Month: November 2022

Wang, Li-Jun published the artcileSynthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents, Name: 4-Bromo-1-(bromomethyl)-2-fluorobenzene, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(10), 3473-3479, database is CAplus and MEDLINE.

Fifty-seven derivatives of glycyrrhetinic acid (GA) were synthesized, and their anti-hepatitis B virus (HBV) activity was evaluated in HepG 2.2.15 cells. Among them, sixteen compounds showed greater anti-HBV activity than GA, especially, compounds I (R = 4-iodobenzyl), I (R = 4-(trifluoromethyl)benzyl), I (R = 4-nitrobenzyl), I (R = (2-methylthiazol-4-yl)methyl) exhibited significantly inhibitory activities against HBV DNA replication with IC₅₀ values of 5.71, 5.36, 8.90 and 9.08 μM, resp. The structure-activity relationships (SARs) of GA derivatives were discussed for exploring novel anti-HBV agents.

Bioorganic & Medicinal Chemistry Letters published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C17H18N3NaO3S, Name: 4-Bromo-1-(bromomethyl)-2-fluorobenzene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Suchaud, Virginie published the artcileIdentification of 1,6-dihydropyrazolo[4,3-c]carbazoles and 3,6-dihydropyrazolo[3,4-c]carbazoles as new Pim kinase inhibitors, Product Details of C7H8BBrO3, the publication is Bioorganic & Medicinal Chemistry (2013), 21(14), 4102-4111, database is CAplus and MEDLINE.

New 1,6-dihydropyrazolo[4,3-c]carbazoles and 3,6-dihydropyrazolo[3,4-c]carbazoles were prepared and evaluated for their Pim kinase inhibitory potencies as well as their antiproliferative activities toward two prostatic cancer cell lines. Pyrazolocarbazole I was found to be a potent Pim kinase modulator with inhibitory potency toward the three isoforms. Compound II strongly inhibited Pim-3 with weaker effects toward Pim-1 and Pim-2, and thus could be used as an interesting mol. tool to study Pim-3 biol. functions.

Bioorganic & Medicinal Chemistry published new progress about 89694-44-0. 89694-44-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 2-Bromo-5-methoxybenzene boronic acid, and the molecular formula is C13H17BrO3, Product Details of C7H8BBrO3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Galli, Diana published the artcileSuppressing the Surface Recombination and Tuning the Open-Circuit Voltage of Polymer/Fullerene Solar Cells by Implementing an Aggregative Ternary Compound, Safety of 2,5-Dibromo-3,4-dinitrothiophene, the publication is ACS Applied Materials & Interfaces (2018), 10(34), 28803-28811, database is CAplus and MEDLINE.

The authors present a novel small mol. based on dithienylthienothiadiazole units (named SM1) acting as an efficient component in ternary blend organic solar cells to modify the hole extraction at the interface. The SM1 suppresses the surface recombination and enhances the open-circuit voltage (V_oc). By introducing SM1 in a host system composed of poly(3-hexylthiophene) (P3HT) and [6,6]-phenyl-C₆₁-butyric acid Me ester (PCBM), the authors obtained V_oc values of up to 0.75 V and fill factors larger than 70% for the ternary blends. As a consequence, the power conversion efficiency is improved by ∼30% compared to P3HT:PCBM binary devices. External quantum efficiency and absorption spectra in the near-IR region do not show any contribution of SM1 in dried films. Instead, the addition of the small mol. improves the V_oc by reducing the surface recombination losses. To shed light on the recombination processes, the authors carried out Fourier-transform photocurrent spectroscopy and impedance spectroscopy measurements. The ternary concept can also have functionalities other than photosensitization and can even act as a morphol.-directing agent or an interface modifier.

ACS Applied Materials & Interfaces published new progress about 52431-30-8. 52431-30-8 belongs to bromides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 2,5-Dibromo-3,4-dinitrothiophene, and the molecular formula is C4Br2N2O4S, Safety of 2,5-Dibromo-3,4-dinitrothiophene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wroblewska, Elwira Katarzyna published the artcile5-(3-Bromo-4-hydroxy-5-methoxyphenyl)-7,7-dimethyl-7H-indolo[1,2-a]quinolinium perchlorate as a new indicator for anionic surface active agents determination. Part II. Influence of pH on the titration results, Application of Dimidium bromide, the publication is Tenside, Surfactants, Detergents (2011), 48(2), 127-129, database is CAplus.

The work refers to the already published modification of widely used method for anionic active agents determination which concerns the replacement of the mixed indicator, consisting of Acid Blue 1 and carcinogenic Dimidium Bromide, applied in the International Standard ISO 2271:1989 with solvatochromic dye, i.e. 5-(3-bromo-4-hydroxy-5-methoxyphenyl)-7,7-dimethyl-7H-indolo[1,2-a]quinolinium perchlorate (1). The value of pK_a for examined dye (1) amounts to 6.59, and the effect of pH of the probes on the anal. results was studied, i.e. precision of determination of titration endpoint. The change of pH for aqueous and apparent pH for organic phase were determined during the titration process. It was shown that there was no effect of the pH change in the range from 3.5 to 5.0 on the results. The modification of the method for the probes which pH do not fit to the above range is presented.

Tenside, Surfactants, Detergents published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C9H21NO3, Application of Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wroblewska, E. K. published the artcile5-(3-bromo-4-hydroxy-5-methoxyphenyl)-7,7-dimethyl-7H-indolo[1,2-a] quinolinium perchlorate as a new indicator for anionic surface active agents determination, Synthetic Route of 518-67-2, the publication is Tenside, Surfactants, Detergents (2010), 47(2), 119-122, database is CAplus.

5-(3-Bromo-4-hydroxy-5-methoxyphenyl)-7,7-dimethyl-7H-indolo[1,2-a]quinolinium perchlorate (la) was used as an indicator for anionic surface active agents determination in the manual direct two-phase titration according to the International Standard [ISO 2271: 1989] Surface active agents. The solvatochromic dye (la) can successfully replace the recommended mixed indicator consisting of a mixture of Acid Blue I and carcinogenic dimidium bromide. The detection of the titration endpoint with use of this dye turned out much easier than with the use of the mixed indicator. The procedure was also modified replacing carcinogenic and mutagenic chloroform with less toxic dichloromethane. The concentrations of the anionic surface – active substances in few com. available products were determined using modified two-phase titration method.

Tenside, Surfactants, Detergents published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C22H12F6O6S2, Synthetic Route of 518-67-2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Blake, Matthew R. published the artcileSmall Molecules Targeting PTPσ-Trk Interactions Promote Sympathetic Nerve Regeneration, Category: bromides-buliding-blocks, the publication is ACS Chemical Neuroscience (2022), 13(5), 688-699, database is CAplus and MEDLINE.

Chondroitin sulfate proteoglycans (CSPGs) prevent sympathetic nerve regeneration in the heart after myocardial infarction and prevent central nerve regrowth after traumatic brain injury and spinal cord injury. Currently, there are no small-mol. therapeutics to promote nerve regeneration through CSPG-containing scars. CSPGs bind to monomers of receptor protein tyrosine phosphatase sigma (PTPσ) on the surface of neurons, enhancing the ability of PTPσ to bind and dephosphorylate tropomyosin receptor kinases (Trks), inhibiting their activity and preventing axon outgrowth. Targeting PTPσ-Trk interactions is thus a potential therapeutic target. Here, we describe the development and synthesis of small mols. (HJ-01 and HJ-02) that disrupt PTPσ interactions with Trks, enhance Trk signaling, and promote sympathetic nerve regeneration over CSPGs.

ACS Chemical Neuroscience published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mattarella, Martin published the artcileNanomolar cholera toxin inhibitors based on symmetrical pentavalent ganglioside GM1os-sym-corannulenes, Safety of (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Organic & Biomolecular Chemistry (2013), 11(26), 4333-4339, database is CAplus and MEDLINE.

Eight sym. and pentavalent corannulene derivatives were functionalized with galactose and the ganglioside GM1-oligosaccharide (GM1os) via copper-catalyzed alkyne-azide cycloaddition (CuAAC) reactions. The compounds were evaluated for their ability to inhibit the binding of the pentavalent cholera toxin to its natural ligand, ganglioside GM1. In this assay, all ganglioside GM1os-sym-corannulenes proved to be highly potent nanomolar inhibitors of cholera toxin.

Organic & Biomolecular Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Safety of (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wang, Zhiming published the artcileHighly π-extended polymers based on phenanthro-pyrazine: Synthesis, characterization, theoretical calculation and photovoltaic properties, Formula: C4Br2N2O4S, the publication is Polymer (2013), 54(22), 6191-6199, database is CAplus.

Two novel narrow bandgap conjugated polymers containing phenanthro-pyrazine unit have been successfully synthesized by the Stille coupling reaction. Comparing to the common polymers containing dithiophen-quinoxaline or dithiophen-thieno[3,4-b]pyrazine moiety, the conjugation degree of these new polymers is extended through the direction perpendicular to the main chain by introducing phenanthrene-9,10-dione to maintain a rigid conjugated bridge. The obtained polymers exhibit solution-processing ability, high thermal stabilities, broad visible absorption bands and narrow optical bandgaps. Theor. studies disclose that the P2 exhibits wholly coplanar conformation in 1-D and 2-D direction, and the PCE value is 6-folded higher than P1 under the same photovoltaic measurement condition.

Polymer published new progress about 52431-30-8. 52431-30-8 belongs to bromides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 2,5-Dibromo-3,4-dinitrothiophene, and the molecular formula is C13H26N2, Formula: C4Br2N2O4S.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wang, Wei published the artcileBuilding fluorescent sensors by template polymerization: the preparation of a fluorescent sensor for D-fructose, Application In Synthesis of 166821-88-1, the publication is Organic Letters (1999), 1(8), 1209-1212, database is CAplus and MEDLINE.

The application of mol. imprinting in making fluorescent sensors was hampered by the lack of suitable fluorescent tags, which would respond to the binding event with significant fluorescence intensity changes. The authors have designed and synthesized a fluorescent monomer which allows for the preparation of fluorescent sensors of cis diols using mol. imprinting methods. This monomer was used for the preparation of sensitive fluorescent sensors for D-fructose.

Organic Letters published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C7H8BFO2, Application In Synthesis of 166821-88-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Hu, Qinglian published the artcileMitochondria-Targeted Cancer Therapy Using a Light-Up Probe with Aggregation-Induced-Emission Characteristics, Safety of 4-((6-Bromohexyl)oxy)-2-hydroxybenzaldehyde, the publication is Angewandte Chemie, International Edition (2014), 53(51), 14225-14229, database is CAplus and MEDLINE.

Subcellular organelle-specific reagents for simultaneous tumor targeting, imaging, and treatment are of enormous interest in cancer therapy. Herein, the authors present a mitochondria-targeting probe (AIE-mito-TPP) by conjugating a triphenylphosphine (TPP) with a fluorogen which can undergo aggregation-induced emission (AIE). Owing to the more neg. mitochondrial membrane potential of cancer cells than normal cells, the AIE-mito-TPP probe can selectively accumulate in cancer-cell mitochondria and light up its fluorescence. More importantly, the probe exhibits selective cytotoxicity for studied cancer cells over normal cells. The high potency of AIE-mito-TPP correlates with its strong ability to aggregate in mitochondria, which can efficiently decrease the mitochondria membrane potential and increase the level of intracellular reactive oxygen species (ROS) in cancer cells. The mitochondrial light-up probe provides a unique strategy for potential image-guided therapy of cancer cells.

Angewandte Chemie, International Edition published new progress about 1207448-58-5. 1207448-58-5 belongs to bromides-buliding-blocks, auxiliary class Bromide,Benzene,Phenol,Ether,Aldehyde, name is 4-((6-Bromohexyl)oxy)-2-hydroxybenzaldehyde, and the molecular formula is C13H17BrO3, Safety of 4-((6-Bromohexyl)oxy)-2-hydroxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary