Anxiolytic properties of 1-aryl-4-(phthalimidoalkyl)piperazines and their affinity to 5-HT1A serotonin and D2 dopamine receptors was written by Andronati, S. A.;Soboleva, S. G.;Makan, S. Yu.;Sava, V. M.;Kolodeev, G. E.;Voronina, T. A.;Molodavkin, G. M.. And the article was included in Pharmaceutical Chemistry Journal (Translation of Khimiko-Farmatsevticheskii Zhurnal) in 2003.Computed Properties of C13H14BrNO2 This article mentions the following:
Phthalimidoalkylpiperazines with variable polymethylene spacer lengths and different aryl fragment structures were synthesized. Their affinity to 5-HT1A serotonin and D2 dopamine receptors in rat brain and anxiolytic properties were studied. The initial ω-5-bromoalkylphthalimides were synthesized by boiling potassium phthalimide with excess dibromoalkane in acetone; bromomethylphthalimide was obtained via reaction of a 48% aqueous hydrobromic acid solution with N-(hydroxymethyl)phthalimide. Radioligand anal. showed that compounds containing one- or two-unit methylene spacer possess virtually no affinity to 5-HT1A serotonin and D2 dopamine central nervous system receptors. Substituting Me group for chlorine in the aromatic fragment leads to a significant decrease in the affinity to both 5-HT1A receptors and D2 dopamine receptors. An increase in length of the polymethylene spacer significantly decreases the binding to D2 dopamine receptors, thus rendering the compounds more selective with respect to 5-HT1A receptors. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Computed Properties of C13H14BrNO2).
N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Computed Properties of C13H14BrNO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary