Month: November 2022

Zhang, Wen-Jin published the artcileSynthesis and identification of quinoline derivatives as topoisomerase I inhibitors with potent antipsoriasis activity in an animal model, Category: bromides-buliding-blocks, the publication is Bioorganic Chemistry (2019), 102899, database is CAplus and MEDLINE.

Psoriasis is a chronic inflammatory and immune-mediated skin disease. Although certain agents have shown clin. success in treating psoriasis, development of safe and effective strategies for the treatment of this condition remains important. Research suggests that DNA topoisomerase I (Topo I) inhibitors may have potent psoriasis-ameliorating effects. Here, 25 quinoline derivatives were synthesized and identified as Topo I inhibitors. These compounds inhibited the 12-O-tetradecanoylphorbol-13-acetate-induced mouse ear inflammation. The most potent analogs, 5i and 5l, suppressed the expression of inflammatory cytokines in lipopolysaccharide-stimulated HaCaT cells. Addnl., the lead compounds significantly improved imiquimod-induced psoriasis-like inflammation in mice. Moreover, the expression levels of cytokines and inflammatory mediators, such as interleukin (IL)-17A, IL-22, IL-23, nuclear factor-κB subunit p65, tumor necrosis factor-α, and interferon-γ, were dramatically inhibited in the dorsal skin of 5i- and 5l-treated mice. These findings indicate that the inhibition of Topo I activity may potentially be an effective strategy for psoriasis treatment.

Bioorganic Chemistry published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C42H63O3P, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Pan, Xiujiao published the artcileBiosafety-inspired structural optimization of triazolium ionic liquids based on structure-toxicity relationships, Related Products of bromides-buliding-blocks, the publication is Journal of Hazardous Materials (2022), 424(Part_C), 127521, database is CAplus and MEDLINE.

Ionic liquids (ILs), owing to their low vapor pressure and excellent solvating ability, are being increasingly applied in various industries to replace highly toxic organic solvents. They mainly pollute aquatic environment and soils, directly endangering eco-environment and human health. Therefore, it is critical to understand and optimize structural motifs of ILs with reduced toxicity. Considering human oral exposure is the major route, our investigations employed a human cell panel (modeling oral exposures) including human stomach (GES-1), intestinal (FHC), liver (HepG2) and kidney (HEK293) cells using a series of exptl. and computational approaches to explore the cytotoxicity and mol. mechanism of ILs. We discovered that the cytotoxicity of triazolium and imidazolium ILs was human cell line-dependent with cytotoxicity in an order of FHC > GES-1 > HepG2 > HEK293. For this reason, a toxicity assay using a single cell line was highly inappropriate. Compared to anions (Br-, OTs-, OTMBS-) we tested, the cation of ILs played a major role in causing cytotoxicity. Ionic liquids with cations having longer hydrophobic sidechains (IL09 vs. IL01) readily insert into cell membranes with enhanced membrane and lipidomic perturbations, induce cytotoxicity by triggering cell cycle arrest and apoptosis. Reducing sidechain length and incorporating three nitrogen atoms (triazolium) instead of two (imidazolium) in the cation core alleviated cytotoxicity by reducing cell membrane perturbations and cell function interference. These findings provide important guiding principles for the design of the next-generation of “green” and safe ILs.

Journal of Hazardous Materials published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Liu, Xingqiang published the artcileA Coordination Complex System for Generic, Ultrafast, and Sensitive Multimode Fluorescent Staining of Biomolecules, HPLC of Formula: 52431-30-8, the publication is Inorganic Chemistry (2012), 51(1), 188-192, database is CAplus and MEDLINE.

Gel electrophoresis staining methodologies documented thus far are largely utilized in a biomol. context-dependent manner. The authors report herein the development of a generic, ultrafast, and sensitive multimode fluorescent system for the efficient identification of DNA, RNA, and proteins. Interaction between a pos. charged, planar ligand-based coordination complex with partner biomol. leads to aggregation-induced fluorescence quenching and allows for the image contrast generation within one minute. Alternatively, successive reactions of the biomol.-loaded gel with cation and ligand, in either order of sequence, provide an equally effective staining efficacy. Image contrast reversal is accomplished through a facile washing or photobleaching procedure. The versatility in the applicable target species and signal generation modes provides a hint at the design of novel staining structures and potentially enables the high-throughput readout of biomols.

Inorganic Chemistry published new progress about 52431-30-8. 52431-30-8 belongs to bromides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 2,5-Dibromo-3,4-dinitrothiophene, and the molecular formula is C4Br2N2O4S, HPLC of Formula: 52431-30-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Li, Zhong-Yuan published the artcileRuthenium-Catalyzed meta-Selective C-H Mono- and Difluoromethylation of Arenes through ortho-Metalation Strategy, Application of Ethylbromofluoroacetate, the publication is Chemistry – A European Journal (2017), 23(14), 3285-3290, database is CAplus and MEDLINE.

The first example for the ruthenium-catalyzed ligand-directed meta-selective C-H mono- and difluoromethylation is developed, affording a variety of new meta-mono- and difluoromethylated 2-phenylpyridines, 2-phenylpyrimidines, and 1-phenylpyrazoles in moderate-to-good yields. This new transformation exhibits broad substrate scope, good functional group tolerance, and high efficiency, and offers a practical approach to synthesize mono- and difluoromethylated arenes. Mechanistic studies indicate that a reaction pathway involving palladium-initiated radical species is involved in the catalytic cycle. The new dual catalytic system consisting of compatible ruthenium(II) and palladium(0) complexes enables the key processes of C-H activation and mono-/difluoromethyl-radical formation to occur and achieves the meta-selective functionalization efficiently. In addition, the present protocol can also be extended to non-fluoromethylation.

Chemistry – A European Journal published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Application of Ethylbromofluoroacetate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lv, You published the artcileDesign, synthesis and fungicidal activity of 3,4-dichloroisothiazolocoumarin-containing strobilurins, SDS of cas: 401-55-8, the publication is Molecular Diversity (2022), 26(2), 951-961, database is CAplus and MEDLINE.

Twenty-one novel 3,4-dichloroisothiazolocoumarin-containing strobilurins I (R¹ = H, F, Cl, Me, Et; R² = H, 6-Me, 8-Me, 8-Cl), II were rationally designed and synthesized. Preliminary bioassay showed that compounds I (R¹ = H, R² = 8-Cl (III); R¹ = Cl, R² = 6-Me; R¹ = Me, R² = 6-Me) exhibited over 80% inhibitory rate against Sclerotinia sclerotiorum at 50μg/mL, compound III exhibited good activity against S. sclerotiorum with median effective concentration (EC₅₀) of 4.08μ/mL, while the pos. control coumoxystrobin showed EC₅₀ of 1.00μg/mL. In addition, compound I (R¹ = H, R² = 6-Me) showed better fungicidal activity with a lower EC₅₀ value of 7.65μg/mL against Botrytis cinerea than that of pos. control trifloxystrobin with its EC₅₀ value of 21.96μg/mL. In this study, it was indicated that 3,4-dichloroisothiazolocoumarin-containing strobilurins I, II were promising fungicide lead deserved for further study.

Molecular Diversity published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, SDS of cas: 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lv, You published the artcileSynthesis, crystal structure and fungicidal activity of 3-chloro-4-(3,4-dichloroisothiazol-5-yl)-5-hydroxy-7-methyl-2H-chromen-2-ones, SDS of cas: 401-55-8, the publication is Chinese Journal of Structural Chemistry (2021), 40(8), 1068-1074, database is CAplus.

3-Chloro-4-(3,4-dichloroisothiazol-5-yl)-5-hydroxy-7-methyl-2H-chromen-2-ones I [R = H, Me, Et, F, Cl] coumarin derivatives, were synthesized by β-ketoester formation and cyclization. Target compound I [R = Cl] was crystallized from methanol for structural identification as monoclinic crystal system, space group C2/c with a = 16.2700(6), b = 7.1801(5), c = 23.4861(10) Å, V = 2742.6(2) Å3, Z = 8, Dc = 1.756 g/cm3, F(000) = 1456 and μ = 0.827 mm-1. 8308 Reflections were collected (6.01≤2θ≤50.05°), of which 2428 were unique (Rint = 0.0432) and used in all calculations The final R = 0.0408 (I > 2σ(I)) and wR = 0.1056 (reflections). In-vitro bioassay indicated that compounds I [R = F, Cl] possessed good activity against Botrytis cinerea, Physalospora piricola, Rhizoctonia solani, and Sclerotinia sclerotiorum with lower EC₅₀ values falling between 0.50 and 4.85μg/mL than that of pos. control osthole with its EC₅₀ values between 7.38 and 74.59μg/mL. In-vivo screening showed that I [R = Cl] exhibited 98% and 95% efficacy against Pseudoperonospora cubensis (Berk. & Curt.) Rostov. at 100 and 50μg/mL, resp. These studies observed that the combination of bioactive substructures of isothiazole with coumarin were an effective way to novel fungicide development.

Chinese Journal of Structural Chemistry published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, SDS of cas: 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Li, Qing published the artcileSynthesis and characterization of thieno[3,4-b]pyrazine materials for solution-processible organic red light-emitting diodes, Product Details of C4Br2N2O4S, the publication is Chemistry Letters (2011), 40(4), 417-419, database is CAplus.

Two novel thieno[3,4-b]pyrazine-cored mols., P-DTP and TP-DTP, are synthesized and are characterized by extra large Stokes shifts of over 300 nm. The bulky polyaromatic arms enable these mols. to be solution processible and provide site-isolation on the planar emissive core. They exhibit saturated red electroluminescence in non-oped organic light-emitting diodes fabricated by spin coating.

Chemistry Letters published new progress about 52431-30-8. 52431-30-8 belongs to bromides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 2,5-Dibromo-3,4-dinitrothiophene, and the molecular formula is C4Br2N2O4S, Product Details of C4Br2N2O4S.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Li, Qing published the artcileNovel red-emitting thieno-[3,4-b]-pyrazine derivatives suitable for vacuum evaporation and solution method to fabricate non-doped OLEDs, Related Products of bromides-buliding-blocks, the publication is Dyes and Pigments (2012), 92(1), 674-680, database is CAplus.

Two novel red-emitting thieno-[3,4-b]-pyrazine-cored mols. with phenyls (TP) or polyphenyls (Muellen type dendron, DTP) as peripheral groups were designed and synthesized. They have large Stokes shifts over 100 nm. DTP is thermally stable with decomposition temperature up to 458°C. More importantly, it is amorphous with a remarkably high glass transition temperature of 262°C. DTP can be made into thin films either by solution method or vacuum evaporation Red OLEDs were fabricated using either spin coated or vacuum evaporated DTP film as emitting layer. The evaporated device exhibited a maximum brightness of 1753 cd m^-2 and a luminous efficiency of 0.74 cd A^-1, which are among the best data ever reported for thieno-[3,4-b]-pyrazine derivatives so far. In contrast, TP failed to produce satisfactory red emission in its evaporated OLEDs.

Dyes and Pigments published new progress about 52431-30-8. 52431-30-8 belongs to bromides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 2,5-Dibromo-3,4-dinitrothiophene, and the molecular formula is C4Br2N2O4S, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Li, Qing published the artcileSolution-processible Thieno-[3,4-b]-pyrazine Derivatives with Large Stokes Shifts for Non-doped Red Light-emitting Diodes, Product Details of C4Br2N2O4S, the publication is Macromolecular Rapid Communications (2011), 32(9-10), 736-743, database is CAplus and MEDLINE.

A group of novel thieno-[3,4-b]-pyrazine-cored mols. containing polyphenyl dendrons with or without arylamino or carbazolyl surface groups (DTP, N-DTP and C-DTP) are synthesized and investigated. They are characterized by extra large Stokes shifts of over 250 nm. In addition, to provide the site-isolation effect on the planar emissive core, the bulky dendrons enable these mols. to be solution processible. The peripheral carbazolyl or arylamino units facilitate the hole transporting ability in the neat films of these mols. These dendritic materials are used as a non-doped emitting layer to fabricate organic light-emitting diodes (OLEDs) using a spin coating technique and saturated red emission is obtained. The dendritic mols. with arylamino or carbazolyl surface groups (N-DTP and C-DTP) exhibit a brightness of 1020 cd m^-2 and a luminous efficiency of 0.6 cd A^-1, both higher than the dendritic analog without the surface functional groups (DTP), even superior to the small mol. reference compound which fails to transmit pure red emission under identical conditions. This performance is also comparable with that from vacuum deposited thieno-[3,4-b]-pyrazine-based counterparts and that for some other solution processible red fluorescent dendrimers. This is the first example of solution processible thieno-[3,4-b]-pyrazine derivatives for OLED applications.

Macromolecular Rapid Communications published new progress about 52431-30-8. 52431-30-8 belongs to bromides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 2,5-Dibromo-3,4-dinitrothiophene, and the molecular formula is C4Br2N2O4S, Product Details of C4Br2N2O4S.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Ding, Rui published the artcileA Highly Efficient Method for the Bromination of Alkenes, Alkynes and Ketones Using Dimethyl Sulfoxide and Oxalyl Bromide, Application In Synthesis of 594-81-0, the publication is Synthesis (2018), 50(21), 4325-4335, database is CAplus.

The pairing of DMSO and oxalyl bromide is reported as a highly efficient brominating reagent for various alkenes, alkynes and ketones. This bromination approach demonstrates remarkable advantages, such as mild conditions, low cost, short reaction times, provides excellent yields in most cases and represents a very attractive alternative for the preparation of dibromides and α-bromoketones.

Synthesis published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Application In Synthesis of 594-81-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary