Month: November 2022

Sabbaghan, Maryam published the artcileThe effect of aromatic and non-aromatic ionic liquids on the optical nonlinearity responses of porphyrins, Synthetic Route of 111-83-1, the publication is Journal of Molecular Liquids (2022), 118398, database is CAplus.

The effects of adding aromatic and nonaromatic ionic liquids (ILs) on third-order nonlinear optical (NLO) responses of 5,10,15,20-Tetrakis(4-methoxycarbonylphenyl) porphyrin (S1) and [5,10,15,20-Tetrakis(4-methoxycarbonylphenyl)-porphyrin]-Co (II) (S2) at 532 nm were investigated using the Z-scan technique. ILs show negligible nonlinear response in compare with porphyrins. A significant increase in NLO response with adding DABCO-based IL to S1 was observed which approx. equal to Cobalt(II) ion substitution at the core of porphyrin structure. The obtained value of nonlinear absorption coefficient β (cm/W) and the nonlinear refractive index n₂ (cm²/W), are of the order of 10^-4 and 10^-8, resp. The pos. synergetic effects were interpreted for enhanced nonlinear optical response by adding imidazolium-based IL and Cobalt(II) ion substitution at the core of porphyrin structure. Using ILs as additive led to excellent nonlinear properties which implies their promising applications in the optical devices.

Journal of Molecular Liquids published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Synthetic Route of 111-83-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Nachtergaele, Sigrid published the artcileOxysterols are allosteric activators of the oncoprotein Smoothened, SDS of cas: 69361-41-7, the publication is Nature Chemical Biology (2012), 8(2), 211-220, database is CAplus and MEDLINE.

Oxysterols are a class of endogenous signaling mols. that can activate the Hedgehog pathway, which has critical roles in development, regeneration and cancer. However, it has been unclear how oxysterols influence Hedgehog signaling, including whether their effects are mediated through a protein target or indirectly through effects on membrane properties. To answer this question, we synthesized the enantiomer and an epimer of the most potent oxysterol, 20(S)-hydroxycholesterol. Using these mols., we show that the effects of oxysterols on Hedgehog signaling are exquisitely stereoselective, consistent with the hypothesis that they function through a specific protein target. We present several lines of evidence that this protein target is the seven-pass transmembrane protein Smoothened (Smo), a major drug target in oncol. Our work suggests that these enigmatic sterols, which have multiple effects on cell physiol., may act as ligands for signaling receptors and provides a generally applicable framework for probing sterol signaling mechanisms.

Nature Chemical Biology published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, SDS of cas: 69361-41-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Negoro, Toshiyuki published the artcileNovel, Highly Potent Aldose Reductase Inhibitors: (R)-(-)-2-(4-Bromo-2-fluorobenzyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine- 4-spiro-3′-pyrrolidine-1,2′,3,5′-tetrone (AS-3201) and Its Congeners, COA of Formula: C7H8BrClFN, the publication is Journal of Medicinal Chemistry (1998), 41(21), 4118-4129, database is CAplus and MEDLINE.

A series of novel tetrahydropyrrolo[1,2-a]pyrazine derivatives were synthesized and evaluated as aldose reductase inhibitors on the basis of their abilities to inhibit porcine lens aldose reductase in vitro and to inhibit sorbitol accumulation in the sciatic nerve of streptozotocin-induced diabetic rats in vivo. Of these compounds, spirosuccinimide-fused tetrahydropyrrolo[1,2-a]pyrazine-1,3-dione derivatives showed significantly potent aldose reductase inhibitory activity. In the in vivo activity of these derivatives, 2-(4-bromo-2-fluorobenzyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-4-spiro-3′-pyrrolidine-1,2′,3,5′-tetrone (I) (SX-3030) showed the best oral activity. The enantiomers of I were synthesized, and the biol. activities were evaluated. It was found that aldose reductase inhibitory activity resides in the (-)-I (AS-3201), which was 10 times more potent in inhibition of the aldose reductase (IC₅₀ = 1.5 × 10^-8 M) and 500 times more potent in the in vivo activity (ED₅₀ = 0.18 mg/kg/day for 5 days) than the corresponding (+)-I (SX-3202). From these results, AS-3201 was selected as the candidate for clin. development. The absolute configuration of AS-3201 was also established to be (R)-form by single-crystal X-ray anal. In this article we report the preparation and structure-activity relationship of tetrahydropyrrolopyrazine derivatives including a novel aldose reductase inhibitor, AS-3201.

Journal of Medicinal Chemistry published new progress about 147181-08-6. 147181-08-6 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Salt,Amine,Benzene, name is (4-Bromo-2-fluorophenyl)methanamine hydrochloride, and the molecular formula is C7H8BrClFN, COA of Formula: C7H8BrClFN.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Tamaoku, Katsumi published the artcileNew water-soluble hydrogen donors for the enzymatic spectrophotometric determination of hydrogen peroxide, Product Details of C3H6BrNaO3S, the publication is Analytica Chimica Acta (1982), 121-7, database is CAplus.

Eight N-alkyl-N-sulfopropylaniline derivatives were synthesized and assessed as water-soluble H donors for the spectrophotometric determination of H₂O₂ in the presence of peroxidase. The Na salts of N-ethyl-N-sulfopropylaniline (I), N-ethyl-N-sulfopropyl-m-toluidine (II), and N-ethyl-N-sulfopropyl-m-anisidine (III) are recommended. They have excellent water solubilities, and the optimum pH range for oxidative condensation with 4-aminoantipyrine in the presence of H₂O₂ and peroxidase is 5.5-9.5. The absorbances of the resulting chromogens are 2-3-fold higher than that achieved with PhOH. The molar absorptivities of the chromogens with 4-aminoantipyrine are 41,300 (I, γ_max 561 nm), 37,400 (II, γ_max 550 nm) and 27,900 (III, γ_max 540 nm). Calibration graphs for the determination of H₂O₂ in the presence of a control serum are linear for 7-40 × 10^-6 mol H₂O₂/L.

Analytica Chimica Acta published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C13H16O2, Product Details of C3H6BrNaO3S.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Miura, Yozo published the artcileNew Method for the Synthesis of N-tert-Alkoxyarylaminyl Radicals, Category: bromides-buliding-blocks, the publication is Journal of Organic Chemistry (2006), 71(13), 4786-4794, database is CAplus and MEDLINE.

The reactions of 2,4-diaryl-6-tert-butylnitrosobenzenes with 2,2′-azobis[2-(methoxycarbonyl)propane] (5a), 2,2′-azobis(2-cyano-4-methylpentane) (5b), and 2,2′-azobis(2-cyano-4-methyl-4-methoxypentane) (5c) in refluxing benzene gave stable N-tert-alkoxy-2,4-diaryl-6-tert-butylphenylaminyls, which were successfully isolated as radical crystals in 13-52% yields after column chromatog. The radical yields depended on the reaction time and the molar ratio of azo compounds to nitroso compounds In the same manner, acetyl- and cyano-group-carrying N-tert-alkoxyarylaminyls were generated by the reaction of 2-phenyl-4-(4-acetylphenyl)-6-tert-butylnitrosobenzene and 2-phenyl-4-(4-cyanophenyl)-6-tert-butylnitrosobenzene with 5a and 5b, and they were isolated as radical crystals. X-ray crystallog. analyses were performed for two radicals, and their mol. structures were discussed. The magnetic properties were measured for the two isolated radicals with SQUID in the temperature range 1.8-300 K. One radical showed a weak ferromagnetic interaction (θ = 0.2 K) between the radicals, and the other showed a weak antiferromagnetic interaction (θ = -3.8 K). The ferromagnetic interaction was analyzed based on the x-ray crystallog. structure.

Journal of Organic Chemistry published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kolundzic, Filip published the artcileA Cyclization-Rearrangement Cascade for the Synthesis of Structurally Complex Chiral Gold(I)-Aminocarbene Complexes, SDS of cas: 69361-41-7, the publication is Angewandte Chemie, International Edition (2014), 53(31), 8122-8126, database is CAplus and MEDLINE.

A facile synthesis of chiral cyclic alkyl aminocarbene-Au(I) complexes from Au-free 1,7-enyne substrates was developed. The novel cyclization-rearrangement reaction sequence is triggered by the addition of (Me₂S)AuCl to different 1,7-enynes and leads to structurally unique carbene-Au(I) complexes in high yields. These novel complexes are catalytically active and inhibit the proliferation of different human cancer cell lines.

Angewandte Chemie, International Edition published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, SDS of cas: 69361-41-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kajigaeshi, Shoji published the artcileOxidation using quaternary ammonium polyhalides. IV. Selective oxidation of sulfides to sulfoxides with benzyltrimethylammonium tribromide, Recommanded Product: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Bulletin of the Chemical Society of Japan (1989), 62(10), 3376-7, database is CAplus.

The reaction of sulfides with a stoichiometric amount of benzyltrimethylammonium tribromide and aqueous sodium hydroxide in dichloromethane at room temperature or in 1,2-dichloroethane under reflux gave the corresponding sulfoxides in good yields.

Bulletin of the Chemical Society of Japan published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Recommanded Product: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kajigaeshi, Shoji published the artcileOxidation of thiols to disulfides with benzyltrimethylammonium tribromide, Quality Control of 111865-47-5, the publication is Chemistry Express (1991), 6(2), 129-32, database is CAplus.

Oxidation of RSH (R = Me₂CH, Me(CH₂)_n, n = 2-5, 7, PhCH₂, p-MeC₆H₄, p-ClC₆H₄, Ph, o-, p-tolyl, 2-benzothiazolyl) with benzyltrimethylammonium tribromide and NaOH in CH₂Cl₂-H₂O at room temperature gave 60-99% 13 RSSR.

Chemistry Express published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Quality Control of 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kono, Takahiro published the artcileSynthesis and photo-electrochemical properties of novel thienopyrazine and quinoxaline derivatives, and their dye-sensitized solar cell performance, Quality Control of 52431-30-8, the publication is Organic Electronics (2012), 13(12), 3097-3101, database is CAplus.

Light absorption from visible to NIR region is required to increase the photocurrent and to enhance the photo-energy conversion efficiencies in dye-sensitized solar cells (DSSCs). We have now developed novel thienopyrazine dye TP1 which has absorption up to 700 nm. Quinoxaline dye QX2 with absorption at shorter wavelengths than TP1 has been synthesized for comparisons. The power conversion efficiencies of DSSCs with TP1 and QX2 showed 4.4% and 3.2%, resp. The absorption edge in IPCE of TP1 reached 800 nm and the open circuit voltage (Voc) of QX2 was high (0.77 V). To improve the device performances, QX2 was used as a co-adsorbent dye with TP1. In the mixed sensitizer based DSSC, a high power conversion efficiency of 6.2% was achieved due to the effective light harvesting and steric effect of QX2.

Organic Electronics published new progress about 52431-30-8. 52431-30-8 belongs to bromides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 2,5-Dibromo-3,4-dinitrothiophene, and the molecular formula is C4Br2N2O4S, Quality Control of 52431-30-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Rakowitz, Dietmar published the artcileOn the synthesis of bioisosteres of O-benzothiazolyl-oxybenzoic acids and evaluation as aldose reductase inhibitors, Formula: C7H5Br2F, the publication is Archiv der Pharmazie (Weinheim, Germany) (2005), 338(9), 419-426, database is CAplus and MEDLINE.

A series of compounds characterized by bioisosteric replacement of pharmacophores were prepd, e.g., I (R = CH(=NOH) or NO₂) and tested as aldose reductase inhibitors (ARIs). On the one hand, the acidic function was formally replaced by an oxime or a nitro group and on the other hand the lipophilic substituent was modified. The results of the biol. evaluation of these derivatives permitted to gain insight into structural features critical for the aldose reductase inhibition.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Formula: C7H5Br2F.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary