Modifications of primaquine as antimalarials. 4. 5-Alkoxy derivatives of primaquine was written by Chen, Eugene H.;Tanabe, Keiichi;Saggiomo, Andrew J.;Nodiff, Edward A.. And the article was included in Journal of Medicinal Chemistry in 1987.Product Details of 50592-87-5 This article mentions the following:
32 5-Alkoxyprimaquines, e.g., I, were prepared, in general, by O-alkylation of hydroxynitroquinoline derivatives, e.g., II (R = H, 4-Me, etc.), with the appropriate alkyl halide, reduction of the nitro group with Fe filings in water-AcOH-Bu2O, N-alkylation of the resulting amino group with 4-halo-1-phthalimidopentane, and reaction of that product with hydrazine. The 5-alkoxyprimaquines were evaluated as blood and tissue schizonticides. Although toxicity was not completely eliminated, 4-methyl-5-pentyloxy- and 4-methyl-5-hexyloxyprimaquine were remarkably effective blood and tissue schizonticides. In the experiment, the researchers used many compounds, for example, 1-Bromo-6-methoxyhexane (cas: 50592-87-5Product Details of 50592-87-5).
1-Bromo-6-methoxyhexane (cas: 50592-87-5) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Product Details of 50592-87-5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary