Month: November 2022

Armstrong, Megan K. published the artcileDifferential Dihydrofunctionalization of Terminal Alkynes: Synthesis of Benzylic Alkyl Boronates through Reductive Three-Component Coupling, Formula: C7H11Br, the publication is Journal of the American Chemical Society (2019), 141(15), 6173-6179, database is CAplus and MEDLINE.

The differential dihydrofunctionalization of terminal alkynes is accomplished through the reductive three-component coupling of terminal alkynes, aryl halides, and pinacolborane. The transformation results in hydrofunctionalization of both π-bonds of an alkyne in a single reaction promoted by cooperative action of a Cu/Pd catalyst system. The differential dihydrofunctionalization reaction has excellent substrate scope and can be accomplished in the presence of esters, nitriles, alkyl halides, epoxides, acetals, alkenes, aryl halides, and silyl ethers. Mechanistic experiments indicate that the reaction proceeds through Cu-catalyzed hydroboration followed by a 2nd hydrocupration. The resulting heterobimetallic complex is the key intermediate that participates in the subsequent Pd-catalyzed cross-coupling, which furnishes benzylic alkyl boronate products.

Journal of the American Chemical Society published new progress about 81216-14-0. 81216-14-0 belongs to bromides-buliding-blocks, auxiliary class Linker,PROTAC Linker, name is 7-Bromohept-1-yne, and the molecular formula is C7H11Br, Formula: C7H11Br.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Levitz, Andrew published the artcileSynthesis and effect of heterocycle modification on the spectroscopic properties of a series of unsymmetrical trimethine cyanine dyes, Name: Sodium 3-bromopropane-1-sulfonate, the publication is Dyes and Pigments (2014), 238-249, database is CAplus.

Carbocyanine dyes are a class of organic compounds that contain two heterocycles that act as electron donors and acceptors connected by a conjugated methine bridge. Herein the synthesis of a series of 16 novel unsym. trimethine cyanine dyes is reported. Their structures were characterized by various spectroscopic techniques, and their optical properties were measured. Absorption maxima of the dyes were calculated using the time-dependent d.-functional theory method and the computational absorption maxima are consistent with the exptl. data. The addition of electron withdrawing substituents such as halogens on the heterocycle gave more favorable optical properties such as higher quantum yield and molar absorptivity. The aggregation of these cyanine dyes was studied and compared to a similar series of sym. cyanine dyes. It was determined that the heterocycle has more effect on aggregation than the side chain and a dye with two different heterocycles will aggregate less than a dye with the same heterocycle. The dyes were also investigated for Lipinski Rule violations as their use is becoming more prevalent for in vivo applications.

Dyes and Pigments published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Name: Sodium 3-bromopropane-1-sulfonate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kuznetsova, Lidia I. published the artcileOxidative Bromination of Alkenes Mediated with Nitrite in Ionic Liquids, Recommanded Product: 2,3-Dibromo-2,3-dimethylbutane, the publication is Catalysis Letters (2014), 144(9), 1499-1506, database is CAplus.

An oxidative bromination of C₂-C₈ alkenes with HBr-NaNO₂-O₂ in solutions of BMImBr, HMImBr or BMImBF₄ containing 16-28 wt% H₂O was studied using a volumetric method, GC-MS anal., ¹⁴N NMR and UV-VIS spectroscopy. The optimal conditions to conduct the reaction at high selectivity for 1,2-dibromoalkanes in BMImBr were determined The composition of ionic liquid affects the catalytic performance. Although in BMImBF₄ the reaction runs with equal rate as in bromide ionic liquid, the fraction of bromohydrin in the reaction products increases to 20%. Generated from NaNO₂, NO_x operated as a catalyst in the oxidation of bromide ion (Br^–) and was oxidized to catalytically inert nitrate (NO₃^–) anions when complete conversion of HBr was attained. The synthesis of the target compounds was achieved using 1-butyl-3-methylimidazolium bromide as ionic liquid Alkenes included 1-propene, 1-butene (α-alkenes), 2-methyl-1-propene, cyclohexene, 1-octene, 2,3-dimethyl-2-butene. The title compounds thus formed included 1,2-dibromopropane, 1,2-dibromobutane, 1,2-dibromo-2-methylpropane and similar substances. Alcs., such as 1-bromo-2-propanol, 1-bromo-2-butanol, 1-bromo-2-methyl-2-propanol, 2-bromocyclohexanol, 1-bromo-2-octanol, 2-bromoethanol were also observed Formation of 2,3-dimethyl-2,3-dinitrobutane and 2,2,3,3-tetramethyloxirane was reported.

Catalysis Letters published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Recommanded Product: 2,3-Dibromo-2,3-dimethylbutane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kuznetsova, Darya A. published the artcileCationic Imidazolium Amphiphiles Bearing a Methoxyphenyl Fragment: Synthesis, Self-Assembly Behavior, and Antimicrobial Activity, Recommanded Product: 1-Bromododecane, the publication is Langmuir (2022), 38(16), 4921-4934, database is CAplus and MEDLINE.

Novel cationic amphiphiles of the 3-alkyl-1-(4-methoxyphenyl)-1H-imidazol-3-ium bromide series bearing methoxyphenyl fragments (MPI-n) have been synthesized. Their aggregation properties in aqueous solutions, solubilization capacity, and hemolytic and antimicrobial activities have been investigated by a number of physicochem. methods. Using tensiometry, conductometry, and fluorescence spectroscopy, it was shown that the MPI-n have lower CMCs than their nonfunctionalized counterparts. The unusual alkyl-chain-length-dependent morphol. of aggregates is testified for this homol. series. Amphiphiles with 12, 14, and 16 alkyl tails are characterized by the formation of micellar aggregates, while a surfactant with a decyl tail is characterized by the formation of larger aggregates with lower surface curvature. The MPI-10 aggregate morphol. was rationalized in terms of the packing parameter consideration and was supported by size measurements and the fluorescence probe techniques, which showed that vesicle-like aggregates in close-packing mode probably occur. MPI-n aggregates have exhibited a high solubilization capacity toward hydrophobic azo dye Orange OT. Importantly, amphiphiles studied showed (i) high bacteriostatic activity at the level of ciprofloxacin; (ii) high bactericidal action against all Gram-pos. bacteria, including methicillin-resistant strains; (iii) bactericidal properties against Gram-neg. bacteria; and (iv) low hemolytic activity.

Langmuir published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, Recommanded Product: 1-Bromododecane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Saito, Hitoshi published the artcileFacile synthesis of fluorene-based π-conjugated polymers via sequential bromination/direct arylation polycondensation, Safety of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2015), 53(19), 2198-2201, database is CAplus.

The synthesis of fluorene-based p-conjugated polymers via sequential bromination and direct arylation was demonstrated. Bromination of 9,9-dioctylfluorene using BTMA Br3 efficiently proceeded and barely inhibited the following direct arylation polycondensation, successfully giving π-conjugated polymers. This is the first example of the facile synthesis of π-conjugated polymers in a one-pot fashion, without the need for prior preparation and purification of dibrominated aromatic monomers as well as organometallic monomers, and the bromination reaction using BTMA Br3 is also available to other aromatic compounds such as thiophene and carbazole derivatives Therefore, the fundamental step-economical protocol described here should present new insights for the synthesis of π-conjugated semiconducting materials.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Safety of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kosmalski, Tomasz published the artcileNew heterocyclic oxime ethers of 1-(benzofuran-2-yl)ethan-1-one and their antimicrobial activity, Recommanded Product: 4-Bromo-1-(bromomethyl)-2-fluorobenzene, the publication is Acta Poloniae Pharmaceutica (2015), 72(2), 289-295, database is CAplus.

A series of benzofurans I (R = 4-CF₃, 4-Br-2-F, 2,6-F₂, etc.) were synthesized starting from 2-acetylbenzofuran. Antimicrobial activities of the compounds were examined and notable activity was observed

Acta Poloniae Pharmaceutica published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Recommanded Product: 4-Bromo-1-(bromomethyl)-2-fluorobenzene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Miura, Yozo published the artcilePurely organic magnetism of pyridyl-substituted stable thioaminyl radicals, Application In Synthesis of 111865-47-5, the publication is Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals (1999), 195-204, database is CAplus.

N-[(4-Nitrophenyl)thio]- (1a) and N-[(2,4-dichlorophenyl)(thio)]-2,6-diphenyl-4-(3-pyridyl)phenylaminyl (1b), N-[(4-nitrophenyl)thio]- (2a) and N-[(2,4-dichlorophenyl)thio]-4-phenyl-2,6-di(3-pyridyl)phenylaminyl (2b) were generated by PbO₂ oxidation of the corresponding precursors and isolated as radical crystals. For 1b x-ray crystallog. anal. was performed. The magnetic susceptibility measurements were carried out for the isolated radicals using a SQUID magnetometer at 1.8-300 K. The susceptibilities of 1a and 2a were analyzed in terms of a 1-dimensional (1D) antiferromagnetic (AFM) regular Heisenberg model with exchange interaction of 2J/k_B=-63.4 and -17.8 K, resp., and that of 1b was interpreted in terms of a 1-dimensional AFM alternating Heisenberg model with 2J/k_B = -12.8 K and α 0.91. However, that of 2b was explained in terms of a 1-dimensional ferromagnetic regular Heisenberg model with 2J/k_B = 22.4 K.

Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Application In Synthesis of 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Miura, Yozo published the artcilePyridyl-Substituted Thioaminyl Stable Free Radicals: Isolation, ESR Spectra, and Magnetic Characterization, Name: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Journal of Organic Chemistry (1998), 63(23), 8295-8303, database is CAplus.

N-[(4-Nitrophenyl)thio]- (1a) and N-[(2,4-dichlorophenyl)thio]-2,6-diphenyl-4-(3-pyridyl)phenylaminyl (1b), N-[(4-nitrophenyl)thio]- (2a) and N-[(2,4-dichlorophenyl)thio]-4-phenyl-2,6-di(3-pyridyl)phenylaminyl (2b), and N-[(2,4-dichlorophenyl)thio]-2,6-diphenyl(4-pyridyl)aminyl (3) were generated by PbO₂ oxidation of the corresponding precursors. Although 3 was not sufficiently stable to be isolated, both 1 and 2 persisted in solution without decomposition and could be isolated as radical crystals. X-ray crystallog. anal. of 1b revealed that the Ar-N-S-Ar’ π-framework is approx. planar and the 2- and 6-Ph groups are significantly twisted from this plane. The magnetic susceptibility measurements for the isolated radical crystals were carried out using a SQUID magnetometer in the temperature range 1.8-300 K. The susceptibilities of 1a and 2a were explained in terms of a 1-dimensional (1D) antiferromagnetic (AFM) regular Heisenberg model with an exchange interaction of 2J/k_B = -63.4 and -17.8 K, resp., and that of 1b was interpreted in terms of a 1-dimensional AFM alternating Heisenberg model with 2J/k_B = -12.8 K and α (alternation parameter) = 0.91. However, that of 2b was explained in terms of a 1-dimensional ferromagnetic regular Heisenberg model with 2J/k_B = 22.4 K.

Journal of Organic Chemistry published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Name: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Rastyanite, L. published the artcileSulfoalkylation of 1,2-dihydro-3,6-pyridazine- and 2,3-dihydro-1,4-phthalazinediones and their N-phenyl derivatives by 1,3-propanesultone and bromoalkanesulfonates, Related Products of bromides-buliding-blocks, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) (2002), 38(11), 1363-1367, database is CAplus.

When 1,2-dihydropyridazine-3,6-dione, 2,3-dihydrophthalazine-1,4-dione, 1-phenyl-1,2-dihydropyridazine-3,6-dione, and 2-phenyl-2,3-dihydrophthalazine-1,4-dione react with 1,3-propanesultone and bromoalkanesulfonates, depending on the nature of the sulfoalkylating agent in the case of 1,2-dihydropyridazine-3,6-dione and 2,3-dihydrophthalazine-1,4-dione, either N,O- or O,O’-disulfoalkylated compounds may be formed, while O-monosulfoalkylated reaction products may be formed in the case of the N-phenyl-substituted derivatives of the above-indicated azinediones.

Chemistry of Heterocyclic Compounds (New York, NY, United States)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Yin, Hongfei published the artcilePalladium Catalyzed Carbonylative Coupling of Alkyl Boron Reagents with Bromodifluoroacetamides, HPLC of Formula: 401-55-8, the publication is ACS Catalysis (2018), 8(5), 3853-3858, database is CAplus.

A catalytic protocol for the preparation of α,α-difluoro-β-alkyl-β-ketoamides is developed employing a Pd-mediated carbonylative Suzuki coupling between alkylboron reagents and bromodifluoroacetamides with COgen as the CO source. The reaction reveals good functional group tolerance providing a broad selection of α,α-difluoro-β-alkyl-β-ketoamides in moderate to good yields, which represent useful precursors for further synthetic manipulation. Finally, the methodol. is amenable to ¹³C-isotope labeling at the ketone carbon applying ¹³C-COgen.

ACS Catalysis published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C16H14O6, HPLC of Formula: 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary