Chen, Dongdong et al. published their research in Journal of Medicinal Chemistry in 2022 | CAS: 179232-29-2

Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Category: bromides-buliding-blocks

Discovery of Novel cccDNA Reducers toward the Cure of Hepatitis B Virus Infection was written by Chen, Dongdong;Tan, Xuefei;Chen, Wenming;Liu, Yongfu;Li, Chao;Wu, Jun;Zheng, Jiamin;Shen, Hong C.;Zhang, Meifang;Wu, Waikwong;Wang, Lin;Xiong, Jing;Dai, Jieyu;Sun, Kai;Zhang, Jitao David;Xiang, Kunlun;Li, Baocun;Ni, XiaoJu;Zhu, Qihui;Gao, Lu;Wang, Li;Feng, Song. And the article was included in Journal of Medicinal Chemistry in 2022.Category: bromides-buliding-blocks This article mentions the following:

Chronic hepatitis B virus (HBV) infection is a worldwide disease that causes thousands of deaths per yr. Currently, there is no therapeutic that can completely cure already infected HBV patients due to the inability of humans to eliminate covalently closed circular DNA (cccDNA), which serves as the template to (re)initiate an infection even after prolonged viral suppression. Through phenotypic screening, xanthone series I (X = -C(O)-, -CH2-, -SO2-, etc.; Y = CH, N; Z = CH, N, CCN, etc.; R = H, Me, F, CN, etc.; R1 = pyrrolidin-1-yl, 4-methylpiperazin-1-yl, 3-carboxypyrrolidin-1-yl, etc.; R2 = H, Cl, F) that hits as novel HBV cccDNA reducers was discovered, and subsequent structure optimization led to the identification of a lead compound with improved antiviral activity and pharmacokinetic profiles. A representative compound I (X = -C(O)-; Y = Z = CH; R = H; R1 = (3R)-3-carboxypyrrolidin-1-yl; R2 = Cl) (II) demonstrated good potency and oral bioavailability with no cellular toxicity. In an HBVcircle mouse model, compound II showed excellent efficacy in significantly reducing HBV antigens, DNA, and intrahepatic cccDNA levels. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2Category: bromides-buliding-blocks).

Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary