Denny, R. Aldrin et al. published their research in Journal of Medicinal Chemistry in 2017 | CAS: 14425-64-0

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Quality Control of 1-(2-Bromoethyl)-4-methoxybenzene

Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain was written by Denny, R. Aldrin;Flick, Andrew C.;Coe, Jotham;Langille, Jonathan;Basak, Arindrajit;Liu, Shenping;Stock, Ingrid;Sahasrabudhe, Parag;Bonin, Paul;Hay, Duncan A.;Brennan, Paul E.;Pletcher, Mathew;Jones, Lyn H.;Chekler, Eugene L. Piatnitski. And the article was included in Journal of Medicinal Chemistry in 2017.Quality Control of 1-(2-Bromoethyl)-4-methoxybenzene This article mentions the following:

Chem. probes are required for preclin. target validation to interrogate novel biol. targets and pathways. Selective inhibitors of the CREB binding protein (CREBBP)/EP300 bromodomains are required to facilitate the elucidation of biol. associated with these important epigenetic targets. Medicinal chem. optimization that paid particular attention to physiochem. properties delivered chem. probes with desirable potency, selectivity, and permeability attributes. An important feature of the optimization process was the successful application of rational structure-based drug design to address bromodomain selectivity issues (particularly against the structurally related BRD4 protein). In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Quality Control of 1-(2-Bromoethyl)-4-methoxybenzene).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Quality Control of 1-(2-Bromoethyl)-4-methoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary