Breen, Meghan E. published the artcileSubstrate Activity Screening with Kinases: Discovery of Small-Molecule Substrate-Competitive c-Src Inhibitors, HPLC of Formula: 1998-61-4, the publication is Angewandte Chemie, International Edition (2014), 53(27), 7010-7013, database is CAplus and MEDLINE.
Substrate-competitive kinase inhibitors represent a promising class of kinase inhibitors, however, there is no methodol. to selectively identify this type of inhibitor. Substrate activity screening was applied to tyrosine kinases. By using this methodol., the first small-mol. substrates for any protein kinase were discovered, as well as the first substrate-competitive inhibitors of c-Src with activity in both biochem. and cellular assays. Characterization of the lead inhibitor demonstrates that substrate-competitive kinase inhibitors possess unique properties, including cellular efficacy that matches biochem. potency and synergy with ATP-competitive inhibitors.
Angewandte Chemie, International Edition published new progress about 1998-61-4. 1998-61-4 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzene,Phenol, name is 4-Bromo-2,3,5,6-tetrafluorophenol, and the molecular formula is C6HBrF4O, HPLC of Formula: 1998-61-4.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary