Benzo[1,2-c]1,2,5-oxadiazole N-oxide derivatives as potential antitrypanosomal drugs. Structure-activity relationships. Part II was written by Aguirre, Gabriela;Cerecetto, Hugo;Di Maio, Rossanna;Gonzalez, Mercedes;Porcal, Williams;Seoane, Gustavo;Ortega, Miguel A.;Aldana, Ignacio;Monge, Antonio;Denicola, Ana. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2002.HPLC of Formula: 827-24-7 This article mentions the following:
The preparation of new derivatives of benzo[1,2-c]1,2,5-oxadiazole N-oxide is described. These derivatives were chosen to investigate and confirm previous structural features found necessary to display an adequate antitrypanosomal activity. The compounds synthesized were tested in vitro against epimastigote forms of Trypanosoma cruzi. The presence of a bromine atom in the benzo system produced compounds less active than the corresponding de-halo analogs. However, 5-(bromomethyl)-7-bromobenzo[1,2-c]oxadiazole N-oxide was the most cytotoxic compound against T. cruzi. For this, the 50% ID was determined, it was of the same order as that of Nifurtimox. From statistical anal., a relationship between lipophilic-hydrophilic balance of the derivatives with their effectiveness as antichagasic compounds could be established. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7HPLC of Formula: 827-24-7).
2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.HPLC of Formula: 827-24-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary