Calcium-catalyzed carboarylation of alkynes was written by Fu, Liang;Niggemann, Meike. And the article was included in Chemistry – A European Journal in 2015.Application of 14425-64-0 This article mentions the following:
The first transition-metal-free carboarylation of alkynes with com. and readily available alcs. as alkylating agents was realized in the presence of an environmentally benign calcium catalyst. Thereby, a novel protocol for the one-step synthesis of highly congested, all-carbon tetrasubstituted alkenes, as incorporated in potentially bioactive, complex dihydronaphthalene, chromene and dihydroquinoline structures, e.g., I, was provided. The reaction features an unprecedented, particularly wide substrate scope, good functional-group tolerance and simple exptl. operation under mild reaction conditions. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Application of 14425-64-0).
1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Application of 14425-64-0
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary