Phosphorylation of per-6-bromo-per-6-deoxy-β-cyclodextrin was written by Grachev, M. K.;Mustafin, I. G.;Nifant’ev, E. E.. And the article was included in Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) in 1998.Safety of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin This article mentions the following:
Phosphorylation of per-6-bromo-per-6-deoxy-β-cyclodextrin with alkylene phosphochloridites was studied with the aim of preparing phosphorus-containing cyclodextrins substituted with polar groups and capable of definite orientation on an organic liquid-water phase boundary. The bromodeoxy derivative of β-cyclodextrin alkylates pyridine with a high yield to give the corresponding pyridinium salts readily soluble in water and polar solvents. Trimethylsilyl derivatives of β-cyclodextrin were obtained, which are highly soluble in organic solvents and are regioselectively phosphorylated with phosphochloridites. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Safety of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin).
Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Safety of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary