Poly-6-cationic amphiphilic cyclodextrins designed for gene delivery was written by Byrne, Colin;Sallas, Florence;Rai, Dilip K.;Ogier, Julien;Darcy, Raphael. And the article was included in Organic & Biomolecular Chemistry in 2009.Related Products of 53784-83-1 This article mentions the following:
A new series of amphiphilic cyclodextrins containing cationic groups at the 6-positions and alkyl or bio-labile ester groups at the 2-positions has been synthesized. Selective 2-O-allylation followed by photochem. addition of lipophilic thiols made it possible to control lipophilicity in these meso-mols. and allow solubility and self-assembly in water. The cationic groups are cysteamine-derived, while the alkyl and ester groups are C1-C16 and benzyl ester groups. This is a new general synthetic route to a potentially wide range of polycationic cyclodextrins capable of acting as gene delivery vectors by condensing DNA and forming liquid crystalline complexes with oligonucleotides. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Related Products of 53784-83-1).
Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Related Products of 53784-83-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary