Month: November 2022

Porres, Laurent published the artcileEnhanced two-photon absorption with novel octupolar propeller-shaped fluorophores derived from triphenylamine, HPLC of Formula: 21101-63-3, the publication is Organic Letters (2004), 6(1), 47-50, database is CAplus and MEDLINE.

Novel octupolar fluorophores derived from the sym. functionalization of a triphenylamine core with strong acceptor peripheral groups via phenylene-ethynylene linkers have been synthesized and shown to exhibit high fluorescence quantum yields, very large two-photon-absorption cross-sections in the red-NIR region, and suitable photostability.

Organic Letters published new progress about 21101-63-3. 21101-63-3 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,sulfides,Benzyl bromide,Benzene, name is (4-(Bromomethyl)phenyl)(trifluoromethyl)sulfane, and the molecular formula is C8H6BrF3S, HPLC of Formula: 21101-63-3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Caputo, Romualdo published the artcileSelective debromination of substituted vic-dibromides, Computed Properties of 594-81-0, the publication is Rendiconto dell’Accademia delle Scienze Fisiche e Matematiche, Naples (1983), 50(2), 299-300, database is CAplus.

Vicinal dibromides possessing at least 1 bromine atom bonded to a tertiary carbon were debrominated by heating in DMF at 60°. Thus, heating 2β,3α-dibromo-3β-methyl-5α-cholestane in DMF 1 h gave 90% 3-methyl-5α-cholest-2-ene; heating Me₂CBrCBrMe₂ in DMF 9 h gave 80% Me₂C:CMe₂.

Rendiconto dell’Accademia delle Scienze Fisiche e Matematiche, Naples published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Computed Properties of 594-81-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Adam, Rosa published the artcileSelf-Assembly of Catalytically Active Supramolecular Coordination Compounds within Metal-Organic Frameworks, Category: bromides-buliding-blocks, the publication is Journal of the American Chemical Society (2019), 141(26), 10350-10360, database is CAplus and MEDLINE.

Supramol. coordination compounds (SCCs) represent the power of coordination chem. methodologies to self-assemble discrete architectures with targeted properties. SCCs are generally synthesized in solution, with isolated fully coordinated metal atoms as structural nodes, thus severely limited as metal-based catalysts. Metal-organic frameworks (MOFs) show unique features to act as chem. nanoreactors for the in situ synthesis and stabilization of otherwise not accessible functional species. Here, authors present the self-assembly of Pd^II SCCs within the confined space of a pre-formed MOF (SCCs@MOF) and its post-assembly metalation to give a Pd^II-Au^III supramol. assembly, crystallog. underpinned. These SCCs@MOFs catalyze the coupling of boronic acids and/or alkynes, representative multi-site metal-catalyzed reactions in which traditional SCCs tend to decompose, and retain their structural integrity as a consequence of the synergetic hybridization between SCCs and MOFs. These results open new avenues in both the synthesis of novel SCCs and their use in heterogeneous metal-based supramol. catalysis.

Journal of the American Chemical Society published new progress about 16523-02-7. 16523-02-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Sulfone,Aliphatic hydrocarbon chain, name is 2-Bromoethyl Methyl Sulfone, and the molecular formula is C3H7BrO2S, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Miura, Yozo published the artcileExceptionally persistent nitrogen-centered free radicals. Magnetic behavior and x-ray crystallographic structures of N-(arylthio)-2-tert-butyl-4,6-diarylphenylaminyl and N-(aryl-thio)-4-tert-butyl-2,6-diarylphenylaminyl radicals, Name: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals (1997), 271-278, database is CAplus.

The generation, isolation, X-ray crystallog. structures, and magnetic behavior of N-(arylthio)-2-tert-butyl-4,6-diarylphenylaminyls (2) and N-(arylthio)-4-tert-butyl-2,6-diarylphenylaminyls (3) are described. Radicals 2 and 3 were generated by PbO₂ oxidation of N-(arylthio)-2-tert-butyl-4,6-diarylanilines and N-(arylthio)-4-tert-butyl-2,6-diarylanilines, and seven radicals were isolated as the pure radical crystals. The X-ray crystallog. structures of N-[(4-nitrophenyl)thio]-6-tert-butyl-2,4-diphenylphenylaminyl and N-[(4-nitrophenyl)thio]-4-tert-butyl-2,6-diphenylphenylaminyl radicals were determined The magnetic susceptibility measurements for the isolated radicals were carried out in the temperature range 1.8-300 K with a SQUID magnetometer. Among the four radicals studied the two were analyzed by an alternating one-dimensional Heisenberg model with J₁/k = -1.8 (α = 0.86) and -18.2 K (α = 0.16), and the other two were analyzed by a one-dimensional regular Heisenberg model with J₁/k = -30.8 K or a singlet-triplet dimer model with J₁/k = -45.2 K.

Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Name: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wenny, Malia B. published the artcileUnderstanding Relationships between Free Volume and Oxygen Absorption in Ionic Liquids, HPLC of Formula: 111-83-1, the publication is Journal of Physical Chemistry B (2022), 126(6), 1268-1274, database is CAplus and MEDLINE.

Understanding the factors that govern gas absorption in ionic liquids is critical to the development of high-capacity solvents for catalysis, electrochem., and gas separations Here, we report exptl. probes of liquid structure that provide insights into how free volume impacts the O₂ absorption properties of ionic liquids Specifically, we establish that isothermal compressibility-measured rapidly and accurately through small-angle X-ray scattering-reports on the size distribution of transient voids within a representative series of ionic liquids and is correlated with O₂ absorption capacity. Addnl., O₂ absorption capacities are correlated with thermal expansion coefficients, reflecting the beneficial effect of weak intermol. interactions in ionic liquids on free volume and gas absorption capacity. Mol. dynamics simulations show that the void size distribution-in particular, the probability of forming larger voids within an ionic liquid-has a greater impact on O₂ absorption than the total free volume These results establish relationships between the ionic liquid structure and gas absorption properties that offer design strategies for ionic liquids with high gas solubilities.

Journal of Physical Chemistry B published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C25H47NO8, HPLC of Formula: 111-83-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Prakash, Chandran published the artcileSynthesis of angularly fused carbocycles via tandem radical cyclization of α-carbonyl radicals, Category: bromides-buliding-blocks, the publication is European Journal of Organic Chemistry (2008), 1535-1543, database is CAplus.

An α-carbonyl radical cyclization approach towards the synthesis of angularly fused tricyclic systems is described. On reduction with tributyltin hydride, bromo ketones yield a α-carbonyl radical that undergoes successive 5-exo-dig/trig cyclizations, resulting in two or four contiguous stereocenters.

European Journal of Organic Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Abdelhafiz, Fatma M. published the artcileDesigning of quaternized hyperbranched polyamidoamines dendrimers: Surface activity, pharmaceutical efficacy, and safety approach, HPLC of Formula: 143-15-7, the publication is Journal of Drug Delivery Science and Technology (2022), 102929, database is CAplus.

The low solubility of the drug considers a major challenge for pharmaceutical formulation of both oral and parenteral products. In this work various generations of cationic hyperbranched polyamidoamine (PAMAM) quaternary ammonium salt dendrimers terminated with amine end groups were synthesized. The pharmaceutical application of these quaternized cationic surfactants ended with amine end groups and those ended with ester end groups which prepared in an earlier study were investigated. These dendrimers were compared as solubilizing agents for coenzyme Q10 (poorly soluble drug) and the dendrimers that showed high solubilizing potential (G_2.5 C₈, G_2.5 C₁₂) were selected to be evaluated as a dendrimer in dissolution study for coenzyme Q10 or Ledipasvir drug. In our investigation a comparison between four dissolution media with different surfactants namely, G_2.5 C₈, G_2.5 C₁₂, CTAB and Labrasol used for the dissolution test of Q10 was carried out. The results revealed that % Q10 released after 4 h was 86.7, 70.5, 43 and 10.5% for these dissolution media, resp. These results indicated the priority of the synthesized cationic surfactants than the known com. cationic surfactant (CTAB) or than Labrasol as recommended surfactant in previous lectures. Therefore, the profiles of the ledipasvir dissolution in the three-dissolution media G_2.5 C₈, G_2.5 C₁₂ and FDA surfactant (1.5% tween 80 and 0.0075 mg/mL Butylated Hydroxytoluene (BHT)) are similar. The obtained results emphasized that the new surfactants can be used as alternative to FDA surfactant in the dissolution media of Ledipasvir. Eventually, the toxicity study was performed for two selected compounds from the prepared dendrimers, and these compounds were proved to be safe.

Journal of Drug Delivery Science and Technology published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, HPLC of Formula: 143-15-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Abdelhafiz, Fatma M. published the artcileDesigning of quaternized hyperbranched polyamidoamines dendrimers: Surface activity, pharmaceutical efficacy, and safety approach, Recommanded Product: 1-Bromooctane, the publication is Journal of Drug Delivery Science and Technology (2022), 102929, database is CAplus.

The low solubility of the drug considers a major challenge for pharmaceutical formulation of both oral and parenteral products. In this work various generations of cationic hyperbranched polyamidoamine (PAMAM) quaternary ammonium salt dendrimers terminated with amine end groups were synthesized. The pharmaceutical application of these quaternized cationic surfactants ended with amine end groups and those ended with ester end groups which prepared in an earlier study were investigated. These dendrimers were compared as solubilizing agents for coenzyme Q10 (poorly soluble drug) and the dendrimers that showed high solubilizing potential (G_2.5 C₈, G_2.5 C₁₂) were selected to be evaluated as a dendrimer in dissolution study for coenzyme Q10 or Ledipasvir drug. In our investigation a comparison between four dissolution media with different surfactants namely, G_2.5 C₈, G_2.5 C₁₂, CTAB and Labrasol used for the dissolution test of Q10 was carried out. The results revealed that % Q10 released after 4 h was 86.7, 70.5, 43 and 10.5% for these dissolution media, resp. These results indicated the priority of the synthesized cationic surfactants than the known com. cationic surfactant (CTAB) or than Labrasol as recommended surfactant in previous lectures. Therefore, the profiles of the ledipasvir dissolution in the three-dissolution media G_2.5 C₈, G_2.5 C₁₂ and FDA surfactant (1.5% tween 80 and 0.0075 mg/mL Butylated Hydroxytoluene (BHT)) are similar. The obtained results emphasized that the new surfactants can be used as alternative to FDA surfactant in the dissolution media of Ledipasvir. Eventually, the toxicity study was performed for two selected compounds from the prepared dendrimers, and these compounds were proved to be safe.

Journal of Drug Delivery Science and Technology published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Recommanded Product: 1-Bromooctane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Khudolei, V. V. published the artcileThe study of mutagenic activity of carcinogens and other chemical agents with Salmonella typhimurium assays: testing of 126 compounds, Quality Control of 97845-58-4, the publication is Archiv fuer Geschwulstforschung (1987), 57(6), 453-62, database is CAplus and MEDLINE.

A total of 126 chem. compounds were tested in the Ames assay with S. typhimurium of 8 various strains (mainly TA98 + TA100). For metabolic activation liver S₉ from arochlor-treated rats was used. In the first group of substances tested (51 compounds with confirmed carcinogenicity for animals) 45 agents possessed mutagenicity and 6 gave false-neg. response (1,2-dimethylhydrazine, urethane, DDT, chloroform, carbon tetrachloride, 1,4-dioxane). In group 2 (27 compounds which did not possess carcinogenic activity) 22 agents were correctly identified and the other 5 gave false-pos. responses (acrolein, styrene oxide, acridine orange, 1-naphthylamine, dichloromethane). After summation of data obtained, test sensitivity for both groups together made 88.2%; specificity 81.5% and predictive value 90%. In group 3 (48 compounds, presented by chem., pharmaceutical and food industries, for which either there are insufficient data on their carcinogenicity, or they were tested for the first time), 8 appeared mutagenic (1-aminoanthraquinone, 2-aminoanthraquinone, 1-amino-4-chloroanthraquinone, 2-amino-3-oxyanthraquinone, Rhoduline blue 5B, dinitrochlorbenzene, nitrosodiphenylamine and 2,3,5-trinitronaphthalene).

Archiv fuer Geschwulstforschung published new progress about 97845-58-4. 97845-58-4 belongs to bromides-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Bromide, name is 5-(2-Bromoethyl)-2,2-dimethyl-1,3-dioxane, and the molecular formula is C8H15BrO2, Quality Control of 97845-58-4.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Matsumoto, Mutsuyoshi published the artcileReversible Light-Induced Morphological Change in Langmuir-Blodgett Films, Recommanded Product: Sodium 3-bromopropane-1-sulfonate, the publication is Journal of the American Chemical Society (1998), 120(7), 1479-1484, database is CAplus.

An amphiphilic anionic azobenzene derivative, soluble in water, formed a monolayer on an aqueous subphase containing a water-soluble polycation. The monolayers were transferred onto solid substrate by the Langmuir-Blodgett (LB) technique. XPS measurements showed that ion exchange reaction proceeded almost completely at the air-water interface and that the ratio of the monomer unit of the polycation to the azobenzene was almost unity. UV/visible absorption and IR measurements indicated that the azobenzene photoisomerized reversibly in the LB films on alternate illumination with UV and visible light. Furthermore, a reversible morphol. change induced by light was observed in the LB films with AFM. Before illumination, the surface of the single-layer LB film was very smooth with a surface undulation of less than 1 nm. On illumination with UV light, however, a number of hills, with the height of ca. 5 nm and the diameter of the base of ca. 100 nm, appeared on the film surface. These structures almost disappeared on illumination with visible light. This indicates that the widely accepted assumption that photoisomerization should not change the two-dimensional structures significantly does not hold in the present case.

Journal of the American Chemical Society published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Recommanded Product: Sodium 3-bromopropane-1-sulfonate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary