Month: November 2022

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 20469-65-2, formula is C8H9BrO2, Name is 1-Bromo-3,5-dimethoxybenzene, Application of C8H9BrO2

Tian, Xianhai;Kaur, Jaspreet;Yakubov, Shahboz;Barham, Joshua P. research published 《 α-Amino Radical Halogen Atom Transfer Agents for Metallaphotoredox-Catalyzed Cross-Electrophile Couplings of Distinct Organic Halides》, the research content is summarized as follows. α-Amino radicals from simple tertiary amines were employed as halogen atom transfer (XAT) agents in metallaphotoredox catalysis for cross-electrophile couplings of organic bromides with organic iodides. This XAT strategy proved to be efficient for the generation of carbon radicals from a range of partners (alkyl, aryl, alkenyl, and alkynyl iodides). The reactivities of these radical intermediates were captured by nickel catalysis with organobromides including aryl, heteroaryl, alkenyl, and alkyl bromides, enabling six diverse C-C bond formations. Classic named reactions including Negishi, Suzuki, Heck, and Sonogashira reactions were readily achieved in a net-reductive fashion under mild conditions. More importantly, the cross coupling was viable with either organic bromide or iodide as limiting reactant based on the availability of substrates, which is beneficial to the late-stage functionalization of complex mols. The scalability of this method in batch and flow was investigated, further demonstrating its applicability.

Application of C8H9BrO2, 1-Bromo-3,5-dimethoxybenzene, also known as 1-Bromo-3,5-dimethoxybenzene, is a useful research compound. Its molecular formula is C8H9BrO2 and its molecular weight is 217.06 g/mol. The purity is usually 95%.
1-Bromo-3,5-dimethoxybenzene is used as an intermediate in the synthetic preparation of pharmaceutical inhibitors via cross-coupling reactions.
1-Bromo-3,5-dimethoxybenzene can be synthesized by using 1,3-dimethoxybenzene via iridium-catalyzed arene borylation.
1-Bromo-3,5-dimethoxybenzene (1BDMB) is a synthetic molecule that can be used as an electron acceptor in organic photovoltaic cells. 1BDMB is a salt of the sodium salt of resorcylic acid and 1,3-dibromo-5,5-dimethoxybenzene. It has been shown to have a radical mechanism for the generation of free radicals. The radical mechanism is initiated by light absorption by the ruthenium complex at the center of the molecule which induces photoinduced electron transfer from the ruthenium to 1BDMB. This process results in electron transfer from the donor to an acceptor molecule, such as oxygen or nitrogen. The pharmacokinetic properties of this compound are not well known; however, it has been demonstrated that it can be synthesized through a cross-coupling reaction with other aromatic compounds such as stemofuran., 20469-65-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. HPLC of Formula: 2576-47-8.

Tian, Dongjie;Lai, Zhiwei;Xu, Han;Lin, Fangyuan;Jiang, Yaqi;Huang, Yipeng;Wang, Shuya;Cai, Yuting;Jin, Jingwen;Xie, Rong-Jun;Chen, Xi research published 《 Low-Dimensional Organic Lead Halides with Organic-Inorganic Collaborative Luminescence Regulated by Anion in Dimension》, the research content is summarized as follows. Low-dimensional (LD) organic-metal halides (OMHs) have been extensively investigated because of their excellent optical properties. However, the rational synthetic control (dimension regulation) of LD-OMHs has not yet been established well. The effect of organic cations on the luminescence also remains unexplored. Here, we designed a double-chain ammonium salt 1 with two amine functional groups. Using hydrogen bonding between -N-H₃ protons and halogen ions synthesized zero-dimensional (0D) OMH C₁₂H₃₀N₄Pb₂Br₈ (2). Furthermore, through introducing other ionic interactions to regulate the dimension of OMHs, we obtained one-dimensional (1D) OMH C₁₂H₃₀N₄Pb₂Cl_7.5Br_0.5 (3) by anion exchange of 2. Through the in-depth anal. of their crystal structure, it is understood that the design of organic cations and the exchange of anions can regulate the dimension of OMHs through the change of hydrogen bonds in the structure. This sets a foundation for the formation of a synthesis mechanism for LD-OMHs and effective regulation of OMHs dimension. Through crystal structure anal., experiments, and theor. calculations, this work proves that the emission of 2 is not dominated by a single factor of organic cations or metal halogen octahedrons but by the interaction of organic cations and metal octahedrons. Moreover, the 1D-OMH 3 shows tunable emissions from blue to white light under varying excitation wavelengths, which provides a foundation for expanding the application of OMHs.

2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., HPLC of Formula: 2576-47-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Synthetic Route of 585-76-2.

Thiruvengetam, Prabaharan;Chand, Dillip Kumar research published 《 Controlled and Predictably Selective Oxidation of Activated and Unactivated C(sp³)-H Bonds Catalyzed by a Molybdenum-Based Metallomicellar Catalyst in Water》, the research content is summarized as follows. The synthesis of carbonyl derivatives from renewable feedstocks, by direct oxidation/functionalization of activated and unactivated C(sp³)-H bonds under a controlled and predictably selective fashion, especially in late stages, remains a formidable challenge. Herein, for the first time, cost-effective and widely applicable protocols for controlled and predictably selective oxidation of petroleum waste and feedstock ingredients like methyl-/alkylarenes to corresponding value-added carbonyls have been developed, using a surfactant-based oxodiperoxo molybdenum catalyst in water. The methodologies use hydrogen peroxide (H₂O₂) as an environmentally benign green oxidant, and the reactions preclude the need of any external base, additive, or cocatalyst and can be operated under mild eco-friendly conditions. The developed protocols show a wide substrate scope and eminent functional group tolerance, especially oxidation-liable and reactive boronic acid groups. Upscaled multigram synthesis of complex steroid mols. by late-stage oxidation proves the robustness and practical utility of the current protocol since it employs an inexpensive recyclable catalyst and an easily available oxidant. A plausible mechanism has been proposed with the help of few controlled experiments and kinetic and computational studies.

585-76-2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , Synthetic Route of 585-76-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. COA of Formula: C8H6BrF3.

Thirugnanasambandam, Eswaramoorthi;Shanmugam, Ganesan;Selvaraj, Balamurugan research published 《 A Newly Synthesized Copper Redox Couple Electrolyte with Activated Carbon Electrode from Samanea saman Wood Tissue for Flexible Supercapacitor》, the research content is summarized as follows. The search for new superior electrode materials and modifications of electrolyte portions is one of the most significant responsibilities in developing supercapacitors. To enhance the cell voltage and efficiency of supercapacitors, we propose using activated Samanea saman wood shell carbon as an electrode and a new unique copper metal complex as an electrolyte for the first time. We synthesized a sheet-like structure of activated Samanea saman wood shell carbon using a pyrolysis process and synthesized a new novel copper metal complex bound with the H₂SO₄ electrolyte in this combination fabrication for a supercapacitor (RESC). The redox couple aided SC exhibits an outstanding electrochem. performance that is attributed to the maximum specific capacitance value of 599 F g^-1 and long lifespan of 98.9% specific capacitance after 8500 charge-discharge cycles in the half (three-electrode)-cell configuration. The activated carbon as cathode, graphite as anode, and gel formation of the copper metal complex bound with H₂SO₄ electrolyte were used to construct the (RESC) supercapacitor device. This RESC device achieved 70.7 W h kg^-1 energy d. and power d. of 534.75 W kg^-1. The combination of activated carbon electrode material and copper metal complex mediator provided the way for the development of a more efficient material for supercapacitors (SCs).

402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., COA of Formula: C8H6BrF3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Organic compounds having carbon bonded to bromine are called organic bromides. SDS of cas: 90-59-5.

Thekkeppat, Nipun P.;Bhattacharya, Biswajit;Tothadi, Srinu;Ghosh, Soumyajit research published 《 Mechanically flexible crystals of styryl quinoline derivatives》, the research content is summarized as follows. Three crystals of styryl quinoline derivatives are reported. All these 3 crystals are mech. flexible crystals, isostructural and also all of them comply with the common underlying features for elastic flexibility like absence of slip plane, criss-cross packing arrangement of neighboring tapes, presence of weak and dispersive interactions such as halogen bonds, H bonds etc. The interactions facilitate easy movement of mols. under application of pressure thereby imparting elasticity. The crystals are blue light emitting making them promising candidates for optical waveguides. The optical properties were combined with flexibility by using crystal engineering approach towards achieving various applications such as flexible OLEDs, optical waveguides, flexible optoelectronics, etc.

SDS of cas: 90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

3,5-Dibromosalicylaldehyde, also known as 3,5-Dibromosalicylaldehyde, is a useful research compound. Its molecular formula is C7H4Br2O2 and its molecular weight is 279.91 g/mol. The purity is usually 95%.

3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes. 3,5-Dibromosalicylaldehyde can be used in the synthesis of Schiff base and can be used as reactant for synthesis of Schiff base ligands which forms mononuclear complexes with copper(II), nickel(II), zinc(II) and cobalt(II).

3,5-Dibromosalicylaldehyde is a copper complex that has been synthesized from 3,5-dibromosalicylaldehyde and copper chloride. FTIR spectroscopy revealed that the coordination geometry of the copper complex is octahedral with two nitrogen atoms in the equatorial plane. The presence of hydrogen bonding interactions was confirmed by homologous protein adsorption experiments. This chemical structure was determined using X-ray crystallography and fluorescence probe experiments. The copper complex showed high affinity for malonic acid, which is an ester hydrochloride. The molecular mechanism of this interaction is based on adsorption, which occurs through hydrogen bonding interactions and hydrophobic interactions. Structural analysis revealed that the polymeric matrix consists of a three-dimensional network of crosslinked chains, while FTIR analysis indicated a possible disulfide bond between two cysteine residues., 90-59-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Organic compounds having carbon bonded to bromine are called organic bromides. Synthetic Route of 402-49-3.

Tezcan, Burcu;Gok, Yetkin;Sevincek, Resul;Taslimi, Parham;Taskin-Tok, Tugba;Aktas, Aydin;Guezel, Bilgehan;Ayguen, Muhittin;Guelcin, Ilhami research published 《 Benzimidazolium salts bearing the trifluoromethyl group as organofluorine compounds: Synthesis, characterization, crystal structure, in silico study, and inhibitory profiles against acetylcholinesterase and α-glycosidase》, the research content is summarized as follows. Here, we report the synthesis, characterization, and biol. activities of a series of benzimidazolium salts bearing the trifluoromethylbenzyl group. All benzimidazolium salts were characterized by using NMR (NMR) (1H NMR and 13C NMR), Fourier transform-IR spectroscopy, and elemental anal. techniques. The crystal structures of some of these compounds were obtained by the single-crystal X-ray diffraction method. Furthermore, the acetylcholinesterase (AChE) and α-glycosidase (α-Gly) enzyme inhibition activities of these compounds were investigated. The obtained results revealed that 2e, with Ki value of 1.36 ± 0.34 μM against AChE and 3d with Ki value of 91.37 ± 10.38 μM against α-Gly, were the most potent compounds against both assigned enzymes. It should be noted that most of the synthesized compounds were more potent than standard inhibitor tacrine (TAC) against AChE. In silico studies, we focused on compound 2e, 3d, 3e, and 3f as potent inhibitors of AChE and α-Gly, the compound 2e showed good binding energy (-10.23 kcal/mol), among the three selected compounds and pos. control (-10.18, -10.08, and -7.37 kcal/mol for 3d, 3f, and TAC, resp.). Likewise, as a result of the same compounds against the α-Gly enzyme, the compound 3d had the highest binding affinity (-8.39 kcal/mol) between the four selected compounds and the pos. control (-8.27, -8.10, -8.06, and -7.53 kcal/mol for 3f, 3e, 2e, and acarbose, resp.). From the absorption, distribution, metabolism, excretion, and toxicity analyses, it can be concluded that the compounds under consideration exhibited more drug-likeness properties in the prediction studies compared to pos. controls.

Synthetic Route of 402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., 402-49-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Organic compounds having carbon bonded to bromine are called organic bromides. Product Details of C5H7BrO3.

Teshima, Yoshikazu;Saito, Masahiko;Mikie, Tsubasa;Komeyama, Kimihiro;Osaka, Itaru research published 《 Bithiazole Dicarboxylate Ester: An Easily Accessible Electron-Deficient Building Unit for π-Conjugated Polymers Enabling Electron Transport》, the research content is summarized as follows. Thiazole has been less focused, compared to thiophene, as the building unit for π-conjugated polymers that are used in organic electronic devices despite its electron deficiency and ability to coplanarize the polymer backbone, which are crucial for design of such π-conjugated polymers. Here, we show that bithiazole dicarboxylate ester (BETz), which is quite easily synthesized, is a promising building unit for π-conjugated polymers. Copolymers based on BETz, having unsubstituted bithiophene and bithiazole as counits, indeed form highly crystalline structures in thin films, which is beneficial for semiconducting properties. Of particular interest is that the BETz-based polymers are found to show electron-transport property even though the LUMO energy levels are not very low, as they show ambipolar and unipolar n-channel behaviors depending on the counit in organic transistor devices. We believe that BETz allows us to design a wide variety of π-conjugated polymers that provide fascinating functions in organic electronic devices.

Product Details of C5H7BrO3, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 629-04-9, formula is C7H15Br, Name is 1-Bromoheptane. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. HPLC of Formula: 629-04-9.

Teoh, Wei-Jing;Tun Nur Iskandar, Nur Amanina Juniasari;Yeap, Guan-Yeow;Kaneko, Kazuyoshi;Shimizu, Akio;Ito, Masato M. research published 《 Experimental and computational studies of laterally ethoxy Schiff base-ester liquid crystalline magnets》, the research content is summarized as follows. A series of liquid crystals 4-X-(3′-ethoxy-4′-alkyoxyphenyimino)anilines I (X = Me, MeO, Cl; n = 7, 8) with elongated mol. axis through the introduction of alkoxy chains containing different substituents was synthesized. The thermal-optical behaviors of these organic magnets were characterized by differential scanning calorimetry and polarized optical microscopy. Elemental anal., FT-IR and ¹H-NMR were employed to elucidate the mol. structures of the target compounds Exptl. data show that the nematic phase temperature range increases in the order of CH₃ < Cl < OCH₃. The laterally ethoxy Schiff base-ester liquid crystal with the most electroneg. Cl atom is presumed to outweigh both analogs containing CH₃ and OCH₃, leading to the highest clearing temperature (Tc) value, but the present work proved that the presence of the O atom from OCH₃ is inclined to orientate in a parallel arrangement that increases the length-to-breadth ratio and the polarizability of the mol. Computational studies on the different substituents against its kinetic stability were carried out based on the variation in the energy value of HOMO-LUMO gap (ΔE_gap). A relationship between the energy gap and the substituents under the present study shows that when the ΔE_gap increases from OCH₃ < Cl < CH₃, the chem. reactivity decreases, leading to the lowering of the clearing temperature

HPLC of Formula: 629-04-9, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., 629-04-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 402-49-3, formula is C8H6BrF3, The most pervasive is the naturally produced bromomethane. Computed Properties of 402-49-3

Tao, Sibei;Tao, Shaohua;Guo, Fan;Zhang, Lidan;Zhao, Lifeng;Fu, Ping;Ma, Liang research published 《 Discovery of indol-6-yl-pyrrolo[2,3-c]pyridin-7-one derivatives as bromodomain-containing protein 4 (BRD4) inhibitors for the treatment of kidney fibrosis》, the research content is summarized as follows. In the study, authors synthesized a series of indol-6-yl-pyrrolo[2,3-c]pyridin-7-one derivatives I (R¹ = 2-Bu, Bn, pyridin-2-ylmethyl, etc.) and biol. evaluated against BRD4 for structure-activity relationship (SAR). Notably, I (R¹ = pyridin-2-ylmethyl) (ZLD2218) exhibited the most potent inhibitory activity against BRD4, with the IC₅₀ value of 107 nM, which was comparative to 92 nM of pos. control JQ-1. Importantly, at the dose of 15 and 30 mg/kg/d for consecutive 8 days, ZLD2218 alleviated kidney injury and fibrosis in unilateral ureteral obstruction (UUO) mice, with the 30 mg/kg/d being competitive to 100 mg/kd/d of JQ1. Mech., ZLD2218 inhibited BRD4 expression and further suppressed fibrotic signaling in the kidneys of UUO mice and TGF-β1-stimulated TCMK-1 cells. Furthermore, ZLD2218 at the dose of 30 mg/kg/d for 8 days to C57BL/6J mice did not affect liver, kidney function and organ pathol. changes. Collectively, I (R¹ = pyridin-2-ylmethyl) (ZLD2218) might be a promising lead compound of BRD4 inhibitor for the treatment of kidney fibrosis.

402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., Computed Properties of 402-49-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid, Application of C6H11BrO2

Tao, Lei;Yang, Wen;Zhao, Wanxiang research published 《 Synthesis of Carboxylic Acids, Esters, and Amides from 1,1-Dibromoalkenes via Oxidation of Alkynyl Boronate Intermediates》, the research content is summarized as follows. An efficient and practical method for the synthesis of carboxylic acids RCH₂COOH (R = cyclohexyl, biphenyl-4-yl, thiophen-2-yl, etc.), esters RCH₂C(O)OR¹ (R¹ = Me, Bn, cyclopropylmethyl, etc.), and amides RCH₂C(O)NR²R³ [R² = H, Et, i-Pr, Cy, Bn; R³ = n-Bu, cycloproyl, t-Bu, Et, i-Pr, Cy, Bn; R²R³ = -(CH₂)₂O(CH₂)₂-] from 1,1-dibromoalkenes RCH=CBr₂Me has been developed. The reactions proceed through a key process, the C(sp)-B bond oxidation of alkynyl boronate intermediates with Oxone. This protocol features broad substrate scope, good efficiency, and good functional group compatibility. Moreover, the synthetic practicability was demonstrated by easy gram-scale preparation and the synthesis of drug mols., e.g., diclofenac.

4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., Application of C6H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary