugated linoleic acids and 9-nitro-conjugated linolenic acid) in six or seven steps from com. available starting materials for biol. evaluation of these naturally occurring biomols.

629-04-9, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., HPLC of Formula: 629-04-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Reference of 244205-40-1.

Wood, James M.;Satam, Nishikant S.;Almeida, Renata G.;Cristani, Vinicius S.;de Lima, Denis P.;Dantas-Pereira, Luiza;Salomao, Kelly;Menna-Barreto, Rubem F. S.;Namboothiri, Irishi N. N.;Bower, John F.;da Silva, Eufranio N. Junior research published 《 Strategies towards potent trypanocidal drugs: Application of Rh-catalyzed [2 + 2 + 2] cycloadditions, sulfonyl phthalide annulation and nitroalkene reactions for the synthesis of substituted quinones and their evaluation against Trypanosoma cruzi》, the research content is summarized as follows. Rhodium-catalyzed [2 + 2 + 2] cycloadditions, sulfonyl phthalide annulations and nitroalkene reactions were employed for the synthesis of 56 quinone-based compounds such as I [R¹ = H, I, OMe, NMePh, etc.; R² = H, Me, Ph, etc.], II [R = 2-Me, 2-OMe, 4-OEt, etc.] and III [X = O, NBu, NPh, etc.; Ar = Ph, 4-tolyl, 2-furyl, etc.]. These were evaluated against Trypanosoma cruzi, the parasite that causes Chagas disease. The reactions described here were part of a program that aims to utilize modern, versatile and efficient synthetic methods for the one or two step preparation of trypanocidal compounds Among the tested compounds 9 compounds were identified with potent activity against the parasite; 3 of these were 30-fold more potent than benznidazole, a drug used for the treatment of Chagas disease. This article provides a comprehensive outline of reactions involving over 120 compounds aimed at the discovery of new quinone-based frameworks with activity against T. cruzi.

Reference of 244205-40-1, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Quality Control of 90-59-5.

Wongsuwan, Sutthida;Chatwichien, Jaruwan;Pinchaipat, Bussaba;Kumphune, Sarawut;Harding, David J.;Harding, Phimphaka;Boonmak, Jaursup;Youngme, Sujittra;Chotima, Ratanon research published 《 Synthesis, characterization and anticancer activity of Fe(II) and Fe(III) complexes containing N-(8-quinolyl)salicylaldimine Schiff base ligands》, the research content is summarized as follows. A series of Fe(II) complexes [(L)₂Fe] and Fe(III) complexes [(L)₂Fe]Cl from Fe(II)/(III) chlorides and N-(8-quinolyl)-X-salicylaldimine Schiff base ligands (HL, Hqsal-X₂/X: X = 3,5-Br₂, 3,5-Cl₂, 5-Br, 5-Cl) were successfully synthesized and characterized by spectroscopic (FT-IR, ¹H-NMR), mass spectrometry, thermogravimetric anal. (TGA), and single crystal X-ray crystallog. techniques. The interaction of complexes 1-8 with calf thymus DNA (CT-DNA) was determined by UV-Vis and fluorescence spectroscopy. The complexes exhibited good DNA-binding activity via intercalation. The mol. docking between a selected complex and DNA was also investigated. The in vitro anticancer activity of the Schiff base ligands and their complexes were screened against the A549 human lung adenocarcinoma cell line. The complexes showed anticancer activity toward A549 cancer cells while the free ligands and iron chloride salts showed no inhibitory effects at 100μM. In this series, complex [Fe(qsal-Cl₂)₂]Cl (6) showed the highest anticancer activity against A549 cells (IC₅₀ = 10μM). This is better than two well-known anticancer agents (Etoposide and Cisplatin). Furthermore, the possible mechanism for complexes 1–8 penetrating A549 cells through intracellular ROS generation was investigated. The complexes containing dihalogen substituents 1, 2, 5, and 6 can increase ROS in A549 cells, leading to DNA or macromol. damage and cell-death induction.

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

3,5-Dibromosalicylaldehyde, also known as 3,5-Dibromosalicylaldehyde, is a useful research compound. Its molecular formula is C7H4Br2O2 and its molecular weight is 279.91 g/mol. The purity is usually 95%.

3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes. 3,5-Dibromosalicylaldehyde can be used in the synthesis of Schiff base and can be used as reactant for synthesis of Schiff base ligands which forms mononuclear complexes with copper(II), nickel(II), zinc(II) and cobalt(II).

3,5-Dibromosalicylaldehyde is a copper complex that has been synthesized from 3,5-dibromosalicylaldehyde and copper chloride. FTIR spectroscopy revealed that the coordination geometry of the copper complex is octahedral with two nitrogen atoms in the equatorial plane. The presence of hydrogen bonding interactions was confirmed by homologous protein adsorption experiments. This chemical structure was determined using X-ray crystallography and fluorescence probe experiments. The copper complex showed high affinity for malonic acid, which is an ester hydrochloride. The molecular mechanism of this interaction is based on adsorption, which occurs through hydrogen bonding interactions and hydrophobic interactions. Structural analysis revealed that the polymeric matrix consists of a three-dimensional network of crosslinked chains, while FTIR analysis indicated a possible disulfide bond between two cysteine residues., Quality Control of 90-59-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Product Details of C2H7Br2N.

Willinger, Max;Reimhult, Erik research published 《 Thermoresponsive Nanoparticles with Cyclic-Polymer-Grafted Shells Are More Stable than with Linear-Polymer-Grafted Shells: Effect of Polymer Topology, Molecular Weight, and Core Size》, the research content is summarized as follows. Polymer brush-grafted superparamagnetic iron oxide nanoparticles can change their aggregation state in response to temperature and are potential smart materials for many applications. Recently, the shell morphol. imposed by grafting to a nanoparticle core was shown to strongly influence the thermoresponsiveness through a coupling of intrashell solubility transitions and nanoparticle aggregation. We investigate how a change from linear to cyclic polymer topol. affects the thermoresponsiveness of poly(2-isopropyl-2-oxazoline) brush-grafted superparamagnetic iron oxide nanoparticles. Linear and cyclic polymers with three different mol. weights (7, 18, and 24.5 kg mol^-1) on two different core sizes (3.7 and 9.2 nm) and as free polymer were investigated. We observed the critical flocculation temperature (CFT) during temperature cycling dynamic light scattering experiments, the critical solution temperature (CST), and the transition enthalpy per monomer during differential scanning calorimetry measurements. When all conditions are identical, cyclic polymers increase the colloidal stability and the critical flocculation temperature compared to their linear counterparts. Furthermore, the cyclic polymer shows only one uniform transition, while we observe multiple transitions for the linear polymer shells. We link the single transition and higher colloidal stability to the absence in cyclic PiPrOx shells of a dilute outer part where the particle shells can interdigitate.

2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., Product Details of C2H7Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 629-04-9, formula is C7H15Br, The most pervasive is the naturally produced bromomethane. Quality Control of 629-04-9

Wilhelmsen, Christopher A.;Zhang, Xuntong;Myhill, Jesse A.;Morken, James P. research published 《 Enantioselective Synthesis of Tertiary β-Boryl Amides by Conjunctive Cross-Coupling of Alkenyl Boronates and Carbamoyl Chlorides》, the research content is summarized as follows. Synthesis of versatile β tert-boryl amides is accomplished by conjunctive cross-coupling of α-substituted alkenyl boron “ate” complexes and carbamoyl chloride electrophiles. This reaction can be accomplished in an enantioselective fashion using a palladium catalyst in combination with MandyPhos. The addition of water results in enhanced chemoselectivity for the conjunctive coupling product relative to the Suzuki-Miyaura cross-coupling product. Transformations of the reaction products were examined as well as application to the synthesis of (+)-adalinine.

Quality Control of 629-04-9, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., 629-04-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 823-78-9, formula is C7H6Br2, Name is 1-Bromo-3-(bromomethyl)benzene. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Electric Literature of 823-78-9.

Weng, Yangyang;Zhang, Chenhuan;Tang, Zaiquan;Shrestha, Mohini;Huang, Wenyi;Qu, Jingping;Chen, Yifeng research published 《 Nickel-catalyzed allylic carbonylative coupling of alkyl zinc reagents with tert-butyl isocyanide》, the research content is summarized as follows. By leveraging easily accessible tert-Bu isocyanide as the CO surrogate, a nickel-catalyzed allylic carbonylative coupling with alkyl zinc reagent RZnX (R = Me, n-Bu, Bn, cyclopentyl, 2-chloropyridin-5-yl, etc.; X = Br, Cl), allowing for the practical and straightforward preparation of synthetically important β,γ-unsaturated ketones R¹CH=C(R²)CH(R³)C(O)R (R¹ = n-Pr, Ph, cyclohexyl, furan-2-yl, etc.; R² = H, Me; R³ = H, Me, Et, cyclopropyl) in a linear-selective fashion with excellent trans-selectivity under mild conditions was described. Moreover, the undesired polycarbonylation process which is often encountered in palladium chem. could be completely suppressed. This nickel-based method features excellent functional group tolerance, even including the active aryl iodide functionality to allow the orthogonal derivatization of β,γ-unsaturated ketones. Preliminary mechanistic studies suggest that the reaction proceeds via π-allylnickel intermediate.

823-78-9, 3-Bromobenzyl bromide undergoes reduction with diethylzinc in the presence of Pd(PPh3)4 to yield corresponding hydrocarbon.

3-Bromobenzyl bromide is a useful research compound. Its molecular formula is C7H6Br2 and its molecular weight is 249.93 g/mol. The purity is usually 95%.

3-Bromobenzyl bromide is a molecule that has been synthesized and shown to have anticancer activity. It inhibits the activity of cancer cells by binding to amines in these cells and preventing the formation of hydrogen bonds between these molecules. 3-Bromobenzyl bromide has also been shown to selectively inhibit the activity of NS5B polymerase, an enzyme that is important in the replication of the hepatitis C virus. The synthetic nature of this molecule makes it an attractive target for analytical methods such as nuclear magnetic resonance spectroscopy. This molecule also shows significant cytotoxicity against cancer cell lines in vitro, as well as inducing tumor necrosis factor-alpha (TNF-α) production in lps-stimulated murine macrophages., Electric Literature of 823-78-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary