New Pyrano-4H-benzo[g]chromene-5,10-diones with Antiparasitic and Antioxidant Activities was written by Al Nasr, Ibrahim S.;Jentzsch, Jana;Shaikh, Amin;Singh Shuveksh, Priti;Koko, Waleed S.;Khan, Tariq A.;Ahmed, Khursheed;Schobert, Rainer;Ersfeld, Klaus;Biersack, Bernhard. And the article was included in Chemistry & Biodiversity in 2021.Synthetic Route of C8H6Br2O2 This article mentions the following:
New pyranonaphthoquinone derivatives were synthesized and investigated for their activity against Trypanosoma brucei, Leishmania major, and Toxoplasma gondii parasites. The pentafluorophenyl derivative was efficacious against T. brucei with single digit micromolar EC50 values and against T. gondii with even sub-micromolar values. The 3-chloro-4,5-dimethoxyphenyl derivative showed an activity against amastigotes of Leishmania major parasites comparable to that of amphotericin B. In addition, antioxidant activities were observed for the bromophenyl derivatives, and their redox behavior was studied by cyclovoltammetry. Anti-parasitic and antioxidative activities of the new naphthoquinone derivatives appear uncorrelated. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Synthetic Route of C8H6Br2O2).
3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Synthetic Route of C8H6Br2O2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary