Rawale, Dattatraya Gautam published the artcileLinchpins empower promiscuous electrophiles to enable site-selective modification of histidine and aspartic acid in proteins, Formula: C13H17BrO3, the publication is Chemical Science (2021), 12(19), 6732-6736, database is CAplus and MEDLINE.
The conservation of chemoselectivity becomes invalid for multiple electrophilic warheads during protein bioconjugation. Consequently, it leads to unpredictable heterogeneous labeling of proteins. Here, we report that a linchpin can create a unique chem. space to enable site-selectivity for histidine and aspartic acid modifications overcoming the pre-requisite of chemoselectivity.
Chemical Science published new progress about 1207448-58-5. 1207448-58-5 belongs to bromides-buliding-blocks, auxiliary class Bromide,Benzene,Phenol,Ether,Aldehyde, name is 4-((6-Bromohexyl)oxy)-2-hydroxybenzaldehyde, and the molecular formula is C13H17BrO3, Formula: C13H17BrO3.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary