November 2022 - Page 75 of 288 - Bromides-buliding-blocks

Peglion, Jean-Louis et al. published their research in Journal of Medicinal Chemistry in 2002 | CAS: 746638-33-5

8-Bromo-6-fluorochroman (cas: 746638-33-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.SDS of cas: 746638-33-5

Improvement in the Selectivity and Metabolic Stability of the Serotonin 5-HT_1A Ligand, S 15535: A Series of cis- and trans-2-(Arylcycloalkylamine) 1-Indanols was written by Peglion, Jean-Louis;Goument, Bertrand;Despaux, Nicole;Charlot, Valerie;Giraud, Helene;Nisole, Christian;Newman-Tancredi, Adrian;Dekeyne, Anne;Bertrand, Marc;Genissel, Patrick;Millan, Mark J.. And the article was included in Journal of Medicinal Chemistry in 2002.SDS of cas: 746638-33-5 The following contents are mentioned in the article:

S 15535 (1) displays a distinctive profile of agonist and antagonist (weak partial agonist) activity at pre- and postsynaptic 5-HT_1A receptors, resp. It has proven to be active in several models predictive of anxiolytic, antidepressant, and procognitive properties. In an attempt to increase its selectivity and metabolic stability, and guided by the results of human metabolic studies, we prepared a series of cis- and trans-2-(arylcycloalkylamine) 1-indanols. Irresp. of the nature of the arylcycloalkylamine moiety or the presence of substituents on the indanol ring, trans isomers invariably showed the highest affinity for human, recombinant h5-HT_1A receptors. Among them, compounds 39, 42, 45, 49, 52, 53, 54, 57, 61, 64, 67, and 70 displayed similar or higher affinity than the parent compound 1 (pK_i ≥ 9.1). Lack of selectivity toward α₁-adrenoceptors has been frequently encountered with 5-HT_1A ligands. While S 15535 itself presents reasonable selectivity (158-fold) in this respect, trans piperazine derivatives 4-trans, 35, 39, 41, 47, 64, 68, 69, 70, 71 displayed even more pronounced selectivity vs α₁-adrenoceptors, with the nitro derivative 70 being highly selective (1259-fold). However, among the set of trans piperidines prepared, only 64, which also bears a nitro on the indanol ring, displayed selectivity greater than the parent compound 1. All trans derivatives behaved as partial agonists at h5-HT_1A receptors, as determined by their submaximal stimulation of [³⁵S]GTPγS binding to a level comparable to that observed with S 15535. In metabolic stability studies in vitro using human microsomes and hepatocytes, only trans piperazines and, in particular, 35, 39, 41, 68, 69, and 70, showed an improvement relative to 1, whereas trans piperidines did not. Compounds 35, 39, 41, and 70, which combined both improved selectivity and metabolic stability, and which retained the distinctive pharmacol. characteristics of S 15535, were evaluated in animal models of anxiety. Of these, 35, which showed the highest oral bioavailability in vivo in rats, was resolved into its two isomers 36 and 37. The eutomer 37 displayed 47% oral bioavailability in the rat and was potently active (0.1-0.5 mg/kg, s.c.) in the rat ultrasonic vocalization and social interaction models, predictive of anxiolytic activity. In conclusion, 2-(arylcycloalkylamine) 1-indanols represent a novel class of potent 5-HT_1A ligands in which the presence of the hydroxyl group in the benzylic position enhances selectivity, while substituents on the Ph ring of the indanol moiety improve both selectivity and metabolic stability. This study involved multiple reactions and reactants, such as 8-Bromo-6-fluorochroman (cas: 746638-33-5SDS of cas: 746638-33-5).

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Schwarzbauer, Jan et al. published their research in Environmental Science and Pollution Research in 2010 | CAS: 1261675-06-2

3-(4-Bromo-2-methoxyphenyl)propanoic acid (cas: 1261675-06-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Reference of 1261675-06-2

Non-target screening analysis of river water as compound-related base for monitoring measures was written by Schwarzbauer, Jan;Ricking, Mathias. And the article was included in Environmental Science and Pollution Research in 2010.Reference of 1261675-06-2 The following contents are mentioned in the article:

Building up a comprehensive accurate monitoring program requires the knowledge on the contamination in principal, complemented by detailed information on individual contaminants. The selection of pollutants to be considered in monitoring actions is based dominantly on the information available about their environmental relevance (e.g., persistence, bioaccumulation potential, toxicol. and ecotoxicol. properties) and their occurrence within the affected environmental system. Therefore, this study focused on the identification of organic contaminants in selected German and European rivers to demonstrate the usefulness of a screening approach as complementary base for the compound selection process within monitoring activities. Gas chromatog.-mass spectrometry-based screening analyses were performed on five and six samples from German and European rivers, resp. Identification of individual contaminants was based on the investigation of mass spectral and gas chromatog. properties compared with databases and reference materials. This study summarized the results of non-target screening analyses applied to river water samples and focused dominantly on, so far, unnoticed organic contaminants. Numerous compounds have been identified belonging to the groups of pharmaceuticals, tech. additives, pesticides, personal care products, and oxygen-, nitrogen-, and sulfur-containing compounds of obviously anthropogenic origin. They are discussed in terms of their structural properties, their possible application or usage, and the environmental information available so far. Generally, two different groups of compounds have been differentiated that might contribute to potential monitoring programs. Firstly, more specific contaminants characterizing the individual riverine systems have been depicted (e.g., 4-chloro-2-(trifluoromethyl)aniline, di-iso-propylurea). The consideration of these substances in monitoring analyses to be applied to the corresponding catchment areas is recommended in order to monitor the real state of pollution. Secondly, contaminants have been introduced that appeared with higher multiplicity throughout the different river systems (e.g., TMDD, TXIB). Since these compounds tend to obviously have an elevated environmental stability accompanied by a widespread distribution, it is recommended to consider them in international high-scale monitoring programs. For monitoring purposes, a fundamental knowledge on the diversity of pollutants is an important precondition, which can be supported by screening analyses. Obviously, numerous organic contaminants have been neglected so far in environmental studies on river water, comprising also investigation on potential harmful effects and, therefore, their implementation in monitoring activities has been hindered. Therefore, based on the results of this study, screening analyses should be established as principle tools to improve and complement the substance spectra for monitoring purposes. Secondly, scientific efforts should be strengthened to expand our knowledge on actually appearing organic contaminants in riverine systems. This study involved multiple reactions and reactants, such as 3-(4-Bromo-2-methoxyphenyl)propanoic acid (cas: 1261675-06-2Reference of 1261675-06-2).

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ignatenko, Vasily A.’s team published research in Organic Letters in 12 | CAS: 25753-84-8

Organic Letters published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C30H24BrCuN2P, Application In Synthesis of 25753-84-8.

Ignatenko, Vasily A. published the artcileBranch-Selective Synthesis of Oxindole and Indene Scaffolds: Transition Metal-Controlled Intramolecular Aryl Amidation Leading to C3 Reverse-Prenylated Oxindoles, Application In Synthesis of 25753-84-8, the publication is Organic Letters (2010), 12(16), 3594-3597, database is CAplus and MEDLINE.

In an effort to access biol. important scaffolds, a concise branch-selective synthesis of C3 tertiary oxindoles by Cu(I)-catalyzed aryl amidation and 2,2-dimethylindene by Pd(0)-catalyzed Heck cyclization has been accomplished from acyclic reverse-prenylated intermediates. Oxindole C3-enolate generation using NaH followed by alkylation in the presence of appropriate electrophiles provides a novel route to quaternary C3 reverse-prenylated oxindoles.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Liautard, Virginie’s team published research in Chemical Communications (Cambridge, United Kingdom) in 58 | CAS: 401-55-8

Chemical Communications (Cambridge, United Kingdom) published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Computed Properties of 401-55-8.

Liautard, Virginie published the artcileIn situ generation of radical initiators using amine-borane complexes for carbohalogenation of alkenes, Computed Properties of 401-55-8, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(13), 2124-2127, database is CAplus and MEDLINE.

Atom transfer radical addition of alkyl halides to alkenes was developed using a low amount of a stable initiator, amine borane complexes. Thanks to a slow hydroboration step, the overall carbohalogenation process led to good isolated yields.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Molander, Gary A.’s team published research in Tetrahedron in 54 | CAS: 69361-41-7

Tetrahedron published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, COA of Formula: C7H13BrSi.

Molander, Gary A. published the artcileSequential epoxide fragmentation/radical cyclizations mediated by samarium(II) iodide, COA of Formula: C7H13BrSi, the publication is Tetrahedron (1998), 54(22), 5819-5832, database is CAplus.

A sequential reductive coupling process promoted by samarium(II) iodide is described. Cascade epoxide ring opening and two sequential radical cyclizations lead to a variety of bicyclo[m.n.0] systems as mixtures of diastereomers. The cyclization of epoxide I gave II in 62% yield.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Sels, Bert F.’s team published research in Journal of the American Chemical Society in 123 | CAS: 594-81-0

Journal of the American Chemical Society published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C5H10O2S, Name: 2,3-Dibromo-2,3-dimethylbutane.

Sels, Bert F. published the artcileUse of WO₄^2- on layered double hydroxides for mild oxidative bromination and bromide-assisted epoxidation with H₂O₂, Name: 2,3-Dibromo-2,3-dimethylbutane, the publication is Journal of the American Chemical Society (2001), 123(34), 8350-8359, database is CAplus and MEDLINE.

Tungstate, exchanged on a (Ni,Al) layered double hydroxide, is applied as a heterogeneous catalyst in the oxidation of bromide with H₂O₂ and the ensuing electrophilic bromination of olefins. The high halogenation activity of the catalyst in essentially neutral conditions mimics the activity of V-bromoperoxidase enzymes. In water, aromatic and aliphatic olefins are selectively converted to bromohydrins; in methanol, methoxybromides are produced. In appropriate solvent conditions, the bromohydroxylation of geminally di-, tri-, and tetrasubstituted olefins proceeds via dehydrobromination to the epoxide. Evidence for this mechanism is provided by kinetic and labeling experiments This one-pot alternative for the two-step halohydrin epoxidation process is enabled by the mild pH conditions; bromide is effective in substoichiometric, catalytic amounts All new catalytic procedures are characterized by a high oxidative stability of the catalyst, high productivity of the catalyst on weight basis, high W turnover frequencies in ambient conditions (up to 50 mol of product per W per h), and high chemo-, regio-, and stereoselectivities.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

de Paula, Fernando H. M.’s team published research in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 634 | CAS: 143-15-7

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, Application of 1-Bromododecane.

de Paula, Fernando H. M. published the artcileAlkyl glyceryl ethers as water-based lubricant additives in mixtures with xanthan gum, Application of 1-Bromododecane, the publication is Colloids and Surfaces, A: Physicochemical and Engineering Aspects (2022), 127881, database is CAplus.

Water-based lubricants are greener and more environmentally friendly than comparable oil-based lubricants. However, water-based lubricants typically have a poorer performance and, thus, need to be formulated with various additives. Here, alkyl glyceryl ethers, a class of nonionic surfactants, were investigated as lubricant additives. To this purpose, aqueous solutions of newly synthesized ethers (with different alkyl chain lengths, C8, C10, C12, and C14) were formulated with xanthan gum. The lubrication performance of these formulations was then tested exptl. Clearly, alkyl glyceryl ethers showed a significantly improved performance (higher friction reduction) with increasing the alkyl chain length. However, the ethers had to be formulated with xanthan gum, with which they formed a complex, which promoted ether dispersion and probably adsorption on the metal surface in the aqueous phase, thereby drastically reducing friction. Thus, the alkyl glyceryl ethers synthesized in this work are attractive green and highly efficient lubricant additives, which can improve the sustainability of industrial lubrication processes.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

de Paula, Fernando H. M.’s team published research in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 634 | CAS: 111-83-1

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Recommanded Product: 1-Bromooctane.

de Paula, Fernando H. M. published the artcileAlkyl glyceryl ethers as water-based lubricant additives in mixtures with xanthan gum, Recommanded Product: 1-Bromooctane, the publication is Colloids and Surfaces, A: Physicochemical and Engineering Aspects (2022), 127881, database is CAplus.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Arrechea-Marcos, I.’s team published research in Physical Chemistry Chemical Physics in 19 | CAS: 52431-30-8

Physical Chemistry Chemical Physics published new progress about 52431-30-8. 52431-30-8 belongs to bromides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 2,5-Dibromo-3,4-dinitrothiophene, and the molecular formula is C4Br2N2O4S, Name: 2,5-Dibromo-3,4-dinitrothiophene.

Arrechea-Marcos, I. published the artcileMolecular aggregation of naphthalimide organic semiconductors assisted by amphiphilic and lipophilic interactions: a joint theoretical and experimental study, Name: 2,5-Dibromo-3,4-dinitrothiophene, the publication is Physical Chemistry Chemical Physics (2017), 19(8), 6206-6215, database is CAplus and MEDLINE.

Amphiphilic and lipophilic donor-acceptor naphthalimide-oligothiophene assemblies exhibiting almost identical intramol. properties, but differing in their intermol. interactions, were synthesized. Here the authors analyze the effect of replacing the normally used lipophilic alkyl chains with hydrophilic ones in directing mol. aggregation from an antiparallel to a parallel stacking. This different mol. packing of the amphiphilic, NIP-3T_Amphi, and lipophilic, NIP-3T_Lipo, systems is assessed by electronic spectroscopies, scanning electronic microscopy and DFT quantum-chem. calculations Theor. calculations indicate that the presence of amphiphilic interactions promotes a face-to-face parallel arrangement of neighbor mols., which induces improved electronic coupling and therefore enhances the charge transport ability and photoconducting properties of this type of materials. Time of flight and photoconducting measurements are used to determine the impact of the amphiphilic and lipophilic interactions on their possible performance in optoelectronic devices.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Braude, Irwin A.’s team published research in Journal of Biological Chemistry in 254 | CAS: 518-67-2

Journal of Biological Chemistry published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Synthetic Route of 518-67-2.

Braude, Irwin A. published the artcileMechanism of interaction of sodium dodecyl sulfate with mouse interferon, Synthetic Route of 518-67-2, the publication is Journal of Biological Chemistry (1979), 254(16), 7758-64, database is CAplus and MEDLINE.

Na dodecyl sulfate (SDS) and other alkyl sulfates, provided they contained a min. of 12 C atoms (or ≥22 Å in length), stabilized mouse interferon (MIF) in the presence of urea, 2-mercaptoethanol, and heat. When MIF was treated with the alkyl sulfates in the absence of urea and 2-mercaptoethanol, all alkyl sulfates inactivated MIF to the same extent, suggesting that the stabilizing effect of SDS on MIF most likely occurs during the refolding process. Unlike SDS, other amphiphiles such as dodecylamine, Li dodecyl sulfate, and Na 1-dodecane sulfonate did not have an appreciable stabilizing effect on MIF, thus emphasizing the necessity of specific counter-ions and polar groups for SDS to affect MIF stability. Subsequent to its reaction with SDS, MIF no longer was bound to controlled pore glass (CPG) beads. This is most likely due to SDS masking the protein’s silanol-binding sites. Furthermore, after it had reacted with interferon, a portion (∼20 to 50%) of the SDS was no longer retained by the anion exchange resin AG1-X10. Conversely, interferon (which does not bind to AG1-X2, a resin with a larger pore size than AG1-X10) was retained by the resin AG1-X2 after it has reacted with SDS. In addition, SDS-treated MIF was able to bind to the immobilized hydrophobic ligand hexyl-agarose under conditions where the majority of the MIF itself was not retained. Some SDS co-eluted with MIF from AG1-X10, indicating that SDS binds to MIF. Furthermore, since SDS-treated MIF was retained by AG1-X2 and hexyl-agarose, at least some of the detergent’s polar and hydrophobic regions are located at the surface of the interferon mol.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary