Month: November 2022

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Recommanded Product: 6-Bromohexanoic acid.

Tsyganov, Dmitry V.;Samet, Alexander V.;Silyanova, Eugenia A.;Ushkarov, Vladimir I.;Varakutin, Alexander E.;Chernysheva, Natalia B.;Chuprov-Netochin, Roman N.;Khomutov, Andrey A.;Volkova, Anna S.;Leonov, Sergey V.;Semenova, Marina N.;Semenov, Victor V. research published 《 Synthesis and Antiproliferative Activity of Triphenylphosphonium Derivatives of Natural Allylpolyalkoxybenzenes》, the research content is summarized as follows. Derivatives of natural allylpolyalkoxybenzenes conjugated to triphenylphosphonium (TPP) cations by aliphatic linkers of three, six, seven, and eight atoms were synthesized to examine the role of the polyalkoxybenzene pharmacophore, TPP fragment, and linker length in antiproliferative activities. The key synthetic procedures included (i) hydroboration-oxidation of apiol, dillapiol, myristicin, and allyltetramethoxybenzene; (ii) acylation of polyalkoxybenzyl alcs. or amines; and (iii) condensation of polyalkoxybenzaldehydes followed by hydrogenation and cyclopropyl-homoallyl rearrangement. The targeted TPP conjugates as well as the starting allylbenzenes, the corresponding alkylpolyalkoxybenzenes, and the resp. alkyl-TPP salts were evaluated for cytotoxicity in a panel of human cancer cell lines using MTT and Click-iT-EdU assays and in a sea urchin embryo model. The linker of three carbon atoms was identified as favorable for selective cancer cell growth inhibition. Although the propyl-TPP salt was cytotoxic at low micromolar concentrations, the introduction of a polyalkoxybenzene moiety significantly potentiated inhibition of both cell growth and de novo DNA synthesis in several human cancer cell lines, HST-116 colon cancer, A375 melanoma, PC-3 prostate cancer, and T-47D breast carcinoma cells, while it failed to produce any developmental abnormalities in the sea urchin embryos.

4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., Recommanded Product: 6-Bromohexanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Application In Synthesis of 402-49-3.

Tsai, Wan-Chen;Gilbert, Nathan C.;Ohler, Amanda;Armstrong, Michelle;Perry, Steven;Kalyanaraman, Chakrapani;Yasgar, Adam;Rai, Ganesha;Simeonov, Anton;Jadhav, Ajit;Standley, Melissa;Lee, Hsiau-Wei;Crews, Phillip;Iavarone, Anthony T.;Jacobson, Matthew P.;Neau, David B.;Offenbacher, Adam R.;Newcomer, Marcia;Holman, Theodore R. research published 《 Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2》, the research content is summarized as follows. Human epithelial 15-lipoxygenase-2 (h15-LOX-2, ALOX15B) is expressed in many tissues and has been implicated in atherosclerosis, cystic fibrosis and ferroptosis. However, there are few reported potent/selective inhibitors that are active ex vivo. In the current work, we report newly discovered mols. that are more potent and structurally distinct from our previous inhibitors, MLS000545091 and MLS000536924 (Jameson et al, PLoS One, 2014, 9, e104094), in that they contain a central imidazole ring, which is substituted at the 1-position with a Ph moiety and with a benzylthio moiety at the 2-position. The initial three mols. were mixed-type, non-reductive inhibitors, with IC50 values of 0.34 ± 0.05 μM for MLS000327069, 0.53 ± 0.04 μM for MLS000327186 and 0.87 ± 0.06 μM for MLS000327206 and greater than 50-fold selectivity vs. h5-LOX, h12-LOX, h15-LOX-1, COX-1 and COX-2. A small set of focused analogs was synthesized to demonstrate the validity of the hits. In addition, a binding model was developed for the three imidazole inhibitors based on computational docking and a co-structure of h15-LOX-2 with MLS000536924. Hydrogen/deuterium exchange (HDX) results indicate a similar binding mode between MLS000536924 and MLS000327069, however, the latter restricts protein motion of helix-α2 more, consistent with its greater potency. Given these results, we designed, docked, and synthesized novel inhibitors of the imidazole scaffold and confirmed our binding mode hypothesis. Importantly, four of the five inhibitors mentioned above are active in an h15-LOX-2/HEK293 cell assay and thus they could be important tool compounds in gaining a better understanding of h15-LOX-2′s role in human biol. As such, a suite of similar pharmacophores that target h15-LOX-2 both in vitro and ex vivo are presented in the hope of developing them as therapeutic agents.

Application In Synthesis of 402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., 402-49-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Safety of (2-Bromophenyl)boronic acid.

Trzepizur, Damian;Brodzka, Anna;Koszelewski, Dominik;Wilk, Monika;Ostaszewski, Ryszard research published 《 Selective Palladium-Catalyzed α,β-Homodiarylation of Vinyl Esters in Aqueous Medium》, the research content is summarized as follows. A palladium-catalyzed 1,2-diarylation of vinyl esters RC(O)OCH=CH₂ (R = Me, Ph, CH₂Cl, etc.) with arylboronic acids R¹B(OH)₂ (R¹ = Ph, 3,4-dimethoxyphenyl, 2-bromophenyl, etc.) in water has been developed. This newly elaborated protocol features a good functional group tolerance and provides one-step access to 1,2-diarylethanol derivatives R¹CH₂CH(R¹)OC(O)R under mild reaction conditions. The presented reaction can be carried out in the water at ambient temperature without the addition of any ligands, making this procedure environmentally benign. The transformation occurs within a single catalytic cycle and is feasible due to the modification of transition metal catalytic activity through the influence of π-acceptor olefin (benzoquinone) as well as water as a medium. Moreover, this protocol allows to generate entire compound libraries (highly profitable in medicinal chem.) and utilizes sustainable arylboronic acids as coupling partners under mild conditions. It is also noted that the structure of boron moiety has a great impact on the reaction selectivity, the usage of sterically hindered esters of arylboronic acids influence the reaction course towards stilbenes.

Safety of (2-Bromophenyl)boronic acid, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 4897-84-1, formula is C5H9BrO2, The most pervasive is the naturally produced bromomethane. Product Details of C5H9BrO2

Trukhin, D. V.;Rogozhnikova, O. Yu.;Troitskaya, T. I.;Kuzhelev, A. A.;Amosov, E. V.;Halpern, H. J.;Koval’, V. V.;Tormyshev, V. M. research published 《 New Spin Probes: Tri- and Hexacationic Derivatives of Stable Tetrathiatriarylmethyl Radicals》, the research content is summarized as follows. The reaction of Finland trityl with tertiary aliphatic alcs. containing a terminal tertiary amino group, followed by quaternization of the amino groups, afforded new highly polar tri- and hexacationic derivatives The obtained compounds were characterized by a sharp singlet signal in the EPR spectrum and were soluble in water over a wide pH range.

4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., Product Details of C5H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. HPLC of Formula: 4897-84-1.

Trivedi, Prakruti;Adhikari, Nilanjan;Amin, Sk. Abdul;Bobde, Yamini;Ganesh, Routholla;Jha, Tarun;Ghosh, Balaram research published 《 Design, synthesis, biological evaluation and molecular docking study of arylcarboxamido piperidine and piperazine-based hydroxamates as potential HDAC8 inhibitors with promising anticancer activity》, the research content is summarized as follows. Some new hydroxamate derivatives with alkylpiperidine and alkylpiperazine linker moieties were designed, synthesized and biol. evaluated. All these compounds were effective HDAC8 inhibitors comprising more or less similar cytotoxic potential against different cancer cell lines. It was observed that the piperazine scaffold containing compound was more active than the compound with piperidine scaffold for exerting HDAC8 inhibitory activity. Moreover, the 4-quinolyl cap group was better than the biphenyl group which was better than the benzyl group for producing higher HDAC8 inhibition as well as cytotoxicity. These compounds displayed selective HDAC8 inhibition over HDAC3. Moreover, these compounds showed an increased caspase3/7 activity suggesting their anticancer potential through modulation of apoptotic pathways. Mol. docking study with three potent compounds was performed with both HDAC3 and HDAC8 enzymes to understand the selectivity profile of these compounds Compound containing 4-quinolyl cap group with alkyl piperazinyl urea linker moiety was emerged out as the lead mol. that may be further modified to design more effective and selective HDAC8 inhibitors in future.

HPLC of Formula: 4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 629-04-9, formula is C7H15Br, Name is 1-Bromoheptane. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application of C7H15Br.

Trinklein, Timothy J.;Warren, Cable G.;Synovec, Robert E. research published 《 Determination of the signal-to-noise ratio enhancement in comprehensive three-dimensional gas chromatography》, the research content is summarized as follows. We investigate the extent to which comprehensive three-dimensional gas chromatog. (GC³) provides a signal enhancement (SE) and a signal-to-noise ratio enhancement (S/N_Rel) relative to one-dimensional (1D)-GC. Specifically, the SE is defined as the ratio of the tallest ³D peak height from the GC³ separation to the 1D peak height from the unmodulated 1D-GC separation A model is proposed which allows the analyst to predict the theor. attainable SE (SE_T) based upon the peak width and sampling d. inputs. The model is validated via comparison of the SE_T to the exptl. measured SE (SE_M) obtained using total-transfer GC³ (100% duty cycle for both modulators) with time-of-flight mass spectrometry detection. Two exptl. conditions were studied using the same GC³ column set, differing principally in the modulation period from the ¹D to ²D columns: 4 s vs. 8 s. Under the first set of conditions, the average SE_M was 97 (±22), in excellent agreement with the SE_T of 97 (±18). The second set of conditions improved the average SE_M to 181 (±27), also in agreement with the average SE_T of 176 (±26). The average S/N_Rel following correction for the mass spectrum acquisition frequency was 38.8 (±11.2) and 59.0 (±27.2) for the two sets of conditions. The enhancement in S/N is largely attributed to moving the signal to a higher frequency domain where the impact of “low frequency” noise is less detrimental. The findings here provide strong evidence that GC³ separations can provide enhanced detectability relative to 1D-GC and comprehensive two-dimensional gas chromatog. (GCxGC) separations

Application of C7H15Br, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., 629-04-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid, Recommanded Product: 6-Bromohexanoic acid

Tremblay, Marie-Helene;Schutt, Kelly;Pulvirenti, Federico;Schultz, Thorsten;Wegner, Berthold;Jia, Xiaojia;Zhang, Yadong;Longhi, Elena;Dasari, Raghunath R.;Fuentes-Hernandez, Canek;Kippelen, Bernard;Koch, Norbert;Snaith, Henry J.;Barlow, Stephen;Marder, Seth R. research published 《 Benzocyclobutene polymer as an additive for a benzocyclobutene-fullerene: application in stable p-i-n perovskite solar cells》, the research content is summarized as follows. A poly(methacrylate) with benzocyclobutene side chains, CL, has been synthesized by radical polymerization for use as a crosslinking additive for a previously reported benzocyclobutene-functionalized fullerene, PCBCB, which can be thermally insolubilized following solution processing. Films of PCBCB incorporating CL and n-doped with (IrCp*Cp)₂ exhibit in-plane elec. conductivities around ten times higher than those of n-doped films without CL, while the use of CL also reduces leaching of dopant ions from the film upon washing. The performance and stability of perovskite solar cells using insolubilized PCBCB:CL, insolubilized PCBCB, or PCBM as top electron-extraction layers are compared; cells with undoped PCBCB:CL extraction layers exhibit higher average and maximum power conversion efficiencies (16 and 18.5%, resp.) than their PCBM and PCBCB counterparts. Devices with undoped PCBCB:CL extraction layers also showed excellent thermal stability, retaining 92% of their stabilized power output after aging for 3000 h at 85 °C in the dark in a nitrogen atm.

4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., Recommanded Product: 6-Bromohexanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 629-04-9, formula is C7H15Br, Name is 1-Bromoheptane. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Synthetic Route of 629-04-9.

Trapani, M.;Castriciano, M. A.;Elemans, J. A. A. W.;Nicosia, A.;Mineo, P.;Cordaro, M. research published 《 A Convenient Approach to meso-Uracil-4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene Derivatives》, the research content is summarized as follows. An effective and convenient protocol for the synthesis of 1-substituted uracil-6-carbaldehyde derivatives has been developed. A three-step sequence permits the preparation of uracil-6-carbaldehydes with various substituents at the N-1 in large quantities by using low-cost precursors. The aldehyde-functionalized uracils served as useful precursors for the preparation of meso-(1-substituted 6-uracil)-derivatives of 4,4-difluoro-4-bora-3a,4a-diaza- s-indacene (BODIPY). In this way, regioselectively functionalized BODIPYs with a direct connection to a nucleobase were prepared in yields of 30-45%. MALDI-TOF mass spectrometry, NMR, UV/vis absorption, and steady-state and time-resolved fluorescence spectroscopies were used to characterize the structures and the spectroscopic/photophys. properties of the resultant dyes.

Synthetic Route of 629-04-9, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., 629-04-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Related Products of 1575-37-7.

Tran, Duc N.;Zhdanko, Alexander;Barroso, Santiago;Nieste, Patrick;Rahmani, Ramdane;Holan, Jan;Hoefnagels, Roel;Reniers, Peter;Vermoortele, Frederik;Duguid, Stewart;Cazanave, Lionel;Figlus, Marek;Muir, Colin;Elliott, Alain;Zhao, Peichao;Paden, Warren;Diaz, Cristina Hernandez;Bell, Stephen J.;Hashimoto, Akihiro;Phadke, Avinash;Wiles, Jason A.;Vogels, Ilse;Farina, Vittorio research published 《 Development of a Commercial Process for Odalasvir》, the research content is summarized as follows. Odalasvir is a selective inhibitor of hepatitis C virus NS5A protein, a key target for combination therapies. This paper described the chem. process development for the synthesis of this API and the improvements that were achieved over the medicinal chem. Optimization of all the reaction conditions and crystallizations resulted in higher throughput and a highly improved process mass intensity (PMI). The process was robust and it was scaled up to ∼100 kg batches without issues.

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Related Products of 1575-37-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 20469-65-2, formula is C8H9BrO2, Name is 1-Bromo-3,5-dimethoxybenzene. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Quality Control of 20469-65-2.

Trammel, Grace L.;Kuniyil, Rositha;Crook, Phillip F.;Liu, Peng;Brown, M. Kevin research published 《 Nickel-Catalyzed Dearomative Arylboration of Indoles: Regioselective Synthesis of C2- and C3-Borylated Indolines》, the research content is summarized as follows. Indole dearomatization is an important strategy to access indolines: a motif present in a variety of natural products and biol. active mols. Herein, a method for transition-metal catalyzed regioselective dearomative arylboration of indoles to generate diverse indolines is presented. The method accomplishes intermol. dearomatization of simple indoles through a migratory insertion pathway on substrates that lack activating or directing groups on the C2- or C3-positions. Synthetically useful C2- and C3-borylated indolines can be accessed through a simple change in N-protecting group in high regio- and diastereoselectivities (up to >40:1 rr and >40:1 dr) from readily available starting materials. Addnl., the origin of regioselectivity was explored exptl. and computationally to uncover the remarkable interplay between carbonyl orientation of the N-protecting group on indole, electronics of the C2-C3 π-bond, and sterics. The method enabled the 1st enantioselective synthesis of (-)-azamedicarpin.

Quality Control of 20469-65-2, 1-Bromo-3,5-dimethoxybenzene, also known as 1-Bromo-3,5-dimethoxybenzene, is a useful research compound. Its molecular formula is C8H9BrO2 and its molecular weight is 217.06 g/mol. The purity is usually 95%.
1-Bromo-3,5-dimethoxybenzene is used as an intermediate in the synthetic preparation of pharmaceutical inhibitors via cross-coupling reactions.
1-Bromo-3,5-dimethoxybenzene can be synthesized by using 1,3-dimethoxybenzene via iridium-catalyzed arene borylation.
1-Bromo-3,5-dimethoxybenzene (1BDMB) is a synthetic molecule that can be used as an electron acceptor in organic photovoltaic cells. 1BDMB is a salt of the sodium salt of resorcylic acid and 1,3-dibromo-5,5-dimethoxybenzene. It has been shown to have a radical mechanism for the generation of free radicals. The radical mechanism is initiated by light absorption by the ruthenium complex at the center of the molecule which induces photoinduced electron transfer from the ruthenium to 1BDMB. This process results in electron transfer from the donor to an acceptor molecule, such as oxygen or nitrogen. The pharmacokinetic properties of this compound are not well known; however, it has been demonstrated that it can be synthesized through a cross-coupling reaction with other aromatic compounds such as stemofuran., 20469-65-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary